Gene Symbol | Sytl4 |
Entrez Gene ID | 27359 |
Full Name | synaptotagmin-like 4 |
Synonyms | Gph,Slp4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Sytl4 cDNA ORF clone
gRNAs
Gene Symbol | Sytl4 |
Entrez Gene ID | 27359 |
Full Name | synaptotagmin-like 4 |
Synonyms | Gph,Slp4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_013757.2 | NP_038785.1 | synaptotagmin-like protein 4 isoform 1 |
NM_001290718.1 | NP_001277647.1 | synaptotagmin-like protein 4 isoform 2 |
XM_006528551.2 | XP_006528614.1 | synaptotagmin-like protein 4 isoform X1 |
NM_001290717.1 | NP_001277646.1 | synaptotagmin-like protein 4 isoform 2 |
NM_001290719.1 | NP_001277648.1 | synaptotagmin-like protein 4 isoform 3 |
XM_006528551.3 | XP_006528614.1 | synaptotagmin-like protein 4 isoform X1 |
Rattus norvegicus (Norway rat) | Sytl4 | NP_536335.1 |
Canis lupus familiaris (dog) | SYTL4 | XP_005641613.1 |
Mus musculus (house mouse) | Sytl4 | NP_038785.1 |
Danio rerio (zebrafish) | LOC100535893 | XP_003199981.2 |
Homo sapiens (human) | SYTL4 | NP_001123368.1 |
Danio rerio (zebrafish) | sytl4 | NP_001074457.1 |
Xenopus tropicalis (tropical clawed frog) | sytl4 | XP_002940484.1 |
Pan troglodytes (chimpanzee) | SYTL4 | XP_003317604.1 |
LOC700889 | XP_002808587.1 | |
Bos taurus (cattle) | SYTL4 | NP_001179362.1 |
Drosophila melanogaster (fruit fly) | btsz | NP_001262582.1 |
Gallus gallus (chicken) | SYTL4 | XP_004940758.1 |
?-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development.
Abdellatif AM, Oishi H, Itagaki T, Jung Y, Shawki HH, Okita Y, Hasegawa Y, Suzuki H, El-Morsy SE, El-Sayed MA, Shoaib MB, Sugiyama F, Takahashi S
PloS one11(2)e0150010(2016)
The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane.
Wang H, Ishizaki R, Xu J, Kasai K, Kobayashi E, Gomi H, Izumi T
Molecular biology of the cell24(3)319-30(2013 Feb)
Modular genetic control of sexually dimorphic behaviors.
Xu X, Coats JK, Yang CF, Wang A, Ahmed OM, Alvarado M, Izumi T, Shah NM
Cell148(3)596-607(2012 Feb)
Loss of granuphilin and loss of syntaxin-1A cause differential effects on insulin granule docking and fusion.
Wang H, Ishizaki R, Kobayashi E, Fujiwara T, Akagawa K, Izumi T
The Journal of biological chemistry286(37)32244-50(2011 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Granuphilin and exophilin7, differentially regulate the exocytosis of either stably or minimally docked granules, respectively.
Title: The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane.
granuphilin binds to syntaxin-2 and syntaxin-3 as well as syntaxin-1a, it likely mediates granule docking through interactions with those multiple syntaxins on the plasma membrane.
Title: Loss of granuphilin and loss of syntaxin-1A cause differential effects on insulin granule docking and fusion.
It is shown that the granuphilin promoter is a target of SREBP-1c, a transcription factor that controls fatty acid synthesis, and MafA, a beta cell differentiation factor
Title: Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice.
granuphilin promotes the plasma membrane targeting of insulin granules via interaction with syntaxin 1a
Title: Rab27 effector granuphilin promotes the plasma membrane targeting of insulin granules via interaction with syntaxin 1a.
Synaptotagmin-like protein 4 (Slp4)/granuphilin-a contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slp4 specifically and directly binds the GTP-bound form of Rab3A, Rab8, and Rab27A.
Title: The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.
The following Sytl4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sytl4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu17017 | |
Clone ID Related Accession (Same CDS sequence) | NM_001290718.1 , NM_001290717.1 | |
Accession Version | NM_001290718.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1509bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-20 | |
Organism | Mus musculus(house mouse) | |
Product | synaptotagmin-like protein 4 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX510358.4, AK030401.1 and AB025258.1. On Mar 19, 2014 this sequence version replaced XM_006528553.1. Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and lacks three alternate exons, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2 and 3 encode the same isoform (2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK030401.1, SRR1660825.77123.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTCGGAGA TACTAGACCT CTCTTTTCTG TCCGAGATGG AAAGGGATTT GATCCTCGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001277647.1 |
CDS | 188..1696 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001290718.1 |
1 | ATGTCGGAGA TACTAGACCT CTCTTTTCTG TCCGAGATGG AAAGGGATTT GATCCTCGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu17017 | |
Clone ID Related Accession (Same CDS sequence) | NM_001290718.1 , NM_001290717.1 | |
Accession Version | NM_001290717.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1509bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-05 | |
Organism | Mus musculus(house mouse) | |
Product | synaptotagmin-like protein 4 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX510358.4, AK161582.1, AL691421.9 and AB025258.1. On Mar 19, 2014 this sequence version replaced XM_006528552.1. Transcript Variant: This variant (2) lacks three alternate exons, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2 and 3 encode the same isoform (2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB025259.1, AK161582.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTCGGAGA TACTAGACCT CTCTTTTCTG TCCGAGATGG AAAGGGATTT GATCCTCGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001277646.1 |
CDS | 215..1723 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001290717.1 |
1 | ATGTCGGAGA TACTAGACCT CTCTTTTCTG TCCGAGATGG AAAGGGATTT GATCCTCGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu14296 | |
Clone ID Related Accession (Same CDS sequence) | NM_013757.2 , XM_006528551.2 , XM_006528551.3 | |
Accession Version | NM_013757.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2022bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-05 | |
Organism | Mus musculus(house mouse) | |
Product | synaptotagmin-like protein 4 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX510358.4 and AB025258.1. On Mar 19, 2014 this sequence version replaced NM_013757.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB025258.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTCGGAGA TACTAGACCT CTCTTTTCTG TCCGAGATGG AAAGGGATTT GATCCTCGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_038785.1 |
CDS | 215..2236 |
Translation |
Target ORF information:
Target ORF information:
|
NM_013757.2 |
1 | ATGTCGGAGA TACTAGACCT CTCTTTTCTG TCCGAGATGG AAAGGGATTT GATCCTCGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu14296 | |
Clone ID Related Accession (Same CDS sequence) | NM_013757.2 , XM_006528551.2 , XM_006528551.3 | |
Accession Version | XM_006528551.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2022bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | synaptotagmin-like protein 4 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006528551.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCGGAGA TACTAGACCT CTCTTTTCTG TCCGAGATGG AAAGGGATTT GATCCTCGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006528614.1 |
CDS | 198..2219 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006528551.2 |
1 | ATGTCGGAGA TACTAGACCT CTCTTTTCTG TCCGAGATGG AAAGGGATTT GATCCTCGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu14322 | |
Clone ID Related Accession (Same CDS sequence) | NM_001290719.1 | |
Accession Version | NM_001290719.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1509bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-05 | |
Organism | Mus musculus(house mouse) | |
Product | synaptotagmin-like protein 4 isoform 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX510358.4, AB025258.1 and AL691421.9. Transcript Variant: This variant (4) lacks multiple 3' coding exons and its transcription extends past a splice site used in variant 1, resulting in a different 3' coding region and 3' UTR. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC026819.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTCGGAGA TACTAGACCT CTCTTTTCTG TCCGAGATGG AAAGGGATTT GATCCTCGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001277648.1 |
CDS | 215..1723 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001290719.1 |
1 | ATGTCGGAGA TACTAGACCT CTCTTTTCTG TCCGAGATGG AAAGGGATTT GATCCTCGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu14296 | |
Clone ID Related Accession (Same CDS sequence) | NM_013757.2 , XM_006528551.2 , XM_006528551.3 | |
Accession Version | XM_006528551.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2022bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | synaptotagmin-like protein 4 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006528551.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCGGAGA TACTAGACCT CTCTTTTCTG TCCGAGATGG AAAGGGATTT GATCCTCGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006528614.1 |
CDS | 197..2218 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006528551.3 |
1 | ATGTCGGAGA TACTAGACCT CTCTTTTCTG TCCGAGATGG AAAGGGATTT GATCCTCGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
?-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development. |
The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane. |
Modular genetic control of sexually dimorphic behaviors. |
Loss of granuphilin and loss of syntaxin-1A cause differential effects on insulin granule docking and fusion. |