Gene Symbol | Ric8b |
Entrez Gene ID | 237422 |
Full Name | RIC8 guanine nucleotide exchange factor B |
Synonyms | BC051080,Ric-8,Ric-8b |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Ric8b cDNA ORF clone
gRNAs
Gene Symbol | Ric8b |
Entrez Gene ID | 237422 |
Full Name | RIC8 guanine nucleotide exchange factor B |
Synonyms | BC051080,Ric-8,Ric-8b |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006513625.2 | XP_006513688.1 | synembryn-B isoform X1 |
XM_006513625.3 | XP_006513688.1 | synembryn-B isoform X1 |
NM_001013441.2 | NP_001013459.1 | synembryn-B isoform 1 |
NM_183172.2 | NP_898995.1 | synembryn-B isoform 2 |
Pan troglodytes (chimpanzee) | RIC8B | XP_003952332.1 |
Mus musculus (house mouse) | Ric8b | NP_898995.1 |
Homo sapiens (human) | RIC8B | NP_060627.2 |
Bos taurus (cattle) | RIC8B | XP_002687709.2 |
Rattus norvegicus (Norway rat) | Ric8b | NP_783188.1 |
Gallus gallus (chicken) | RIC8B | XP_416305.3 |
Danio rerio (zebrafish) | ric8b | NP_001005293.1 |
Canis lupus familiaris (dog) | RIC8B | XP_005626003.1 |
Xenopus tropicalis (tropical clawed frog) | ric8b | XP_002942248.2 |
Conditional Deletion of
Machado CF, Nagai MH, Lyra CS, Reis-Silva TM, Xavier AM, Glezer I, Felicio LF, Malnic B
The Journal of neuroscience : the official journal of the Society for Neuroscience37(50)12202-12213(2017 12)
High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)
Expression Pattern and Localization Dynamics of Guanine Nucleotide Exchange Factor RIC8 during Mouse Oogenesis.
Saare M, Lulla S, T?nissoo T, Meier R, Kask K, Ruisu K, Karis A, Salumets A, Pooga M
PloS one10(6)e0129131(2015)
A functional N-terminal domain in C/EBP?-LAP* is required for interacting with SWI/SNF and to repress Ric-8B gene transcription in osteoblasts.
Aguilar R, Grandy R, Meza D, Sepulveda H, Pihan P, van Wijnen AJ, Lian JB, Stein GS, Stein JL, Montecino M
Journal of cellular physiology229(10)1521-8(2014 Oct)
Increased ubiquitination and the crosstalk of G protein signaling in cardiac myocytes: involvement of Ric-8B in Gs suppression by Gq signal.
Jenie RI, Nishimura M, Fujino M, Nakaya M, Mizuno N, Tago K, Kurose H, Itoh H
Genes to cells : devoted to molecular & cellular mechanisms18(12)1095-106(2013 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data show that the localization of maternally expressed RIC8 protein is highly dynamic and is dependent on the stage of folliculogenesis, oogenesis and cleavage, and imply that it may have a regulatory function in mammalian gametogenesis.
Title: Expression Pattern and Localization Dynamics of Guanine Nucleotide Exchange Factor RIC8 during Mouse Oogenesis.
Results indicate that a functional N-terminus in C/EBPbeta-LAP* is required for interacting with SWI/SNF and for Ric-8B gene repression in osteoblasts.
Title: A functional N-terminal domain in C/EBP?-LAP* is required for interacting with SWI/SNF and to repress Ric-8B gene transcription in osteoblasts.
a new role of Ric-8B in the crosstalk of two distinct G protein signaling pathways, which are possibly involved in a part of mechanisms of chronic heart failure.
Title: Increased ubiquitination and the crosstalk of G protein signaling in cardiac myocytes: involvement of Ric-8B in Gs suppression by Gq signal.
data suggest that Ric-8 proteins are molecular chaperones required for the initial association of nascent Galpha subunits with cellular membranes
Title: Ric-8 proteins are molecular chaperones that direct nascent G protein ? subunit membrane association.
The following Ric8b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ric8b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu08443 | |
Clone ID Related Accession (Same CDS sequence) | NM_183172.2 | |
Accession Version | NM_183172.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1683bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-21 | |
Organism | Mus musculus(house mouse) | |
Product | synembryn-B isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY272676.1, BC051080.1 and BC040762.1. On Oct 13, 2012 this sequence version replaced NM_183172.1. Transcript Variant: This variant (2) contains an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2, which is longer than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.274670.1, SRR1660815.101227.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGATGAAG AGCGCGCCCT CTACATCGTC CGGGCCGGCG AGGCGGGGGC TATCGAGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_898995.1 |
CDS | 130..1812 |
Translation |
Target ORF information:
Target ORF information:
|
NM_183172.2 |
1 | ATGGATGAAG AGCGCGCCCT CTACATCGTC CGGGCCGGCG AGGCGGGGGC TATCGAGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu11526 | |
Clone ID Related Accession (Same CDS sequence) | NM_001013441.2 | |
Accession Version | NM_001013441.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-21 | |
Organism | Mus musculus(house mouse) | |
Product | synembryn-B isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY272676.1, AY940667.1 and BC040762.1. On Oct 13, 2012 this sequence version replaced NM_001013441.1. Transcript Variant: This variant (1) encodes isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY940667.1, AK132369.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGATGAAG AGCGCGCCCT CTACATCGTC CGGGCCGGCG AGGCGGGGGC TATCGAGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001013459.1 |
CDS | 130..1692 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001013441.2 |
1 | ATGGATGAAG AGCGCGCCCT CTACATCGTC CGGGCCGGCG AGGCGGGGGC TATCGAGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu44487 | |
Clone ID Related Accession (Same CDS sequence) | XM_006513625.2 , XM_006513625.3 | |
Accession Version | XM_006513625.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1611bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | synembryn-B isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006513625.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATGAAG AGCGCGCCCT CTACATCGTC CGGGCCGGCG AGGCGGGGGC TATCGAGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006513688.1 |
CDS | 494..2104 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006513625.2 |
1 | ATGGATGAAG AGCGCGCCCT CTACATCGTC CGGGCCGGCG AGGCGGGGGC TATCGAGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu44487 | |
Clone ID Related Accession (Same CDS sequence) | XM_006513625.2 , XM_006513625.3 | |
Accession Version | XM_006513625.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1611bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | synembryn-B isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006513625.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATGAAG AGCGCGCCCT CTACATCGTC CGGGCCGGCG AGGCGGGGGC TATCGAGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006513688.1 |
CDS | 475..2085 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006513625.3 |
1 | ATGGATGAAG AGCGCGCCCT CTACATCGTC CGGGCCGGCG AGGCGGGGGC TATCGAGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Conditional Deletion of |
High-throughput discovery of novel developmental phenotypes. |
Expression Pattern and Localization Dynamics of Guanine Nucleotide Exchange Factor RIC8 during Mouse Oogenesis. |
A functional N-terminal domain in C/EBP?-LAP* is required for interacting with SWI/SNF and to repress Ric-8B gene transcription in osteoblasts. |
Increased ubiquitination and the crosstalk of G protein signaling in cardiac myocytes: involvement of Ric-8B in Gs suppression by Gq signal. |