DGCR6L cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DGCR6L
Entrez Gene ID	85359
Full Name	DiGeorge syndrome critical region gene 6 like
Synonyms	DGCR6
General protein information	Preferred Names DiGeorge syndrome critical region gene 6 like Names protein DGCR6L diGeorge syndrome critical region 6-like protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q11.21
Summary	This gene, the result of a duplication at this locus, is one of two functional genes encoding nearly identical proteins that have similar expression patterns. The product of this gene is a protein that shares homology with the Drosophila gonadal protein, expressed in gonadal tissues and germ cells, and with the human laminin gamma-1 chain that functions in cell attachment and migration. This gene is located in a region of chromosome 22 implicated in the DiGeorge syndrome, one facet of a broader collection of anomalies referred to as the CATCH 22 syndrome. [provided by RefSeq, Jul 2008].
Disorder MIM:	609459

mRNA and Protein(s)

mRNA	Protein	Name
NM_033257.4	NP_150282.2	protein DGCR6L
NM_033257.3	NP_150282.2	protein DGCR6L

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Corominas R, Yang X, Lin GN, Kang S, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Trigg SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T, Vidal M, Iakoucheva LM
Nature communications53650(2014 Apr)

Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome.
Das Chakraborty R, Chakraborty D, Bernal AJ, Schoch K, Howard TD, Ip EH, Hooper SR, Keshavan MS, Jirtle RL, Shashi V
Translational psychiatry2e105(2012 Apr)

Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses.
Simonis N, Rual JF, Lemmens I, Boxus M, Hirozane-Kishikawa T, Gatot JS, Dricot A, Hao T, Vertommen D, Legros S, Daakour S, Klitgord N, Martin M, Willaert JF, Dequiedt F, Navratil V, Cusick ME, Burny A, Van Lint C, Hill DE, Tavernier J, Kettmann R, Vidal M, Twizere JC
Retrovirology926(2012 Mar)

DGCR6L, a novel PAK4 interaction protein, regulates PAK4-mediated migration of human gastric cancer cell via LIMK1.
Li X, Ke Q, Li Y, Liu F, Zhu G, Li F
The international journal of biochemistry & cell biology42(1)70-9(2010 Jan)

Biochemical characterisation of the proteins encoded by the DiGeorge critical region 6 (DGCR6) genes.
Pfuhl T, D?rr M, Spurk A, Schwalbert B, Nord R, Mysliwietz J, Kremmer E, Gr?sser FA
Human genetics117(1)70-80(2005 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Further studies are now needed to test the usefulness of DGCR6 and DGCR6L expression and alterations in the epigenome at these loci in predicting childhood anxiety and associated adult-onset pathologies in 22q11DS subjects.
Title: Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome.

DGCR6L, a novel PAK4 interacting protein, regulated PAK4-mediated migration of human gastric cancer cells via LIMK1.
Title: DGCR6L, a novel PAK4 interaction protein, regulates PAK4-mediated migration of human gastric cancer cell via LIMK1.

The following DGCR6L gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DGCR6L cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27707	NM_033257.4 Latest version!	Homo sapiens DiGeorge syndrome critical region gene 6 like (DGCR6L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu27707	NM_033257.3	Homo sapiens DiGeorge syndrome critical region gene 6 like (DGCR6L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DGCR6L ( NM_033257.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_150282.2 Homo sapiens DiGeorge syndrome critical region gene 6 like (DGCR6L), mRNA.

Price & Availability↑

CloneID	OHu27707
Clone ID Related Accession (Same CDS sequence)	NM_033257.4 , NM_033257.3
Accession Version	NM_033257.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	protein DGCR6L
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007663.29 and BC000682.2. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_033257.3. ##Evidence-Data-START## Transcript exon combination :: SRR7410570.684320.1, SRR1163655.203191.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000248879.8/ ENSP00000248879.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGCT ACGCGGCCGC CTTGGAGGAG GTGGCGGACG GTGCCCGGCA GCAGGAGCGA 
CACTACCAGT TGCTGTCGGC GCTACAGAGC CTGGTGAAGG AGTTGCCCAG CTCTTTCCAG 
CAGCGCCTGT CCTACACCAC GCTCAGCGAC CTGGCCCTGG CGCTTCTCGA CGGCACCGTG 
TTCGAAATCG TGCAGGGGCT ACTGGAGATC CAGCACCTCA CCGAAAAGAG CCTGTACAAC 
CAGCGCCTGC GCCTACAGAA CGAGCACCGA GTGCTCAGGC AGGCGCTGCG GCAGAAGCAC 
CAGGAAGCCC AGCAGGCCTG CCGGCCCCAC AACCTGCCTG TGGTTCAGGC GGCTCAGCAG 
CGAGAACTAG AGGCCGTGGA ACACCGGATC CGTGAGGAGC AGCGGGCGAT GGACCAGAAG 
ATCATCCTGG AGCTGGACCG GAAGGTGGCT GACCAGCAGA GCACACTGGA GAAGGCGGGG 
GTGGCTGGCT TCTACGTGAC CACCAACCCA CAGGAGCTGA TGCTGCAGAT GAACCTGCTG 
GAACTCATCC GAAAGCTGCA GCAGAGGGGC TGCCGGGCAG GGAATGCAGC CCTGGGACTG 
GGAGGTCCCT GGCAGTCGCC TGCTGCCCAG TGTGACCAGA AAGGCAGCCC TGTCCCACCA 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_150282.2
CDS	73..735
Translation	MERYAAALEEVADGARQQERHYQLLSALQSLVKELPSSFQQRLSYTTLSDLALALLDGTVFEIVQGLLEIQHLTEKSLYNQRLRLQNEHRVLRQALRQKHQEAQQACRPHNLPVVQAAQQRELEAVEHRIREEQRAMDQKIILELDRKVADQQSTLEKAGVAGFYVTTNPQELMLQMNLLELIRKLQQRGCRAGNAALGLGGPWQSPAAQCDQKGSPVPP

Target ORF information:

RefSeq Version	NM_033257.4
Organism	Homo sapiens(human)
Definition	Homo sapiens DiGeorge syndrome critical region gene 6 like (DGCR6L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033257.4

ORF Insert Sequence:

ATGGAGCGCT ACGCGGCCGC CTTGGAGGAG GTGGCGGACG GTGCCCGGCA GCAGGAGCGA 
CACTACCAGT TGCTGTCGGC GCTACAGAGC CTGGTGAAGG AGTTGCCCAG CTCTTTCCAG 
CAGCGCCTGT CCTACACCAC GCTCAGCGAC CTGGCCCTGG CGCTTCTCGA CGGCACCGTG 
TTCGAAATCG TGCAGGGGCT ACTGGAGATC CAGCACCTCA CCGAAAAGAG CCTGTACAAC 
CAGCGCCTGC GCCTACAGAA CGAGCACCGA GTGCTCAGGC AGGCGCTGCG GCAGAAGCAC 
CAGGAAGCCC AGCAGGCCTG CCGGCCCCAC AACCTGCCTG TGGTTCAGGC GGCTCAGCAG 
CGAGAACTAG AGGCCGTGGA ACACCGGATC CGTGAGGAGC AGCGGGCGAT GGACCAGAAG 
ATCATCCTGG AGCTGGACCG GAAGGTGGCT GACCAGCAGA GCACACTGGA GAAGGCGGGG 
GTGGCTGGCT TCTACGTGAC CACCAACCCA CAGGAGCTGA TGCTGCAGAT GAACCTGCTG 
GAACTCATCC GAAAGCTGCA GCAGAGGGGC TGCCGGGCAG GGAATGCAGC CCTGGGACTG 
GGAGGTCCCT GGCAGTCGCC TGCTGCCCAG TGTGACCAGA AAGGCAGCCC TGTCCCACCA 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DGCR6L ( NM_033257.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_150282.2 Homo sapiens DiGeorge syndrome critical region gene 6 like (DGCR6L), mRNA.

Price & Availability↑

CloneID	OHu27707
Clone ID Related Accession (Same CDS sequence)	NM_033257.4 , NM_033257.3
Accession Version	NM_033257.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	protein DGCR6L
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007663.29 and BC000682.2. This sequence is a reference standard in the RefSeqGene project. On Jul 29, 2010 this sequence version replaced NM_033257.2. ##Evidence-Data-START## Transcript exon combination :: AF228708.1, AK289952.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGCT ACGCGGCCGC CTTGGAGGAG GTGGCGGACG GTGCCCGGCA GCAGGAGCGA 
CACTACCAGT TGCTGTCGGC GCTACAGAGC CTGGTGAAGG AGTTGCCCAG CTCTTTCCAG 
CAGCGCCTGT CCTACACCAC GCTCAGCGAC CTGGCCCTGG CGCTTCTCGA CGGCACCGTG 
TTCGAAATCG TGCAGGGGCT ACTGGAGATC CAGCACCTCA CCGAAAAGAG CCTGTACAAC 
CAGCGCCTGC GCCTACAGAA CGAGCACCGA GTGCTCAGGC AGGCGCTGCG GCAGAAGCAC 
CAGGAAGCCC AGCAGGCCTG CCGGCCCCAC AACCTGCCTG TGGTTCAGGC GGCTCAGCAG 
CGAGAACTAG AGGCCGTGGA ACACCGGATC CGTGAGGAGC AGCGGGCGAT GGACCAGAAG 
ATCATCCTGG AGCTGGACCG GAAGGTGGCT GACCAGCAGA GCACACTGGA GAAGGCGGGG 
GTGGCTGGCT TCTACGTGAC CACCAACCCA CAGGAGCTGA TGCTGCAGAT GAACCTGCTG 
GAACTCATCC GAAAGCTGCA GCAGAGGGGC TGCCGGGCAG GGAATGCAGC CCTGGGACTG 
GGAGGTCCCT GGCAGTCGCC TGCTGCCCAG TGTGACCAGA AAGGCAGCCC TGTCCCACCA 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_150282.2
CDS	118..780
Translation	MERYAAALEEVADGARQQERHYQLLSALQSLVKELPSSFQQRLSYTTLSDLALALLDGTVFEIVQGLLEIQHLTEKSLYNQRLRLQNEHRVLRQALRQKHQEAQQACRPHNLPVVQAAQQRELEAVEHRIREEQRAMDQKIILELDRKVADQQSTLEKAGVAGFYVTTNPQELMLQMNLLELIRKLQQRGCRAGNAALGLGGPWQSPAAQCDQKGSPVPP

Target ORF information:

RefSeq Version	NM_033257.3
Organism	Homo sapiens(human)
Definition	Homo sapiens DiGeorge syndrome critical region gene 6 like (DGCR6L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033257.3

ORF Insert Sequence:

ATGGAGCGCT ACGCGGCCGC CTTGGAGGAG GTGGCGGACG GTGCCCGGCA GCAGGAGCGA 
CACTACCAGT TGCTGTCGGC GCTACAGAGC CTGGTGAAGG AGTTGCCCAG CTCTTTCCAG 
CAGCGCCTGT CCTACACCAC GCTCAGCGAC CTGGCCCTGG CGCTTCTCGA CGGCACCGTG 
TTCGAAATCG TGCAGGGGCT ACTGGAGATC CAGCACCTCA CCGAAAAGAG CCTGTACAAC 
CAGCGCCTGC GCCTACAGAA CGAGCACCGA GTGCTCAGGC AGGCGCTGCG GCAGAAGCAC 
CAGGAAGCCC AGCAGGCCTG CCGGCCCCAC AACCTGCCTG TGGTTCAGGC GGCTCAGCAG 
CGAGAACTAG AGGCCGTGGA ACACCGGATC CGTGAGGAGC AGCGGGCGAT GGACCAGAAG 
ATCATCCTGG AGCTGGACCG GAAGGTGGCT GACCAGCAGA GCACACTGGA GAAGGCGGGG 
GTGGCTGGCT TCTACGTGAC CACCAACCCA CAGGAGCTGA TGCTGCAGAT GAACCTGCTG 
GAACTCATCC GAAAGCTGCA GCAGAGGGGC TGCCGGGCAG GGAATGCAGC CCTGGGACTG 
GGAGGTCCCT GGCAGTCGCC TGCTGCCCAG TGTGACCAGA AAGGCAGCCC TGTCCCACCA 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Nature communications53650(2014 Apr)
Corominas R,Yang X,Lin GN,Kang S,Shen Y,Ghamsari L,Broly M,Rodriguez M,Tam S,Trigg SA,Fan C,Yi S,Tasan M,Lemmens I,Kuang X,Zhao N,Malhotra D,Michaelson JJ,Vacic V,Calderwood MA,Roth FP,Tavernier J,Horvath S,Salehi-Ashtiani K,Korkin D,Sebat J,Hill DE,Hao T,Vidal M,Iakoucheva LM

Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome.
Translational psychiatry2e105(2012 Apr)
Das Chakraborty R,Chakraborty D,Bernal AJ,Schoch K,Howard TD,Ip EH,Hooper SR,Keshavan MS,Jirtle RL,Shashi V

Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses.
Retrovirology926(2012 Mar)
Simonis N,Rual JF,Lemmens I,Boxus M,Hirozane-Kishikawa T,Gatot JS,Dricot A,Hao T,Vertommen D,Legros S,Daakour S,Klitgord N,Martin M,Willaert JF,Dequiedt F,Navratil V,Cusick ME,Burny A,Van Lint C,Hill DE,Tavernier J,Kettmann R,Vidal M,Twizere JC

DGCR6L, a novel PAK4 interaction protein, regulates PAK4-mediated migration of human gastric cancer cell via LIMK1.
The international journal of biochemistry & cell biology42(1)70-9(2010 Jan)
Li X,Ke Q,Li Y,Liu F,Zhu G,Li F

Biochemical characterisation of the proteins encoded by the DiGeorge critical region 6 (DGCR6) genes.
Human genetics117(1)70-80(2005 Jun)
Pfuhl T,D?rr M,Spurk A,Schwalbert B,Nord R,Mysliwietz J,Kremmer E,Gr?sser FA

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DGCR6L cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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