ESAM cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ESAM
Entrez Gene ID	90952
Full Name	endothelial cell adhesion molecule
Synonyms	W117m
General protein information	Preferred Names endothelial cell adhesion molecule Names endothelial cell-selective adhesion molecule 2310008D05Rik HUEL (C4orf1)-interacting protein LP4791 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q24.2
Disorder MIM:	614281

mRNA and Protein(s)

mRNA	Protein	Name
XM_011543060.2	XP_011541362.1	endothelial cell-selective adhesion molecule isoform X1
NM_138961.3	NP_620411.2	endothelial cell-selective adhesion molecule precursor
XM_005271720.4	XP_005271777.1	endothelial cell-selective adhesion molecule isoform X2
NM_138961.2	NP_620411.2	endothelial cell-selective adhesion molecule precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ESAM	NP_001071534.1
Gallus gallus (chicken)	ESAM	XP_417851.4
Pan troglodytes (chimpanzee)	ESAM	XP_508839.1
Canis lupus familiaris (dog)	ESAM	XP_546427.2
Rattus norvegicus (Norway rat)	Esam	NP_001004245.1
Danio rerio (zebrafish)	esama	NP_001108538.1
Danio rerio (zebrafish)	LOC562934	XP_691391.5
Xenopus tropicalis (tropical clawed frog)	esam	NP_001135525.1
Homo sapiens (human)	ESAM	NP_620411.2
	ESAM	XP_001110293.1
Mus musculus (house mouse)	Esam	NP_081378.1

Gene Ontology
Bibliography

Related articles in PubMed

ESAM is a novel human hematopoietic stem cell marker associated with a subset of human leukemias.
Ishibashi T, Yokota T, Tanaka H, Ichii M, Sudo T, Satoh Y, Doi Y, Ueda T, Tanimura A, Hamanaka Y, Ezoe S, Shibayama H, Oritani K, Kanakura Y
Experimental hematology44(4)269-81.e1(2016 Apr)

Platelet endothelial cell adhesion molecule-1 (PECAM1) plays a critical role in the maintenance of human vascular endothelial barrier function.
Ren Q, Ren L, Ren C, Liu X, Dong C, Zhang X
Cell biochemistry and function33(8)560-5(2015 Dec)

Soluble endothelial cell selective adhesion molecule and cardiovascular outcomes in patients with stable coronary disease: A report from the Heart and Soul Study.
Park M, Kulkarni A, Beatty A, Ganz P, Regan M, Vittinghoff E, Whooley M
Atherosclerosis243(2)546-52(2015 Dec)

Biological insights from 108 schizophrenia-associated genetic loci.

Nature511(7510)421-7(2014 Jul)

Relationship of endothelial cell selective adhesion molecule to markers of oxidative stress in type 2 diabetes.
Kacso IM, Potra AR, Rusu A, Moldovan D, Rusu CC, Kacso G, Hancu ND, Muresan A, Bondor CI
Scandinavian journal of clinical and laboratory investigation74(2)170-6(2014 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ESAM is a novel human hematopoietic stem cell marker associated with a subset of human leukemias
Title: ESAM is a novel human hematopoietic stem cell marker associated with a subset of human leukemias.

sESAM levels associate with myocardial infarction, heart failure, and death after adjustment for demographic and clinical risk factors, but not after adjustment for kidney function.
Title: Soluble endothelial cell selective adhesion molecule and cardiovascular outcomes in patients with stable coronary disease: A report from the Heart and Soul Study.

Serum ESAM is higher in type 2 diabetes mellitus than in controls and parallels oxidative stress.
Title: Relationship of endothelial cell selective adhesion molecule to markers of oxidative stress in type 2 diabetes.

sESAM is associated with albuminuria and reduced kidney function in patients with coronary artery disease in both cross-sectional and longitudinal analyses.
Title: Role of soluble endothelial cell-selective adhesion molecule biomarker in albuminuria and kidney function changes in patients with coronary artery disease: the Heart and Soul Study.

ESAM regulates tumor metastasis through endothelial cell migration and tube formation in metastatic nodules.
Title: Role of endothelial cell-selective adhesion molecule in hematogeneous metastasis.

The following ESAM gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ESAM cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10493	NM_138961.3 Latest version!	Homo sapiens endothelial cell adhesion molecule (ESAM), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$164.50-$230.30 $329.00
OHu74274	XM_011543060.2 Latest version!	Homo sapiens endothelial cell adhesion molecule (ESAM), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu45919	XM_005271720.4 Latest version!	Homo sapiens endothelial cell adhesion molecule (ESAM), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu10493	NM_138961.2	Homo sapiens endothelial cell adhesion molecule (ESAM), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$164.50-$230.30 $329.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ESAM ( NM_138961.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_620411.2 Homo sapiens endothelial cell adhesion molecule (ESAM), mRNA.

Price & Availability↑

CloneID	OHu10493
Clone ID Related Accession (Same CDS sequence)	NM_138961.3 , NM_138961.2
Accession Version	NM_138961.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1173bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	endothelial cell-selective adhesion molecule precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK075396.1 and AP000866.4. On Nov 22, 2018 this sequence version replaced NM_138961.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK075396.1, SRR3476690.660945.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000278927.10/ ENSP00000278927.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATTTCCC TCCCGGGGCC CCTGGTGACC AACTTGCTGC GGTTTTTGTT CCTGGGGCTG 
AGTGCCCTCG CGCCCCCCTC GCGGGCCCAG CTGCAACTGC ACTTGCCCGC CAACCGGTTG 
CAGGCGGTGG AGGGAGGGGA AGTGGTGCTT CCAGCGTGGT ACACCTTGCA CGGGGAGGTG 
TCTTCATCCC AGCCATGGGA GGTGCCCTTT GTGATGTGGT TCTTCAAACA GAAAGAAAAG 
GAGGATCAGG TGTTGTCCTA CATCAATGGG GTCACAACAA GCAAACCTGG AGTATCCTTG 
GTCTACTCCA TGCCCTCCCG GAACCTGTCC CTGCGGCTGG AGGGTCTCCA GGAGAAAGAC 
TCTGGCCCCT ACAGCTGCTC CGTGAATGTG CAAGACAAAC AAGGCAAATC TAGGGGCCAC 
AGCATCAAAA CCTTAGAACT CAATGTACTG GTTCCTCCAG CTCCTCCATC CTGCCGTCTC 
CAGGGTGTGC CCCATGTGGG GGCAAACGTG ACCCTGAGCT GCCAGTCTCC AAGGAGTAAG 
CCCGCTGTCC AATACCAGTG GGATCGGCAG CTTCCATCCT TCCAGACTTT CTTTGCACCA 
GCATTAGATG TCATCCGTGG GTCTTTAAGC CTCACCAACC TTTCGTCTTC CATGGCTGGA 
GTCTATGTCT GCAAGGCCCA CAATGAGGTG GGCACTGCCC AATGTAATGT GACGCTGGAA 
GTGAGCACAG GGCCTGGAGC TGCAGTGGTT GCTGGAGCTG TTGTGGGTAC CCTGGTTGGA 
CTGGGGTTGC TGGCTGGGCT GGTCCTCTTG TACCACCGCC GGGGCAAGGC CCTGGAGGAG 
CCAGCCAATG ATATCAAGGA GGATGCCATT GCTCCCCGGA CCCTGCCCTG GCCCAAGAGC 
TCAGACACAA TCTCCAAGAA TGGGACCCTT TCCTCTGTCA CCTCCGCACG AGCCCTCCGG 
CCACCCCATG GCCCTCCCAG GCCTGGTGCA TTGACCCCCA CGCCCAGTCT CTCCAGCCAG 
GCCCTGCCCT CACCAAGACT GCCCACGACA GATGGGGCCC ACCCTCAACC AATATCCCCC 
ATCCCTGGTG GGGTTTCTTC CTCTGGCTTG AGCCGCATGG GTGCTGTGCC TGTGATGGTG 
CCTGCCCAGA GTCAAGCTGG CTCTCTGGTA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620411.2
CDS	137..1309
Translation	MISLPGPLVTNLLRFLFLGLSALAPPSRAQLQLHLPANRLQAVEGGEVVLPAWYTLHGEVSSSQPWEVPFVMWFFKQKEKEDQVLSYINGVTTSKPGVSLVYSMPSRNLSLRLEGLQEKDSGPYSCSVNVQDKQGKSRGHSIKTLELNVLVPPAPPSCRLQGVPHVGANVTLSCQSPRSKPAVQYQWDRQLPSFQTFFAPALDVIRGSLSLTNLSSSMAGVYVCKAHNEVGTAQCNVTLEVSTGPGAAVVAGAVVGTLVGLGLLAGLVLLYHRRGKALEEPANDIKEDAIAPRTLPWPKSSDTISKNGTLSSVTSARALRPPHGPPRPGALTPTPSLSSQALPSPRLPTTDGAHPQPISPIPGGVSSSGLSRMGAVPVMVPAQSQAGSLV

Target ORF information:

RefSeq Version	NM_138961.3
Organism	Homo sapiens(human)
Definition	Homo sapiens endothelial cell adhesion molecule (ESAM), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138961.3

ORF Insert Sequence:

ATGATTTCCC TCCCGGGGCC CCTGGTGACC AACTTGCTGC GGTTTTTGTT CCTGGGGCTG 
AGTGCCCTCG CGCCCCCCTC GCGGGCCCAG CTGCAACTGC ACTTGCCCGC CAACCGGTTG 
CAGGCGGTGG AGGGAGGGGA AGTGGTGCTT CCAGCGTGGT ACACCTTGCA CGGGGAGGTG 
TCTTCATCCC AGCCATGGGA GGTGCCCTTT GTGATGTGGT TCTTCAAACA GAAAGAAAAG 
GAGGATCAGG TGTTGTCCTA CATCAATGGG GTCACAACAA GCAAACCTGG AGTATCCTTG 
GTCTACTCCA TGCCCTCCCG GAACCTGTCC CTGCGGCTGG AGGGTCTCCA GGAGAAAGAC 
TCTGGCCCCT ACAGCTGCTC CGTGAATGTG CAAGACAAAC AAGGCAAATC TAGGGGCCAC 
AGCATCAAAA CCTTAGAACT CAATGTACTG GTTCCTCCAG CTCCTCCATC CTGCCGTCTC 
CAGGGTGTGC CCCATGTGGG GGCAAACGTG ACCCTGAGCT GCCAGTCTCC AAGGAGTAAG 
CCCGCTGTCC AATACCAGTG GGATCGGCAG CTTCCATCCT TCCAGACTTT CTTTGCACCA 
GCATTAGATG TCATCCGTGG GTCTTTAAGC CTCACCAACC TTTCGTCTTC CATGGCTGGA 
GTCTATGTCT GCAAGGCCCA CAATGAGGTG GGCACTGCCC AATGTAATGT GACGCTGGAA 
GTGAGCACAG GGCCTGGAGC TGCAGTGGTT GCTGGAGCTG TTGTGGGTAC CCTGGTTGGA 
CTGGGGTTGC TGGCTGGGCT GGTCCTCTTG TACCACCGCC GGGGCAAGGC CCTGGAGGAG 
CCAGCCAATG ATATCAAGGA GGATGCCATT GCTCCCCGGA CCCTGCCCTG GCCCAAGAGC 
TCAGACACAA TCTCCAAGAA TGGGACCCTT TCCTCTGTCA CCTCCGCACG AGCCCTCCGG 
CCACCCCATG GCCCTCCCAG GCCTGGTGCA TTGACCCCCA CGCCCAGTCT CTCCAGCCAG 
GCCCTGCCCT CACCAAGACT GCCCACGACA GATGGGGCCC ACCCTCAACC AATATCCCCC 
ATCCCTGGTG GGGTTTCTTC CTCTGGCTTG AGCCGCATGG GTGCTGTGCC TGTGATGGTG 
CCTGCCCAGA GTCAAGCTGG CTCTCTGGTA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ESAM ( NM_138961.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_620411.2 Homo sapiens endothelial cell adhesion molecule (ESAM), mRNA.

Price & Availability↑

CloneID	OHu10493
Clone ID Related Accession (Same CDS sequence)	NM_138961.3 , NM_138961.2
Accession Version	NM_138961.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1173bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	endothelial cell-selective adhesion molecule precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA257581.1, AK075396.1 and AP000866.4. On Jun 7, 2007 this sequence version replaced NM_138961.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK075396.1, SRR1803613.54262.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGATTTCCC TCCCGGGGCC CCTGGTGACC AACTTGCTGC GGTTTTTGTT CCTGGGGCTG 
AGTGCCCTCG CGCCCCCCTC GCGGGCCCAG CTGCAACTGC ACTTGCCCGC CAACCGGTTG 
CAGGCGGTGG AGGGAGGGGA AGTGGTGCTT CCAGCGTGGT ACACCTTGCA CGGGGAGGTG 
TCTTCATCCC AGCCATGGGA GGTGCCCTTT GTGATGTGGT TCTTCAAACA GAAAGAAAAG 
GAGGATCAGG TGTTGTCCTA CATCAATGGG GTCACAACAA GCAAACCTGG AGTATCCTTG 
GTCTACTCCA TGCCCTCCCG GAACCTGTCC CTGCGGCTGG AGGGTCTCCA GGAGAAAGAC 
TCTGGCCCCT ACAGCTGCTC CGTGAATGTG CAAGACAAAC AAGGCAAATC TAGGGGCCAC 
AGCATCAAAA CCTTAGAACT CAATGTACTG GTTCCTCCAG CTCCTCCATC CTGCCGTCTC 
CAGGGTGTGC CCCATGTGGG GGCAAACGTG ACCCTGAGCT GCCAGTCTCC AAGGAGTAAG 
CCCGCTGTCC AATACCAGTG GGATCGGCAG CTTCCATCCT TCCAGACTTT CTTTGCACCA 
GCATTAGATG TCATCCGTGG GTCTTTAAGC CTCACCAACC TTTCGTCTTC CATGGCTGGA 
GTCTATGTCT GCAAGGCCCA CAATGAGGTG GGCACTGCCC AATGTAATGT GACGCTGGAA 
GTGAGCACAG GGCCTGGAGC TGCAGTGGTT GCTGGAGCTG TTGTGGGTAC CCTGGTTGGA 
CTGGGGTTGC TGGCTGGGCT GGTCCTCTTG TACCACCGCC GGGGCAAGGC CCTGGAGGAG 
CCAGCCAATG ATATCAAGGA GGATGCCATT GCTCCCCGGA CCCTGCCCTG GCCCAAGAGC 
TCAGACACAA TCTCCAAGAA TGGGACCCTT TCCTCTGTCA CCTCCGCACG AGCCCTCCGG 
CCACCCCATG GCCCTCCCAG GCCTGGTGCA TTGACCCCCA CGCCCAGTCT CTCCAGCCAG 
GCCCTGCCCT CACCAAGACT GCCCACGACA GATGGGGCCC ACCCTCAACC AATATCCCCC 
ATCCCTGGTG GGGTTTCTTC CTCTGGCTTG AGCCGCATGG GTGCTGTGCC TGTGATGGTG 
CCTGCCCAGA GTCAAGCTGG CTCTCTGGTA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620411.2
CDS	174..1346
Translation	MISLPGPLVTNLLRFLFLGLSALAPPSRAQLQLHLPANRLQAVEGGEVVLPAWYTLHGEVSSSQPWEVPFVMWFFKQKEKEDQVLSYINGVTTSKPGVSLVYSMPSRNLSLRLEGLQEKDSGPYSCSVNVQDKQGKSRGHSIKTLELNVLVPPAPPSCRLQGVPHVGANVTLSCQSPRSKPAVQYQWDRQLPSFQTFFAPALDVIRGSLSLTNLSSSMAGVYVCKAHNEVGTAQCNVTLEVSTGPGAAVVAGAVVGTLVGLGLLAGLVLLYHRRGKALEEPANDIKEDAIAPRTLPWPKSSDTISKNGTLSSVTSARALRPPHGPPRPGALTPTPSLSSQALPSPRLPTTDGAHPQPISPIPGGVSSSGLSRMGAVPVMVPAQSQAGSLV

Target ORF information:

RefSeq Version	NM_138961.2
Organism	Homo sapiens(human)
Definition	Homo sapiens endothelial cell adhesion molecule (ESAM), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138961.2

ORF Insert Sequence:

ATGATTTCCC TCCCGGGGCC CCTGGTGACC AACTTGCTGC GGTTTTTGTT CCTGGGGCTG 
AGTGCCCTCG CGCCCCCCTC GCGGGCCCAG CTGCAACTGC ACTTGCCCGC CAACCGGTTG 
CAGGCGGTGG AGGGAGGGGA AGTGGTGCTT CCAGCGTGGT ACACCTTGCA CGGGGAGGTG 
TCTTCATCCC AGCCATGGGA GGTGCCCTTT GTGATGTGGT TCTTCAAACA GAAAGAAAAG 
GAGGATCAGG TGTTGTCCTA CATCAATGGG GTCACAACAA GCAAACCTGG AGTATCCTTG 
GTCTACTCCA TGCCCTCCCG GAACCTGTCC CTGCGGCTGG AGGGTCTCCA GGAGAAAGAC 
TCTGGCCCCT ACAGCTGCTC CGTGAATGTG CAAGACAAAC AAGGCAAATC TAGGGGCCAC 
AGCATCAAAA CCTTAGAACT CAATGTACTG GTTCCTCCAG CTCCTCCATC CTGCCGTCTC 
CAGGGTGTGC CCCATGTGGG GGCAAACGTG ACCCTGAGCT GCCAGTCTCC AAGGAGTAAG 
CCCGCTGTCC AATACCAGTG GGATCGGCAG CTTCCATCCT TCCAGACTTT CTTTGCACCA 
GCATTAGATG TCATCCGTGG GTCTTTAAGC CTCACCAACC TTTCGTCTTC CATGGCTGGA 
GTCTATGTCT GCAAGGCCCA CAATGAGGTG GGCACTGCCC AATGTAATGT GACGCTGGAA 
GTGAGCACAG GGCCTGGAGC TGCAGTGGTT GCTGGAGCTG TTGTGGGTAC CCTGGTTGGA 
CTGGGGTTGC TGGCTGGGCT GGTCCTCTTG TACCACCGCC GGGGCAAGGC CCTGGAGGAG 
CCAGCCAATG ATATCAAGGA GGATGCCATT GCTCCCCGGA CCCTGCCCTG GCCCAAGAGC 
TCAGACACAA TCTCCAAGAA TGGGACCCTT TCCTCTGTCA CCTCCGCACG AGCCCTCCGG 
CCACCCCATG GCCCTCCCAG GCCTGGTGCA TTGACCCCCA CGCCCAGTCT CTCCAGCCAG 
GCCCTGCCCT CACCAAGACT GCCCACGACA GATGGGGCCC ACCCTCAACC AATATCCCCC 
ATCCCTGGTG GGGTTTCTTC CTCTGGCTTG AGCCGCATGG GTGCTGTGCC TGTGATGGTG 
CCTGCCCAGA GTCAAGCTGG CTCTCTGGTA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ESAM ( XM_011543060.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011541362.1 Homo sapiens endothelial cell adhesion molecule (ESAM), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu74274
Clone ID Related Accession (Same CDS sequence)	XM_011543060.2
Accession Version	XM_011543060.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 864bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	endothelial cell-selective adhesion molecule isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011543060.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCTCCC GGAACCTGTC CCTGCGGCTG GAGGGTCTCC AGGAGAAAGA CTCTGGCCCC 
TACAGCTGCT CCGTGAATGT GCAAGACAAA CAAGGCAAAT CTAGGGGCCA CAGCATCAAA 
ACCTTAGAAC TCAATGTACT GGTTCCTCCA GCTCCTCCAT CCTGCCGTCT CCAGGGTGTG 
CCCCATGTGG GGGCAAACGT GACCCTGAGC TGCCAGTCTC CAAGGAGTAA GCCCGCTGTC 
CAATACCAGT GGGATCGGCA GCTTCCATCC TTCCAGACTT TCTTTGCACC AGCATTAGAT 
GTCATCCGTG GGTCTTTAAG CCTCACCAAC CTTTCGTCTT CCATGGCTGG AGTCTATGTC 
TGCAAGGCCC ACAATGAGGT GGGCACTGCC CAATGTAATG TGACGCTGGA AGTGAGCACA 
GGGCCTGGAG CTGCAGTGGT TGCTGGAGCT GTTGTGGGTA CCCTGGTTGG ACTGGGGTTG 
CTGGCTGGGC TGGTCCTCTT GTACCACCGC CGGGGCAAGG CCCTGGAGGA GCCAGCCAAT 
GATATCAAGG AGGATGCCAT TGCTCCCCGG ACCCTGCCCT GGCCCAAGAG CTCAGACACA 
ATCTCCAAGA ATGGGACCCT TTCCTCTGTC ACCTCCGCAC GAGCCCTCCG GCCACCCCAT 
GGCCCTCCCA GGCCTGGTGC ATTGACCCCC ACGCCCAGTC TCTCCAGCCA GGCCCTGCCC 
TCACCAAGAC TGCCCACGAC AGATGGGGCC CACCCTCAAC CAATATCCCC CATCCCTGGT 
GGGGTTTCTT CCTCTGGCTT GAGCCGCATG GGTGCTGTGC CTGTGATGGT GCCTGCCCAG 
AGTCAAGCTG GCTCTCTGGT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011541362.1
CDS	246..1109
Translation	MPSRNLSLRLEGLQEKDSGPYSCSVNVQDKQGKSRGHSIKTLELNVLVPPAPPSCRLQGVPHVGANVTLSCQSPRSKPAVQYQWDRQLPSFQTFFAPALDVIRGSLSLTNLSSSMAGVYVCKAHNEVGTAQCNVTLEVSTGPGAAVVAGAVVGTLVGLGLLAGLVLLYHRRGKALEEPANDIKEDAIAPRTLPWPKSSDTISKNGTLSSVTSARALRPPHGPPRPGALTPTPSLSSQALPSPRLPTTDGAHPQPISPIPGGVSSSGLSRMGAVPVMVPAQSQAGSLV

Target ORF information:

RefSeq Version	XM_011543060.2
Organism	Homo sapiens(human)
Definition	Homo sapiens endothelial cell adhesion molecule (ESAM), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011543060.2

ORF Insert Sequence:

ATGCCCTCCC GGAACCTGTC CCTGCGGCTG GAGGGTCTCC AGGAGAAAGA CTCTGGCCCC 
TACAGCTGCT CCGTGAATGT GCAAGACAAA CAAGGCAAAT CTAGGGGCCA CAGCATCAAA 
ACCTTAGAAC TCAATGTACT GGTTCCTCCA GCTCCTCCAT CCTGCCGTCT CCAGGGTGTG 
CCCCATGTGG GGGCAAACGT GACCCTGAGC TGCCAGTCTC CAAGGAGTAA GCCCGCTGTC 
CAATACCAGT GGGATCGGCA GCTTCCATCC TTCCAGACTT TCTTTGCACC AGCATTAGAT 
GTCATCCGTG GGTCTTTAAG CCTCACCAAC CTTTCGTCTT CCATGGCTGG AGTCTATGTC 
TGCAAGGCCC ACAATGAGGT GGGCACTGCC CAATGTAATG TGACGCTGGA AGTGAGCACA 
GGGCCTGGAG CTGCAGTGGT TGCTGGAGCT GTTGTGGGTA CCCTGGTTGG ACTGGGGTTG 
CTGGCTGGGC TGGTCCTCTT GTACCACCGC CGGGGCAAGG CCCTGGAGGA GCCAGCCAAT 
GATATCAAGG AGGATGCCAT TGCTCCCCGG ACCCTGCCCT GGCCCAAGAG CTCAGACACA 
ATCTCCAAGA ATGGGACCCT TTCCTCTGTC ACCTCCGCAC GAGCCCTCCG GCCACCCCAT 
GGCCCTCCCA GGCCTGGTGC ATTGACCCCC ACGCCCAGTC TCTCCAGCCA GGCCCTGCCC 
TCACCAAGAC TGCCCACGAC AGATGGGGCC CACCCTCAAC CAATATCCCC CATCCCTGGT 
GGGGTTTCTT CCTCTGGCTT GAGCCGCATG GGTGCTGTGC CTGTGATGGT GCCTGCCCAG 
AGTCAAGCTG GCTCTCTGGT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ESAM ( XM_005271720.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005271777.1 Homo sapiens endothelial cell adhesion molecule (ESAM), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu45919
Clone ID Related Accession (Same CDS sequence)	XM_005271720.4
Accession Version	XM_005271720.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	endothelial cell-selective adhesion molecule isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005271720.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATTTCCC TCCCGGGGCC CCTGGTGACC AACTTGCTGC GGTTTTTGTT CCTGGGGCTG 
AGTGCCCTCG ATGTCATCCG TGGGTCTTTA AGCCTCACCA ACCTTTCGTC TTCCATGGCT 
GGAGTCTATG TCTGCAAGGC CCACAATGAG GTGGGCACTG CCCAATGTAA TGTGACGCTG 
GAAGTGAGCA CAGGGCCTGG AGCTGCAGTG GTTGCTGGAG CTGTTGTGGG TACCCTGGTT 
GGACTGGGGT TGCTGGCTGG GCTGGTCCTC TTGTACCACC GCCGGGGCAA GGCCCTGGAG 
GAGCCAGCCA ATGATATCAA GGAGGATGCC ATTGCTCCCC GGACCCTGCC CTGGCCCAAG 
AGCTCAGACA CAATCTCCAA GAATGGGACC CTTTCCTCTG TCACCTCCGC ACGAGCCCTC 
CGGCCACCCC ATGGCCCTCC CAGGCCTGGT GCATTGACCC CCACGCCCAG TCTCTCCAGC 
CAGGCCCTGC CCTCACCAAG ACTGCCCACG ACAGATGGGG CCCACCCTCA ACCAATATCC 
CCCATCCCTG GTGGGGTTTC TTCCTCTGGC TTGAGCCGCA TGGGTGCTGT GCCTGTGATG 
GTGCCTGCCC AGAGTCAAGC TGGCTCTCTG GTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005271777.1
CDS	132..767
Translation	MISLPGPLVTNLLRFLFLGLSALDVIRGSLSLTNLSSSMAGVYVCKAHNEVGTAQCNVTLEVSTGPGAAVVAGAVVGTLVGLGLLAGLVLLYHRRGKALEEPANDIKEDAIAPRTLPWPKSSDTISKNGTLSSVTSARALRPPHGPPRPGALTPTPSLSSQALPSPRLPTTDGAHPQPISPIPGGVSSSGLSRMGAVPVMVPAQSQAGSLV

Target ORF information:

RefSeq Version	XM_005271720.4
Organism	Homo sapiens(human)
Definition	Homo sapiens endothelial cell adhesion molecule (ESAM), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005271720.4

ORF Insert Sequence:

ATGATTTCCC TCCCGGGGCC CCTGGTGACC AACTTGCTGC GGTTTTTGTT CCTGGGGCTG 
AGTGCCCTCG ATGTCATCCG TGGGTCTTTA AGCCTCACCA ACCTTTCGTC TTCCATGGCT 
GGAGTCTATG TCTGCAAGGC CCACAATGAG GTGGGCACTG CCCAATGTAA TGTGACGCTG 
GAAGTGAGCA CAGGGCCTGG AGCTGCAGTG GTTGCTGGAG CTGTTGTGGG TACCCTGGTT 
GGACTGGGGT TGCTGGCTGG GCTGGTCCTC TTGTACCACC GCCGGGGCAA GGCCCTGGAG 
GAGCCAGCCA ATGATATCAA GGAGGATGCC ATTGCTCCCC GGACCCTGCC CTGGCCCAAG 
AGCTCAGACA CAATCTCCAA GAATGGGACC CTTTCCTCTG TCACCTCCGC ACGAGCCCTC 
CGGCCACCCC ATGGCCCTCC CAGGCCTGGT GCATTGACCC CCACGCCCAG TCTCTCCAGC 
CAGGCCCTGC CCTCACCAAG ACTGCCCACG ACAGATGGGG CCCACCCTCA ACCAATATCC 
CCCATCCCTG GTGGGGTTTC TTCCTCTGGC TTGAGCCGCA TGGGTGCTGT GCCTGTGATG 
GTGCCTGCCC AGAGTCAAGC TGGCTCTCTG GTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ESAM is a novel human hematopoietic stem cell marker associated with a subset of human leukemias.
Experimental hematology44(4)269-81.e1(2016 Apr)
Ishibashi T,Yokota T,Tanaka H,Ichii M,Sudo T,Satoh Y,Doi Y,Ueda T,Tanimura A,Hamanaka Y,Ezoe S,Shibayama H,Oritani K,Kanakura Y

Platelet endothelial cell adhesion molecule-1 (PECAM1) plays a critical role in the maintenance of human vascular endothelial barrier function.
Cell biochemistry and function33(8)560-5(2015 Dec)
Ren Q,Ren L,Ren C,Liu X,Dong C,Zhang X

Soluble endothelial cell selective adhesion molecule and cardiovascular outcomes in patients with stable coronary disease: A report from the Heart and Soul Study.
Atherosclerosis243(2)546-52(2015 Dec)
Park M,Kulkarni A,Beatty A,Ganz P,Regan M,Vittinghoff E,Whooley M

Biological insights from 108 schizophrenia-associated genetic loci.
Nature511(7510)421-7(2014 Jul)

Relationship of endothelial cell selective adhesion molecule to markers of oxidative stress in type 2 diabetes.
Scandinavian journal of clinical and laboratory investigation74(2)170-6(2014 Mar)
Kacso IM,Potra AR,Rusu A,Moldovan D,Rusu CC,Kacso G,Hancu ND,Muresan A,Bondor CI