COX7C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COX7C
Entrez Gene ID	1350
Full Name	cytochrome c oxidase subunit 7C
General protein information	Preferred Names cytochrome c oxidase subunit 7C Names cytochrome c oxidase subunit 7C, mitochondrial cytochrome c oxidase polypeptide VIIc cytochrome c oxidase subunit VIIc cytochrome-c oxidase chain VIIc
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q14.3
Summary	Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13. [provided by RefSeq, Jul 2008].
Disorder MIM:	603774

mRNA and Protein(s)

mRNA	Protein	Name
NM_001867.2	NP_001858.1	cytochrome c oxidase subunit 7C, mitochondrial precursor
NM_001867.3	NP_001858.1	cytochrome c oxidase subunit 7C, mitochondrial precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	COX7C	NP_001858.1
Pan troglodytes (chimpanzee)	COX7C	NP_001073391.1
	LOC100423151	XP_002804747.1
Pan troglodytes (chimpanzee)	LOC740780	XP_003950243.1
Canis lupus familiaris (dog)	LOC100686264	XP_005638433.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
Evans DM, Zhu G, Dy V, Heath AC, Madden PA, Kemp JP, McMahon G, St Pourcain B, Timpson NJ, Golding J, Lawlor DA, Steer C, Montgomery GW, Martin NG, Smith GD, Whitfield JB
Human molecular genetics22(19)3998-4006(2013 Oct)

Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes.
Zhao X, Le?n IR, Bak S, Mogensen M, Wrzesinski K, H?jlund K, Jensen ON
Molecular & cellular proteomics : MCP10(1)M110.000299(2011 Jan)

Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells.
Sirchia R, Luparello C
Biological chemistry388(5)457-65(2007 May)

Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping.
Hofmann S, Lichtner P, Schuffenhauer S, Gerbitz KD, Meitinger T
Cytogenetics and cell genetics83(3-4)226-7(1998)

Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex.
Lenka N, Vijayasarathy C, Mullick J, Avadhani NG
Progress in nucleic acid research and molecular biology61309-44(1998)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following COX7C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COX7C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13217	NM_001867.3 Latest version!	Homo sapiens cytochrome c oxidase subunit 7C (COX7C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu13217	NM_001867.2	Homo sapiens cytochrome c oxidase subunit 7C (COX7C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COX7C ( NM_001867.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001858.1 Homo sapiens cytochrome c oxidase subunit 7C (COX7C), mRNA.

Price & Availability↑

CloneID	OHu13217
Clone ID Related Accession (Same CDS sequence)	NM_001867.2 , NM_001867.3
Accession Version	NM_001867.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 192bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 7C, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC001005.2. On Jan 10, 2002 this sequence version replaced NM_001867.1. ##Evidence-Data-START## Transcript exon combination :: BC001005.2, BG500846.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTGGGCC AGAGCATCCG GAGGTTCACA ACCTCTGTGG TCCGTAGGAG CCACTATGAG 
GAGGGCCCTG GGAAGAATTT GCCATTTTCA GTGGAAAACA AGTGGTCGTT ACTAGCTAAG 
ATGTGTTTGT ACTTTGGATC TGCATTTGCT ACACCCTTCC TTGTAGTAAG ACACCAACTG 
CTTAAAACAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001858.1
CDS	90..281
Translation	MLGQSIRRFTTSVVRRSHYEEGPGKNLPFSVENKWSLLAKMCLYFGSAFATPFLVVRHQLLKT

Target ORF information:

RefSeq Version	NM_001867.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 7C (COX7C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001867.2

ORF Insert Sequence:

ATGTTGGGCC AGAGCATCCG GAGGTTCACA ACCTCTGTGG TCCGTAGGAG CCACTATGAG 
GAGGGCCCTG GGAAGAATTT GCCATTTTCA GTGGAAAACA AGTGGTCGTT ACTAGCTAAG 
ATGTGTTTGT ACTTTGGATC TGCATTTGCT ACACCCTTCC TTGTAGTAAG ACACCAACTG 
CTTAAAACAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX7C ( NM_001867.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001858.1 Homo sapiens cytochrome c oxidase subunit 7C (COX7C), mRNA.

Price & Availability↑

CloneID	OHu13217
Clone ID Related Accession (Same CDS sequence)	NM_001867.2 , NM_001867.3
Accession Version	NM_001867.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 192bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 7C, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC108110.3 and BC001005.2. On Nov 22, 2018 this sequence version replaced NM_001867.2. ##Evidence-Data-START## Transcript exon combination :: CD175575.1, SRR5189667.237129.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000247655.4/ ENSP00000247655.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTGGGCC AGAGCATCCG GAGGTTCACA ACCTCTGTGG TCCGTAGGAG CCACTATGAG 
GAGGGCCCTG GGAAGAATTT GCCATTTTCA GTGGAAAACA AGTGGTCGTT ACTAGCTAAG 
ATGTGTTTGT ACTTTGGATC TGCATTTGCT ACACCCTTCC TTGTAGTAAG ACACCAACTG 
CTTAAAACAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001858.1
CDS	116..307
Translation	MLGQSIRRFTTSVVRRSHYEEGPGKNLPFSVENKWSLLAKMCLYFGSAFATPFLVVRHQLLKT

Target ORF information:

RefSeq Version	NM_001867.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 7C (COX7C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001867.3

ORF Insert Sequence:

ATGTTGGGCC AGAGCATCCG GAGGTTCACA ACCTCTGTGG TCCGTAGGAG CCACTATGAG 
GAGGGCCCTG GGAAGAATTT GCCATTTTCA GTGGAAAACA AGTGGTCGTT ACTAGCTAAG 
ATGTGTTTGT ACTTTGGATC TGCATTTGCT ACACCCTTCC TTGTAGTAAG ACACCAACTG 
CTTAAAACAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
Human molecular genetics22(19)3998-4006(2013 Oct)
Evans DM,Zhu G,Dy V,Heath AC,Madden PA,Kemp JP,McMahon G,St Pourcain B,Timpson NJ,Golding J,Lawlor DA,Steer C,Montgomery GW,Martin NG,Smith GD,Whitfield JB

Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes.
Molecular & cellular proteomics : MCP10(1)M110.000299(2011 Jan)
Zhao X,Le?n IR,Bak S,Mogensen M,Wrzesinski K,H?jlund K,Jensen ON

Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells.
Biological chemistry388(5)457-65(2007 May)
Sirchia R,Luparello C

Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping.
Cytogenetics and cell genetics83(3-4)226-7(1998)
Hofmann S,Lichtner P,Schuffenhauer S,Gerbitz KD,Meitinger T

Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex.
Progress in nucleic acid research and molecular biology61309-44(1998)
Lenka N,Vijayasarathy C,Mullick J,Avadhani NG