NHLH2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NHLH2
Entrez Gene ID	4808
Full Name	nescient helix-loop-helix 2
Synonyms	HEN2,NSCL2,bHLHa34
General protein information	Preferred Names nescient helix-loop-helix 2 Names helix-loop-helix protein 2 HEN-2 NSCL-2 class A basic helix-loop-helix protein 34
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p13.1
Disorder MIM:	162361

mRNA and Protein(s)

mRNA	Protein	Name
NM_001111061.1	NP_001104531.1	helix-loop-helix protein 2
NM_001111061.2	NP_001104531.1	helix-loop-helix protein 2
NM_005599.3	NP_005590.1	helix-loop-helix protein 2
XM_017001370.1	XP_016856859.1	helix-loop-helix protein 2 isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Nhlh2	NP_001099927.1
Homo sapiens (human)	NHLH2	NP_001104531.1
Canis lupus familiaris (dog)	NHLH2	XP_005630709.1
Mus musculus (house mouse)	Nhlh2	NP_848892.1
Pan troglodytes (chimpanzee)	NHLH2	XP_001148497.1
Gallus gallus (chicken)	NHLH2	NP_990128.1
Danio rerio (zebrafish)	nhlh2	NP_991232.1
	LOC709920	XP_001112098.1
Bos taurus (cattle)	NHLH2	NP_001103473.1

Gene Ontology
Bibliography

Related articles in PubMed

A Genetic Basis for Motivated Exercise.
Good DJ, Li M, Deater-Deckard K
Exercise and sport sciences reviews43(4)231-7(2015 Oct)

Leptin signaling regulates hypothalamic expression of nescient helix-loop-helix 2 (Nhlh2) through signal transducer and activator 3 (Stat3).
Al Rayyan N, Zhang J, Burnside AS, Good DJ
Molecular and cellular endocrinology384(1-2)134-42(2014 Mar)

Two single nucleotide polymorphisms in the human nescient helix-loop-helix 2 (NHLH2) gene reduce mRNA stability and DNA binding.
Al Rayyan N, Wankhade UD, Bush K, Good DJ
Gene512(1)134-42(2013 Jan)

SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive.
Libert S, Pointer K, Bell EL, Das A, Cohen DE, Asara JM, Kapur K, Bergmann S, Preisig M, Otowa T, Kendler KS, Chen X, Hettema JM, van den Oord EJ, Rubio JP, Guarente L
Cell147(7)1459-72(2011 Dec)

Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1.
Isogai E, Ohira M, Ozaki T, Oba S, Nakamura Y, Nakagawara A
PloS one6(5)e19297(2011 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data support part of our hypothesis that NHLH2 or MAO-A polymorphism is associated with sedentary behavior.
Title: A Genetic Basis for Motivated Exercise.

Leptin signaling regulates hypothalamic expression of Nhlh2 through Stat3.
Title: Leptin signaling regulates hypothalamic expression of nescient helix-loop-helix 2 (Nhlh2) through signal transducer and activator 3 (Stat3).

Two single nucleotide polymorphisms in the human nescient helix-loop-helix 2 (NHLH2) gene reduce mRNA stability or reduce helical structure in the DNA binding domain of the protein.
Title: Two single nucleotide polymorphisms in the human nescient helix-loop-helix 2 (NHLH2) gene reduce mRNA stability and DNA binding.

The present results suggest that a transcriptional complex of LMO3 and HEN2 may contribute to the genesis and malignant phenotype of neuroblastoma by inhibiting HES1 which suppresses the transactivation of Mash1.
Title: Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.

The following NHLH2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NHLH2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05087	NM_005599.3 Latest version!	Homo sapiens nescient helix-loop-helix 2 (NHLH2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu05087	NM_001111061.2 Latest version!	Homo sapiens nescient helix-loop-helix 2 (NHLH2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu90062	XM_017001370.1 Latest version!	Homo sapiens nescient helix-loop-helix 2 (NHLH2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
View Old Accession Versions >>
OHu05087	NM_001111061.1	Homo sapiens nescient helix-loop-helix 2 (NHLH2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NHLH2 ( NM_001111061.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001104531.1 Homo sapiens nescient helix-loop-helix 2 (NHLH2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu05087
Clone ID Related Accession (Same CDS sequence)	NM_001111061.1 , NM_001111061.2 , NM_005599.3
Accession Version	NM_001111061.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 408bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	helix-loop-helix protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL449264.18 and BC096360.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA696650.1, SRR1803617.30686.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END##

ATGATGCTGA GTCCGGACCA AGCAGCAGAT TCGGACCATC CCAGCTCGGC GCACTCGGAT 
CCGGAGTCCC TGGGCGGCAC GGACACCAAG GTGCTCGGCA GCGTGTCGGA CCTGGAGCCG 
GTGGAGGAGG CCGAGGGCGA CGGCAAGGGC GGCAGCCGAG CCGCGCTCTA CCCGCACCCG 
CAGCAGCTGA GCCGCGAGGA GAAGCGCCGC CGCCGGCGCG CCACGGCCAA GTACCGCTCG 
GCCCACGCCA CCCGCGAGCG CATCCGCGTG GAAGCCTTCA ACTTGGCCTT CGCCGAGCTC 
CGCAAATTGC TGCCCACGCT GCCCCCGGAC AAGAAGCTCT CCAAGATCGA GATCCTGCGC 
CTGGCCATCT GCTACATCTC CTATCTCAAC CACGTCCTGG ACGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001104531.1
CDS	506..913
Translation	MMLSPDQAADSDHPSSAHSDPESLGGTDTKVLGSVSDLEPVEEAEGDGKGGSRAALYPHPQQLSREEKRRRRRATAKYRSAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLDV

Target ORF information:

RefSeq Version	NM_001111061.1
Organism	Homo sapiens(human)
Definition	Homo sapiens nescient helix-loop-helix 2 (NHLH2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001111061.1

ORF Insert Sequence:

ATGATGCTGA GTCCGGACCA AGCAGCAGAT TCGGACCATC CCAGCTCGGC GCACTCGGAT 
CCGGAGTCCC TGGGCGGCAC GGACACCAAG GTGCTCGGCA GCGTGTCGGA CCTGGAGCCG 
GTGGAGGAGG CCGAGGGCGA CGGCAAGGGC GGCAGCCGAG CCGCGCTCTA CCCGCACCCG 
CAGCAGCTGA GCCGCGAGGA GAAGCGCCGC CGCCGGCGCG CCACGGCCAA GTACCGCTCG 
GCCCACGCCA CCCGCGAGCG CATCCGCGTG GAAGCCTTCA ACTTGGCCTT CGCCGAGCTC 
CGCAAATTGC TGCCCACGCT GCCCCCGGAC AAGAAGCTCT CCAAGATCGA GATCCTGCGC 
CTGGCCATCT GCTACATCTC CTATCTCAAC CACGTCCTGG ACGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NHLH2 ( NM_001111061.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001104531.1 Homo sapiens nescient helix-loop-helix 2 (NHLH2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu05087
Clone ID Related Accession (Same CDS sequence)	NM_001111061.1 , NM_001111061.2 , NM_005599.3
Accession Version	NM_001111061.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 408bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	helix-loop-helix protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL449264.18 and BC096360.1. On May 31, 2019 this sequence version replaced NM_001111061.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.342002.1, SRR1803612.226746.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END##

ATGATGCTGA GTCCGGACCA AGCAGCAGAT TCGGACCATC CCAGCTCGGC GCACTCGGAT 
CCGGAGTCCC TGGGCGGCAC GGACACCAAG GTGCTCGGCA GCGTGTCGGA CCTGGAGCCG 
GTGGAGGAGG CCGAGGGCGA CGGCAAGGGC GGCAGCCGAG CCGCGCTCTA CCCGCACCCG 
CAGCAGCTGA GCCGCGAGGA GAAGCGCCGC CGCCGGCGCG CCACGGCCAA GTACCGCTCG 
GCCCACGCCA CCCGCGAGCG CATCCGCGTG GAAGCCTTCA ACTTGGCCTT CGCCGAGCTC 
CGCAAATTGC TGCCCACGCT GCCCCCGGAC AAGAAGCTCT CCAAGATCGA GATCCTGCGC 
CTGGCCATCT GCTACATCTC CTATCTCAAC CACGTCCTGG ACGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001104531.1
CDS	497..904
Translation	MMLSPDQAADSDHPSSAHSDPESLGGTDTKVLGSVSDLEPVEEAEGDGKGGSRAALYPHPQQLSREEKRRRRRATAKYRSAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLDV

Target ORF information:

RefSeq Version	NM_001111061.2
Organism	Homo sapiens(human)
Definition	Homo sapiens nescient helix-loop-helix 2 (NHLH2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001111061.2

ORF Insert Sequence:

ATGATGCTGA GTCCGGACCA AGCAGCAGAT TCGGACCATC CCAGCTCGGC GCACTCGGAT 
CCGGAGTCCC TGGGCGGCAC GGACACCAAG GTGCTCGGCA GCGTGTCGGA CCTGGAGCCG 
GTGGAGGAGG CCGAGGGCGA CGGCAAGGGC GGCAGCCGAG CCGCGCTCTA CCCGCACCCG 
CAGCAGCTGA GCCGCGAGGA GAAGCGCCGC CGCCGGCGCG CCACGGCCAA GTACCGCTCG 
GCCCACGCCA CCCGCGAGCG CATCCGCGTG GAAGCCTTCA ACTTGGCCTT CGCCGAGCTC 
CGCAAATTGC TGCCCACGCT GCCCCCGGAC AAGAAGCTCT CCAAGATCGA GATCCTGCGC 
CTGGCCATCT GCTACATCTC CTATCTCAAC CACGTCCTGG ACGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NHLH2 ( NM_005599.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005590.1 Homo sapiens nescient helix-loop-helix 2 (NHLH2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu05087
Clone ID Related Accession (Same CDS sequence)	NM_001111061.1 , NM_001111061.2 , NM_005599.3
Accession Version	NM_005599.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 408bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	helix-loop-helix protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA608185.1, BC096360.1 and AL449264.18. On Dec 1, 2007 this sequence version replaced NM_005599.2. Transcript Variant: This variant (1) represents the longer transcript. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M96740.1, SRR1660805.46135.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147596, SAMN03465402 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000320238.3/ ENSP00000322087.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##

ATGATGCTGA GTCCGGACCA AGCAGCAGAT TCGGACCATC CCAGCTCGGC GCACTCGGAT 
CCGGAGTCCC TGGGCGGCAC GGACACCAAG GTGCTCGGCA GCGTGTCGGA CCTGGAGCCG 
GTGGAGGAGG CCGAGGGCGA CGGCAAGGGC GGCAGCCGAG CCGCGCTCTA CCCGCACCCG 
CAGCAGCTGA GCCGCGAGGA GAAGCGCCGC CGCCGGCGCG CCACGGCCAA GTACCGCTCG 
GCCCACGCCA CCCGCGAGCG CATCCGCGTG GAAGCCTTCA ACTTGGCCTT CGCCGAGCTC 
CGCAAATTGC TGCCCACGCT GCCCCCGGAC AAGAAGCTCT CCAAGATCGA GATCCTGCGC 
CTGGCCATCT GCTACATCTC CTATCTCAAC CACGTCCTGG ACGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005590.1
CDS	517..924
Translation	MMLSPDQAADSDHPSSAHSDPESLGGTDTKVLGSVSDLEPVEEAEGDGKGGSRAALYPHPQQLSREEKRRRRRATAKYRSAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLDV

Target ORF information:

RefSeq Version	NM_005599.3
Organism	Homo sapiens(human)
Definition	Homo sapiens nescient helix-loop-helix 2 (NHLH2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005599.3

ORF Insert Sequence:

ATGATGCTGA GTCCGGACCA AGCAGCAGAT TCGGACCATC CCAGCTCGGC GCACTCGGAT 
CCGGAGTCCC TGGGCGGCAC GGACACCAAG GTGCTCGGCA GCGTGTCGGA CCTGGAGCCG 
GTGGAGGAGG CCGAGGGCGA CGGCAAGGGC GGCAGCCGAG CCGCGCTCTA CCCGCACCCG 
CAGCAGCTGA GCCGCGAGGA GAAGCGCCGC CGCCGGCGCG CCACGGCCAA GTACCGCTCG 
GCCCACGCCA CCCGCGAGCG CATCCGCGTG GAAGCCTTCA ACTTGGCCTT CGCCGAGCTC 
CGCAAATTGC TGCCCACGCT GCCCCCGGAC AAGAAGCTCT CCAAGATCGA GATCCTGCGC 
CTGGCCATCT GCTACATCTC CTATCTCAAC CACGTCCTGG ACGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NHLH2 ( XM_017001370.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016856859.1 Homo sapiens nescient helix-loop-helix 2 (NHLH2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu90062
Clone ID Related Accession (Same CDS sequence)	XM_017001370.1
Accession Version	XM_017001370.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 723bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	helix-loop-helix protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGCTCC GGGAGCCTGC GAGGGCATCG GAGTCAATTT TCTTTTTAAA GGCTCCCCCA 
CGTTTGTTTA GTCATTTCTT TACGATTTCG GAGAAGCGCG AGGGGTCCAA GAAGCCTTCC 
CGCCCCCAGC CACTGGCTCT CCGCCTGCGC TCCAGGATGG GGATTCCTGA CCGGCCGCAC 
CCCAGAGCCA GGCGCCCCCG GCGCAGCCCC AGACCAGCGC CAGGCCCTCG GGCGCCGCGG 
CTGCCGGGTT GCTTCGCCGG AGGCCCTCGG GGCGAGAAGT GCACCCCGCG TCTCCCCGCC 
CCCGTGAAAA CCCAGATGTA TTCGTTGTTC GAAATCGCTC GTTTGTCCGG GAAGGGGACG 
AAGGGAGGGA GGAGGAATAG CGCGGTTGGC ATTTGGCCGG AAGAGGCACA AAAACCCAGT 
CGCGACCCCA CAGGCCTGCG GTTGTTCCCC AGGCCCAGGG CCACAGGCCC GCTGTGGCCG 
TCTGCAAGTC GAGGTGTCCA GTCTAGTATG CGGCCTGGGT CAACCGCGTC CCCGCCGGCT 
CCCGCGCCAG GGCGAGGCGC AGGGCTCGCG CCCTCGGGCC AGATCCTATC GGCGCCCTCC 
CGCGTCGCGC GCCGGCCTGC TGTGGGGAGG GGGCCCGGGC CGCGCGTCCG CTGGGAGGAC 
CGGCGTGGTA GGCCTCGGCA GCCATCCTTC CAGCAAAATA CCCTGATTCC TTTTACTGAT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016856859.1
CDS	1602..2324
Translation	MVLREPARASESIFFLKAPPRLFSHFFTISEKREGSKKPSRPQPLALRLRSRMGIPDRPHPRARRPRRSPRPAPGPRAPRLPGCFAGGPRGEKCTPRLPAPVKTQMYSLFEIARLSGKGTKGGRRNSAVGIWPEEAQKPSRDPTGLRLFPRPRATGPLWPSASRGVQSSMRPGSTASPPAPAPGRGAGLAPSGQILSAPSRVARRPAVGRGPGPRVRWEDRRGRPRQPSFQQNTLIPFTD

Target ORF information:

RefSeq Version	XM_017001370.1
Organism	Homo sapiens(human)
Definition	Homo sapiens nescient helix-loop-helix 2 (NHLH2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017001370.1

ORF Insert Sequence:

ATGGTGCTCC GGGAGCCTGC GAGGGCATCG GAGTCAATTT TCTTTTTAAA GGCTCCCCCA 
CGTTTGTTTA GTCATTTCTT TACGATTTCG GAGAAGCGCG AGGGGTCCAA GAAGCCTTCC 
CGCCCCCAGC CACTGGCTCT CCGCCTGCGC TCCAGGATGG GGATTCCTGA CCGGCCGCAC 
CCCAGAGCCA GGCGCCCCCG GCGCAGCCCC AGACCAGCGC CAGGCCCTCG GGCGCCGCGG 
CTGCCGGGTT GCTTCGCCGG AGGCCCTCGG GGCGAGAAGT GCACCCCGCG TCTCCCCGCC 
CCCGTGAAAA CCCAGATGTA TTCGTTGTTC GAAATCGCTC GTTTGTCCGG GAAGGGGACG 
AAGGGAGGGA GGAGGAATAG CGCGGTTGGC ATTTGGCCGG AAGAGGCACA AAAACCCAGT 
CGCGACCCCA CAGGCCTGCG GTTGTTCCCC AGGCCCAGGG CCACAGGCCC GCTGTGGCCG 
TCTGCAAGTC GAGGTGTCCA GTCTAGTATG CGGCCTGGGT CAACCGCGTC CCCGCCGGCT 
CCCGCGCCAG GGCGAGGCGC AGGGCTCGCG CCCTCGGGCC AGATCCTATC GGCGCCCTCC 
CGCGTCGCGC GCCGGCCTGC TGTGGGGAGG GGGCCCGGGC CGCGCGTCCG CTGGGAGGAC 
CGGCGTGGTA GGCCTCGGCA GCCATCCTTC CAGCAAAATA CCCTGATTCC TTTTACTGAT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Genetic Basis for Motivated Exercise.
Exercise and sport sciences reviews43(4)231-7(2015 Oct)
Good DJ,Li M,Deater-Deckard K

Leptin signaling regulates hypothalamic expression of nescient helix-loop-helix 2 (Nhlh2) through signal transducer and activator 3 (Stat3).
Molecular and cellular endocrinology384(1-2)134-42(2014 Mar)
Al Rayyan N,Zhang J,Burnside AS,Good DJ

Two single nucleotide polymorphisms in the human nescient helix-loop-helix 2 (NHLH2) gene reduce mRNA stability and DNA binding.
Gene512(1)134-42(2013 Jan)
Al Rayyan N,Wankhade UD,Bush K,Good DJ

SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive.
Cell147(7)1459-72(2011 Dec)
Libert S,Pointer K,Bell EL,Das A,Cohen DE,Asara JM,Kapur K,Bergmann S,Preisig M,Otowa T,Kendler KS,Chen X,Hettema JM,van den Oord EJ,Rubio JP,Guarente L

Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1.
PloS one6(5)e19297(2011 May)
Isogai E,Ohira M,Ozaki T,Oba S,Nakamura Y,Nakagawara A

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NHLH2 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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