PSENEN cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PSENEN
Entrez Gene ID	55851
Full Name	presenilin enhancer gamma-secretase subunit
Synonyms	ACNINV2,MDS033,MSTP064,PEN-2,PEN2
General protein information	Preferred Names presenilin enhancer gamma-secretase subunit Names gamma-secretase subunit PEN-2 hematopoietic stem/progenitor cells protein MDS033 presenilin enhancer 2 homolog
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 19 Map Location: 19q13.12
Summary	Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Disorder MIM:	607632
Disorder Html:	Acne inversa, familial, 2, with or without Dowling-Degos disease, 613736 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001281532.2	NP_001268461.1	gamma-secretase subunit PEN-2
NM_172341.4	NP_758844.1	gamma-secretase subunit PEN-2
NM_172341.2	NP_758844.1	gamma-secretase subunit PEN-2
NM_001281532.3	NP_001268461.1	gamma-secretase subunit PEN-2
NM_172341.3	NP_758844.1	gamma-secretase subunit PEN-2
NM_001281532.1	NP_001268461.1	gamma-secretase subunit PEN-2

Pathways from BioSystems

Homologies

Homo sapiens (human)	PSENEN	NP_001268461.1
	PSENEN	XP_002801231.1
Drosophila melanogaster (fruit fly)	pen-2	NP_788401.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008094	XP_317362.2
Xenopus tropicalis (tropical clawed frog)	psenen	NP_001016336.1
Pan troglodytes (chimpanzee)	PSENEN	XP_512600.1
Mus musculus (house mouse)	Psenen	NP_079774.1
Canis lupus familiaris (dog)	PSENEN	XP_533689.1
Bos taurus (cattle)	PSENEN	NP_001008669.1
Rattus norvegicus (Norway rat)	Psenen	NP_001008764.1
Danio rerio (zebrafish)	psenen	NP_991139.1
Caenorhabditis elegans (roundworm)	pen-2	NP_499459.1

Gene Ontology
Bibliography

Related articles in PubMed

?-Secretase inhibitor reduces immunosuppressive cells and enhances tumour immunity in head and neck squamous cell carcinoma.
Mao L, Zhao ZL, Yu GT, Wu L, Deng WW, Li YC, Liu JF, Bu LL, Liu B, Kulkarni AB, Zhang WF, Zhang L, Sun ZJ
International journal of cancer142(5)999-1009(2018 Mar)

A phenotype combining hidradenitis suppurativa with Dowling-Degos disease caused by a founder mutation in PSENEN.
Pavlovsky M, Sarig O, Eskin-Schwartz M, Malchin N, Bochner R, Mohamad J, Gat A, Peled A, Hafner A, Sprecher E
The British journal of dermatology(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PSENEN mutations can indeed cause a comanifestation of Dowling-Degos disease and acne inversa (AI) that is likely triggered by predisposing factors for AI.
Title: Mutations in ?-secretase subunit-encoding PSENEN underlie Dowling-Degos disease associated with acne inversa.

zinc, copper inhibited Abeta production by directly targeting the subunits presenilin and nicastrin in the gamma-secretase complex
Title: Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by ?-Secretase and Amyloid-? Peptide Production.

APP substrate occupancy of these three pockets of gamma-secretase occurs after initial substrate binding but precedes catalysis, suggesting a conformational change in substrate may be required for cleavage.
Title: The amyloid-beta forming tripeptide cleavage mechanism of ?-secretase.

Remarkably, PEN-2 was identified besides nicastrin as additional substrate-binding subunit.
Title: Substrate recruitment of ?-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping.

PSENEN may play a crucial role in the progression of atopic dermatitis by participating in the Notch signaling pathway.
Title: Identification of candidate genes in atopic dermatitis based on bioinformatic methods.

The following PSENEN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSENEN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00537	NM_001281532.3 Latest version!	Homo sapiens presenilin enhancer, gamma-secretase subunit (PSENEN), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu00537	NM_172341.4 Latest version!	Homo sapiens presenilin enhancer, gamma-secretase subunit (PSENEN), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu00537	NM_172341.2	Homo sapiens presenilin enhancer gamma secretase subunit (PSENEN), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu00537	NM_001281532.2	Homo sapiens presenilin enhancer, gamma-secretase subunit (PSENEN), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu00537	NM_172341.3	Homo sapiens presenilin enhancer gamma-secretase subunit (PSENEN), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu00537	NM_001281532.1	Homo sapiens presenilin enhancer gamma secretase subunit (PSENEN), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PSENEN ( NM_001281532.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001268461.1 Homo sapiens presenilin enhancer, gamma-secretase subunit (PSENEN), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu00537
Clone ID Related Accession (Same CDS sequence)	NM_001281532.2 , NM_172341.4 , NM_172341.2 , NM_001281532.3 , NM_172341.3 , NM_001281532.1
Accession Version	NM_001281532.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	gamma-secretase subunit PEN-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB136623.1, AF220053.1, BC009575.1, BE563017.1, AA252937.1 and AI215167.1. On Oct 26, 2016 this sequence version replaced NM_001281532.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC009575.1, BE730034.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACCTGG AGCGAGTGTC CAATGAGGAG AAATTGAACC TGTGCCGGAA GTACTACCTG 
GGGGGGTTTG CTTTCCTGCC TTTTCTCTGG TTGGTCAACA TCTTCTGGTT CTTCCGAGAG 
GCCTTCCTTG TCCCAGCCTA CACAGAACAG AGCCAAATCA AAGGCTATGT CTGGCGCTCA 
GCTGTGGGCT TCCTCTTCTG GGTGATAGTG CTCACCTCCT GGATCACCAT CTTCCAGATC 
TACCGGCCCC GCTGGGGTGC CCTTGGGGAC TACCTCTCCT TCACCATACC CCTGGGCACC 
CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001268461.1
CDS	183..488
Translation	MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRPRWGALGDYLSFTIPLGTP

Target ORF information:

RefSeq Version	NM_001281532.2
Organism	Homo sapiens(human)
Definition	Homo sapiens presenilin enhancer, gamma-secretase subunit (PSENEN), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001281532.2

ORF Insert Sequence:

ATGAACCTGG AGCGAGTGTC CAATGAGGAG AAATTGAACC TGTGCCGGAA GTACTACCTG 
GGGGGGTTTG CTTTCCTGCC TTTTCTCTGG TTGGTCAACA TCTTCTGGTT CTTCCGAGAG 
GCCTTCCTTG TCCCAGCCTA CACAGAACAG AGCCAAATCA AAGGCTATGT CTGGCGCTCA 
GCTGTGGGCT TCCTCTTCTG GGTGATAGTG CTCACCTCCT GGATCACCAT CTTCCAGATC 
TACCGGCCCC GCTGGGGTGC CCTTGGGGAC TACCTCTCCT TCACCATACC CCTGGGCACC 
CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSENEN ( NM_172341.4 ) cDNA ORF clone, Homo sapiens(Human) -> NP_758844.1 Homo sapiens presenilin enhancer, gamma-secretase subunit (PSENEN), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00537
Clone ID Related Accession (Same CDS sequence)	NM_001281532.2 , NM_172341.4 , NM_172341.2 , NM_001281532.3 , NM_172341.3 , NM_001281532.1
Accession Version	NM_172341.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	gamma-secretase subunit PEN-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF220053.1, BE563017.1, AA252937.1 and AI215167.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_172341.3. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DB291008.1, SRR1163658.469143.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000587708.7/ ENSP00000468411.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAACCTGG AGCGAGTGTC CAATGAGGAG AAATTGAACC TGTGCCGGAA GTACTACCTG 
GGGGGGTTTG CTTTCCTGCC TTTTCTCTGG TTGGTCAACA TCTTCTGGTT CTTCCGAGAG 
GCCTTCCTTG TCCCAGCCTA CACAGAACAG AGCCAAATCA AAGGCTATGT CTGGCGCTCA 
GCTGTGGGCT TCCTCTTCTG GGTGATAGTG CTCACCTCCT GGATCACCAT CTTCCAGATC 
TACCGGCCCC GCTGGGGTGC CCTTGGGGAC TACCTCTCCT TCACCATACC CCTGGGCACC 
CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_758844.1
CDS	147..452
Translation	MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRPRWGALGDYLSFTIPLGTP

Target ORF information:

RefSeq Version	NM_172341.4
Organism	Homo sapiens(human)
Definition	Homo sapiens presenilin enhancer, gamma-secretase subunit (PSENEN), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172341.4

ORF Insert Sequence:

ATGAACCTGG AGCGAGTGTC CAATGAGGAG AAATTGAACC TGTGCCGGAA GTACTACCTG 
GGGGGGTTTG CTTTCCTGCC TTTTCTCTGG TTGGTCAACA TCTTCTGGTT CTTCCGAGAG 
GCCTTCCTTG TCCCAGCCTA CACAGAACAG AGCCAAATCA AAGGCTATGT CTGGCGCTCA 
GCTGTGGGCT TCCTCTTCTG GGTGATAGTG CTCACCTCCT GGATCACCAT CTTCCAGATC 
TACCGGCCCC GCTGGGGTGC CCTTGGGGAC TACCTCTCCT TCACCATACC CCTGGGCACC 
CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSENEN ( NM_172341.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_758844.1 Homo sapiens presenilin enhancer gamma secretase subunit (PSENEN), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00537
Clone ID Related Accession (Same CDS sequence)	NM_001281532.2 , NM_172341.4 , NM_172341.2 , NM_001281532.3 , NM_172341.3 , NM_001281532.1
Accession Version	NM_172341.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	gamma-secretase subunit PEN-2
Comment

ATGAACCTGG AGCGAGTGTC CAATGAGGAG AAATTGAACC TGTGCCGGAA GTACTACCTG 
GGGGGGTTTG CTTTCCTGCC TTTTCTCTGG TTGGTCAACA TCTTCTGGTT CTTCCGAGAG 
GCCTTCCTTG TCCCAGCCTA CACAGAACAG AGCCAAATCA AAGGCTATGT CTGGCGCTCA 
GCTGTGGGCT TCCTCTTCTG GGTGATAGTG CTCACCTCCT GGATCACCAT CTTCCAGATC 
TACCGGCCCC GCTGGGGTGC CCTTGGGGAC TACCTCTCCT TCACCATACC CCTGGGCACC 
CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_758844.1
Translation	MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRPRWGALGDYLSFTIPLGTP

Target ORF information:

RefSeq Version	NM_172341.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens presenilin enhancer gamma secretase subunit (PSENEN), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172341.2

ORF Insert Sequence:

ATGAACCTGG AGCGAGTGTC CAATGAGGAG AAATTGAACC TGTGCCGGAA GTACTACCTG 
GGGGGGTTTG CTTTCCTGCC TTTTCTCTGG TTGGTCAACA TCTTCTGGTT CTTCCGAGAG 
GCCTTCCTTG TCCCAGCCTA CACAGAACAG AGCCAAATCA AAGGCTATGT CTGGCGCTCA 
GCTGTGGGCT TCCTCTTCTG GGTGATAGTG CTCACCTCCT GGATCACCAT CTTCCAGATC 
TACCGGCCCC GCTGGGGTGC CCTTGGGGAC TACCTCTCCT TCACCATACC CCTGGGCACC 
CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSENEN ( NM_001281532.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001268461.1 Homo sapiens presenilin enhancer, gamma-secretase subunit (PSENEN), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu00537
Clone ID Related Accession (Same CDS sequence)	NM_001281532.2 , NM_172341.4 , NM_172341.2 , NM_001281532.3 , NM_172341.3 , NM_001281532.1
Accession Version	NM_001281532.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-17
Organism	Homo sapiens(human)
Product	gamma-secretase subunit PEN-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF220053.1, BC009575.1, BE563017.1, AA252937.1 and AI215167.1. On May 31, 2019 this sequence version replaced NM_001281532.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC009575.1, BI032144.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACCTGG AGCGAGTGTC CAATGAGGAG AAATTGAACC TGTGCCGGAA GTACTACCTG 
GGGGGGTTTG CTTTCCTGCC TTTTCTCTGG TTGGTCAACA TCTTCTGGTT CTTCCGAGAG 
GCCTTCCTTG TCCCAGCCTA CACAGAACAG AGCCAAATCA AAGGCTATGT CTGGCGCTCA 
GCTGTGGGCT TCCTCTTCTG GGTGATAGTG CTCACCTCCT GGATCACCAT CTTCCAGATC 
TACCGGCCCC GCTGGGGTGC CCTTGGGGAC TACCTCTCCT TCACCATACC CCTGGGCACC 
CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001268461.1
CDS	109..414
Translation	MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRPRWGALGDYLSFTIPLGTP

Target ORF information:

RefSeq Version	NM_001281532.3
Organism	Homo sapiens(human)
Definition	Homo sapiens presenilin enhancer, gamma-secretase subunit (PSENEN), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001281532.3

ORF Insert Sequence:

ATGAACCTGG AGCGAGTGTC CAATGAGGAG AAATTGAACC TGTGCCGGAA GTACTACCTG 
GGGGGGTTTG CTTTCCTGCC TTTTCTCTGG TTGGTCAACA TCTTCTGGTT CTTCCGAGAG 
GCCTTCCTTG TCCCAGCCTA CACAGAACAG AGCCAAATCA AAGGCTATGT CTGGCGCTCA 
GCTGTGGGCT TCCTCTTCTG GGTGATAGTG CTCACCTCCT GGATCACCAT CTTCCAGATC 
TACCGGCCCC GCTGGGGTGC CCTTGGGGAC TACCTCTCCT TCACCATACC CCTGGGCACC 
CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSENEN ( NM_172341.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_758844.1 Homo sapiens presenilin enhancer gamma-secretase subunit (PSENEN), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00537
Clone ID Related Accession (Same CDS sequence)	NM_001281532.2 , NM_172341.4 , NM_172341.2 , NM_001281532.3 , NM_172341.3 , NM_001281532.1
Accession Version	NM_172341.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	gamma-secretase subunit PEN-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB136623.1, AF220053.1, BE563017.1, AA252937.1 and AI215167.1. This sequence is a reference standard in the RefSeqGene project. On Oct 26, 2016 this sequence version replaced NM_172341.2. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB136623.1, SRR1163658.469143.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACCTGG AGCGAGTGTC CAATGAGGAG AAATTGAACC TGTGCCGGAA GTACTACCTG 
GGGGGGTTTG CTTTCCTGCC TTTTCTCTGG TTGGTCAACA TCTTCTGGTT CTTCCGAGAG 
GCCTTCCTTG TCCCAGCCTA CACAGAACAG AGCCAAATCA AAGGCTATGT CTGGCGCTCA 
GCTGTGGGCT TCCTCTTCTG GGTGATAGTG CTCACCTCCT GGATCACCAT CTTCCAGATC 
TACCGGCCCC GCTGGGGTGC CCTTGGGGAC TACCTCTCCT TCACCATACC CCTGGGCACC 
CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_758844.1
CDS	221..526
Translation	MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRPRWGALGDYLSFTIPLGTP

Target ORF information:

RefSeq Version	NM_172341.3
Organism	Homo sapiens(human)
Definition	Homo sapiens presenilin enhancer gamma-secretase subunit (PSENEN), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172341.3

ORF Insert Sequence:

ATGAACCTGG AGCGAGTGTC CAATGAGGAG AAATTGAACC TGTGCCGGAA GTACTACCTG 
GGGGGGTTTG CTTTCCTGCC TTTTCTCTGG TTGGTCAACA TCTTCTGGTT CTTCCGAGAG 
GCCTTCCTTG TCCCAGCCTA CACAGAACAG AGCCAAATCA AAGGCTATGT CTGGCGCTCA 
GCTGTGGGCT TCCTCTTCTG GGTGATAGTG CTCACCTCCT GGATCACCAT CTTCCAGATC 
TACCGGCCCC GCTGGGGTGC CCTTGGGGAC TACCTCTCCT TCACCATACC CCTGGGCACC 
CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSENEN ( NM_001281532.1 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001268461.1 Homo sapiens presenilin enhancer gamma secretase subunit (PSENEN), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu00537
Clone ID Related Accession (Same CDS sequence)	NM_001281532.2 , NM_172341.4 , NM_172341.2 , NM_001281532.3 , NM_172341.3 , NM_001281532.1
Accession Version	NM_001281532.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	gamma-secretase subunit PEN-2
Comment

ATGAACCTGG AGCGAGTGTC CAATGAGGAG AAATTGAACC TGTGCCGGAA GTACTACCTG 
GGGGGGTTTG CTTTCCTGCC TTTTCTCTGG TTGGTCAACA TCTTCTGGTT CTTCCGAGAG 
GCCTTCCTTG TCCCAGCCTA CACAGAACAG AGCCAAATCA AAGGCTATGT CTGGCGCTCA 
GCTGTGGGCT TCCTCTTCTG GGTGATAGTG CTCACCTCCT GGATCACCAT CTTCCAGATC 
TACCGGCCCC GCTGGGGTGC CCTTGGGGAC TACCTCTCCT TCACCATACC CCTGGGCACC 
CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001268461.1
Translation	MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRPRWGALGDYLSFTIPLGTP

Target ORF information:

RefSeq Version	NM_001281532.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens presenilin enhancer gamma secretase subunit (PSENEN), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001281532.1

ORF Insert Sequence:

ATGAACCTGG AGCGAGTGTC CAATGAGGAG AAATTGAACC TGTGCCGGAA GTACTACCTG 
GGGGGGTTTG CTTTCCTGCC TTTTCTCTGG TTGGTCAACA TCTTCTGGTT CTTCCGAGAG 
GCCTTCCTTG TCCCAGCCTA CACAGAACAG AGCCAAATCA AAGGCTATGT CTGGCGCTCA 
GCTGTGGGCT TCCTCTTCTG GGTGATAGTG CTCACCTCCT GGATCACCAT CTTCCAGATC 
TACCGGCCCC GCTGGGGTGC CCTTGGGGAC TACCTCTCCT TCACCATACC CCTGGGCACC 
CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

?-Secretase inhibitor reduces immunosuppressive cells and enhances tumour immunity in head and neck squamous cell carcinoma.
International journal of cancer142(5)999-1009(2018 Mar)
Mao L,Zhao ZL,Yu GT,Wu L,Deng WW,Li YC,Liu JF,Bu LL,Liu B,Kulkarni AB,Zhang WF,Zhang L,Sun ZJ

A phenotype combining hidradenitis suppurativa with Dowling-Degos disease caused by a founder mutation in PSENEN.
The British journal of dermatology(2017 Sep)
Pavlovsky M,Sarig O,Eskin-Schwartz M,Malchin N,Bochner R,Mohamad J,Gat A,Peled A,Hafner A,Sprecher E

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PSENEN cDNA ORF clone, Homo sapiens(Human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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