Gene Symbol | mlc1 |
Entrez Gene ID | 559990 |
Full Name | megalencephalic leukoencephalopathy with subcortical cysts 1 |
Synonyms | si:ch211-192n14.1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Danio rerio(zebrafish) |
ORF » Species Summary » Danio rerio » mlc1 cDNA ORF clone
gRNAs
Gene Symbol | mlc1 |
Entrez Gene ID | 559990 |
Full Name | megalencephalic leukoencephalopathy with subcortical cysts 1 |
Synonyms | si:ch211-192n14.1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Danio rerio(zebrafish) |
mRNA | Protein | Name |
---|---|---|
XM_005169941.3 | XP_005169998.1 | membrane protein MLC1 isoform X1 |
XM_005169943.3 | XP_005170000.1 | membrane protein MLC1 isoform X2 |
XM_017351934.2 | XP_017207423.1 | membrane protein MLC1 isoform X1 |
XM_005169941.4 | XP_005169998.1 | membrane protein MLC1 isoform X1 |
XM_021467665.1 | XP_021323340.1 | membrane protein MLC1 isoform X1 |
XM_005169943.4 | XP_005170000.1 | membrane protein MLC1 isoform X2 |
XM_017351934.1 | XP_017207423.1 | membrane protein MLC1 isoform X1 |
NM_001104939.1 | NP_001098409.1 | membrane protein MLC1 |
MLC1 | XP_001111622.1 | |
Mus musculus (house mouse) | Mlc1 | NP_573504.1 |
Rattus norvegicus (Norway rat) | Mlc1 | NP_001101575.1 |
Danio rerio (zebrafish) | mlc1 | NP_001098409.1 |
Homo sapiens (human) | MLC1 | NP_631941.1 |
Gallus gallus (chicken) | MLC1 | XP_004937559.1 |
Xenopus tropicalis (tropical clawed frog) | mlc1 | NP_001072921.1 |
Canis lupus familiaris (dog) | MLC1 | XP_848790.2 |
Pan troglodytes (chimpanzee) | MLC1 | XP_515212.3 |
Bos taurus (cattle) | MLC1 | NP_001070420.1 |
Evolution of complexity in the zebrafish synapse proteome.
Bay?s ?, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A, Choudhary JS, Emes RD, Grant SG
Nature communications814613(2017 Mar)
Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)
RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)
Megalencephalic leukoencephalopathy with subcortical cysts protein 1 regulates glial surface localization of GLIALCAM from fish to humans.
Sirisi S, Folgueira M, L?pez-Hern?ndez T, Minieri L, P?rez-Rius C, Gait?n-Pe?as H, Zang J, Mart?nez A, Capdevila-Nortes X, De La Villa P, Roy U, Alia A, Neuhauss S, Ferroni S, Nunes V, Est?vez R, Barrallo-Gimeno A
Human molecular genetics23(19)5069-86(2014 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
we demonstrate an evolutionary conserved role for MLC1 in regulating glial surface levels of GLIALCAM, and this interrelationship explains why patients with mutations in either gene (MLC1 or GLIALCAM) share the same clinical phenotype.
Title: Megalencephalic leukoencephalopathy with subcortical cysts protein 1 regulates glial surface localization of GLIALCAM from fish to humans.
The following mlc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the mlc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ODa31747 | |
Clone ID Related Accession (Same CDS sequence) | NM_001104939.1 | |
Accession Version | NM_001104939.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1176bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-30 | |
Organism | Danio rerio(zebrafish) | |
Product | membrane protein MLC1 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC151967.1. On Sep 16, 2007 this sequence version replaced XM_683381.1. ##Evidence-Data-START## Transcript exon combination :: BC151967.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGCAGCGAG AGGAGGCATC GGCTCAGGAA GTGTTCAGCT ATGCCCAGAT GTCCACCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001098409.1 |
CDS | 204..1379 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001104939.1 |
1 | ATGCAGCGAG AGGAGGCATC GGCTCAGGAA GTGTTCAGCT ATGCCCAGAT GTCCACCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ODa23165 | |
Clone ID Related Accession (Same CDS sequence) | XM_005169941.3 , XM_017351934.2 , XM_005169941.4 , XM_021467665.1 , XM_017351934.1 | |
Accession Version | XM_005169941.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-23 | |
Organism | Danio rerio(Zebrafish) | |
Product | membrane protein MLC1 isoform X1 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007129.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XM_005169941.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATTTGA GGATGCAGCG AGAGGAGGCA TCGGCTCAGG AAGTGTTCAG CTATGCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005169998.1 |
CDS | 289..1476 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005169941.3 |
1 | ATGGATTTGA GGATGCAGCG AGAGGAGGCA TCGGCTCAGG AAGTGTTCAG CTATGCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ODa23165 | |
Clone ID Related Accession (Same CDS sequence) | XM_005169941.3 , XM_017351934.2 , XM_005169941.4 , XM_021467665.1 , XM_017351934.1 | |
Accession Version | XM_017351934.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-06-14 | |
Organism | Danio rerio(zebrafish) | |
Product | membrane protein MLC1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007129.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XM_017351934.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATTTGA GGATGCAGCG AGAGGAGGCA TCGGCTCAGG AAGTGTTCAG CTATGCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017207423.1 |
CDS | 273..1460 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017351934.2 |
1 | ATGGATTTGA GGATGCAGCG AGAGGAGGCA TCGGCTCAGG AAGTGTTCAG CTATGCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ODa23165 | |
Clone ID Related Accession (Same CDS sequence) | XM_005169941.3 , XM_017351934.2 , XM_005169941.4 , XM_021467665.1 , XM_017351934.1 | |
Accession Version | XM_005169941.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-06-14 | |
Organism | Danio rerio(zebrafish) | |
Product | membrane protein MLC1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007129.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XM_005169941.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATTTGA GGATGCAGCG AGAGGAGGCA TCGGCTCAGG AAGTGTTCAG CTATGCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005169998.1 |
CDS | 294..1481 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005169941.4 |
1 | ATGGATTTGA GGATGCAGCG AGAGGAGGCA TCGGCTCAGG AAGTGTTCAG CTATGCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ODa23165 | |
Clone ID Related Accession (Same CDS sequence) | XM_005169941.3 , XM_017351934.2 , XM_005169941.4 , XM_021467665.1 , XM_017351934.1 | |
Accession Version | XM_021467665.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-06-14 | |
Organism | Danio rerio(zebrafish) | |
Product | membrane protein MLC1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007129.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATTTGA GGATGCAGCG AGAGGAGGCA TCGGCTCAGG AAGTGTTCAG CTATGCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_021323340.1 |
CDS | 118..1305 |
Translation |
Target ORF information:
Target ORF information:
|
XM_021467665.1 |
1 | ATGGATTTGA GGATGCAGCG AGAGGAGGCA TCGGCTCAGG AAGTGTTCAG CTATGCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ODa23165 | |
Clone ID Related Accession (Same CDS sequence) | XM_005169941.3 , XM_017351934.2 , XM_005169941.4 , XM_021467665.1 , XM_017351934.1 | |
Accession Version | XM_017351934.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-23 | |
Organism | Danio rerio(Zebrafish) | |
Product | membrane protein MLC1 isoform X1 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007129.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATTTGA GGATGCAGCG AGAGGAGGCA TCGGCTCAGG AAGTGTTCAG CTATGCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017207423.1 |
CDS | 268..1455 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017351934.1 |
1 | ATGGATTTGA GGATGCAGCG AGAGGAGGCA TCGGCTCAGG AAGTGTTCAG CTATGCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ODa23167 | |
Clone ID Related Accession (Same CDS sequence) | XM_005169943.3 , XM_005169943.4 | |
Accession Version | XM_005169943.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1185bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-23 | |
Organism | Danio rerio(Zebrafish) | |
Product | membrane protein MLC1 isoform X2 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007129.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XM_005169943.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATTTGA GGATGCAGCG AGAGGAGGCA TCGGCTCAGG AAGTGTTCAG CTATGCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005170000.1 |
CDS | 246..1430 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005169943.3 |
1 | ATGGATTTGA GGATGCAGCG AGAGGAGGCA TCGGCTCAGG AAGTGTTCAG CTATGCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ODa23167 | |
Clone ID Related Accession (Same CDS sequence) | XM_005169943.3 , XM_005169943.4 | |
Accession Version | XM_005169943.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1185bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-06-14 | |
Organism | Danio rerio(zebrafish) | |
Product | membrane protein MLC1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007129.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XM_005169943.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATTTGA GGATGCAGCG AGAGGAGGCA TCGGCTCAGG AAGTGTTCAG CTATGCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005170000.1 |
CDS | 252..1436 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005169943.4 |
1 | ATGGATTTGA GGATGCAGCG AGAGGAGGCA TCGGCTCAGG AAGTGTTCAG CTATGCCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Evolution of complexity in the zebrafish synapse proteome. |
Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. |
RFX transcription factors are essential for hearing in mice. |
Megalencephalic leukoencephalopathy with subcortical cysts protein 1 regulates glial surface localization of GLIALCAM from fish to humans. |