Suv39h2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Suv39h2
Entrez Gene ID	64707
Full Name	suppressor of variegation 3-9 2
Synonyms	4930507K23Rik,AA536750,D030054H19Rik,D2Ertd544e,KMT1B
General protein information	Preferred Names suppressor of variegation 3-9 2 Names histone-lysine N-methyltransferase SUV39H2 H3-K9-HMTase 2 Suv39h histone methyltransferase histone H3-K9 methyltransferase 2 su(var)3-9 homolog 2 suppressor of variegation 3-9 homolog 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 A1\|2 1.95 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_022724.4	NP_073561.2	histone-lysine N-methyltransferase SUV39H2

Pathways from BioSystems

Homologies

	SUV39H2	XP_002805605.1
Bos taurus (cattle)	SUV39H2	NP_001032556.1
Rattus norvegicus (Norway rat)	Suv39h2	NP_001102353.1
Xenopus tropicalis (tropical clawed frog)	suv39h2	NP_001016508.1
Pan troglodytes (chimpanzee)	SUV39H2	XP_001147642.1
Canis lupus familiaris (dog)	SUV39H2	XP_535179.2
Gallus gallus (chicken)	SUV39H2	NP_001026541.1
Mus musculus (house mouse)	Suv39h2	NP_073561.2
Homo sapiens (human)	SUV39H2	NP_001180353.1

Gene Ontology
Bibliography

Related articles in PubMed

Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin.
Matsuura T, Miyazaki S, Miyazaki T, Tashiro F, Miyazaki JI
Scientific reports7(1)12462(2017 Sep)

Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation.
Velazquez Camacho O, Galan C, Swist-Rosowska K, Ching R, Gamalinda M, Karabiber F, De La Rosa-Velazquez I, Engist B, Koschorz B, Shukeir N, Onishi-Seebacher M, van de Nobelen S, Jenuwein T
eLife6(2017 Aug)

YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis.
Lin C, Yao E, Zhang K, Jiang X, Croll S, Thompson-Peer K, Chuang PT
eLife6(2017 Mar)

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.
Yang G, Weng X, Zhao Y, Zhang X, Hu Y, Dai X, Liang P, Wang P, Ma L, Sun X, Hou L, Xu H, Fang M, Li Y, Jenuwein T, Xu Y, Sun A
Nature communications814941(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that histone methyltransferase Suv39h2 expression is up-regulated in the liver in liver steatosis.
Title: Suv39h2 deficiency ameliorates diet-induced steatosis in mice.

Repeat-associated, Suv39h-dependent H3K9me3 displays a dynamic distribution that differs in the epigenome of pluripotent versus more committed cells.
Title: Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells.

Taken together, the results indicate epigenetic regulation of telomere length in mammals by Suv39h1 and Suv39h2.
Title: Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases.

ESET histone methyltransferase can form a large, multi-protein complex(es) with mSin3A/B co-repressors and HDAC1/2 that participates in multiple pathways of transcriptional repression.
Title: An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B.

The following Suv39h2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Suv39h2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12923	NM_022724.4 Latest version!	Mus musculus suppressor of variegation 3-9 2 (Suv39h2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$279.30 $399.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Suv39h2 ( NM_022724.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_073561.2 Mus musculus suppressor of variegation 3-9 2 (Suv39h2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu12923
Clone ID Related Accession (Same CDS sequence)	NM_022724.4
Accession Version	NM_022724.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1434bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	histone-lysine N-methyltransferase SUV39H2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CX227854.1, AK083457.1 and AL732620.14. On Apr 23, 2009 this sequence version replaced NM_022724.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK083457.1, AF149205.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CCAGGGCCAA GGCACGGGGC AGTGAGGCAG GAGCGCGGTG TCACCGGGCT 
CCAGGTCCGC CCCCGAGGCC CAAGGCCAGG CGAACGGCGA GACGCCGCCG CGCGGAGACC 
CTGACGGCGC GACGCTCGCG GCCGTCTGCG GGCGAGAGGC GCGCCGGCTC CCAGCGAGCG 
TGGTCCGGAG CTCCGCGGGC CGCGGTCTTT GGCGACGAGT GTGCACGAGG TGCCTTATTC 
AAGGCCTGGT GTGTGCCTTG CCTAGTTTCA CTTGATACTC TCCAGGAATT ATGTAGAAAA 
GAAAAGCTCA CATGTAAATC GATTGGAATC ACCAAAAGGA ATCTAAACAA TTATGAGGTG 
GAGTACTTGT GTGACTACAA GGTAGCAAAG GGTGTGGAAT ATTATCTTGT AAAATGGAAA 
GGATGGCCAG ATTCTACAAA CACCTGGGAG CCCTTGAGAA ACCTCAGGTG TCCACAGCTC 
CTGCGGCAGT TCTCTGATGA CAAGAAGACT TACTTAGCTC AGGAAAGGAA ATGCAAGGCT 
GTCAATTCAA AATCCTTGCA ACCTGCAATT GCTGAGTATA TTGTACAGAA AGCTAAGCAA 
AGAATAGCTC TGCAGAGATG GCAAGATTAC CTCAACAGAA GAAAGAACCA TAAGGGGATG 
ATATTTGTTG AAAACACTGT TGACTTGGAG GGCCCACCTT TAGACTTCTA CTACATTAAC 
GAGTACAGGC CAGCTCCCGG GATCAGCATA AACAGTGAAG CCACCTTTGG ATGTTCATGT 
ACAGACTGCT TCTTTGACAA GTGTTGTCCT GCTGAAGCTG GAGTTGTGTT GGCTTATAAT 
AAGAAGCAAC AAATTAAAAT CCAACCAGGC ACTCCCATCT ACGAATGCAA CTCAAGGTGT 
CGATGTGGAC CTGAATGTCC CAATAGGATT GTACAAAAAG GCACACAATA TTCACTGTGC 
ATCTTTAGAA CTAGCAATGG CTGTGGTTGG GGTGTAAAAA CCCTTGTGAA GATTAAAAGA 
ATGAGTTTTG TCATGGAATA TGTTGGAGAG GTGATCACAA GTGAAGAGGC CGAGAGACGG 
GGACAGTTCT ATGACAACAA AGGGATCACC TACCTCTTTG ACCTGGACTA CGAGTCTGAT 
GAGTTCACAG TGGATGCAGC TCGATATGGA AACGTATCCC ATTTTGTGAA TCATAGTTGT 
GACCCAAATC TTCAGGTGTT TAGTGTTTTC ATCGATAACC TTGATACTCG GCTGCCCAGG 
ATAGCATTGT TCTCTACAAG AACCATAAAC GCTGGAGAAG AGCTGACTTT TGACTATCAA 
ATGAAAGGTT CTGGAGAAGC ATCTTCAGAC TCCATTGACC ACAGCCCTGC CAAAAAAAGG 
GTCAGAACCC AATGTAAATG TGGAGCCGAG ACTTGCAGAG GTTACCTCAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_073561.2
CDS	41..1474
Translation	MAAARAKARGSEAGARCHRAPGPPPRPKARRTARRRRAETLTARRSRPSAGERRAGSQRAWSGAPRAAVFGDECARGALFKAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVAKGVEYYLVKWKGWPDSTNTWEPLRNLRCPQLLRQFSDDKKTYLAQERKCKAVNSKSLQPAIAEYIVQKAKQRIALQRWQDYLNRRKNHKGMIFVENTVDLEGPPLDFYYINEYRPAPGISINSEATFGCSCTDCFFDKCCPAEAGVVLAYNKKQQIKIQPGTPIYECNSRCRCGPECPNRIVQKGTQYSLCIFRTSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGEASSDSIDHSPAKKRVRTQCKCGAETCRGYLN

Target ORF information:

RefSeq Version	NM_022724.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus suppressor of variegation 3-9 2 (Suv39h2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022724.4

ORF Insert Sequence:

ATGGCGGCGG CCAGGGCCAA GGCACGGGGC AGTGAGGCAG GAGCGCGGTG TCACCGGGCT 
CCAGGTCCGC CCCCGAGGCC CAAGGCCAGG CGAACGGCGA GACGCCGCCG CGCGGAGACC 
CTGACGGCGC GACGCTCGCG GCCGTCTGCG GGCGAGAGGC GCGCCGGCTC CCAGCGAGCG 
TGGTCCGGAG CTCCGCGGGC CGCGGTCTTT GGCGACGAGT GTGCACGAGG TGCCTTATTC 
AAGGCCTGGT GTGTGCCTTG CCTAGTTTCA CTTGATACTC TCCAGGAATT ATGTAGAAAA 
GAAAAGCTCA CATGTAAATC GATTGGAATC ACCAAAAGGA ATCTAAACAA TTATGAGGTG 
GAGTACTTGT GTGACTACAA GGTAGCAAAG GGTGTGGAAT ATTATCTTGT AAAATGGAAA 
GGATGGCCAG ATTCTACAAA CACCTGGGAG CCCTTGAGAA ACCTCAGGTG TCCACAGCTC 
CTGCGGCAGT TCTCTGATGA CAAGAAGACT TACTTAGCTC AGGAAAGGAA ATGCAAGGCT 
GTCAATTCAA AATCCTTGCA ACCTGCAATT GCTGAGTATA TTGTACAGAA AGCTAAGCAA 
AGAATAGCTC TGCAGAGATG GCAAGATTAC CTCAACAGAA GAAAGAACCA TAAGGGGATG 
ATATTTGTTG AAAACACTGT TGACTTGGAG GGCCCACCTT TAGACTTCTA CTACATTAAC 
GAGTACAGGC CAGCTCCCGG GATCAGCATA AACAGTGAAG CCACCTTTGG ATGTTCATGT 
ACAGACTGCT TCTTTGACAA GTGTTGTCCT GCTGAAGCTG GAGTTGTGTT GGCTTATAAT 
AAGAAGCAAC AAATTAAAAT CCAACCAGGC ACTCCCATCT ACGAATGCAA CTCAAGGTGT 
CGATGTGGAC CTGAATGTCC CAATAGGATT GTACAAAAAG GCACACAATA TTCACTGTGC 
ATCTTTAGAA CTAGCAATGG CTGTGGTTGG GGTGTAAAAA CCCTTGTGAA GATTAAAAGA 
ATGAGTTTTG TCATGGAATA TGTTGGAGAG GTGATCACAA GTGAAGAGGC CGAGAGACGG 
GGACAGTTCT ATGACAACAA AGGGATCACC TACCTCTTTG ACCTGGACTA CGAGTCTGAT 
GAGTTCACAG TGGATGCAGC TCGATATGGA AACGTATCCC ATTTTGTGAA TCATAGTTGT 
GACCCAAATC TTCAGGTGTT TAGTGTTTTC ATCGATAACC TTGATACTCG GCTGCCCAGG 
ATAGCATTGT TCTCTACAAG AACCATAAAC GCTGGAGAAG AGCTGACTTT TGACTATCAA 
ATGAAAGGTT CTGGAGAAGC ATCTTCAGAC TCCATTGACC ACAGCCCTGC CAAAAAAAGG 
GTCAGAACCC AATGTAAATG TGGAGCCGAG ACTTGCAGAG GTTACCTCAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin.
Scientific reports7(1)12462(2017 Sep)
Matsuura T,Miyazaki S,Miyazaki T,Tashiro F,Miyazaki JI

Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation.
eLife6(2017 Aug)
Velazquez Camacho O,Galan C,Swist-Rosowska K,Ching R,Gamalinda M,Karabiber F,De La Rosa-Velazquez I,Engist B,Koschorz B,Shukeir N,Onishi-Seebacher M,van de Nobelen S,Jenuwein T

YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis.
eLife6(2017 Mar)
Lin C,Yao E,Zhang K,Jiang X,Croll S,Thompson-Peer K,Chuang PT

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.
Nature communications814941(2017 Mar)
Yang G,Weng X,Zhao Y,Zhang X,Hu Y,Dai X,Liang P,Wang P,Ma L,Sun X,Hou L,Xu H,Fang M,Li Y,Jenuwein T,Xu Y,Sun A

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Suv39h2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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