NUPR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NUPR1
Entrez Gene ID	26471
Full Name	nuclear protein 1, transcriptional regulator
Synonyms	COM1,P8
General protein information	Preferred Names nuclear protein 1, transcriptional regulator Names nuclear protein 1 candidate of metastasis 1 nuclear protein, transcriptional regulator, 1 nuclear transcriptional regulator protein 1 protein p8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p11.2
Disorder MIM:	614812

mRNA and Protein(s)

mRNA	Protein	Name
NM_012385.2	NP_036517.1	nuclear protein 1 isoform b
NM_001042483.2	NP_001035948.1	nuclear protein 1 isoform a
NM_001042483.1	NP_001035948.1	nuclear protein 1 isoform a
NM_012385.3	NP_036517.1	nuclear protein 1 isoform b

Pathways from BioSystems

Homologies

Homo sapiens (human)	NUPR1	NP_036517.1
Rattus norvegicus (Norway rat)	Nupr1	NP_446063.1
Rattus norvegicus (Norway rat)	P8	XP_006230263.1
Bos taurus (cattle)	NUPR1	NP_001107987.1
Canis lupus familiaris (dog)	NUPR1	XP_536921.2
Mus musculus (house mouse)	Nupr1	NP_062712.1

Gene Ontology
Bibliography

Related articles in PubMed

NUPR1 maintains autolysosomal efflux by activating SNAP25 transcription in cancer cells.
Mu Y, Yan X, Li D, Zhao D, Wang L, Wang X, Gao D, Yang J, Zhang H, Li Y, Sun Y, Wei Y, Zhang Z, Chang X, Yao Z, Tian S, Zhang K, Terada LS, Ma Z, Liu Z
Autophagy1-17(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Knockdown of nuclear protein-1 inhibits the proliferation of humans glioblastoma cells via ERK1/2, p38 MAPK and caspase-3.
Title: Knockdown of NUPR1 inhibits the proliferation of glioblastoma cells via ERK1/2, p38 MAPK and caspase-3.

dietary protein dilution promotes improved glucose homeostasis through an select nonessential amino acids insufficiency-induced liver NUPR1/FGF21 axis
Title: A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution.

NUPR1/RELB/IER3/RUNX2 pathway has a pivotal role in hepatocarcinogenesis.
Title: NUPR1, a new target in liver cancer: implication in controlling cell growth, migration, invasion and sorafenib resistance.

findings suggest that local interactions and hydrophobic effects play a major role in determining the electrostatic features of NUPR1, whereas long-range charge contributions appear to be of lesser importance.
Title: Determinants of the pKa values of ionizable residues in an intrinsically disordered protein.

Hexavalent Cr(VI) induces Nupr1 and rapidly perturbs gene expression by downregulating H4K16 acetylation, thereby contributing to Cr(VI)-induced carcinogenesis.
Title: Hexavalent Chromium (Cr(VI)) Down-Regulates Acetylation of Histone H4 at Lysine 16 through Induction of Stressor Protein Nupr1.

The following NUPR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NUPR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05101	NM_001042483.2 Latest version!	Homo sapiens nuclear protein 1, transcriptional regulator (NUPR1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu06200	NM_012385.3 Latest version!	Homo sapiens nuclear protein 1, transcriptional regulator (NUPR1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu05101	NM_001042483.1	Homo sapiens nuclear protein 1, transcriptional regulator (NUPR1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu06200	NM_012385.2	Homo sapiens nuclear protein 1, transcriptional regulator (NUPR1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NUPR1 ( NM_001042483.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001035948.1 Homo sapiens nuclear protein 1, transcriptional regulator (NUPR1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu05101
Clone ID Related Accession (Same CDS sequence)	NM_001042483.2 , NM_001042483.1
Accession Version	NM_001042483.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	nuclear protein 1 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP214401.1, BF965595.1, AF069073.1 and AC020765.8. On Jun 2, 2019 this sequence version replaced NM_001042483.1. Transcript Variant: This variant (1) encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU689422.1, SRR7346977.198413.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCACCT TCCCACCAGC AACCAGCGCC CCCCAGCAGC CCCCAGGCCC GGAGGACGAG 
GACTCCAGCC TGGATGAATC TGACCTCTAT AGCCTGGCCC ATTCCTACCT CGGGCCTCTC 
ATCATGCCTA TGCCCACTTC ACCTCTGACT CCTGCCTTGG TTACAGGAGG TGGAGGCCGG 
AAAGGTCGCA CCAAGAGAGA AGCTGCTGCC AACACCAACC GCCCCAGCCC TGGCGGGCAC 
GAGAGGAAAC TGGTGACCAA GCTGCAGAAT TCAGAGAGGA AGAAGCGAGG GGCACGGCGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035948.1
CDS	68..370
Translation	MATFPPATSAPQQPPGPEDEDSSLDESDLYSLAHSYLGPLIMPMPTSPLTPALVTGGGGRKGRTKREAAANTNRPSPGGHERKLVTKLQNSERKKRGARR

Target ORF information:

RefSeq Version	NM_001042483.2
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear protein 1, transcriptional regulator (NUPR1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001042483.2

ORF Insert Sequence:

ATGGCCACCT TCCCACCAGC AACCAGCGCC CCCCAGCAGC CCCCAGGCCC GGAGGACGAG 
GACTCCAGCC TGGATGAATC TGACCTCTAT AGCCTGGCCC ATTCCTACCT CGGGCCTCTC 
ATCATGCCTA TGCCCACTTC ACCTCTGACT CCTGCCTTGG TTACAGGAGG TGGAGGCCGG 
AAAGGTCGCA CCAAGAGAGA AGCTGCTGCC AACACCAACC GCCCCAGCCC TGGCGGGCAC 
GAGAGGAAAC TGGTGACCAA GCTGCAGAAT TCAGAGAGGA AGAAGCGAGG GGCACGGCGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NUPR1 ( NM_001042483.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001035948.1 Homo sapiens nuclear protein 1, transcriptional regulator (NUPR1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu05101
Clone ID Related Accession (Same CDS sequence)	NM_001042483.2 , NM_001042483.1
Accession Version	NM_001042483.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-11
Organism	Homo sapiens(human)
Product	nuclear protein 1 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP214401.1, BF965595.1 and AF069073.1. Transcript Variant: This variant (1) encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU689422.1, BI858472.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCACCT TCCCACCAGC AACCAGCGCC CCCCAGCAGC CCCCAGGCCC GGAGGACGAG 
GACTCCAGCC TGGATGAATC TGACCTCTAT AGCCTGGCCC ATTCCTACCT CGGGCCTCTC 
ATCATGCCTA TGCCCACTTC ACCTCTGACT CCTGCCTTGG TTACAGGAGG TGGAGGCCGG 
AAAGGTCGCA CCAAGAGAGA AGCTGCTGCC AACACCAACC GCCCCAGCCC TGGCGGGCAC 
GAGAGGAAAC TGGTGACCAA GCTGCAGAAT TCAGAGAGGA AGAAGCGAGG GGCACGGCGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035948.1
CDS	268..570
Translation	MATFPPATSAPQQPPGPEDEDSSLDESDLYSLAHSYLGPLIMPMPTSPLTPALVTGGGGRKGRTKREAAANTNRPSPGGHERKLVTKLQNSERKKRGARR

Target ORF information:

RefSeq Version	NM_001042483.1
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear protein 1, transcriptional regulator (NUPR1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001042483.1

ORF Insert Sequence:

ATGGCCACCT TCCCACCAGC AACCAGCGCC CCCCAGCAGC CCCCAGGCCC GGAGGACGAG 
GACTCCAGCC TGGATGAATC TGACCTCTAT AGCCTGGCCC ATTCCTACCT CGGGCCTCTC 
ATCATGCCTA TGCCCACTTC ACCTCTGACT CCTGCCTTGG TTACAGGAGG TGGAGGCCGG 
AAAGGTCGCA CCAAGAGAGA AGCTGCTGCC AACACCAACC GCCCCAGCCC TGGCGGGCAC 
GAGAGGAAAC TGGTGACCAA GCTGCAGAAT TCAGAGAGGA AGAAGCGAGG GGCACGGCGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NUPR1 ( NM_012385.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036517.1 Homo sapiens nuclear protein 1, transcriptional regulator (NUPR1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu06200
Clone ID Related Accession (Same CDS sequence)	NM_012385.2 , NM_012385.3
Accession Version	NM_012385.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 249bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-11
Organism	Homo sapiens(human)
Product	nuclear protein 1 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP214401.1 and AF069073.1. On Jul 1, 2006 this sequence version replaced NM_012385.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF069073.1, ERR279865.917.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCACCT TCCCACCAGC AACCAGCGCC CCCCAGCAGC CCCCAGGCCC GGAGGACGAG 
GACTCCAGCC TGGATGAATC TGACCTCTAT AGCCTGGCCC ATTCCTACCT CGGAGGTGGA 
GGCCGGAAAG GTCGCACCAA GAGAGAAGCT GCTGCCAACA CCAACCGCCC CAGCCCTGGC 
GGGCACGAGA GGAAACTGGT GACCAAGCTG CAGAATTCAG AGAGGAAGAA GCGAGGGGCA 
CGGCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036517.1
CDS	268..516
Translation	MATFPPATSAPQQPPGPEDEDSSLDESDLYSLAHSYLGGGGRKGRTKREAAANTNRPSPGGHERKLVTKLQNSERKKRGARR

Target ORF information:

RefSeq Version	NM_012385.2
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear protein 1, transcriptional regulator (NUPR1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012385.2

ORF Insert Sequence:

ATGGCCACCT TCCCACCAGC AACCAGCGCC CCCCAGCAGC CCCCAGGCCC GGAGGACGAG 
GACTCCAGCC TGGATGAATC TGACCTCTAT AGCCTGGCCC ATTCCTACCT CGGAGGTGGA 
GGCCGGAAAG GTCGCACCAA GAGAGAAGCT GCTGCCAACA CCAACCGCCC CAGCCCTGGC 
GGGCACGAGA GGAAACTGGT GACCAAGCTG CAGAATTCAG AGAGGAAGAA GCGAGGGGCA 
CGGCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NUPR1 ( NM_012385.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036517.1 Homo sapiens nuclear protein 1, transcriptional regulator (NUPR1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu06200
Clone ID Related Accession (Same CDS sequence)	NM_012385.2 , NM_012385.3
Accession Version	NM_012385.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 249bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	nuclear protein 1 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF069073.1 and AC020765.8. On Jun 3, 2019 this sequence version replaced NM_012385.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.1075112.1, SRR7346977.1273103.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCACCT TCCCACCAGC AACCAGCGCC CCCCAGCAGC CCCCAGGCCC GGAGGACGAG 
GACTCCAGCC TGGATGAATC TGACCTCTAT AGCCTGGCCC ATTCCTACCT CGGAGGTGGA 
GGCCGGAAAG GTCGCACCAA GAGAGAAGCT GCTGCCAACA CCAACCGCCC CAGCCCTGGC 
GGGCACGAGA GGAAACTGGT GACCAAGCTG CAGAATTCAG AGAGGAAGAA GCGAGGGGCA 
CGGCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036517.1
CDS	68..316
Translation	MATFPPATSAPQQPPGPEDEDSSLDESDLYSLAHSYLGGGGRKGRTKREAAANTNRPSPGGHERKLVTKLQNSERKKRGARR

Target ORF information:

RefSeq Version	NM_012385.3
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear protein 1, transcriptional regulator (NUPR1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012385.3

ORF Insert Sequence:

ATGGCCACCT TCCCACCAGC AACCAGCGCC CCCCAGCAGC CCCCAGGCCC GGAGGACGAG 
GACTCCAGCC TGGATGAATC TGACCTCTAT AGCCTGGCCC ATTCCTACCT CGGAGGTGGA 
GGCCGGAAAG GTCGCACCAA GAGAGAAGCT GCTGCCAACA CCAACCGCCC CAGCCCTGGC 
GGGCACGAGA GGAAACTGGT GACCAAGCTG CAGAATTCAG AGAGGAAGAA GCGAGGGGCA 
CGGCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NUPR1 maintains autolysosomal efflux by activating SNAP25 transcription in cancer cells.
Autophagy1-17(2017 Nov)
Mu Y,Yan X,Li D,Zhao D,Wang L,Wang X,Gao D,Yang J,Zhang H,Li Y,Sun Y,Wei Y,Zhang Z,Chang X,Yao Z,Tian S,Zhang K,Terada LS,Ma Z,Liu Z

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NUPR1 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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