| Gene Symbol | MKL1 |
| Entrez Gene ID | 57591 |
| Full Name | megakaryoblastic leukemia (translocation) 1 |
| Synonyms | BSAC,MAL,MKL,MRTF-A |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]. |
| Disorder MIM: | |
| Disorder Html: | Megakaryoblastic leukemia, acute (3) |

User Manual