Acat2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Gene Symbol	Acat2
Entrez Gene ID	308100
Full Name	acetyl-CoA acetyltransferase 2
Synonyms	Ab2-076,Acat3
General protein information	Preferred Names acetyl-CoA acetyltransferase 2 Names acetyl-CoA acetyltransferase, cytosolic acetyl-Coenzyme A acetyltransferase 2 acetyl-Coenzyme A acetyltransferase 3 cytosolic acetoacetyl-CoA thiolase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q11

mRNA and Protein(s)

mRNA Protein Name

NM_001006995.1 NP_001006996.1 acetyl-CoA acetyltransferase, cytosolic
Pathways from BioSystems

mRNA	Protein	Name
NM_001006995.1	NP_001006996.1	acetyl-CoA acetyltransferase, cytosolic

Homologies

Pan troglodytes (chimpanzee)	ACAT2	XP_001143759.2
	ACAT2	XP_001106967.1
Bos taurus (cattle)	ACAT2	NP_001069017.1
Mus musculus (house mouse)	Acat3	NP_694791.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001318	XP_321828.3
Canis lupus familiaris (dog)	ACAT2	XP_541180.3
Gallus gallus (chicken)	ACAT2	NP_001034376.2
Drosophila melanogaster (fruit fly)	CG9149	NP_612094.2
Xenopus tropicalis (tropical clawed frog)	acat2	NP_988965.1
Mus musculus (house mouse)	Acat2	NP_033364.2
Homo sapiens (human)	ACAT2	NP_005882.2
Rattus norvegicus (Norway rat)	Acat2	NP_001006996.1
Rattus norvegicus (Norway rat)	RGD1562948	XP_003748745.2
Danio rerio (zebrafish)	acat2	NP_571445.2

Gene Ontology
Bibliography

Related articles in PubMed

The association and significance of H3K27me3 and a folate metabolic gene ACat2 in neural tube defects.
Zhai S, Zhao M, Zhou C, Lu F, Zhang H, Na L, Feng S, Qiang X, Du Y
Nutrition journal15(1)95(2016 11)

Cerebral ketone body metabolism.
Morris AA
Journal of inherited metabolic disease28(2)109-21(2005)

Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients.
McCarthy JJ, Meyer J, Moliterno DJ, Newby LK, Rogers WJ, Topol EJ,
Human genetics114(1)87-98(2003 Dec)

The effects of dietary n-3 polyunsaturated fatty acids delivered in chylomicron remnants on the transcription of genes regulating synthesis and secretion of very-low-density lipoprotein by the liver: modulation by cellular oxidative state.
Botham KM, Zheng X, Napolitano M, Avella M, Cavallari C, Rivabene R, Bravo E
Experimental biology and medicine (Maywood, N.J.)228(2)143-51(2003 Feb)

Dual action of neutral sphingomyelinase on rat hepatocytes: activation of cholesteryl ester metabolism and biliary cholesterol secretion and inhibition of VLDL secretion.
Liza M, Chico Y, Fresnedo O, Ochoa B
Lipids38(1)53-63(2003 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The increased H3K27me3 expression might cause a disorder of folate metabolic pathway by silencing ACat2 expression, leading to reduced proliferation and differentiation of neural stem cells, and ultimately the occurrence of neural tube defects.
Title: The association and significance of H3K27me3 and a folate metabolic gene ACat2 in neural tube defects.

The following Acat2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Acat2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10950	NM_001006995.1 Latest version!	Rattus norvegicus acetyl-CoA acetyltransferase 2 (Acat2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Acat2 ( NM_001006995.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001006996.1 Rattus norvegicus acetyl-CoA acetyltransferase 2 (Acat2), mRNA.

Price & Availability↑

CloneID	ORa10950
Clone ID Related Accession (Same CDS sequence)	NM_001006995.1
Accession Version	NM_001006995.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1194bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-04
Organism	Rattus norvegicus(Norway rat)
Product	acetyl-CoA acetyltransferase, cytosolic
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC083872.1. On Nov 22, 2004 this sequence version replaced XM_217796.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC083872.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAATGCAG GCTCGGACCC CGTCGTCATC ATCTCAGCGG CGCGGACCGC CATAGGTTCC 
TTCAATGGTG CCCTGTCCAC CGTGCCTGTC CACAACCTGG GGACAACTGT TATCAAAGAA 
GTCCTTCAGA GAGCCAAAGT GGCTCCAGAA GAGGTGTCCG AGGTCATATT TGGACACGTT 
TTGACTGCAG GCTGTGGGCA GAATCCTACT CGACAAGCCA GTGTGGGTGC GGGGATCCCC 
TACTCGGTGC CAGCATGGAG CTGCCAGATG ATCTGTGGCT CGGGCCTAAA AGCCGTGTGC 
CTTGCAGCTC AGTCCATAGC CATGGGTGAC TCCACCATCG TGGTTGCTGG AGGCATGGAG 
AACATGAGCA AGGCCCCTCA CTTGGCTCAC CTGAGATCAG GAGTGAAGAT GGGTGAGGTG 
CCACTCGCCG ACAGCATCCT CTGTGATGGC CTCACAGATG CGTTTCACAA CTACCACATG 
GGCATCACAG CTGAAAACGT AGCCAAAAAA TGGCAAGTGA GCAGAGAGGC CCAGGACAAG 
GTTGCTGTTG TGTCCCAGAA TAGGGCGGAG CATGCGCAGA AAGCTGGCCA CTTTGACAAG 
GAGATTGTGC CAGTGCACGT GTCTTCTAGA AAAGGTCTTA CTGAAGTGAA AATCGATGAG 
TTTCCTCGTC ATGGGAGTAA CCTTGAAGCC ATGAGCAAGC TGAAGCCTTA CTTTCTTACT 
GATGGGACTG GAACGGTCAC CCCAGCGAAT GCATCAGGAA TGAACGATGG TGCTGCTGCT 
GTGGTTCTTA TGAAGAAGAC GGAAGCTGAG AGTCGGATGC TGAAACCTTT AGCACAAGTG 
GTCTCCTGGT CACAAGCCGG TGTGGAGCCT TCTGTCATGG GAGTAGGACC GATTCCAGCC 
ATAAAGCAAG CTGTTGCAAA GGCAGGCTGG TCCCTGGAGG ATGTTGACGT GTTTGAAATC 
AATGAAGCCT TTGCAGCAGT GTCTGCAGCA ATAGCTAAAG AACTTGGATT AAGCCCCGAG 
AAGGTGAACA TCGATGGAGG AGCCATTGCC TTGGGACATC CTCTGGGAGC ATCTGGCTGT 
AGGATTCTAG TGACCTTGTT ACACACCCTG GAGAGAGTGG GTGGGACTCG TGGTGTTGCA 
GCCCTGTGCA TTGGGGGTGG TATGGGGATC GCAATGTGTG TTCAGAGAGG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001006996.1
CDS	27..1220
Translation	MNAGSDPVVIISAARTAIGSFNGALSTVPVHNLGTTVIKEVLQRAKVAPEEVSEVIFGHVLTAGCGQNPTRQASVGAGIPYSVPAWSCQMICGSGLKAVCLAAQSIAMGDSTIVVAGGMENMSKAPHLAHLRSGVKMGEVPLADSILCDGLTDAFHNYHMGITAENVAKKWQVSREAQDKVAVVSQNRAEHAQKAGHFDKEIVPVHVSSRKGLTEVKIDEFPRHGSNLEAMSKLKPYFLTDGTGTVTPANASGMNDGAAAVVLMKKTEAESRMLKPLAQVVSWSQAGVEPSVMGVGPIPAIKQAVAKAGWSLEDVDVFEINEAFAAVSAAIAKELGLSPEKVNIDGGAIALGHPLGASGCRILVTLLHTLERVGGTRGVAALCIGGGMGIAMCVQRG

Target ORF information:

RefSeq Version	NM_001006995.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus acetyl-CoA acetyltransferase 2 (Acat2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001006995.1

ORF Insert Sequence:

ATGAATGCAG GCTCGGACCC CGTCGTCATC ATCTCAGCGG CGCGGACCGC CATAGGTTCC 
TTCAATGGTG CCCTGTCCAC CGTGCCTGTC CACAACCTGG GGACAACTGT TATCAAAGAA 
GTCCTTCAGA GAGCCAAAGT GGCTCCAGAA GAGGTGTCCG AGGTCATATT TGGACACGTT 
TTGACTGCAG GCTGTGGGCA GAATCCTACT CGACAAGCCA GTGTGGGTGC GGGGATCCCC 
TACTCGGTGC CAGCATGGAG CTGCCAGATG ATCTGTGGCT CGGGCCTAAA AGCCGTGTGC 
CTTGCAGCTC AGTCCATAGC CATGGGTGAC TCCACCATCG TGGTTGCTGG AGGCATGGAG 
AACATGAGCA AGGCCCCTCA CTTGGCTCAC CTGAGATCAG GAGTGAAGAT GGGTGAGGTG 
CCACTCGCCG ACAGCATCCT CTGTGATGGC CTCACAGATG CGTTTCACAA CTACCACATG 
GGCATCACAG CTGAAAACGT AGCCAAAAAA TGGCAAGTGA GCAGAGAGGC CCAGGACAAG 
GTTGCTGTTG TGTCCCAGAA TAGGGCGGAG CATGCGCAGA AAGCTGGCCA CTTTGACAAG 
GAGATTGTGC CAGTGCACGT GTCTTCTAGA AAAGGTCTTA CTGAAGTGAA AATCGATGAG 
TTTCCTCGTC ATGGGAGTAA CCTTGAAGCC ATGAGCAAGC TGAAGCCTTA CTTTCTTACT 
GATGGGACTG GAACGGTCAC CCCAGCGAAT GCATCAGGAA TGAACGATGG TGCTGCTGCT 
GTGGTTCTTA TGAAGAAGAC GGAAGCTGAG AGTCGGATGC TGAAACCTTT AGCACAAGTG 
GTCTCCTGGT CACAAGCCGG TGTGGAGCCT TCTGTCATGG GAGTAGGACC GATTCCAGCC 
ATAAAGCAAG CTGTTGCAAA GGCAGGCTGG TCCCTGGAGG ATGTTGACGT GTTTGAAATC 
AATGAAGCCT TTGCAGCAGT GTCTGCAGCA ATAGCTAAAG AACTTGGATT AAGCCCCGAG 
AAGGTGAACA TCGATGGAGG AGCCATTGCC TTGGGACATC CTCTGGGAGC ATCTGGCTGT 
AGGATTCTAG TGACCTTGTT ACACACCCTG GAGAGAGTGG GTGGGACTCG TGGTGTTGCA 
GCCCTGTGCA TTGGGGGTGG TATGGGGATC GCAATGTGTG TTCAGAGAGG GTGA