Rrm2b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Rrm2b
Entrez Gene ID	382985
Full Name	ribonucleotide reductase M2 B (TP53 inducible)
Synonyms	p53R2
General protein information	Preferred Names ribonucleotide reductase M2 B (TP53 inducible) Names ribonucleoside-diphosphate reductase subunit M2 B TP53-inducible ribonucleotide reductase M2 B p53-inducible ribonucleotide reductase small subunit 2-like protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 B3.1

mRNA and Protein(s)

mRNA	Protein	Name
XM_006520102.3	XP_006520165.1	ribonucleoside-diphosphate reductase subunit M2 B isoform X2
NM_001357022.1	NP_001343951.1	ribonucleoside-diphosphate reductase subunit M2 B isoform 2
XM_011245361.2	XP_011243663.1	ribonucleoside-diphosphate reductase subunit M2 B isoform X3
NM_199476.1	NP_955770.1	ribonucleoside-diphosphate reductase subunit M2 B isoform 1
XM_006520101.2	XP_006520164.1	ribonucleoside-diphosphate reductase subunit M2 B isoform X1
XM_011245361.3	XP_011243663.1	ribonucleoside-diphosphate reductase subunit M2 B isoform X1
NM_001357023.1	NP_001343952.1	ribonucleoside-diphosphate reductase subunit M2 B isoform 3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RRM2B	XP_539109.3
Mus musculus (house mouse)	Rrm2b	NP_955770.1
Homo sapiens (human)	RRM2B	NP_001165948.1
Gallus gallus (chicken)	RRM2B	XP_418364.2
Pan troglodytes (chimpanzee)	RRM2B	XP_001153916.1
Bos taurus (cattle)	RRM2B	XP_002692807.1
Danio rerio (zebrafish)	rrm2b	NP_001007164.1
Arabidopsis thaliana (thale cress)	RNR2A	NP_189000.1
Rattus norvegicus (Norway rat)	Rrm2b	NP_001124015.1
Xenopus tropicalis (tropical clawed frog)	rrm2b	NP_001119973.1

Gene Ontology
Bibliography

Related articles in PubMed

Chromosomal instability triggered by Rrm2b loss leads to IL-6 secretion and plasmacytic neoplasms.
Chang L, Guo R, Huang Q, Yen Y
Cell reports3(5)1389-97(2013 May)

RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence.
Kuo ML, Sy AJ, Xue L, Chi M, Lee MT, Yen T, Chiang MI, Chang L, Chu P, Yen Y
Scientific reports2822(2012)

Synergism between p53 and Mcl-1 in protecting from hepatic injury, fibrosis and cancer.
Weng SY, Yang CY, Li CC, Sun TP, Tung SY, Yen JJ, Tsai TF, Chen CM, Chen SH, Hsiao M, Huang PH, Yang-Yen HF
Journal of hepatology54(4)685-94(2011 Apr)

Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion.
Bourdon A, Minai L, Serre V, Jais JP, Sarzi E, Aubert S, Chr?tien D, de Lonlay P, Paquis-Flucklinger V, Arakawa H, Nakamura Y, Munnich A, R?tig A
Nature genetics39(6)776-80(2007 Jun)

Rapid development of glomerular injury and renal failure in mice lacking p53R2.
Powell DR, Desai U, Sparks MJ, Hansen G, Gay J, Schrick J, Shi ZZ, Hicks J, Vogel P
Pediatric nephrology (Berlin, Germany)20(3)432-40(2005 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rrm2b plays a crucial role in maintaining chromosomal stability and preventing chronic-inflammation-associated tumorigenesis.
Title: Chromosomal instability triggered by Rrm2b loss leads to IL-6 secretion and plasmacytic neoplasms.

Rrm2b deficiency caused higher rates of spontaneous mutation in the kidneys of Rrm2b-/- mice. p53R2 has a pivotal role in maintaining dNTP levels for repair of DNA in resting cells.
Title: Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools.

The following Rrm2b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rrm2b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu09504	NM_199476.1 Latest version!	Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OMu50713	NM_001357022.1 Latest version!	Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu50714	NM_001357023.1 Latest version!	Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu50713	XM_006520101.2 Latest version!	Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu50714	XM_006520102.3 Latest version!	Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu75137	XM_011245361.3 Latest version!	Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu75137	XM_011245361.2	Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rrm2b ( NM_199476.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_955770.1 Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu09504
Clone ID Related Accession (Same CDS sequence)	NM_199476.1
Accession Version	NM_199476.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-11
Organism	Mus musculus(house mouse)
Product	ribonucleoside-diphosphate reductase subunit M2 B isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC058103.1. On Jan 24, 2004 this sequence version replaced XM_356784.1. ##Evidence-Data-START## Transcript exon combination :: BC058103.1, SRR1660811.91829.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164134 [ECO:0000348] ##Evidence-Data-END##

ATGGGCGACC CGGAAAGGCC GGAAGCGGCC AGGCCGGAGA AGGGTGAGCA ATTGTGTTCG 
GAGACAGAAG AAAATGTGGT GAGGTCAAAT GAAGAGCCAC TCCTAAGAAA GAGTTCCCGA 
CGGTTCGTCA TCTTTCCAAT CCAGTATCCT GATATCTGGA GAATGTACAA GCAAGCACAG 
GCATCTTTCT GGACAGCAGA GGAGGTTGAC TTGTCAAAGG ACCTCCCTCA CTGGAACAAG 
CTTAAATCCG ACGAGAAGTA TTTTATCTCC CACATCTTAG CCTTTTTTGC AGCCAGTGAT 
GGAATTGTAA ATGAAAACTT GGTGGAGCGT TTTAGTCAGG AGGTGCAGGT TCCAGAGGCT 
CGCTGCTTCT ATGGCTTTCA GATTCTCATC GAGAATGTTC ACTCAGAGAT GTACAGTTTA 
CTAATAGACA CTTACATCAG AGATCCAAAG AAAAGGGAAT TTTTATTTAA TGCAATTGAA 
ACAATGCCAT ATGTTAAGAA AAAAGCGGAC TGGGCTCTGC GCTGGATAGC AGATAGGAAA 
TCTACTTTTG GGGAAAGAGT GGTGGCCTTT GCTGCTGTGG AAGGAATTTT CTTCTCTGGA 
TCATTTGCTG CAATATTCTG GCTAAAGAAG AGAGGCCTCA TGCCTGGACT GACTTTTTCA 
AATGAACTGA TCAGCAGGGA TGAAGGACTT CACTGTGACT TTGCCTGCCT GATGTTTCAG 
TACTTGGTAA ACAAGCCTTC AGAAGATAGA GTGAGGGAAA TCATTGCTGA TGCTGTTCAA 
ATCGAGCAGG AGTTTTTAAC AGAAGCCTTG CCTGTTGGCC TCATTGGAAT GAACTGTGTT 
TTGATGAAAC AGTACATTGA GTTTGTAGCT GACAGATTAC TTGGAGAACT TGGATTCTCA 
AAGATTTTTC AGGCAGAAAA TCCCTTTGAT TTTATGGAGA ACATTTCATT AGAAGGGAAA 
ACAAATTTCT TTGAGAAACG AGTTTCTGAG TATCAGCGAT TTGCAGTCAT GGCCGAAACC 
ACAGATAATG TCTTCACCTT GGATGCAGAT TTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_955770.1
CDS	165..1220
Translation	MGDPERPEAARPEKGEQLCSETEENVVRSNEEPLLRKSSRRFVIFPIQYPDIWRMYKQAQASFWTAEEVDLSKDLPHWNKLKSDEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGIFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQYLVNKPSEDRVREIIADAVQIEQEFLTEALPVGLIGMNCVLMKQYIEFVADRLLGELGFSKIFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDADF

Target ORF information:

RefSeq Version	NM_199476.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199476.1

ORF Insert Sequence:

ATGGGCGACC CGGAAAGGCC GGAAGCGGCC AGGCCGGAGA AGGGTGAGCA ATTGTGTTCG 
GAGACAGAAG AAAATGTGGT GAGGTCAAAT GAAGAGCCAC TCCTAAGAAA GAGTTCCCGA 
CGGTTCGTCA TCTTTCCAAT CCAGTATCCT GATATCTGGA GAATGTACAA GCAAGCACAG 
GCATCTTTCT GGACAGCAGA GGAGGTTGAC TTGTCAAAGG ACCTCCCTCA CTGGAACAAG 
CTTAAATCCG ACGAGAAGTA TTTTATCTCC CACATCTTAG CCTTTTTTGC AGCCAGTGAT 
GGAATTGTAA ATGAAAACTT GGTGGAGCGT TTTAGTCAGG AGGTGCAGGT TCCAGAGGCT 
CGCTGCTTCT ATGGCTTTCA GATTCTCATC GAGAATGTTC ACTCAGAGAT GTACAGTTTA 
CTAATAGACA CTTACATCAG AGATCCAAAG AAAAGGGAAT TTTTATTTAA TGCAATTGAA 
ACAATGCCAT ATGTTAAGAA AAAAGCGGAC TGGGCTCTGC GCTGGATAGC AGATAGGAAA 
TCTACTTTTG GGGAAAGAGT GGTGGCCTTT GCTGCTGTGG AAGGAATTTT CTTCTCTGGA 
TCATTTGCTG CAATATTCTG GCTAAAGAAG AGAGGCCTCA TGCCTGGACT GACTTTTTCA 
AATGAACTGA TCAGCAGGGA TGAAGGACTT CACTGTGACT TTGCCTGCCT GATGTTTCAG 
TACTTGGTAA ACAAGCCTTC AGAAGATAGA GTGAGGGAAA TCATTGCTGA TGCTGTTCAA 
ATCGAGCAGG AGTTTTTAAC AGAAGCCTTG CCTGTTGGCC TCATTGGAAT GAACTGTGTT 
TTGATGAAAC AGTACATTGA GTTTGTAGCT GACAGATTAC TTGGAGAACT TGGATTCTCA 
AAGATTTTTC AGGCAGAAAA TCCCTTTGAT TTTATGGAGA ACATTTCATT AGAAGGGAAA 
ACAAATTTCT TTGAGAAACG AGTTTCTGAG TATCAGCGAT TTGCAGTCAT GGCCGAAACC 
ACAGATAATG TCTTCACCTT GGATGCAGAT TTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rrm2b ( NM_001357022.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001343951.1 Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu50713
Clone ID Related Accession (Same CDS sequence)	NM_001357022.1 , XM_006520101.2
Accession Version	NM_001357022.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-11
Organism	Mus musculus(house mouse)
Product	ribonucleoside-diphosphate reductase subunit M2 B isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC122291.4. On Oct 17, 2017 this sequence version replaced XM_006520101.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660819.5834.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849387, SAMN01164131 [ECO:0000348] ##Evidence-Data-END##

ATGCAGCAAT TGTGTTCGGA GACAGAAGAA AATGTGGTGA GGTCAAATGA AGAGCCACTC 
CTAAGAAAGA GTTCCCGACG GTTCGTCATC TTTCCAATCC AGTATCCTGA TATCTGGAGA 
ATGTACAAGC AAGCACAGGC ATCTTTCTGG ACAGCAGAGG AGGTTGACTT GTCAAAGGAC 
CTCCCTCACT GGAACAAGCT TAAATCCGAC GAGAAGTATT TTATCTCCCA CATCTTAGCC 
TTTTTTGCAG CCAGTGATGG AATTGTAAAT GAAAACTTGG TGGAGCGTTT TAGTCAGGAG 
GTGCAGGTTC CAGAGGCTCG CTGCTTCTAT GGCTTTCAGA TTCTCATCGA GAATGTTCAC 
TCAGAGATGT ACAGTTTACT AATAGACACT TACATCAGAG ATCCAAAGAA AAGGGAATTT 
TTATTTAATG CAATTGAAAC AATGCCATAT GTTAAGAAAA AAGCGGACTG GGCTCTGCGC 
TGGATAGCAG ATAGGAAATC TACTTTTGGG GAAAGAGTGG TGGCCTTTGC TGCTGTGGAA 
GGAATTTTCT TCTCTGGATC ATTTGCTGCA ATATTCTGGC TAAAGAAGAG AGGCCTCATG 
CCTGGACTGA CTTTTTCAAA TGAACTGATC AGCAGGGATG AAGGACTTCA CTGTGACTTT 
GCCTGCCTGA TGTTTCAGTA CTTGGTAAAC AAGCCTTCAG AAGATAGAGT GAGGGAAATC 
ATTGCTGATG CTGTTCAAAT CGAGCAGGAG TTTTTAACAG AAGCCTTGCC TGTTGGCCTC 
ATTGGAATGA ACTGTGTTTT GATGAAACAG TACATTGAGT TTGTAGCTGA CAGATTACTT 
GGAGAACTTG GATTCTCAAA GATTTTTCAG GCAGAAAATC CCTTTGATTT TATGGAGAAC 
ATTTCATTAG AAGGGAAAAC AAATTTCTTT GAGAAACGAG TTTCTGAGTA TCAGCGATTT 
GCAGTCATGG CCGAAACCAC AGATAATGTC TTCACCTTGG ATGCAGATTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001343951.1
CDS	399..1412
Translation	MQQLCSETEENVVRSNEEPLLRKSSRRFVIFPIQYPDIWRMYKQAQASFWTAEEVDLSKDLPHWNKLKSDEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGIFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQYLVNKPSEDRVREIIADAVQIEQEFLTEALPVGLIGMNCVLMKQYIEFVADRLLGELGFSKIFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDADF

Target ORF information:

RefSeq Version	NM_001357022.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001357022.1

ORF Insert Sequence:

ATGCAGCAAT TGTGTTCGGA GACAGAAGAA AATGTGGTGA GGTCAAATGA AGAGCCACTC 
CTAAGAAAGA GTTCCCGACG GTTCGTCATC TTTCCAATCC AGTATCCTGA TATCTGGAGA 
ATGTACAAGC AAGCACAGGC ATCTTTCTGG ACAGCAGAGG AGGTTGACTT GTCAAAGGAC 
CTCCCTCACT GGAACAAGCT TAAATCCGAC GAGAAGTATT TTATCTCCCA CATCTTAGCC 
TTTTTTGCAG CCAGTGATGG AATTGTAAAT GAAAACTTGG TGGAGCGTTT TAGTCAGGAG 
GTGCAGGTTC CAGAGGCTCG CTGCTTCTAT GGCTTTCAGA TTCTCATCGA GAATGTTCAC 
TCAGAGATGT ACAGTTTACT AATAGACACT TACATCAGAG ATCCAAAGAA AAGGGAATTT 
TTATTTAATG CAATTGAAAC AATGCCATAT GTTAAGAAAA AAGCGGACTG GGCTCTGCGC 
TGGATAGCAG ATAGGAAATC TACTTTTGGG GAAAGAGTGG TGGCCTTTGC TGCTGTGGAA 
GGAATTTTCT TCTCTGGATC ATTTGCTGCA ATATTCTGGC TAAAGAAGAG AGGCCTCATG 
CCTGGACTGA CTTTTTCAAA TGAACTGATC AGCAGGGATG AAGGACTTCA CTGTGACTTT 
GCCTGCCTGA TGTTTCAGTA CTTGGTAAAC AAGCCTTCAG AAGATAGAGT GAGGGAAATC 
ATTGCTGATG CTGTTCAAAT CGAGCAGGAG TTTTTAACAG AAGCCTTGCC TGTTGGCCTC 
ATTGGAATGA ACTGTGTTTT GATGAAACAG TACATTGAGT TTGTAGCTGA CAGATTACTT 
GGAGAACTTG GATTCTCAAA GATTTTTCAG GCAGAAAATC CCTTTGATTT TATGGAGAAC 
ATTTCATTAG AAGGGAAAAC AAATTTCTTT GAGAAACGAG TTTCTGAGTA TCAGCGATTT 
GCAGTCATGG CCGAAACCAC AGATAATGTC TTCACCTTGG ATGCAGATTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rrm2b ( NM_001357023.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001343952.1 Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu50714
Clone ID Related Accession (Same CDS sequence)	XM_006520102.3 , NM_001357023.1
Accession Version	NM_001357023.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-11
Organism	Mus musculus(house mouse)
Product	ribonucleoside-diphosphate reductase subunit M2 B isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC122291.4. On Oct 17, 2017 this sequence version replaced XM_006520102.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.4364.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849381 [ECO:0000348] ##Evidence-Data-END##

ATGTACAAGC AAGCACAGGC ATCTTTCTGG ACAGCAGAGG AGGTTGACTT GTCAAAGGAC 
CTCCCTCACT GGAACAAGCT TAAATCCGAC GAGAAGTATT TTATCTCCCA CATCTTAGCC 
TTTTTTGCAG CCAGTGATGG AATTGTAAAT GAAAACTTGG TGGAGCGTTT TAGTCAGGAG 
GTGCAGGTTC CAGAGGCTCG CTGCTTCTAT GGCTTTCAGA TTCTCATCGA GAATGTTCAC 
TCAGAGATGT ACAGTTTACT AATAGACACT TACATCAGAG ATCCAAAGAA AAGGGAATTT 
TTATTTAATG CAATTGAAAC AATGCCATAT GTTAAGAAAA AAGCGGACTG GGCTCTGCGC 
TGGATAGCAG ATAGGAAATC TACTTTTGGG GAAAGAGTGG TGGCCTTTGC TGCTGTGGAA 
GGAATTTTCT TCTCTGGATC ATTTGCTGCA ATATTCTGGC TAAAGAAGAG AGGCCTCATG 
CCTGGACTGA CTTTTTCAAA TGAACTGATC AGCAGGGATG AAGGACTTCA CTGTGACTTT 
GCCTGCCTGA TGTTTCAGTA CTTGGTAAAC AAGCCTTCAG AAGATAGAGT GAGGGAAATC 
ATTGCTGATG CTGTTCAAAT CGAGCAGGAG TTTTTAACAG AAGCCTTGCC TGTTGGCCTC 
ATTGGAATGA ACTGTGTTTT GATGAAACAG TACATTGAGT TTGTAGCTGA CAGATTACTT 
GGAGAACTTG GATTCTCAAA GATTTTTCAG GCAGAAAATC CCTTTGATTT TATGGAGAAC 
ATTTCATTAG AAGGGAAAAC AAATTTCTTT GAGAAACGAG TTTCTGAGTA TCAGCGATTT 
GCAGTCATGG CCGAAACCAC AGATAATGTC TTCACCTTGG ATGCAGATTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001343952.1
CDS	472..1365
Translation	MYKQAQASFWTAEEVDLSKDLPHWNKLKSDEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGIFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQYLVNKPSEDRVREIIADAVQIEQEFLTEALPVGLIGMNCVLMKQYIEFVADRLLGELGFSKIFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDADF

Target ORF information:

RefSeq Version	NM_001357023.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001357023.1

ORF Insert Sequence:

ATGTACAAGC AAGCACAGGC ATCTTTCTGG ACAGCAGAGG AGGTTGACTT GTCAAAGGAC 
CTCCCTCACT GGAACAAGCT TAAATCCGAC GAGAAGTATT TTATCTCCCA CATCTTAGCC 
TTTTTTGCAG CCAGTGATGG AATTGTAAAT GAAAACTTGG TGGAGCGTTT TAGTCAGGAG 
GTGCAGGTTC CAGAGGCTCG CTGCTTCTAT GGCTTTCAGA TTCTCATCGA GAATGTTCAC 
TCAGAGATGT ACAGTTTACT AATAGACACT TACATCAGAG ATCCAAAGAA AAGGGAATTT 
TTATTTAATG CAATTGAAAC AATGCCATAT GTTAAGAAAA AAGCGGACTG GGCTCTGCGC 
TGGATAGCAG ATAGGAAATC TACTTTTGGG GAAAGAGTGG TGGCCTTTGC TGCTGTGGAA 
GGAATTTTCT TCTCTGGATC ATTTGCTGCA ATATTCTGGC TAAAGAAGAG AGGCCTCATG 
CCTGGACTGA CTTTTTCAAA TGAACTGATC AGCAGGGATG AAGGACTTCA CTGTGACTTT 
GCCTGCCTGA TGTTTCAGTA CTTGGTAAAC AAGCCTTCAG AAGATAGAGT GAGGGAAATC 
ATTGCTGATG CTGTTCAAAT CGAGCAGGAG TTTTTAACAG AAGCCTTGCC TGTTGGCCTC 
ATTGGAATGA ACTGTGTTTT GATGAAACAG TACATTGAGT TTGTAGCTGA CAGATTACTT 
GGAGAACTTG GATTCTCAAA GATTTTTCAG GCAGAAAATC CCTTTGATTT TATGGAGAAC 
ATTTCATTAG AAGGGAAAAC AAATTTCTTT GAGAAACGAG TTTCTGAGTA TCAGCGATTT 
GCAGTCATGG CCGAAACCAC AGATAATGTC TTCACCTTGG ATGCAGATTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rrm2b ( XM_006520101.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006520164.1 Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu50713
Clone ID Related Accession (Same CDS sequence)	NM_001357022.1 , XM_006520101.2
Accession Version	XM_006520101.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(House mouse)
Product	ribonucleoside-diphosphate reductase subunit M2 B isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000081.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006520101.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGCAAT TGTGTTCGGA GACAGAAGAA AATGTGGTGA GGTCAAATGA AGAGCCACTC 
CTAAGAAAGA GTTCCCGACG GTTCGTCATC TTTCCAATCC AGTATCCTGA TATCTGGAGA 
ATGTACAAGC AAGCACAGGC ATCTTTCTGG ACAGCAGAGG AGGTTGACTT GTCAAAGGAC 
CTCCCTCACT GGAACAAGCT TAAATCCGAC GAGAAGTATT TTATCTCCCA CATCTTAGCC 
TTTTTTGCAG CCAGTGATGG AATTGTAAAT GAAAACTTGG TGGAGCGTTT TAGTCAGGAG 
GTGCAGGTTC CAGAGGCTCG CTGCTTCTAT GGCTTTCAGA TTCTCATCGA GAATGTTCAC 
TCAGAGATGT ACAGTTTACT AATAGACACT TACATCAGAG ATCCAAAGAA AAGGGAATTT 
TTATTTAATG CAATTGAAAC AATGCCATAT GTTAAGAAAA AAGCGGACTG GGCTCTGCGC 
TGGATAGCAG ATAGGAAATC TACTTTTGGG GAAAGAGTGG TGGCCTTTGC TGCTGTGGAA 
GGAATTTTCT TCTCTGGATC ATTTGCTGCA ATATTCTGGC TAAAGAAGAG AGGCCTCATG 
CCTGGACTGA CTTTTTCAAA TGAACTGATC AGCAGGGATG AAGGACTTCA CTGTGACTTT 
GCCTGCCTGA TGTTTCAGTA CTTGGTAAAC AAGCCTTCAG AAGATAGAGT GAGGGAAATC 
ATTGCTGATG CTGTTCAAAT CGAGCAGGAG TTTTTAACAG AAGCCTTGCC TGTTGGCCTC 
ATTGGAATGA ACTGTGTTTT GATGAAACAG TACATTGAGT TTGTAGCTGA CAGATTACTT 
GGAGAACTTG GATTCTCAAA GATTTTTCAG GCAGAAAATC CCTTTGATTT TATGGAGAAC 
ATTTCATTAG AAGGGAAAAC AAATTTCTTT GAGAAACGAG TTTCTGAGTA TCAGCGATTT 
GCAGTCATGG CCGAAACCAC AGATAATGTC TTCACCTTGG ATGCAGATTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006520164.1
CDS	399..1412
Translation	MQQLCSETEENVVRSNEEPLLRKSSRRFVIFPIQYPDIWRMYKQAQASFWTAEEVDLSKDLPHWNKLKSDEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGIFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQYLVNKPSEDRVREIIADAVQIEQEFLTEALPVGLIGMNCVLMKQYIEFVADRLLGELGFSKIFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDADF

Target ORF information:

RefSeq Version	XM_006520101.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006520101.2

ORF Insert Sequence:

ATGCAGCAAT TGTGTTCGGA GACAGAAGAA AATGTGGTGA GGTCAAATGA AGAGCCACTC 
CTAAGAAAGA GTTCCCGACG GTTCGTCATC TTTCCAATCC AGTATCCTGA TATCTGGAGA 
ATGTACAAGC AAGCACAGGC ATCTTTCTGG ACAGCAGAGG AGGTTGACTT GTCAAAGGAC 
CTCCCTCACT GGAACAAGCT TAAATCCGAC GAGAAGTATT TTATCTCCCA CATCTTAGCC 
TTTTTTGCAG CCAGTGATGG AATTGTAAAT GAAAACTTGG TGGAGCGTTT TAGTCAGGAG 
GTGCAGGTTC CAGAGGCTCG CTGCTTCTAT GGCTTTCAGA TTCTCATCGA GAATGTTCAC 
TCAGAGATGT ACAGTTTACT AATAGACACT TACATCAGAG ATCCAAAGAA AAGGGAATTT 
TTATTTAATG CAATTGAAAC AATGCCATAT GTTAAGAAAA AAGCGGACTG GGCTCTGCGC 
TGGATAGCAG ATAGGAAATC TACTTTTGGG GAAAGAGTGG TGGCCTTTGC TGCTGTGGAA 
GGAATTTTCT TCTCTGGATC ATTTGCTGCA ATATTCTGGC TAAAGAAGAG AGGCCTCATG 
CCTGGACTGA CTTTTTCAAA TGAACTGATC AGCAGGGATG AAGGACTTCA CTGTGACTTT 
GCCTGCCTGA TGTTTCAGTA CTTGGTAAAC AAGCCTTCAG AAGATAGAGT GAGGGAAATC 
ATTGCTGATG CTGTTCAAAT CGAGCAGGAG TTTTTAACAG AAGCCTTGCC TGTTGGCCTC 
ATTGGAATGA ACTGTGTTTT GATGAAACAG TACATTGAGT TTGTAGCTGA CAGATTACTT 
GGAGAACTTG GATTCTCAAA GATTTTTCAG GCAGAAAATC CCTTTGATTT TATGGAGAAC 
ATTTCATTAG AAGGGAAAAC AAATTTCTTT GAGAAACGAG TTTCTGAGTA TCAGCGATTT 
GCAGTCATGG CCGAAACCAC AGATAATGTC TTCACCTTGG ATGCAGATTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rrm2b ( XM_006520102.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006520165.1 Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu50714
Clone ID Related Accession (Same CDS sequence)	XM_006520102.3 , NM_001357023.1
Accession Version	XM_006520102.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(House mouse)
Product	ribonucleoside-diphosphate reductase subunit M2 B isoform X2
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000081.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006520102.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTACAAGC AAGCACAGGC ATCTTTCTGG ACAGCAGAGG AGGTTGACTT GTCAAAGGAC 
CTCCCTCACT GGAACAAGCT TAAATCCGAC GAGAAGTATT TTATCTCCCA CATCTTAGCC 
TTTTTTGCAG CCAGTGATGG AATTGTAAAT GAAAACTTGG TGGAGCGTTT TAGTCAGGAG 
GTGCAGGTTC CAGAGGCTCG CTGCTTCTAT GGCTTTCAGA TTCTCATCGA GAATGTTCAC 
TCAGAGATGT ACAGTTTACT AATAGACACT TACATCAGAG ATCCAAAGAA AAGGGAATTT 
TTATTTAATG CAATTGAAAC AATGCCATAT GTTAAGAAAA AAGCGGACTG GGCTCTGCGC 
TGGATAGCAG ATAGGAAATC TACTTTTGGG GAAAGAGTGG TGGCCTTTGC TGCTGTGGAA 
GGAATTTTCT TCTCTGGATC ATTTGCTGCA ATATTCTGGC TAAAGAAGAG AGGCCTCATG 
CCTGGACTGA CTTTTTCAAA TGAACTGATC AGCAGGGATG AAGGACTTCA CTGTGACTTT 
GCCTGCCTGA TGTTTCAGTA CTTGGTAAAC AAGCCTTCAG AAGATAGAGT GAGGGAAATC 
ATTGCTGATG CTGTTCAAAT CGAGCAGGAG TTTTTAACAG AAGCCTTGCC TGTTGGCCTC 
ATTGGAATGA ACTGTGTTTT GATGAAACAG TACATTGAGT TTGTAGCTGA CAGATTACTT 
GGAGAACTTG GATTCTCAAA GATTTTTCAG GCAGAAAATC CCTTTGATTT TATGGAGAAC 
ATTTCATTAG AAGGGAAAAC AAATTTCTTT GAGAAACGAG TTTCTGAGTA TCAGCGATTT 
GCAGTCATGG CCGAAACCAC AGATAATGTC TTCACCTTGG ATGCAGATTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006520165.1
CDS	472..1365
Translation	MYKQAQASFWTAEEVDLSKDLPHWNKLKSDEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGIFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQYLVNKPSEDRVREIIADAVQIEQEFLTEALPVGLIGMNCVLMKQYIEFVADRLLGELGFSKIFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDADF

Target ORF information:

RefSeq Version	XM_006520102.3
Organism	Mus musculus(House mouse)
Definition	Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006520102.3

ORF Insert Sequence:

ATGTACAAGC AAGCACAGGC ATCTTTCTGG ACAGCAGAGG AGGTTGACTT GTCAAAGGAC 
CTCCCTCACT GGAACAAGCT TAAATCCGAC GAGAAGTATT TTATCTCCCA CATCTTAGCC 
TTTTTTGCAG CCAGTGATGG AATTGTAAAT GAAAACTTGG TGGAGCGTTT TAGTCAGGAG 
GTGCAGGTTC CAGAGGCTCG CTGCTTCTAT GGCTTTCAGA TTCTCATCGA GAATGTTCAC 
TCAGAGATGT ACAGTTTACT AATAGACACT TACATCAGAG ATCCAAAGAA AAGGGAATTT 
TTATTTAATG CAATTGAAAC AATGCCATAT GTTAAGAAAA AAGCGGACTG GGCTCTGCGC 
TGGATAGCAG ATAGGAAATC TACTTTTGGG GAAAGAGTGG TGGCCTTTGC TGCTGTGGAA 
GGAATTTTCT TCTCTGGATC ATTTGCTGCA ATATTCTGGC TAAAGAAGAG AGGCCTCATG 
CCTGGACTGA CTTTTTCAAA TGAACTGATC AGCAGGGATG AAGGACTTCA CTGTGACTTT 
GCCTGCCTGA TGTTTCAGTA CTTGGTAAAC AAGCCTTCAG AAGATAGAGT GAGGGAAATC 
ATTGCTGATG CTGTTCAAAT CGAGCAGGAG TTTTTAACAG AAGCCTTGCC TGTTGGCCTC 
ATTGGAATGA ACTGTGTTTT GATGAAACAG TACATTGAGT TTGTAGCTGA CAGATTACTT 
GGAGAACTTG GATTCTCAAA GATTTTTCAG GCAGAAAATC CCTTTGATTT TATGGAGAAC 
ATTTCATTAG AAGGGAAAAC AAATTTCTTT GAGAAACGAG TTTCTGAGTA TCAGCGATTT 
GCAGTCATGG CCGAAACCAC AGATAATGTC TTCACCTTGG ATGCAGATTT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rrm2b ( XM_011245361.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011243663.1 Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OMu75137
Clone ID Related Accession (Same CDS sequence)	XM_011245361.2 , XM_011245361.3
Accession Version	XM_011245361.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	ribonucleoside-diphosphate reductase subunit M2 B isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000081.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011245361.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCGACC CGGAAAGGCC GGAAGCGGCC AGGCCGGAGA AGGGTGAGCA ATTGTGTTCG 
GAGACAGAAG AAAATGTGGT GAGGTCAAAT GAAGAGCCAC TCCTAAGAAA GAGTTCCCGA 
CGGTTCGTCA TCTTTCCAAT CCAGTATCCT GATATCTGGA GAATGTACAA GCAAGCACAG 
GCATCTTTCT GGACAGCAGA GGAGGTTGAC TTGTCAAAGG ACCTCCCTCA CTGGAACAAG 
CTTAAATCCG ACGAGAAGTA TTTTATCTCC CACATCTTAG CCTTTTTTGC AGCCAGTGAT 
GGAATTGTAA ATGAAAACTT GGTGGAGCGT TTTAGTCAGG AGGTGCAGGT TCCAGAGGCT 
CGCTGCTTCT ATGGCTTTCA GATTCTCATC GAGAATGTTC ACTCAGAGAT GTACAGTTTA 
CTAATAGACA CTTACATCAG AGATCCAAAG AAAAGGGAAT TTTTATTTAA TGCAATTGAA 
ACAATGCCAT ATGTTAAGAA AAAAGCGGAC TGGGCTCTGC GCTGGATAGC AGATAGGAAA 
TCTACTTTTG GATTTCTGGA GCTCTGCCCA ATGTTTGGCT GTGGGTCTCT CCATCTGTTT 
CCATTGGTGG CTGGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011243663.1
CDS	220..837
Translation	MGDPERPEAARPEKGEQLCSETEENVVRSNEEPLLRKSSRRFVIFPIQYPDIWRMYKQAQASFWTAEEVDLSKDLPHWNKLKSDEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGFLELCPMFGCGSLHLFPLVAG

Target ORF information:

RefSeq Version	XM_011245361.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011245361.2

ORF Insert Sequence:

ATGGGCGACC CGGAAAGGCC GGAAGCGGCC AGGCCGGAGA AGGGTGAGCA ATTGTGTTCG 
GAGACAGAAG AAAATGTGGT GAGGTCAAAT GAAGAGCCAC TCCTAAGAAA GAGTTCCCGA 
CGGTTCGTCA TCTTTCCAAT CCAGTATCCT GATATCTGGA GAATGTACAA GCAAGCACAG 
GCATCTTTCT GGACAGCAGA GGAGGTTGAC TTGTCAAAGG ACCTCCCTCA CTGGAACAAG 
CTTAAATCCG ACGAGAAGTA TTTTATCTCC CACATCTTAG CCTTTTTTGC AGCCAGTGAT 
GGAATTGTAA ATGAAAACTT GGTGGAGCGT TTTAGTCAGG AGGTGCAGGT TCCAGAGGCT 
CGCTGCTTCT ATGGCTTTCA GATTCTCATC GAGAATGTTC ACTCAGAGAT GTACAGTTTA 
CTAATAGACA CTTACATCAG AGATCCAAAG AAAAGGGAAT TTTTATTTAA TGCAATTGAA 
ACAATGCCAT ATGTTAAGAA AAAAGCGGAC TGGGCTCTGC GCTGGATAGC AGATAGGAAA 
TCTACTTTTG GATTTCTGGA GCTCTGCCCA ATGTTTGGCT GTGGGTCTCT CCATCTGTTT 
CCATTGGTGG CTGGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rrm2b ( XM_011245361.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011243663.1 Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu75137
Clone ID Related Accession (Same CDS sequence)	XM_011245361.2 , XM_011245361.3
Accession Version	XM_011245361.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	ribonucleoside-diphosphate reductase subunit M2 B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000081.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011245361.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCGACC CGGAAAGGCC GGAAGCGGCC AGGCCGGAGA AGGGTGAGCA ATTGTGTTCG 
GAGACAGAAG AAAATGTGGT GAGGTCAAAT GAAGAGCCAC TCCTAAGAAA GAGTTCCCGA 
CGGTTCGTCA TCTTTCCAAT CCAGTATCCT GATATCTGGA GAATGTACAA GCAAGCACAG 
GCATCTTTCT GGACAGCAGA GGAGGTTGAC TTGTCAAAGG ACCTCCCTCA CTGGAACAAG 
CTTAAATCCG ACGAGAAGTA TTTTATCTCC CACATCTTAG CCTTTTTTGC AGCCAGTGAT 
GGAATTGTAA ATGAAAACTT GGTGGAGCGT TTTAGTCAGG AGGTGCAGGT TCCAGAGGCT 
CGCTGCTTCT ATGGCTTTCA GATTCTCATC GAGAATGTTC ACTCAGAGAT GTACAGTTTA 
CTAATAGACA CTTACATCAG AGATCCAAAG AAAAGGGAAT TTTTATTTAA TGCAATTGAA 
ACAATGCCAT ATGTTAAGAA AAAAGCGGAC TGGGCTCTGC GCTGGATAGC AGATAGGAAA 
TCTACTTTTG GATTTCTGGA GCTCTGCCCA ATGTTTGGCT GTGGGTCTCT CCATCTGTTT 
CCATTGGTGG CTGGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011243663.1
CDS	229..846
Translation	MGDPERPEAARPEKGEQLCSETEENVVRSNEEPLLRKSSRRFVIFPIQYPDIWRMYKQAQASFWTAEEVDLSKDLPHWNKLKSDEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGFLELCPMFGCGSLHLFPLVAG

Target ORF information:

RefSeq Version	XM_011245361.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011245361.3

ORF Insert Sequence:

ATGGGCGACC CGGAAAGGCC GGAAGCGGCC AGGCCGGAGA AGGGTGAGCA ATTGTGTTCG 
GAGACAGAAG AAAATGTGGT GAGGTCAAAT GAAGAGCCAC TCCTAAGAAA GAGTTCCCGA 
CGGTTCGTCA TCTTTCCAAT CCAGTATCCT GATATCTGGA GAATGTACAA GCAAGCACAG 
GCATCTTTCT GGACAGCAGA GGAGGTTGAC TTGTCAAAGG ACCTCCCTCA CTGGAACAAG 
CTTAAATCCG ACGAGAAGTA TTTTATCTCC CACATCTTAG CCTTTTTTGC AGCCAGTGAT 
GGAATTGTAA ATGAAAACTT GGTGGAGCGT TTTAGTCAGG AGGTGCAGGT TCCAGAGGCT 
CGCTGCTTCT ATGGCTTTCA GATTCTCATC GAGAATGTTC ACTCAGAGAT GTACAGTTTA 
CTAATAGACA CTTACATCAG AGATCCAAAG AAAAGGGAAT TTTTATTTAA TGCAATTGAA 
ACAATGCCAT ATGTTAAGAA AAAAGCGGAC TGGGCTCTGC GCTGGATAGC AGATAGGAAA 
TCTACTTTTG GATTTCTGGA GCTCTGCCCA ATGTTTGGCT GTGGGTCTCT CCATCTGTTT 
CCATTGGTGG CTGGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Chromosomal instability triggered by Rrm2b loss leads to IL-6 secretion and plasmacytic neoplasms.
Cell reports3(5)1389-97(2013 May)
Chang L,Guo R,Huang Q,Yen Y

RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence.
Scientific reports2822(2012)
Kuo ML,Sy AJ,Xue L,Chi M,Lee MT,Yen T,Chiang MI,Chang L,Chu P,Yen Y

Synergism between p53 and Mcl-1 in protecting from hepatic injury, fibrosis and cancer.
Journal of hepatology54(4)685-94(2011 Apr)
Weng SY,Yang CY,Li CC,Sun TP,Tung SY,Yen JJ,Tsai TF,Chen CM,Chen SH,Hsiao M,Huang PH,Yang-Yen HF

Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion.
Nature genetics39(6)776-80(2007 Jun)
Bourdon A,Minai L,Serre V,Jais JP,Sarzi E,Aubert S,Chr?tien D,de Lonlay P,Paquis-Flucklinger V,Arakawa H,Nakamura Y,Munnich A,R?tig A

Rapid development of glomerular injury and renal failure in mice lacking p53R2.
Pediatric nephrology (Berlin, Germany)20(3)432-40(2005 Mar)
Powell DR,Desai U,Sparks MJ,Hansen G,Gay J,Schrick J,Shi ZZ,Hicks J,Vogel P

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Rrm2b cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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