SYNJ2BP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SYNJ2BP
Entrez Gene ID	55333
Full Name	synaptojanin 2 binding protein
Synonyms	ARIP2,OMP25
General protein information	Preferred Names synaptojanin 2 binding protein Names synaptojanin-2-binding protein activin receptor interacting protein 5 mitochondrial outer membrane protein 25
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q24.2
Disorder MIM:	609411

mRNA and Protein(s)

mRNA	Protein	Name
NM_018373.2	NP_060843.2	synaptojanin-2-binding protein
NM_018373.3	NP_060843.2	synaptojanin-2-binding protein

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	SYNJ2BP	NP_001264717.1
Danio rerio (zebrafish)	synj2bp	NP_956211.1
Rattus norvegicus (Norway rat)	Synj2bp	NP_072121.2
Canis lupus familiaris (dog)	SYNJ2BP	NP_001239272.1
Homo sapiens (human)	SYNJ2BP	NP_060843.2
	SYNJ2BP	XP_001111113.1
Mus musculus (house mouse)	Synj2bp	NP_079568.1
Xenopus tropicalis (tropical clawed frog)	synj2bp	NP_001106384.1
Pan troglodytes (chimpanzee)	SYNJ2BP	NP_001230053.1
Bos taurus (cattle)	SYNJ2BP	NP_001030432.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression and anti-inflammatory role of activin receptor-interacting protein 2 in lipopolysaccharide-activated macrophages.
Wu Q, Qi Y, Wu N, Ma C, Feng W, Cui X, Liu Z
Scientific reports7(1)10306(2017 Sep)

SYNJ2BP inhibits tumor growth and metastasis by activating DLL4 pathway in hepatocellular carcinoma.
Liu X, Zhou J, Zhou N, Zhu J, Feng Y, Miao X
Journal of experimental & clinical cancer research : CR35(1)115(2016 Jul)

Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.
Itakura E, Zavodszky E, Shao S, Wohlever ML, Keenan RJ, Hegde RS
Molecular cell63(1)21-33(2016 Jul)

Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
Simino J, Shi G, Bis JC, Chasman DI, Ehret GB, Gu X, Guo X, Hwang SJ, Sijbrands E, Smith AV, Verwoert GC, Bragg-Gresham JL, Cadby G, Chen P, Cheng CY, Corre T, de Boer RA, Goel A, Johnson T, Khor CC, , Llu?s-Ganella C, Luan J, Lyytik?inen LP, Nolte IM, Sim X, S?ber S, van der Most PJ, Verweij N, Zhao JH, Amin N, Boerwinkle E, Bouchard C, Dehghan A, Eiriksdottir G, Elosua R, Franco OH, Gieger C, Harris TB, Hercberg S, Hofman A, James AL, Johnson AD, K?h?nen M, Khaw KT, Kutalik Z, Larson MG, Launer LJ, Li G, Liu J, Liu K, Morrison AC, Navis G, Ong RT, Papanicolau GJ, Penninx BW, Psaty BM, Raffel LJ, Raitakari OT, Rice K, Rivadeneira F, Rose LM, Sanna S, Scott RA, Siscovick DS, Stolk RP, Uitterlinden AG, Vaidya D, van der Klauw MM, Vasan RS, Vithana EN, V?lker U, V?lzke H, Watkins H, Young TL, Aung T, Bochud M, Farrall M, Hartman CA, Laan M, Lakatta EG, Lehtim?ki T, Loos RJ, Lucas G, Meneton P, Palmer LJ, Rettig R, Snieder H, Tai ES, Teo YY, van der Harst P, Wareham NJ, Wijmenga C, Wong TY, Fornage M, Gudnason V, Levy D, Palmas W, Ridker PM, Rotter JI, van Duijn CM, Witteman JC, Chakravarti A, Rao DC
American journal of human genetics95(1)24-38(2014 Jul)

Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis.
Adam MG, Berger C, Feldner A, Yang WJ, W?stehube-Lausch J, Herberich SE, Pinder M, Gesierich S, Hammes HP, Augustin HG, Fischer A
Circulation research113(11)1206-18(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data found that SYNJ2BP was decreased in hepatocellular carcinoma (HCC) tissues and cell lines and provide evidence that SYNJ2BP may act as a tumor suppressor during HCC development activating DLL4 pathway.
Title: SYNJ2BP inhibits tumor growth and metastasis by activating DLL4 pathway in hepatocellular carcinoma.

Ubiquilins are a family of chaperones for cytosolically exposed transmembrane domains and use ubiquitin to triage clients, like Omp25, for degradation via coordinated intra- and intermolecular interactions.
Title: Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.

Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis.
Title: Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

These results suggest that ARIP2 is a putative growth-promoting factor involved in breast tumorigenesis and tumor development.
Title: Identification and characterization of human ARIP2 and its relation to breast cancer.

The following SYNJ2BP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SYNJ2BP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02787	NM_018373.3 Latest version!	Homo sapiens synaptojanin 2 binding protein (SYNJ2BP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu02787	NM_018373.2	Homo sapiens synaptojanin 2 binding protein (SYNJ2BP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SYNJ2BP ( NM_018373.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_060843.2 Homo sapiens synaptojanin 2 binding protein (SYNJ2BP), mRNA.

Price & Availability↑

CloneID	OHu02787
Clone ID Related Accession (Same CDS sequence)	NM_018373.2 , NM_018373.3
Accession Version	NM_018373.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	synaptojanin-2-binding protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP195583.1, BC007704.2, AL356804.4 and BQ775922.1. On Sep 20, 2007 this sequence version replaced NM_018373.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP195583.1, SRR1803613.130329.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMN03267756 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACGGAA GAGTGGATTA TTTGGTCACT GAGGAAGAGA TCAATCTTAC CAGAGGGCCC 
TCAGGGCTGG GCTTCAACAT CGTCGGTGGG ACAGATCAGC AGTATGTCTC CAACGACAGT 
GGCATCTACG TCAGCCGCAT CAAAGAAAAT GGGGCTGCGG CCCTGGATGG GCGGCTCCAG 
GAGGGTGATA AGATCCTTTC GGTAAATGGC CAAGACCTAA AGAACCTGCT GCACCAGGAT 
GCTGTAGACC TCTTTCGTAA TGCAGGCTAT GCTGTGTCTC TGAGAGTGCA GCACAGGTTA 
CAGGTGCAGA ATGGACCTAT AGGACATCGA GGTGAAGGGG ACCCAAGTGG TATTCCCATA 
TTTATGGTGC TGGTGCCAGT GTTTGCCCTC ACCATGGTAG CAGCCTGGGC TTTCATGAGA 
TACCGGCAAC AACTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060843.2
CDS	128..565
Translation	MNGRVDYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQNGPIGHRGEGDPSGIPIFMVLVPVFALTMVAAWAFMRYRQQL

Target ORF information:

RefSeq Version	NM_018373.2
Organism	Homo sapiens(human)
Definition	Homo sapiens synaptojanin 2 binding protein (SYNJ2BP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018373.2

ORF Insert Sequence:

ATGAACGGAA GAGTGGATTA TTTGGTCACT GAGGAAGAGA TCAATCTTAC CAGAGGGCCC 
TCAGGGCTGG GCTTCAACAT CGTCGGTGGG ACAGATCAGC AGTATGTCTC CAACGACAGT 
GGCATCTACG TCAGCCGCAT CAAAGAAAAT GGGGCTGCGG CCCTGGATGG GCGGCTCCAG 
GAGGGTGATA AGATCCTTTC GGTAAATGGC CAAGACCTAA AGAACCTGCT GCACCAGGAT 
GCTGTAGACC TCTTTCGTAA TGCAGGCTAT GCTGTGTCTC TGAGAGTGCA GCACAGGTTA 
CAGGTGCAGA ATGGACCTAT AGGACATCGA GGTGAAGGGG ACCCAAGTGG TATTCCCATA 
TTTATGGTGC TGGTGCCAGT GTTTGCCCTC ACCATGGTAG CAGCCTGGGC TTTCATGAGA 
TACCGGCAAC AACTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SYNJ2BP ( NM_018373.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060843.2 Homo sapiens synaptojanin 2 binding protein (SYNJ2BP), mRNA.

Price & Availability↑

CloneID	OHu02787
Clone ID Related Accession (Same CDS sequence)	NM_018373.2 , NM_018373.3
Accession Version	NM_018373.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-13
Organism	Homo sapiens(human)
Product	synaptojanin-2-binding protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP195583.1, BC007704.2, AL356804.4 and BQ775922.1. On Nov 23, 2018 this sequence version replaced NM_018373.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP195583.1, SRR1803613.130329.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267756 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000256366.6/ ENSP00000256366.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAACGGAA GAGTGGATTA TTTGGTCACT GAGGAAGAGA TCAATCTTAC CAGAGGGCCC 
TCAGGGCTGG GCTTCAACAT CGTCGGTGGG ACAGATCAGC AGTATGTCTC CAACGACAGT 
GGCATCTACG TCAGCCGCAT CAAAGAAAAT GGGGCTGCGG CCCTGGATGG GCGGCTCCAG 
GAGGGTGATA AGATCCTTTC GGTAAATGGC CAAGACCTAA AGAACCTGCT GCACCAGGAT 
GCTGTAGACC TCTTTCGTAA TGCAGGCTAT GCTGTGTCTC TGAGAGTGCA GCACAGGTTA 
CAGGTGCAGA ATGGACCTAT AGGACATCGA GGTGAAGGGG ACCCAAGTGG TATTCCCATA 
TTTATGGTGC TGGTGCCAGT GTTTGCCCTC ACCATGGTAG CAGCCTGGGC TTTCATGAGA 
TACCGGCAAC AACTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060843.2
CDS	128..565
Translation	MNGRVDYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQNGPIGHRGEGDPSGIPIFMVLVPVFALTMVAAWAFMRYRQQL

Target ORF information:

RefSeq Version	NM_018373.3
Organism	Homo sapiens(human)
Definition	Homo sapiens synaptojanin 2 binding protein (SYNJ2BP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018373.3

ORF Insert Sequence:

ATGAACGGAA GAGTGGATTA TTTGGTCACT GAGGAAGAGA TCAATCTTAC CAGAGGGCCC 
TCAGGGCTGG GCTTCAACAT CGTCGGTGGG ACAGATCAGC AGTATGTCTC CAACGACAGT 
GGCATCTACG TCAGCCGCAT CAAAGAAAAT GGGGCTGCGG CCCTGGATGG GCGGCTCCAG 
GAGGGTGATA AGATCCTTTC GGTAAATGGC CAAGACCTAA AGAACCTGCT GCACCAGGAT 
GCTGTAGACC TCTTTCGTAA TGCAGGCTAT GCTGTGTCTC TGAGAGTGCA GCACAGGTTA 
CAGGTGCAGA ATGGACCTAT AGGACATCGA GGTGAAGGGG ACCCAAGTGG TATTCCCATA 
TTTATGGTGC TGGTGCCAGT GTTTGCCCTC ACCATGGTAG CAGCCTGGGC TTTCATGAGA 
TACCGGCAAC AACTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression and anti-inflammatory role of activin receptor-interacting protein 2 in lipopolysaccharide-activated macrophages.
Scientific reports7(1)10306(2017 Sep)
Wu Q,Qi Y,Wu N,Ma C,Feng W,Cui X,Liu Z

SYNJ2BP inhibits tumor growth and metastasis by activating DLL4 pathway in hepatocellular carcinoma.
Journal of experimental & clinical cancer research : CR35(1)115(2016 Jul)
Liu X,Zhou J,Zhou N,Zhu J,Feng Y,Miao X

Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.
Molecular cell63(1)21-33(2016 Jul)
Itakura E,Zavodszky E,Shao S,Wohlever ML,Keenan RJ,Hegde RS

Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
American journal of human genetics95(1)24-38(2014 Jul)
Simino J,Shi G,Bis JC,Chasman DI,Ehret GB,Gu X,Guo X,Hwang SJ,Sijbrands E,Smith AV,Verwoert GC,Bragg-Gresham JL,Cadby G,Chen P,Cheng CY,Corre T,de Boer RA,Goel A,Johnson T,Khor CC,,Llu?s-Ganella C,Luan J,Lyytik?inen LP,Nolte IM,Sim X,S?ber S,van der Most PJ,Verweij N,Zhao JH,Amin N,Boerwinkle E,Bouchard C,Dehghan A,Eiriksdottir G,Elosua R,Franco OH,Gieger C,Harris TB,Hercberg S,Hofman A,James AL,Johnson AD,K?h?nen M,Khaw KT,Kutalik Z,Larson MG,Launer LJ,Li G,Liu J,Liu K,Morrison AC,Navis G,Ong RT,Papanicolau GJ,Penninx BW,Psaty BM,Raffel LJ,Raitakari OT,Rice K,Rivadeneira F,Rose LM,Sanna S,Scott RA,Siscovick DS,Stolk RP,Uitterlinden AG,Vaidya D,van der Klauw MM,Vasan RS,Vithana EN,V?lker U,V?lzke H,Watkins H,Young TL,Aung T,Bochud M,Farrall M,Hartman CA,Laan M,Lakatta EG,Lehtim?ki T,Loos RJ,Lucas G,Meneton P,Palmer LJ,Rettig R,Snieder H,Tai ES,Teo YY,van der Harst P,Wareham NJ,Wijmenga C,Wong TY,Fornage M,Gudnason V,Levy D,Palmas W,Ridker PM,Rotter JI,van Duijn CM,Witteman JC,Chakravarti A,Rao DC

Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis.
Circulation research113(11)1206-18(2013 Nov)
Adam MG,Berger C,Feldner A,Yang WJ,W?stehube-Lausch J,Herberich SE,Pinder M,Gesierich S,Hammes HP,Augustin HG,Fischer A

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SYNJ2BP cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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