** This is a software tool to create a scrambled sequence as negative control for your siRNA experiment.

Please select species:

Please paste in one DNA sequence:


Instruction:
This program is designed to create a negative control for a siRNA. It accepts a short DNA sequence (<= 30 mer), and returns a scrambled sequence.
The scrambled sequence will have the following features:
  • Having the same nucleotide composition as the input sequence.
  • Passed the same siRNA filtering (e.g. no low complex sequence).
  • Having the weakest (or no) match with any mRNA in the mRNA pool for a particular organism.

We will try up-to 1,000,000 combinations for the scrambling process to identify a really good candidate.