RAB4B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RAB4B
Entrez Gene ID	53916
Full Name	RAB4B, member RAS oncogene family
General protein information	Preferred Names RAB4B, member RAS oncogene family Names ras-related protein Rab-4B ras-related GTP-binding protein 4b small GTP binding protein RAB4B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.2
Summary	RAB proteins, such as RAB4B, are members of the RAS superfamily of small GTPases that are involved in vesicular trafficking (He et al., 2002 [PubMed 12450215]).[supplied by OMIM, Aug 2009].
Disorder MIM:	612945

mRNA and Protein(s)

mRNA	Protein	Name
NM_016154.5	NP_057238.3	ras-related protein Rab-4B
NM_016154.4	NP_057238.3	ras-related protein Rab-4B

Pathways from BioSystems

Homologies

Bos taurus (cattle)	RAB4B	NP_001121979.1
Danio rerio (zebrafish)	rab4b	NP_001004002.1
Xenopus tropicalis (tropical clawed frog)	rab4b	NP_001016987.1
Homo sapiens (human)	RAB4B	NP_057238.3
Drosophila melanogaster (fruit fly)	Rab4	NP_523777.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004204	XP_313105.2
Mus musculus (house mouse)	Rab4b	NP_083667.1
Canis lupus familiaris (dog)	RAB4B	NP_001003275.1
Rattus norvegicus (Norway rat)	Rab4b	NP_059051.1

Gene Ontology
Bibliography

Related articles in PubMed

Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients.
Thean LF, Wong YH, Lo M, Loi C, Chew MH, Tang CL, Cheah PY
PloS one12(3)e0173772(2017)

Rab4b controls an early endosome sorting event by interacting with the ?-subunit of the clathrin adaptor complex 1.
Perrin L, Laura P, Lacas-Gervais S, Sandra LG, Gilleron J, J?r?me G, Ceppo F, Franck C, Prodon F, Fran?ois P, Benmerah A, Alexandre B, Tanti JF, Jean-Fran?ois T, Cormont M, Mireille C
Journal of cell science126(Pt 21)4950-62(2013 Nov)

Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.
Khor CC, Davila S, Breunis WB, Lee YC, Shimizu C, Wright VJ, Yeung RS, Tan DE, Sim KS, Wang JJ, Wong TY, Pang J, Mitchell P, Cimaz R, Dahdah N, Cheung YF, Huang GY, Yang W, Park IS, Lee JK, Wu JY, Levin M, Burns JC, Burgner D, Kuijpers TW, Hibberd ML, , , , , ,
Nature genetics43(12)1241-6(2011 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

real-time RT-PCR assays showed that expressions of MIA and MIA-RAB4B located 35 kb upstream of the deletion, were up-regulated in the polyps compared to the matched mucosa of the proband. MIA-RAB4B, the read-through long non-coding RNA (lncRNA), RAB4B, PIM2 and TAOK1 share common binding site of a microRNA, miR-24, in their 3'UTRs
Title: Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients.

Interaction between Rab4b and AP1gamma allows the budding of clathrin-coated vesicles for subsequent traffic to recycling endosomes.
Title: Rab4b controls an early endosome sorting event by interacting with the ?-subunit of the clathrin adaptor complex 1.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Data conclude that Rab4b is a new important player in the control of GLUT4 trafficking in adipocyte.
Title: Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte.

The following RAB4B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAB4B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13864	NM_016154.5 Latest version!	Homo sapiens RAB4B, member RAS oncogene family (RAB4B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu13864	NM_016154.4	Homo sapiens RAB4B, member RAS oncogene family (RAB4B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RAB4B ( NM_016154.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057238.3 Homo sapiens RAB4B, member RAS oncogene family (RAB4B), mRNA.

Price & Availability↑

CloneID	OHu13864
Clone ID Related Accession (Same CDS sequence)	NM_016154.5 , NM_016154.4
Accession Version	NM_016154.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	ras-related protein Rab-4B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG706803.1, BC046927.1 and AI083750.1. On Nov 23, 2018 this sequence version replaced NM_016154.4. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.200270.1, SRR1660809.99136.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000357052.8/ ENSP00000349560.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGAGA CCTACGACTT CCTCTTCAAA TTCCTGGTGA TTGGCAGTGC AGGAACTGGC 
AAATCATGTC TCCTTCATCA GTTCATTGAG AATAAGTTCA AACAGGACTC CAACCACACA 
ATCGGCGTGG AGTTTGGATC CCGGGTGGTC AACGTGGGTG GGAAGACTGT GAAGCTACAG 
ATTTGGGACA CGGCTGGCCA GGAGCGGTTT CGGTCAGTGA CGCGGAGTTA TTACCGAGGG 
GCGGCTGGAG CCCTGCTGGT GTACGACATC ACCAGCCGGG AGACATACAA CTCACTGGCT 
GCCTGGCTGA CGGATGCCCG CACCCTGGCC AGCCCCAACA TCGTGGTCAT CCTCTGTGGC 
AACAAGAAGG ACCTGGACCC TGAGCGGGAG GTCACTTTCC TGGAGGCCTC CCGCTTTGCC 
CAGGAGAATG AGCTGATGTT CCTGGAGACC AGCGCTCTCA CAGGCGAGAA CGTGGAGGAG 
GCGTTCCTCA AGTGTGCCCG CACTATCCTC AACAAGATTG ACTCAGGCGA GCTAGACCCG 
GAGAGGATGG GCTCTGGCAT TCAGTACGGG GATGCGTCCC TCCGCCAGCT TCGGCAGCCT 
CGGAGTGCCC AGGCCGTGGC CCCTCAGCCG TGTGGCTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057238.3
CDS	130..771
Translation	MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDSNHTIGVEFGSRVVNVGGKTVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLASPNIVVILCGNKKDLDPEREVTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDSGELDPERMGSGIQYGDASLRQLRQPRSAQAVAPQPCGC

Target ORF information:

RefSeq Version	NM_016154.5
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB4B, member RAS oncogene family (RAB4B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016154.5

ORF Insert Sequence:

ATGGCTGAGA CCTACGACTT CCTCTTCAAA TTCCTGGTGA TTGGCAGTGC AGGAACTGGC 
AAATCATGTC TCCTTCATCA GTTCATTGAG AATAAGTTCA AACAGGACTC CAACCACACA 
ATCGGCGTGG AGTTTGGATC CCGGGTGGTC AACGTGGGTG GGAAGACTGT GAAGCTACAG 
ATTTGGGACA CGGCTGGCCA GGAGCGGTTT CGGTCAGTGA CGCGGAGTTA TTACCGAGGG 
GCGGCTGGAG CCCTGCTGGT GTACGACATC ACCAGCCGGG AGACATACAA CTCACTGGCT 
GCCTGGCTGA CGGATGCCCG CACCCTGGCC AGCCCCAACA TCGTGGTCAT CCTCTGTGGC 
AACAAGAAGG ACCTGGACCC TGAGCGGGAG GTCACTTTCC TGGAGGCCTC CCGCTTTGCC 
CAGGAGAATG AGCTGATGTT CCTGGAGACC AGCGCTCTCA CAGGCGAGAA CGTGGAGGAG 
GCGTTCCTCA AGTGTGCCCG CACTATCCTC AACAAGATTG ACTCAGGCGA GCTAGACCCG 
GAGAGGATGG GCTCTGGCAT TCAGTACGGG GATGCGTCCC TCCGCCAGCT TCGGCAGCCT 
CGGAGTGCCC AGGCCGTGGC CCCTCAGCCG TGTGGCTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB4B ( NM_016154.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057238.3 Homo sapiens RAB4B, member RAS oncogene family (RAB4B), mRNA.

Price & Availability↑

CloneID	OHu13864
Clone ID Related Accession (Same CDS sequence)	NM_016154.5 , NM_016154.4
Accession Version	NM_016154.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-10
Organism	Homo sapiens(human)
Product	ras-related protein Rab-4B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG706803.1, BC046927.1 and AI083750.1. On Feb 4, 2011 this sequence version replaced NM_016154.3. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.284199.1, SRR1163657.401056.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGAGA CCTACGACTT CCTCTTCAAA TTCCTGGTGA TTGGCAGTGC AGGAACTGGC 
AAATCATGTC TCCTTCATCA GTTCATTGAG AATAAGTTCA AACAGGACTC CAACCACACA 
ATCGGCGTGG AGTTTGGATC CCGGGTGGTC AACGTGGGTG GGAAGACTGT GAAGCTACAG 
ATTTGGGACA CGGCTGGCCA GGAGCGGTTT CGGTCAGTGA CGCGGAGTTA TTACCGAGGG 
GCGGCTGGAG CCCTGCTGGT GTACGACATC ACCAGCCGGG AGACATACAA CTCACTGGCT 
GCCTGGCTGA CGGATGCCCG CACCCTGGCC AGCCCCAACA TCGTGGTCAT CCTCTGTGGC 
AACAAGAAGG ACCTGGACCC TGAGCGGGAG GTCACTTTCC TGGAGGCCTC CCGCTTTGCC 
CAGGAGAATG AGCTGATGTT CCTGGAGACC AGCGCTCTCA CAGGCGAGAA CGTGGAGGAG 
GCGTTCCTCA AGTGTGCCCG CACTATCCTC AACAAGATTG ACTCAGGCGA GCTAGACCCG 
GAGAGGATGG GCTCTGGCAT TCAGTACGGG GATGCGTCCC TCCGCCAGCT TCGGCAGCCT 
CGGAGTGCCC AGGCCGTGGC CCCTCAGCCG TGTGGCTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057238.3
CDS	158..799
Translation	MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDSNHTIGVEFGSRVVNVGGKTVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLASPNIVVILCGNKKDLDPEREVTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDSGELDPERMGSGIQYGDASLRQLRQPRSAQAVAPQPCGC

Target ORF information:

RefSeq Version	NM_016154.4
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB4B, member RAS oncogene family (RAB4B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016154.4

ORF Insert Sequence:

ATGGCTGAGA CCTACGACTT CCTCTTCAAA TTCCTGGTGA TTGGCAGTGC AGGAACTGGC 
AAATCATGTC TCCTTCATCA GTTCATTGAG AATAAGTTCA AACAGGACTC CAACCACACA 
ATCGGCGTGG AGTTTGGATC CCGGGTGGTC AACGTGGGTG GGAAGACTGT GAAGCTACAG 
ATTTGGGACA CGGCTGGCCA GGAGCGGTTT CGGTCAGTGA CGCGGAGTTA TTACCGAGGG 
GCGGCTGGAG CCCTGCTGGT GTACGACATC ACCAGCCGGG AGACATACAA CTCACTGGCT 
GCCTGGCTGA CGGATGCCCG CACCCTGGCC AGCCCCAACA TCGTGGTCAT CCTCTGTGGC 
AACAAGAAGG ACCTGGACCC TGAGCGGGAG GTCACTTTCC TGGAGGCCTC CCGCTTTGCC 
CAGGAGAATG AGCTGATGTT CCTGGAGACC AGCGCTCTCA CAGGCGAGAA CGTGGAGGAG 
GCGTTCCTCA AGTGTGCCCG CACTATCCTC AACAAGATTG ACTCAGGCGA GCTAGACCCG 
GAGAGGATGG GCTCTGGCAT TCAGTACGGG GATGCGTCCC TCCGCCAGCT TCGGCAGCCT 
CGGAGTGCCC AGGCCGTGGC CCCTCAGCCG TGTGGCTGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients.
PloS one12(3)e0173772(2017)
Thean LF,Wong YH,Lo M,Loi C,Chew MH,Tang CL,Cheah PY

Rab4b controls an early endosome sorting event by interacting with the ?-subunit of the clathrin adaptor complex 1.
Journal of cell science126(Pt 21)4950-62(2013 Nov)
Perrin L,Laura P,Lacas-Gervais S,Sandra LG,Gilleron J,J?r?me G,Ceppo F,Franck C,Prodon F,Fran?ois P,Benmerah A,Alexandre B,Tanti JF,Jean-Fran?ois T,Cormont M,Mireille C

Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.
Nature genetics43(12)1241-6(2011 Nov)
Khor CC,Davila S,Breunis WB,Lee YC,Shimizu C,Wright VJ,Yeung RS,Tan DE,Sim KS,Wang JJ,Wong TY,Pang J,Mitchell P,Cimaz R,Dahdah N,Cheung YF,Huang GY,Yang W,Park IS,Lee JK,Wu JY,Levin M,Burns JC,Burgner D,Kuijpers TW,Hibberd ML,,,,,,

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RAB4B cDNA ORF clone, Homo sapiens(human)

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ORF Insert Sequence:

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