COG2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Gene Symbol	COG2
Entrez Gene ID	22796
Full Name	component of oligomeric golgi complex 2
Synonyms	CDG2Q,LDLC
General protein information	Preferred Names component of oligomeric golgi complex 2 Names conserved oligomeric Golgi complex subunit 2 COG complex subunit 2 brefeldin A-sensitive, peripheral Golgi protein conserved oligomeric Golgi complex protein 2 low density lipoprotein receptor defect C complementing low density lipoprotein receptor defect C-complementing protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q42.2
Summary	This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009].
Disorder MIM:	606974
Disorder Html:	?Congenital disorder of glycosylation, type IIq, 617395 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001145036.2	NP_001138508.1	conserved oligomeric Golgi complex subunit 2 isoform 2
NM_001145036.1	NP_001138508.1	conserved oligomeric Golgi complex subunit 2 isoform 2
NM_007357.3	NP_031383.1	conserved oligomeric Golgi complex subunit 2 isoform 1
NM_007357.2	NP_031383.1	conserved oligomeric Golgi complex subunit 2 isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	COG2	XP_001148147.1
Canis lupus familiaris (dog)	COG2	XP_546096.2
Arabidopsis thaliana (thale cress)	AT4G24840	NP_567710.1
Xenopus tropicalis (tropical clawed frog)	cog2	XP_004914700.1
	COG2	XP_002808309.1
Rattus norvegicus (Norway rat)	Cog2	NP_001103964.1
Drosophila melanogaster (fruit fly)	ldlCp	NP_524366.1
Caenorhabditis elegans (roundworm)	cogc-2	NP_501092.1
Homo sapiens (human)	COG2	NP_031383.1
Bos taurus (cattle)	COG2	NP_001070307.2
Mus musculus (house mouse)	Cog2	NP_084022.2
Gallus gallus (chicken)	COG2	XP_419583.2
Danio rerio (zebrafish)	cog2	NP_998519.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003824	XP_310386.6
Oryza sativa (rice)	Os03g0849600	NP_001051898.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in COG2 encoding a subunit of the conserved oligomeric golgi complex cause a congenital disorder of glycosylation.
Kodera H, Ando N, Yuasa I, Wada Y, Tsurusaki Y, Nakashima M, Miyake N, Saitoh S, Matsumoto N, Saitsu H
Clinical genetics87(5)455-60(2015 May)

An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.
Edwards TL, Pericak-Vance M, Gilbert JR, Haines JL, Martin ER, Ritchie MD
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics150B(5)721-35(2009 Jul)

Gene variants associated with ischemic stroke: the cardiovascular health study.
Luke MM, O'Meara ES, Rowland CM, Shiffman D, Bare LA, Arellano AR, Longstreth WT Jr, Lumley T, Rice K, Tracy RP, Devlin JJ, Psaty BM
Stroke40(2)363-8(2009 Feb)

Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.
Shiffman D, O'Meara ES, Bare LA, Rowland CM, Louie JZ, Arellano AR, Lumley T, Rice K, Iakoubova O, Luke MM, Young BA, Malloy MJ, Kane JP, Ellis SG, Tracy RP, Devlin JJ, Psaty BM
Arteriosclerosis, thrombosis, and vascular biology28(1)173-9(2008 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our data strongly suggest that these compound heterozygous mutations in COG2 are causative of CDG.
Title: Mutations in COG2 encoding a subunit of the conserved oligomeric golgi complex cause a congenital disorder of glycosylation.

Observational study of gene-disease association. (HuGE Navigator)
Title: An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene variants associated with ischemic stroke: the cardiovascular health study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.

The interaction between p115 and Cog2 was found to be essential for Golgi ribbon reformation after the disruption of the ribbon by p115 KD or brefeldin A treatment and recovery by re-expression of p115 or drug wash out, respectively.
Title: The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity.

The following COG2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COG2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10393	NM_007357.3 Latest version!	Homo sapiens component of oligomeric golgi complex 2 (COG2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu10528	NM_001145036.2 Latest version!	Homo sapiens component of oligomeric golgi complex 2 (COG2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
View Old Accession Versions >>
OHu10528	NM_001145036.1	Homo sapiens component of oligomeric golgi complex 2 (COG2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OHu10393	NM_007357.2	Homo sapiens component of oligomeric golgi complex 2 (COG2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COG2 ( NM_007357.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_031383.1 Homo sapiens component of oligomeric golgi complex 2 (COG2), transcript variant 1, mRNA.

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CloneID	OHu10393
Clone ID Related Accession (Same CDS sequence)	NM_007357.3 , NM_007357.2
Accession Version	NM_007357.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2217bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	conserved oligomeric Golgi complex subunit 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC349417.1, AL158214.33, DB449302.1, AK312678.1 and BC051906.1. On Nov 23, 2018 this sequence version replaced NM_007357.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC014960.1, SRR1803611.38136.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000366669.9/ ENSP00000355629.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGAAAA GTAGGATGAA CCTGCCCAAG GGGCCGGACA CGCTCTGCTT CGACAAGGAC 
GAGTTCATGA AGGAAGATTT CGATGTCGAT CATTTTGTGT CTGACTGTAG GAAGCGGGTC 
CAGCTGGAAG AACTGAGAGA TGACCTGGAG CTCTACTATA AACTTCTTAA AACAGCCATG 
GTCGAACTCA TCAACAAGGA TTATGCAGAT TTTGTCAATC TTTCAACAAA CTTGGTTGGC 
ATGGACAAAG CCCTCAACCA GCTTTCTGTG CCTTTGGGAC AATTACGAGA AGAGGTTCTG 
AGCCTTAGAT CGTCTGTCAG TGAAGGAATT CGGGCAGTTG ATGAACGAAT GTCTAAACAA 
GAGGACATTA GGAAAAAAAA GATGTGTGTA TTGAGGCTTA TACAAGTTAT TCGGTCAGTT 
GAGAAAATTG AAAAAATCTT AAACTCTCAA AGTTCTAAAG AAACCTCTGC ACTAGAAGCA 
AGCAGCCCCC TTTTGACTGG ACAAATTTTG GAGAGAATTG CCACAGAATT TAATCAGTTA 
CAGTTTCATG CTGTTCAAAG CAAAGGCATG CCTCTTTTGG ACAAAGTAAG ACCGCGTATA 
GCTGGCATTA CAGCCATGTT ACAGCAGTCA CTGGAAGGTC TCCTATTAGA AGGCCTTCAG 
ACGTCTGACG TCGATATAAT ACGGCACTGC TTGCGGACTT ACGCCACGAT TGACAAGACA 
CGGGACGCGG AGGCCTTAGT TGGCCAAGTA CTAGTGAAAC CATACATAGA CGAGGTGATT 
ATAGAGCAGT TTGTTGAATC TCATCCCAAT GGCCTTCAGG TCATGTATAA TAAACTCCTG 
GAGTTTGTTC CTCACCATTG CCGCCTTCTT CGAGAAGTCA CAGGAGGTGC CATCTCCAGT 
GAAAAAGGCA ATACTGTTCC TGGATATGAC TTTTTGGTGA ATTCTGTTTG GCCACAAATA 
GTACAAGGAT TAGAAGAAAA GTTACCCTCG CTTTTTAATC CTGGGAATCC CGATGCATTT 
CATGAGAAAT ATACCATAAG TATGGATTTT GTCAGAAGAT TGGAACGGCA GTGTGGATCA 
CAGGCTAGTG TAAAGAGATT AAGAGCCCAT CCTGCCTATC ACAGCTTCAA TAAGAAGTGG 
AACTTGCCTG TTTATTTTCA AATAAGATTT AGAGAAATAG CGGGATCCTT AGAAGCAGCA 
CTTACAGATG TCCTGGAAGA TGCCCCAGCT GAAAGTCCGT ATTGCCTTTT GGCTTCTCAT 
AGAACTTGGA GCAGCCTTAG GAGGTGTTGG TCAGATGAGA TGTTCTTGCC ATTACTGGTG 
CATCGCCTGT GGAGACTCAC TCTGCAGATT TTGGCACGAT ACTCTGTGTT TGTCAATGAG 
CTTTCACTCA GGCCCATTTC TAATGAAAGT CCCAAGGAGA TCAAGAAACC TTTGGTAACT 
GGTAGCAAAG AACCTTCCAT CACCCAAGGA AACACTGAAG ACCAAGGAAG TGGTCCTTCG 
GAAACAAAGC CTGTGGTTTC CATTTCCCGC ACTCAGCTCG TGTATGTGGT TGCAGACCTG 
GACAAGCTTC AGGAGCAGCT TCCAGAACTC TTGGAAATAA TCAAGCCAAA ACTTGAAATG 
ATTGGCTTTA AGAATTTTTC TTCTATCTCA GCAGCCCTGG AGGACTCCCA GAGCTCTTTT 
TCAGCCTGTG TGCCCTCCTT GAGTAGCAAG ATCATCCAGG ATTTAAGTGA CTCTTGCTTC 
GGTTTCCTAA AAAGCGCCCT GGAGGTTCCC AGGCTTTACC GAAGAACCAA TAAGGAGGTC 
CCAACCACAG CTTCCTCCTA TGTGGACAGT GCTCTGAAGC CCTTATTCCA GCTTCAGAGC 
GGACACAAGG ATAAGCTCAA ACAAGCAATA ATTCAGCAGT GGCTAGAAGG CACTCTCAGT 
GAAAGCACTC ATAAGTACTA TGAAACCGTG TCAGATGTAT TAAACTCTGT GAAGAAGATG 
GAAGAGAGCC TGAAAAGGCT GAAACAAGCC AGAAAAACCA CTCCCGCCAA CCCCGTCGGT 
CCCAGTGGTG GCATGAGCGA CGACGACAAA ATCAGGCTGC AGTTGGCCCT AGATGTTGAG 
TACTTGGGAG AGCAGATACA AAAGTTGGGA CTACAAGCAA GTGACATAAA AAGCTTCTCA 
GCTCTCGCAG AGCTTGTTGC TGCTGCCAAG GACCAGGCAA CAGCAGAGCA GCCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031383.1
CDS	127..2343
Translation	MEKSRMNLPKGPDTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEELRDDLELYYKLLKTAMVELINKDYADFVNLSTNLVGMDKALNQLSVPLGQLREEVLSLRSSVSEGIRAVDERMSKQEDIRKKKMCVLRLIQVIRSVEKIEKILNSQSSKETSALEASSPLLTGQILERIATEFNQLQFHAVQSKGMPLLDKVRPRIAGITAMLQQSLEGLLLEGLQTSDVDIIRHCLRTYATIDKTRDAEALVGQVLVKPYIDEVIIEQFVESHPNGLQVMYNKLLEFVPHHCRLLREVTGGAISSEKGNTVPGYDFLVNSVWPQIVQGLEEKLPSLFNPGNPDAFHEKYTISMDFVRRLERQCGSQASVKRLRAHPAYHSFNKKWNLPVYFQIRFREIAGSLEAALTDVLEDAPAESPYCLLASHRTWSSLRRCWSDEMFLPLLVHRLWRLTLQILARYSVFVNELSLRPISNESPKEIKKPLVTGSKEPSITQGNTEDQGSGPSETKPVVSISRTQLVYVVADLDKLQEQLPELLEIIKPKLEMIGFKNFSSISAALEDSQSSFSACVPSLSSKIIQDLSDSCFGFLKSALEVPRLYRRTNKEVPTTASSYVDSALKPLFQLQSGHKDKLKQAIIQQWLEGTLSESTHKYYETVSDVLNSVKKMEESLKRLKQARKTTPANPVGPSGGMSDDDKIRLQLALDVEYLGEQIQKLGLQASDIKSFSALAELVAAAKDQATAEQP

Target ORF information:

RefSeq Version	NM_007357.3
Organism	Homo sapiens(human)
Definition	Homo sapiens component of oligomeric golgi complex 2 (COG2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007357.3

ORF Insert Sequence:

ATGGAGAAAA GTAGGATGAA CCTGCCCAAG GGGCCGGACA CGCTCTGCTT CGACAAGGAC 
GAGTTCATGA AGGAAGATTT CGATGTCGAT CATTTTGTGT CTGACTGTAG GAAGCGGGTC 
CAGCTGGAAG AACTGAGAGA TGACCTGGAG CTCTACTATA AACTTCTTAA AACAGCCATG 
GTCGAACTCA TCAACAAGGA TTATGCAGAT TTTGTCAATC TTTCAACAAA CTTGGTTGGC 
ATGGACAAAG CCCTCAACCA GCTTTCTGTG CCTTTGGGAC AATTACGAGA AGAGGTTCTG 
AGCCTTAGAT CGTCTGTCAG TGAAGGAATT CGGGCAGTTG ATGAACGAAT GTCTAAACAA 
GAGGACATTA GGAAAAAAAA GATGTGTGTA TTGAGGCTTA TACAAGTTAT TCGGTCAGTT 
GAGAAAATTG AAAAAATCTT AAACTCTCAA AGTTCTAAAG AAACCTCTGC ACTAGAAGCA 
AGCAGCCCCC TTTTGACTGG ACAAATTTTG GAGAGAATTG CCACAGAATT TAATCAGTTA 
CAGTTTCATG CTGTTCAAAG CAAAGGCATG CCTCTTTTGG ACAAAGTAAG ACCGCGTATA 
GCTGGCATTA CAGCCATGTT ACAGCAGTCA CTGGAAGGTC TCCTATTAGA AGGCCTTCAG 
ACGTCTGACG TCGATATAAT ACGGCACTGC TTGCGGACTT ACGCCACGAT TGACAAGACA 
CGGGACGCGG AGGCCTTAGT TGGCCAAGTA CTAGTGAAAC CATACATAGA CGAGGTGATT 
ATAGAGCAGT TTGTTGAATC TCATCCCAAT GGCCTTCAGG TCATGTATAA TAAACTCCTG 
GAGTTTGTTC CTCACCATTG CCGCCTTCTT CGAGAAGTCA CAGGAGGTGC CATCTCCAGT 
GAAAAAGGCA ATACTGTTCC TGGATATGAC TTTTTGGTGA ATTCTGTTTG GCCACAAATA 
GTACAAGGAT TAGAAGAAAA GTTACCCTCG CTTTTTAATC CTGGGAATCC CGATGCATTT 
CATGAGAAAT ATACCATAAG TATGGATTTT GTCAGAAGAT TGGAACGGCA GTGTGGATCA 
CAGGCTAGTG TAAAGAGATT AAGAGCCCAT CCTGCCTATC ACAGCTTCAA TAAGAAGTGG 
AACTTGCCTG TTTATTTTCA AATAAGATTT AGAGAAATAG CGGGATCCTT AGAAGCAGCA 
CTTACAGATG TCCTGGAAGA TGCCCCAGCT GAAAGTCCGT ATTGCCTTTT GGCTTCTCAT 
AGAACTTGGA GCAGCCTTAG GAGGTGTTGG TCAGATGAGA TGTTCTTGCC ATTACTGGTG 
CATCGCCTGT GGAGACTCAC TCTGCAGATT TTGGCACGAT ACTCTGTGTT TGTCAATGAG 
CTTTCACTCA GGCCCATTTC TAATGAAAGT CCCAAGGAGA TCAAGAAACC TTTGGTAACT 
GGTAGCAAAG AACCTTCCAT CACCCAAGGA AACACTGAAG ACCAAGGAAG TGGTCCTTCG 
GAAACAAAGC CTGTGGTTTC CATTTCCCGC ACTCAGCTCG TGTATGTGGT TGCAGACCTG 
GACAAGCTTC AGGAGCAGCT TCCAGAACTC TTGGAAATAA TCAAGCCAAA ACTTGAAATG 
ATTGGCTTTA AGAATTTTTC TTCTATCTCA GCAGCCCTGG AGGACTCCCA GAGCTCTTTT 
TCAGCCTGTG TGCCCTCCTT GAGTAGCAAG ATCATCCAGG ATTTAAGTGA CTCTTGCTTC 
GGTTTCCTAA AAAGCGCCCT GGAGGTTCCC AGGCTTTACC GAAGAACCAA TAAGGAGGTC 
CCAACCACAG CTTCCTCCTA TGTGGACAGT GCTCTGAAGC CCTTATTCCA GCTTCAGAGC 
GGACACAAGG ATAAGCTCAA ACAAGCAATA ATTCAGCAGT GGCTAGAAGG CACTCTCAGT 
GAAAGCACTC ATAAGTACTA TGAAACCGTG TCAGATGTAT TAAACTCTGT GAAGAAGATG 
GAAGAGAGCC TGAAAAGGCT GAAACAAGCC AGAAAAACCA CTCCCGCCAA CCCCGTCGGT 
CCCAGTGGTG GCATGAGCGA CGACGACAAA ATCAGGCTGC AGTTGGCCCT AGATGTTGAG 
TACTTGGGAG AGCAGATACA AAAGTTGGGA CTACAAGCAA GTGACATAAA AAGCTTCTCA 
GCTCTCGCAG AGCTTGTTGC TGCTGCCAAG GACCAGGCAA CAGCAGAGCA GCCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COG2 ( NM_007357.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_031383.1 Homo sapiens component of oligomeric golgi complex 2 (COG2), transcript variant 1, mRNA.

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CloneID	OHu10393
Clone ID Related Accession (Same CDS sequence)	NM_007357.3 , NM_007357.2
Accession Version	NM_007357.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2217bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	conserved oligomeric Golgi complex subunit 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC349417.1, AL158214.33, DB449302.1, AK312678.1, BC051906.1 and CD366946.1. On Feb 10, 2009 this sequence version replaced NM_007357.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.38136.1, SRR1803615.236625.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAAAA GTAGGATGAA CCTGCCCAAG GGGCCGGACA CGCTCTGCTT CGACAAGGAC 
GAGTTCATGA AGGAAGATTT CGATGTCGAT CATTTTGTGT CTGACTGTAG GAAGCGGGTC 
CAGCTGGAAG AACTGAGAGA TGACCTGGAG CTCTACTATA AACTTCTTAA AACAGCCATG 
GTCGAACTCA TCAACAAGGA TTATGCAGAT TTTGTCAATC TTTCAACAAA CTTGGTTGGC 
ATGGACAAAG CCCTCAACCA GCTTTCTGTG CCTTTGGGAC AATTACGAGA AGAGGTTCTG 
AGCCTTAGAT CGTCTGTCAG TGAAGGAATT CGGGCAGTTG ATGAACGAAT GTCTAAACAA 
GAGGACATTA GGAAAAAAAA GATGTGTGTA TTGAGGCTTA TACAAGTTAT TCGGTCAGTT 
GAGAAAATTG AAAAAATCTT AAACTCTCAA AGTTCTAAAG AAACCTCTGC ACTAGAAGCA 
AGCAGCCCCC TTTTGACTGG ACAAATTTTG GAGAGAATTG CCACAGAATT TAATCAGTTA 
CAGTTTCATG CTGTTCAAAG CAAAGGCATG CCTCTTTTGG ACAAAGTAAG ACCGCGTATA 
GCTGGCATTA CAGCCATGTT ACAGCAGTCA CTGGAAGGTC TCCTATTAGA AGGCCTTCAG 
ACGTCTGACG TCGATATAAT ACGGCACTGC TTGCGGACTT ACGCCACGAT TGACAAGACA 
CGGGACGCGG AGGCCTTAGT TGGCCAAGTA CTAGTGAAAC CATACATAGA CGAGGTGATT 
ATAGAGCAGT TTGTTGAATC TCATCCCAAT GGCCTTCAGG TCATGTATAA TAAACTCCTG 
GAGTTTGTTC CTCACCATTG CCGCCTTCTT CGAGAAGTCA CAGGAGGTGC CATCTCCAGT 
GAAAAAGGCA ATACTGTTCC TGGATATGAC TTTTTGGTGA ATTCTGTTTG GCCACAAATA 
GTACAAGGAT TAGAAGAAAA GTTACCCTCG CTTTTTAATC CTGGGAATCC CGATGCATTT 
CATGAGAAAT ATACCATAAG TATGGATTTT GTCAGAAGAT TGGAACGGCA GTGTGGATCA 
CAGGCTAGTG TAAAGAGATT AAGAGCCCAT CCTGCCTATC ACAGCTTCAA TAAGAAGTGG 
AACTTGCCTG TTTATTTTCA AATAAGATTT AGAGAAATAG CGGGATCCTT AGAAGCAGCA 
CTTACAGATG TCCTGGAAGA TGCCCCAGCT GAAAGTCCGT ATTGCCTTTT GGCTTCTCAT 
AGAACTTGGA GCAGCCTTAG GAGGTGTTGG TCAGATGAGA TGTTCTTGCC ATTACTGGTG 
CATCGCCTGT GGAGACTCAC TCTGCAGATT TTGGCACGAT ACTCTGTGTT TGTCAATGAG 
CTTTCACTCA GGCCCATTTC TAATGAAAGT CCCAAGGAGA TCAAGAAACC TTTGGTAACT 
GGTAGCAAAG AACCTTCCAT CACCCAAGGA AACACTGAAG ACCAAGGAAG TGGTCCTTCG 
GAAACAAAGC CTGTGGTTTC CATTTCCCGC ACTCAGCTCG TGTATGTGGT TGCAGACCTG 
GACAAGCTTC AGGAGCAGCT TCCAGAACTC TTGGAAATAA TCAAGCCAAA ACTTGAAATG 
ATTGGCTTTA AGAATTTTTC TTCTATCTCA GCAGCCCTGG AGGACTCCCA GAGCTCTTTT 
TCAGCCTGTG TGCCCTCCTT GAGTAGCAAG ATCATCCAGG ATTTAAGTGA CTCTTGCTTC 
GGTTTCCTAA AAAGCGCCCT GGAGGTTCCC AGGCTTTACC GAAGAACCAA TAAGGAGGTC 
CCAACCACAG CTTCCTCCTA TGTGGACAGT GCTCTGAAGC CCTTATTCCA GCTTCAGAGC 
GGACACAAGG ATAAGCTCAA ACAAGCAATA ATTCAGCAGT GGCTAGAAGG CACTCTCAGT 
GAAAGCACTC ATAAGTACTA TGAAACCGTG TCAGATGTAT TAAACTCTGT GAAGAAGATG 
GAAGAGAGCC TGAAAAGGCT GAAACAAGCC AGAAAAACCA CTCCCGCCAA CCCCGTCGGT 
CCCAGTGGTG GCATGAGCGA CGACGACAAA ATCAGGCTGC AGTTGGCCCT AGATGTTGAG 
TACTTGGGAG AGCAGATACA AAAGTTGGGA CTACAAGCAA GTGACATAAA AAGCTTCTCA 
GCTCTCGCAG AGCTTGTTGC TGCTGCCAAG GACCAGGCAA CAGCAGAGCA GCCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031383.1
CDS	152..2368
Translation	MEKSRMNLPKGPDTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEELRDDLELYYKLLKTAMVELINKDYADFVNLSTNLVGMDKALNQLSVPLGQLREEVLSLRSSVSEGIRAVDERMSKQEDIRKKKMCVLRLIQVIRSVEKIEKILNSQSSKETSALEASSPLLTGQILERIATEFNQLQFHAVQSKGMPLLDKVRPRIAGITAMLQQSLEGLLLEGLQTSDVDIIRHCLRTYATIDKTRDAEALVGQVLVKPYIDEVIIEQFVESHPNGLQVMYNKLLEFVPHHCRLLREVTGGAISSEKGNTVPGYDFLVNSVWPQIVQGLEEKLPSLFNPGNPDAFHEKYTISMDFVRRLERQCGSQASVKRLRAHPAYHSFNKKWNLPVYFQIRFREIAGSLEAALTDVLEDAPAESPYCLLASHRTWSSLRRCWSDEMFLPLLVHRLWRLTLQILARYSVFVNELSLRPISNESPKEIKKPLVTGSKEPSITQGNTEDQGSGPSETKPVVSISRTQLVYVVADLDKLQEQLPELLEIIKPKLEMIGFKNFSSISAALEDSQSSFSACVPSLSSKIIQDLSDSCFGFLKSALEVPRLYRRTNKEVPTTASSYVDSALKPLFQLQSGHKDKLKQAIIQQWLEGTLSESTHKYYETVSDVLNSVKKMEESLKRLKQARKTTPANPVGPSGGMSDDDKIRLQLALDVEYLGEQIQKLGLQASDIKSFSALAELVAAAKDQATAEQP

Target ORF information:

RefSeq Version	NM_007357.2
Organism	Homo sapiens(human)
Definition	Homo sapiens component of oligomeric golgi complex 2 (COG2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007357.2

ORF Insert Sequence:

ATGGAGAAAA GTAGGATGAA CCTGCCCAAG GGGCCGGACA CGCTCTGCTT CGACAAGGAC 
GAGTTCATGA AGGAAGATTT CGATGTCGAT CATTTTGTGT CTGACTGTAG GAAGCGGGTC 
CAGCTGGAAG AACTGAGAGA TGACCTGGAG CTCTACTATA AACTTCTTAA AACAGCCATG 
GTCGAACTCA TCAACAAGGA TTATGCAGAT TTTGTCAATC TTTCAACAAA CTTGGTTGGC 
ATGGACAAAG CCCTCAACCA GCTTTCTGTG CCTTTGGGAC AATTACGAGA AGAGGTTCTG 
AGCCTTAGAT CGTCTGTCAG TGAAGGAATT CGGGCAGTTG ATGAACGAAT GTCTAAACAA 
GAGGACATTA GGAAAAAAAA GATGTGTGTA TTGAGGCTTA TACAAGTTAT TCGGTCAGTT 
GAGAAAATTG AAAAAATCTT AAACTCTCAA AGTTCTAAAG AAACCTCTGC ACTAGAAGCA 
AGCAGCCCCC TTTTGACTGG ACAAATTTTG GAGAGAATTG CCACAGAATT TAATCAGTTA 
CAGTTTCATG CTGTTCAAAG CAAAGGCATG CCTCTTTTGG ACAAAGTAAG ACCGCGTATA 
GCTGGCATTA CAGCCATGTT ACAGCAGTCA CTGGAAGGTC TCCTATTAGA AGGCCTTCAG 
ACGTCTGACG TCGATATAAT ACGGCACTGC TTGCGGACTT ACGCCACGAT TGACAAGACA 
CGGGACGCGG AGGCCTTAGT TGGCCAAGTA CTAGTGAAAC CATACATAGA CGAGGTGATT 
ATAGAGCAGT TTGTTGAATC TCATCCCAAT GGCCTTCAGG TCATGTATAA TAAACTCCTG 
GAGTTTGTTC CTCACCATTG CCGCCTTCTT CGAGAAGTCA CAGGAGGTGC CATCTCCAGT 
GAAAAAGGCA ATACTGTTCC TGGATATGAC TTTTTGGTGA ATTCTGTTTG GCCACAAATA 
GTACAAGGAT TAGAAGAAAA GTTACCCTCG CTTTTTAATC CTGGGAATCC CGATGCATTT 
CATGAGAAAT ATACCATAAG TATGGATTTT GTCAGAAGAT TGGAACGGCA GTGTGGATCA 
CAGGCTAGTG TAAAGAGATT AAGAGCCCAT CCTGCCTATC ACAGCTTCAA TAAGAAGTGG 
AACTTGCCTG TTTATTTTCA AATAAGATTT AGAGAAATAG CGGGATCCTT AGAAGCAGCA 
CTTACAGATG TCCTGGAAGA TGCCCCAGCT GAAAGTCCGT ATTGCCTTTT GGCTTCTCAT 
AGAACTTGGA GCAGCCTTAG GAGGTGTTGG TCAGATGAGA TGTTCTTGCC ATTACTGGTG 
CATCGCCTGT GGAGACTCAC TCTGCAGATT TTGGCACGAT ACTCTGTGTT TGTCAATGAG 
CTTTCACTCA GGCCCATTTC TAATGAAAGT CCCAAGGAGA TCAAGAAACC TTTGGTAACT 
GGTAGCAAAG AACCTTCCAT CACCCAAGGA AACACTGAAG ACCAAGGAAG TGGTCCTTCG 
GAAACAAAGC CTGTGGTTTC CATTTCCCGC ACTCAGCTCG TGTATGTGGT TGCAGACCTG 
GACAAGCTTC AGGAGCAGCT TCCAGAACTC TTGGAAATAA TCAAGCCAAA ACTTGAAATG 
ATTGGCTTTA AGAATTTTTC TTCTATCTCA GCAGCCCTGG AGGACTCCCA GAGCTCTTTT 
TCAGCCTGTG TGCCCTCCTT GAGTAGCAAG ATCATCCAGG ATTTAAGTGA CTCTTGCTTC 
GGTTTCCTAA AAAGCGCCCT GGAGGTTCCC AGGCTTTACC GAAGAACCAA TAAGGAGGTC 
CCAACCACAG CTTCCTCCTA TGTGGACAGT GCTCTGAAGC CCTTATTCCA GCTTCAGAGC 
GGACACAAGG ATAAGCTCAA ACAAGCAATA ATTCAGCAGT GGCTAGAAGG CACTCTCAGT 
GAAAGCACTC ATAAGTACTA TGAAACCGTG TCAGATGTAT TAAACTCTGT GAAGAAGATG 
GAAGAGAGCC TGAAAAGGCT GAAACAAGCC AGAAAAACCA CTCCCGCCAA CCCCGTCGGT 
CCCAGTGGTG GCATGAGCGA CGACGACAAA ATCAGGCTGC AGTTGGCCCT AGATGTTGAG 
TACTTGGGAG AGCAGATACA AAAGTTGGGA CTACAAGCAA GTGACATAAA AAGCTTCTCA 
GCTCTCGCAG AGCTTGTTGC TGCTGCCAAG GACCAGGCAA CAGCAGAGCA GCCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COG2 ( NM_001145036.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138508.1 Homo sapiens component of oligomeric golgi complex 2 (COG2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu10528
Clone ID Related Accession (Same CDS sequence)	NM_001145036.2 , NM_001145036.1
Accession Version	NM_001145036.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2214bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Homo sapiens(human)
Product	conserved oligomeric Golgi complex subunit 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC349417.1, AL158214.33, DB449302.1 and BC051906.1. On Jun 1, 2019 this sequence version replaced NM_001145036.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter isoform (2) compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC051906.1, SRR1803611.228075.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAAAA GTAGGATGAA CCTGCCCAAG GGGCCGGACA CGCTCTGCTT CGACAAGGAC 
GAGTTCATGA AGGAAGATTT CGATGTCGAT CATTTTGTGT CTGACTGTAG GAAGCGGGTC 
CAGCTGGAAG AACTGAGAGA TGACCTGGAG CTCTACTATA AACTTCTTAA AACAGCCATG 
GTCGAACTCA TCAACAAGGA TTATGCAGAT TTTGTCAATC TTTCAACAAA CTTGGTTGGC 
ATGGACAAAG CCCTCAACCA GCTTTCTGTG CCTTTGGGAC AATTACGAGA AGAGGTTCTG 
AGCCTTAGAT CGTCTGTCAG TGAAGGAATT CGGGCAGTTG ATGAACGAAT GTCTAAACAA 
GAGGACATTA GGAAAAAAAA GATGTGTGTA TTGAGGCTTA TACAAGTTAT TCGGTCAGTT 
GAGAAAATTG AAAAAATCTT AAACTCTCAA AGTTCTAAAG AAACCTCTGC ACTAGAAGCA 
AGCAGCCCCC TTTTGACTGG ACAAATTTTG GAGAGAATTG CCACAGAATT TAATCAGTTA 
CAGTTTCATG CTGTTCAAAG CAAAGGCATG CCTCTTTTGG ACAAAGTAAG ACCGCGTATA 
GCTGGCATTA CAGCCATGTT ACAGCAGTCA CTGGAAGGTC TCCTATTAGA AGGCCTTCAG 
ACGTCTGACG TCGATATAAT ACGGCACTGC TTGCGGACTT ACGCCACGAT TGACAAGACA 
CGGGACGCGG AGGCCTTAGT TGGCCAAGTA CTAGTGAAAC CATACATAGA CGAGGTGATT 
ATAGAGCAGT TTGTTGAATC TCATCCCAAT GGCCTTCAGG TCATGTATAA TAAACTCCTG 
GAGTTTGTTC CTCACCATTG CCGCCTTCTT CGAGAAGTCA CAGGAGGTGC CATCTCCAGT 
GAAAAAGGCA ATACTGTTCC TGGATATGAC TTTTTGGTGA ATTCTGTTTG GCCACAAATA 
GTACAAGGAT TAGAAGAAAA GTTACCCTCG CTTTTTAATC CTGGGAATCC CGATGCATTT 
CATGAGAAAT ATACCATAAG TATGGATTTT GTCAGAAGAT TGGAACGGCA GTGTGGATCA 
CAGGCTAGTG TAAAGAGATT AAGAGCCCAT CCTGCCTATC ACAGCTTCAA TAAGAAGTGG 
AACTTGCCTG TTTATTTTCA AATAAGATTT AGAGAAATAG CGGGATCCTT AGAAGCAGCA 
CTTACAGATG TCCTGGAAGA TGCCCCAGCT GAAAGTCCGT ATTGCCTTTT GGCTTCTCAT 
AGAACTTGGA GCAGCCTTAG GAGGTGTTGG TCAGATGAGA TGTTCTTGCC ATTACTGGTG 
CATCGCCTGT GGAGACTCAC TCTGCAGATT TTGGCACGAT ACTCTGTGTT TGTCAATGAG 
CTTTCACTCA GGCCCATTTC TAATGAAAGT CCCAAGGAGA TCAAGAAACC TTTGGTAACT 
GGTAGCAAAG AACCTTCCAT CACCCAAGGA AACACTGAAG ACCAAGGAAG TGGTCCTTCG 
GAAACAAAGC CTGTGGTTTC CATTTCCCGC ACTCAGCTCG TGTATGTGGT TGCAGACCTG 
GACAAGCTTC AGGAGCAGCT TCCAGAACTC TTGGAAATAA TCAAGCCAAA ACTTGAAATG 
ATTGGCTTTA AGAATTTTTC TTCTATCTCA GCCCTGGAGG ACTCCCAGAG CTCTTTTTCA 
GCCTGTGTGC CCTCCTTGAG TAGCAAGATC ATCCAGGATT TAAGTGACTC TTGCTTCGGT 
TTCCTAAAAA GCGCCCTGGA GGTTCCCAGG CTTTACCGAA GAACCAATAA GGAGGTCCCA 
ACCACAGCTT CCTCCTATGT GGACAGTGCT CTGAAGCCCT TATTCCAGCT TCAGAGCGGA 
CACAAGGATA AGCTCAAACA AGCAATAATT CAGCAGTGGC TAGAAGGCAC TCTCAGTGAA 
AGCACTCATA AGTACTATGA AACCGTGTCA GATGTATTAA ACTCTGTGAA GAAGATGGAA 
GAGAGCCTGA AAAGGCTGAA ACAAGCCAGA AAAACCACTC CCGCCAACCC CGTCGGTCCC 
AGTGGTGGCA TGAGCGACGA CGACAAAATC AGGCTGCAGT TGGCCCTAGA TGTTGAGTAC 
TTGGGAGAGC AGATACAAAA GTTGGGACTA CAAGCAAGTG ACATAAAAAG CTTCTCAGCT 
CTCGCAGAGC TTGTTGCTGC TGCCAAGGAC CAGGCAACAG CAGAGCAGCC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138508.1
CDS	127..2340
Translation	MEKSRMNLPKGPDTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEELRDDLELYYKLLKTAMVELINKDYADFVNLSTNLVGMDKALNQLSVPLGQLREEVLSLRSSVSEGIRAVDERMSKQEDIRKKKMCVLRLIQVIRSVEKIEKILNSQSSKETSALEASSPLLTGQILERIATEFNQLQFHAVQSKGMPLLDKVRPRIAGITAMLQQSLEGLLLEGLQTSDVDIIRHCLRTYATIDKTRDAEALVGQVLVKPYIDEVIIEQFVESHPNGLQVMYNKLLEFVPHHCRLLREVTGGAISSEKGNTVPGYDFLVNSVWPQIVQGLEEKLPSLFNPGNPDAFHEKYTISMDFVRRLERQCGSQASVKRLRAHPAYHSFNKKWNLPVYFQIRFREIAGSLEAALTDVLEDAPAESPYCLLASHRTWSSLRRCWSDEMFLPLLVHRLWRLTLQILARYSVFVNELSLRPISNESPKEIKKPLVTGSKEPSITQGNTEDQGSGPSETKPVVSISRTQLVYVVADLDKLQEQLPELLEIIKPKLEMIGFKNFSSISALEDSQSSFSACVPSLSSKIIQDLSDSCFGFLKSALEVPRLYRRTNKEVPTTASSYVDSALKPLFQLQSGHKDKLKQAIIQQWLEGTLSESTHKYYETVSDVLNSVKKMEESLKRLKQARKTTPANPVGPSGGMSDDDKIRLQLALDVEYLGEQIQKLGLQASDIKSFSALAELVAAAKDQATAEQP

Target ORF information:

RefSeq Version	NM_001145036.2
Organism	Homo sapiens(human)
Definition	Homo sapiens component of oligomeric golgi complex 2 (COG2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145036.2

ORF Insert Sequence:

ATGGAGAAAA GTAGGATGAA CCTGCCCAAG GGGCCGGACA CGCTCTGCTT CGACAAGGAC 
GAGTTCATGA AGGAAGATTT CGATGTCGAT CATTTTGTGT CTGACTGTAG GAAGCGGGTC 
CAGCTGGAAG AACTGAGAGA TGACCTGGAG CTCTACTATA AACTTCTTAA AACAGCCATG 
GTCGAACTCA TCAACAAGGA TTATGCAGAT TTTGTCAATC TTTCAACAAA CTTGGTTGGC 
ATGGACAAAG CCCTCAACCA GCTTTCTGTG CCTTTGGGAC AATTACGAGA AGAGGTTCTG 
AGCCTTAGAT CGTCTGTCAG TGAAGGAATT CGGGCAGTTG ATGAACGAAT GTCTAAACAA 
GAGGACATTA GGAAAAAAAA GATGTGTGTA TTGAGGCTTA TACAAGTTAT TCGGTCAGTT 
GAGAAAATTG AAAAAATCTT AAACTCTCAA AGTTCTAAAG AAACCTCTGC ACTAGAAGCA 
AGCAGCCCCC TTTTGACTGG ACAAATTTTG GAGAGAATTG CCACAGAATT TAATCAGTTA 
CAGTTTCATG CTGTTCAAAG CAAAGGCATG CCTCTTTTGG ACAAAGTAAG ACCGCGTATA 
GCTGGCATTA CAGCCATGTT ACAGCAGTCA CTGGAAGGTC TCCTATTAGA AGGCCTTCAG 
ACGTCTGACG TCGATATAAT ACGGCACTGC TTGCGGACTT ACGCCACGAT TGACAAGACA 
CGGGACGCGG AGGCCTTAGT TGGCCAAGTA CTAGTGAAAC CATACATAGA CGAGGTGATT 
ATAGAGCAGT TTGTTGAATC TCATCCCAAT GGCCTTCAGG TCATGTATAA TAAACTCCTG 
GAGTTTGTTC CTCACCATTG CCGCCTTCTT CGAGAAGTCA CAGGAGGTGC CATCTCCAGT 
GAAAAAGGCA ATACTGTTCC TGGATATGAC TTTTTGGTGA ATTCTGTTTG GCCACAAATA 
GTACAAGGAT TAGAAGAAAA GTTACCCTCG CTTTTTAATC CTGGGAATCC CGATGCATTT 
CATGAGAAAT ATACCATAAG TATGGATTTT GTCAGAAGAT TGGAACGGCA GTGTGGATCA 
CAGGCTAGTG TAAAGAGATT AAGAGCCCAT CCTGCCTATC ACAGCTTCAA TAAGAAGTGG 
AACTTGCCTG TTTATTTTCA AATAAGATTT AGAGAAATAG CGGGATCCTT AGAAGCAGCA 
CTTACAGATG TCCTGGAAGA TGCCCCAGCT GAAAGTCCGT ATTGCCTTTT GGCTTCTCAT 
AGAACTTGGA GCAGCCTTAG GAGGTGTTGG TCAGATGAGA TGTTCTTGCC ATTACTGGTG 
CATCGCCTGT GGAGACTCAC TCTGCAGATT TTGGCACGAT ACTCTGTGTT TGTCAATGAG 
CTTTCACTCA GGCCCATTTC TAATGAAAGT CCCAAGGAGA TCAAGAAACC TTTGGTAACT 
GGTAGCAAAG AACCTTCCAT CACCCAAGGA AACACTGAAG ACCAAGGAAG TGGTCCTTCG 
GAAACAAAGC CTGTGGTTTC CATTTCCCGC ACTCAGCTCG TGTATGTGGT TGCAGACCTG 
GACAAGCTTC AGGAGCAGCT TCCAGAACTC TTGGAAATAA TCAAGCCAAA ACTTGAAATG 
ATTGGCTTTA AGAATTTTTC TTCTATCTCA GCCCTGGAGG ACTCCCAGAG CTCTTTTTCA 
GCCTGTGTGC CCTCCTTGAG TAGCAAGATC ATCCAGGATT TAAGTGACTC TTGCTTCGGT 
TTCCTAAAAA GCGCCCTGGA GGTTCCCAGG CTTTACCGAA GAACCAATAA GGAGGTCCCA 
ACCACAGCTT CCTCCTATGT GGACAGTGCT CTGAAGCCCT TATTCCAGCT TCAGAGCGGA 
CACAAGGATA AGCTCAAACA AGCAATAATT CAGCAGTGGC TAGAAGGCAC TCTCAGTGAA 
AGCACTCATA AGTACTATGA AACCGTGTCA GATGTATTAA ACTCTGTGAA GAAGATGGAA 
GAGAGCCTGA AAAGGCTGAA ACAAGCCAGA AAAACCACTC CCGCCAACCC CGTCGGTCCC 
AGTGGTGGCA TGAGCGACGA CGACAAAATC AGGCTGCAGT TGGCCCTAGA TGTTGAGTAC 
TTGGGAGAGC AGATACAAAA GTTGGGACTA CAAGCAAGTG ACATAAAAAG CTTCTCAGCT 
CTCGCAGAGC TTGTTGCTGC TGCCAAGGAC CAGGCAACAG CAGAGCAGCC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COG2 ( NM_001145036.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138508.1 Homo sapiens component of oligomeric golgi complex 2 (COG2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu10528
Clone ID Related Accession (Same CDS sequence)	NM_001145036.2 , NM_001145036.1
Accession Version	NM_001145036.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2214bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	conserved oligomeric Golgi complex subunit 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC349417.1, AL158214.33, DB449302.1, BC051906.1 and CD366946.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter isoform (2) compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.154576.1, SRR1803611.264567.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAAAA GTAGGATGAA CCTGCCCAAG GGGCCGGACA CGCTCTGCTT CGACAAGGAC 
GAGTTCATGA AGGAAGATTT CGATGTCGAT CATTTTGTGT CTGACTGTAG GAAGCGGGTC 
CAGCTGGAAG AACTGAGAGA TGACCTGGAG CTCTACTATA AACTTCTTAA AACAGCCATG 
GTCGAACTCA TCAACAAGGA TTATGCAGAT TTTGTCAATC TTTCAACAAA CTTGGTTGGC 
ATGGACAAAG CCCTCAACCA GCTTTCTGTG CCTTTGGGAC AATTACGAGA AGAGGTTCTG 
AGCCTTAGAT CGTCTGTCAG TGAAGGAATT CGGGCAGTTG ATGAACGAAT GTCTAAACAA 
GAGGACATTA GGAAAAAAAA GATGTGTGTA TTGAGGCTTA TACAAGTTAT TCGGTCAGTT 
GAGAAAATTG AAAAAATCTT AAACTCTCAA AGTTCTAAAG AAACCTCTGC ACTAGAAGCA 
AGCAGCCCCC TTTTGACTGG ACAAATTTTG GAGAGAATTG CCACAGAATT TAATCAGTTA 
CAGTTTCATG CTGTTCAAAG CAAAGGCATG CCTCTTTTGG ACAAAGTAAG ACCGCGTATA 
GCTGGCATTA CAGCCATGTT ACAGCAGTCA CTGGAAGGTC TCCTATTAGA AGGCCTTCAG 
ACGTCTGACG TCGATATAAT ACGGCACTGC TTGCGGACTT ACGCCACGAT TGACAAGACA 
CGGGACGCGG AGGCCTTAGT TGGCCAAGTA CTAGTGAAAC CATACATAGA CGAGGTGATT 
ATAGAGCAGT TTGTTGAATC TCATCCCAAT GGCCTTCAGG TCATGTATAA TAAACTCCTG 
GAGTTTGTTC CTCACCATTG CCGCCTTCTT CGAGAAGTCA CAGGAGGTGC CATCTCCAGT 
GAAAAAGGCA ATACTGTTCC TGGATATGAC TTTTTGGTGA ATTCTGTTTG GCCACAAATA 
GTACAAGGAT TAGAAGAAAA GTTACCCTCG CTTTTTAATC CTGGGAATCC CGATGCATTT 
CATGAGAAAT ATACCATAAG TATGGATTTT GTCAGAAGAT TGGAACGGCA GTGTGGATCA 
CAGGCTAGTG TAAAGAGATT AAGAGCCCAT CCTGCCTATC ACAGCTTCAA TAAGAAGTGG 
AACTTGCCTG TTTATTTTCA AATAAGATTT AGAGAAATAG CGGGATCCTT AGAAGCAGCA 
CTTACAGATG TCCTGGAAGA TGCCCCAGCT GAAAGTCCGT ATTGCCTTTT GGCTTCTCAT 
AGAACTTGGA GCAGCCTTAG GAGGTGTTGG TCAGATGAGA TGTTCTTGCC ATTACTGGTG 
CATCGCCTGT GGAGACTCAC TCTGCAGATT TTGGCACGAT ACTCTGTGTT TGTCAATGAG 
CTTTCACTCA GGCCCATTTC TAATGAAAGT CCCAAGGAGA TCAAGAAACC TTTGGTAACT 
GGTAGCAAAG AACCTTCCAT CACCCAAGGA AACACTGAAG ACCAAGGAAG TGGTCCTTCG 
GAAACAAAGC CTGTGGTTTC CATTTCCCGC ACTCAGCTCG TGTATGTGGT TGCAGACCTG 
GACAAGCTTC AGGAGCAGCT TCCAGAACTC TTGGAAATAA TCAAGCCAAA ACTTGAAATG 
ATTGGCTTTA AGAATTTTTC TTCTATCTCA GCCCTGGAGG ACTCCCAGAG CTCTTTTTCA 
GCCTGTGTGC CCTCCTTGAG TAGCAAGATC ATCCAGGATT TAAGTGACTC TTGCTTCGGT 
TTCCTAAAAA GCGCCCTGGA GGTTCCCAGG CTTTACCGAA GAACCAATAA GGAGGTCCCA 
ACCACAGCTT CCTCCTATGT GGACAGTGCT CTGAAGCCCT TATTCCAGCT TCAGAGCGGA 
CACAAGGATA AGCTCAAACA AGCAATAATT CAGCAGTGGC TAGAAGGCAC TCTCAGTGAA 
AGCACTCATA AGTACTATGA AACCGTGTCA GATGTATTAA ACTCTGTGAA GAAGATGGAA 
GAGAGCCTGA AAAGGCTGAA ACAAGCCAGA AAAACCACTC CCGCCAACCC CGTCGGTCCC 
AGTGGTGGCA TGAGCGACGA CGACAAAATC AGGCTGCAGT TGGCCCTAGA TGTTGAGTAC 
TTGGGAGAGC AGATACAAAA GTTGGGACTA CAAGCAAGTG ACATAAAAAG CTTCTCAGCT 
CTCGCAGAGC TTGTTGCTGC TGCCAAGGAC CAGGCAACAG CAGAGCAGCC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138508.1
CDS	152..2365
Translation	MEKSRMNLPKGPDTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEELRDDLELYYKLLKTAMVELINKDYADFVNLSTNLVGMDKALNQLSVPLGQLREEVLSLRSSVSEGIRAVDERMSKQEDIRKKKMCVLRLIQVIRSVEKIEKILNSQSSKETSALEASSPLLTGQILERIATEFNQLQFHAVQSKGMPLLDKVRPRIAGITAMLQQSLEGLLLEGLQTSDVDIIRHCLRTYATIDKTRDAEALVGQVLVKPYIDEVIIEQFVESHPNGLQVMYNKLLEFVPHHCRLLREVTGGAISSEKGNTVPGYDFLVNSVWPQIVQGLEEKLPSLFNPGNPDAFHEKYTISMDFVRRLERQCGSQASVKRLRAHPAYHSFNKKWNLPVYFQIRFREIAGSLEAALTDVLEDAPAESPYCLLASHRTWSSLRRCWSDEMFLPLLVHRLWRLTLQILARYSVFVNELSLRPISNESPKEIKKPLVTGSKEPSITQGNTEDQGSGPSETKPVVSISRTQLVYVVADLDKLQEQLPELLEIIKPKLEMIGFKNFSSISALEDSQSSFSACVPSLSSKIIQDLSDSCFGFLKSALEVPRLYRRTNKEVPTTASSYVDSALKPLFQLQSGHKDKLKQAIIQQWLEGTLSESTHKYYETVSDVLNSVKKMEESLKRLKQARKTTPANPVGPSGGMSDDDKIRLQLALDVEYLGEQIQKLGLQASDIKSFSALAELVAAAKDQATAEQP

Target ORF information:

RefSeq Version	NM_001145036.1
Organism	Homo sapiens(human)
Definition	Homo sapiens component of oligomeric golgi complex 2 (COG2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145036.1

ORF Insert Sequence:

ATGGAGAAAA GTAGGATGAA CCTGCCCAAG GGGCCGGACA CGCTCTGCTT CGACAAGGAC 
GAGTTCATGA AGGAAGATTT CGATGTCGAT CATTTTGTGT CTGACTGTAG GAAGCGGGTC 
CAGCTGGAAG AACTGAGAGA TGACCTGGAG CTCTACTATA AACTTCTTAA AACAGCCATG 
GTCGAACTCA TCAACAAGGA TTATGCAGAT TTTGTCAATC TTTCAACAAA CTTGGTTGGC 
ATGGACAAAG CCCTCAACCA GCTTTCTGTG CCTTTGGGAC AATTACGAGA AGAGGTTCTG 
AGCCTTAGAT CGTCTGTCAG TGAAGGAATT CGGGCAGTTG ATGAACGAAT GTCTAAACAA 
GAGGACATTA GGAAAAAAAA GATGTGTGTA TTGAGGCTTA TACAAGTTAT TCGGTCAGTT 
GAGAAAATTG AAAAAATCTT AAACTCTCAA AGTTCTAAAG AAACCTCTGC ACTAGAAGCA 
AGCAGCCCCC TTTTGACTGG ACAAATTTTG GAGAGAATTG CCACAGAATT TAATCAGTTA 
CAGTTTCATG CTGTTCAAAG CAAAGGCATG CCTCTTTTGG ACAAAGTAAG ACCGCGTATA 
GCTGGCATTA CAGCCATGTT ACAGCAGTCA CTGGAAGGTC TCCTATTAGA AGGCCTTCAG 
ACGTCTGACG TCGATATAAT ACGGCACTGC TTGCGGACTT ACGCCACGAT TGACAAGACA 
CGGGACGCGG AGGCCTTAGT TGGCCAAGTA CTAGTGAAAC CATACATAGA CGAGGTGATT 
ATAGAGCAGT TTGTTGAATC TCATCCCAAT GGCCTTCAGG TCATGTATAA TAAACTCCTG 
GAGTTTGTTC CTCACCATTG CCGCCTTCTT CGAGAAGTCA CAGGAGGTGC CATCTCCAGT 
GAAAAAGGCA ATACTGTTCC TGGATATGAC TTTTTGGTGA ATTCTGTTTG GCCACAAATA 
GTACAAGGAT TAGAAGAAAA GTTACCCTCG CTTTTTAATC CTGGGAATCC CGATGCATTT 
CATGAGAAAT ATACCATAAG TATGGATTTT GTCAGAAGAT TGGAACGGCA GTGTGGATCA 
CAGGCTAGTG TAAAGAGATT AAGAGCCCAT CCTGCCTATC ACAGCTTCAA TAAGAAGTGG 
AACTTGCCTG TTTATTTTCA AATAAGATTT AGAGAAATAG CGGGATCCTT AGAAGCAGCA 
CTTACAGATG TCCTGGAAGA TGCCCCAGCT GAAAGTCCGT ATTGCCTTTT GGCTTCTCAT 
AGAACTTGGA GCAGCCTTAG GAGGTGTTGG TCAGATGAGA TGTTCTTGCC ATTACTGGTG 
CATCGCCTGT GGAGACTCAC TCTGCAGATT TTGGCACGAT ACTCTGTGTT TGTCAATGAG 
CTTTCACTCA GGCCCATTTC TAATGAAAGT CCCAAGGAGA TCAAGAAACC TTTGGTAACT 
GGTAGCAAAG AACCTTCCAT CACCCAAGGA AACACTGAAG ACCAAGGAAG TGGTCCTTCG 
GAAACAAAGC CTGTGGTTTC CATTTCCCGC ACTCAGCTCG TGTATGTGGT TGCAGACCTG 
GACAAGCTTC AGGAGCAGCT TCCAGAACTC TTGGAAATAA TCAAGCCAAA ACTTGAAATG 
ATTGGCTTTA AGAATTTTTC TTCTATCTCA GCCCTGGAGG ACTCCCAGAG CTCTTTTTCA 
GCCTGTGTGC CCTCCTTGAG TAGCAAGATC ATCCAGGATT TAAGTGACTC TTGCTTCGGT 
TTCCTAAAAA GCGCCCTGGA GGTTCCCAGG CTTTACCGAA GAACCAATAA GGAGGTCCCA 
ACCACAGCTT CCTCCTATGT GGACAGTGCT CTGAAGCCCT TATTCCAGCT TCAGAGCGGA 
CACAAGGATA AGCTCAAACA AGCAATAATT CAGCAGTGGC TAGAAGGCAC TCTCAGTGAA 
AGCACTCATA AGTACTATGA AACCGTGTCA GATGTATTAA ACTCTGTGAA GAAGATGGAA 
GAGAGCCTGA AAAGGCTGAA ACAAGCCAGA AAAACCACTC CCGCCAACCC CGTCGGTCCC 
AGTGGTGGCA TGAGCGACGA CGACAAAATC AGGCTGCAGT TGGCCCTAGA TGTTGAGTAC 
TTGGGAGAGC AGATACAAAA GTTGGGACTA CAAGCAAGTG ACATAAAAAG CTTCTCAGCT 
CTCGCAGAGC TTGTTGCTGC TGCCAAGGAC CAGGCAACAG CAGAGCAGCC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in COG2 encoding a subunit of the conserved oligomeric golgi complex cause a congenital disorder of glycosylation.
Clinical genetics87(5)455-60(2015 May)
Kodera H,Ando N,Yuasa I,Wada Y,Tsurusaki Y,Nakashima M,Miyake N,Saitoh S,Matsumoto N,Saitsu H

An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics150B(5)721-35(2009 Jul)
Edwards TL,Pericak-Vance M,Gilbert JR,Haines JL,Martin ER,Ritchie MD

Gene variants associated with ischemic stroke: the cardiovascular health study.
Stroke40(2)363-8(2009 Feb)
Luke MM,O'Meara ES,Rowland CM,Shiffman D,Bare LA,Arellano AR,Longstreth WT Jr,Lumley T,Rice K,Tracy RP,Devlin JJ,Psaty BM

Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.
Arteriosclerosis, thrombosis, and vascular biology28(1)173-9(2008 Jan)
Shiffman D,O'Meara ES,Bare LA,Rowland CM,Louie JZ,Arellano AR,Lumley T,Rice K,Iakoubova O,Luke MM,Young BA,Malloy MJ,Kane JP,Ellis SG,Tracy RP,Devlin JJ,Psaty BM

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COG2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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