TPC1 cDNA ORF clone, Arabidopsis thaliana(thale cress)

Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.
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Nature402(6763)769-77(1999 Dec)

Structure-function analysis of the Arabidopsis TPC1 channel in planta confirmed that helix S10 operates as the major voltage-sensing site, with Glu450 and Glu478 identified as possible ion-pair partners for voltage-sensing Arg537.
Title: Gating of the two-pore cation channel AtTPC1 in the plant vacuole is based on a single voltage-sensing domain.

This study discovered that the dimerization of a predicted helix within the carboxyl-terminus is essential for the activity of TPC1.
Title: The function of the two-pore channel TPC1 depends on dimerization of its carboxy-terminal helix.

TPC1 role in the systemic response to salt stress
Title: A ROS-Assisted Calcium Wave Dependent on the AtRBOHD NADPH Oxidase and TPC1 Cation Channel Propagates the Systemic Response to Salt Stress.

The domain architecture of TPC1 has been discussed.
Title: Two-pore Channels Enter the Atomic Era: Structure of Plant TPC Revealed.

crystal structure of TPC1 from Arabidopsis thaliana at 2.87 A resolution as a basis for understanding ion permeation, channel activation, the location of voltage-sensing domains and regulatory ion-binding sites
Title: Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana.