Introduction

Growth factors are known for their ability to enhance cellular proliferation, growth and differentiation by regulating tissue morphogenesis, angiogenesis and neurite outgrowth. Growth factors typically act as signaling molecules between cells which play an important role in regulating a variety of cellular processes. Their activities are mediated through binding to transmembrane receptors. The regulation of some growth factors and their receptors is also involved in tumor formation.

GenScript's quality system is registered to the ISO 13485:2016 standard for the design, development, manufacture and distribution of the proteins used for in-vitro diagnostic medical devices to detect infection and markers related to inflammatory diseases, tumors, cardiac disease, and reproductive disorders. With this certificate, GenScript is qualified to provide raw materials or products to customers who manufacture and sell immunodiagnostic medical devices. Our consistent and reliable proteins facilitate the development and approval process of customer's products.

Product Overview

GenScript provides hundreds of high-quality recombinant growth factors covering the following subclasses. Click the subclass of your interest and explore more.

CSFs

Colony-stimulating factors (CSFs) are the cytokines that play a central role in proliferation, differentiation and functional activation of hematopoietic cells of multiple lineages [1], regulating blood formation, leukocyte function and overall immune competence. There are three CSFs members - macrophage-CSF (M-CSF), granulocyte-CSF (G-CSF), and granulocyte/macrophage-CSF (GM-CSF). M-CSF mainly affects the survival, growth, differentiation, and function of mononuclear phagocytes. G-CSF affects the neutrophils, while GM-CSF is less restricted and affects both macrophages and neutrophils [2].

Popular Product List

Cat. No. Product Name Quantity Price Order
Z02914
M-CSF, Human
$90.00
 
Z02930
M-CSF, Mouse
$90.00
 
Z02979
GM-CSF, Mouse
$90.00
 
Z02980
G-CSF, Human(CHO-expressed)
$90.00
 
Z02983
GM-CSF, Human(CHO-expressed)
$90.00
 
Z02992
GM-CSF, Rat
$70.00
 
Z03010
M-CSF, Rat
$70.00
 
Z03101
G-CSF, Rat (HEK 293-expressed)
-
 
Z03163
G-CSF, Mouse
$90.00
 

Reference

  1. Metcalf, Donald. "The colony-stimulating factors and cancer." Nature Reviews Cancer 10.6 (2010): 425-434.
  2. Moore, M. A. "The clinical use of colony stimulating factors." Annual review of immunology 9 (1991): 159-191.

EGFs

Epidermal growth factor (EGF) was first isolated from mouse submaxillary glands. And it is a protein that stimulates cell growth and differentiation by binding to its receptor (EGFR), playing an important role in cellular proliferation, differentiation, and survival [1]. EGFs is found to be expressed in various organs and biological fluids, including platelets, urine, saliva, milk, tears, and blood plasma [2].

Popular Product List

Cat. No. Product Name Quantity Price Order
Z00333
EGF, Human
$30.00
 
Z02938
HB-EGF, Human
$70.00
 
Z02943
HB-EGF, Mouse
$70.00
 
Z02972
EGF, Mouse
$20.00
 
Z03103
Amphiregulin, Human
$45.00
 
Z03107
Epigen, Human(CHO-expressed)
-
 
Z03118
EGF, Rat (CHO-expressed)
$30.00
 
Z03173
Epigen, Human
-
 
Z03194
EGFR, His, Human
$90.00
 
Z03368
EGF, His, Human
$30.00
 

Reference

  1. Herbst, Roy S. "Review of epidermal growth factor receptor biology." International Journal of Radiation Oncology* Biology* Physics 59.2 (2004): S21-S26.
  2. Hoda, Syed A., and Rana S. Hoda. "Robbins and cotran pathologic basis of disease." (2005): 103.

FGFs

Fibroblast growth factors (FGFs) family consists of 22 members that are mainly expressed by macrophages. This family regulates a wide range of cellular functions, including migration, proliferation, differentiation, and survival. FGFs interact with fibroblast growth factor receptors (FGFRs) to inactivate related signaling pathways, playing essential roles in development, metabolism, and tissue homeostasis [1][2].

Popular Product List

Cat. No. Product Name Quantity Price Order
Z02738
FGF-19, Human
-
 
Z02984
FGF-4, Human
$45.00
 
Z02989
FGF-8, Human
$70.00
 
Z03047
KGF/FGF-7, Human
$100.00
 
Z03116
FGF-basic (154aa), Human
$45.00
 
Z03154
KGF/FGF-7, Mouse
$90.00
 
Z03155
FGF-10, Mouse
$70.00
 
Z03166
FGF-basic (146aa), Human
$45.00
 
Z03230
FGF-basic, Bovine
$45.00
 
Z03314
FGF-10, Human
$65.00
 

Reference

  1. Xie, Yangli, et al. "FGF/FGFR signaling in health and disease." Signal transduction and targeted therapy 5.1 (2020): 1-38
  2. Dolegowska, Katarzyna, et al. "FGF19 subfamily members: FGF19 and FGF21." Journal of physiology and biochemistry 75.2 (2019): 229-240.

FLT-3 Ligand

Fms-related tyrosine kinase 3 ligand (FLT-3L) is a kind of cytokine that plays a critical role in regulating differentiation, proliferation and survival of hematopoietic progenitor cells and dendritic cells by activating Fms-like tyrosine kinase 3 (Flt-3) [1].

Popular Product List

Cat. No. Product Name Quantity Price Order
Z02762
Flt-3L, RhesusMacaque
-
 
Z02926
Flt-3L, Human
$90.00
 
Z03227
Flt-3L, His, Mouse
$100.00
 

Reference

  1. Panagiotis, et al. "The Cytokine Flt3-Ligand in Normal and Malignant Hematopoiesis." International Journal of Molecular Sciences 18.6(2017):1115

IGFs

The insulin-like growth factors (IGFs) are proteins with high sequence similarity to insulin. IGFs are part of a complex system that cells use to communicate with their physiological environment. This complex system (often referred to as the IGF "axis") consists of two cell-surface receptors (IGF1R and IGF2R), two ligands (IGF-1 and IGF-2), a family of seven high-affinity IGF-binding proteins (IGFBP1 to IGFBP7), as well as associated IGFBP degrading enzymes, referred to collectively as proteases [1][2].

Popular Product List

Cat. No. Product Name Quantity Price Order
Z02862
IGF-BP-3, Human
$165.00
 
Z03017
IGF-I, Human
$45.00
 
Z03146
IGF-I, Rat
$30.00
 
Z03147
IGF-II, Human
$45.00
 
Z03176
IGF-BP-4, His, Human
$55.00
 
Z03201
IGF-BP-2, His, Human
$55.00
 
Z03298
IGF-I (N-Met), Human
$20.00
 
Z03688
IGF-I, Bovine
$45.00
 

Reference

  1. Talia, Chiara, Lisa Connolly, and Paul A. Fowler. "The insulin-like growth factor system: A target for endocrine disruptors?." Environment international 147 (2021): 106311.
  2. Jones, John I., and David R. Clemmons. "Insulin-like growth factors and their binding proteins: biological actions." Endocrine reviews 16.1 (1995): 3-34.

PDGFs

Platelet-derived growth factors (PDGFs) promote cell proliferation, survival, and migration of cells primarily of mesenchymal origin[1]. Dysfunction of PDGF signaling has been observed in a wide array of pathological conditions, such as cancer, fibrosis, neurological conditions and atherosclerosis. Reported abnormalities of the PDGF pathway include overexpression or amplification of PDGF receptors (PDGFRs), gain of function point mutations, or activating chromosomal translocations. PDGFRs and their ligands have been found to be overexpressed or mis-regulated in many cancers, correlating with reduced overall survival [2].

Popular Product List

Cat. No. Product Name Quantity Price Order
Z02529
PDGF-BB, Human (P. pastoris-expressed)
$100.00
 
Z03080
PDGF-CC, Human
$70.00
 
Z03096
PDGF-BB, Mouse
$90.00
 
Z03179
PDGF-BB, Rat
$90.00
 
Z03195
PDGF-DD, Human
$90.00
 
Z03276
PDGF-AA, Mouse
$95.00
 
Z03707
PDGF-BB, Human
$109.00
 
Z03725
PDGF-BB, Bovine
$109.00
 

Reference

  1. Ding, Hao, et al. "A specific requirement for PDGF-C in palate formation and PDGFR-α signaling." Nature genetics 36.10 (2004): 1111-1116.
  2. Papadopoulos, Natalia, and Johan Lennartsson. "The PDGF/PDGFR pathway as a drug target." Molecular aspects of medicine 62 (2018): 75-88.

SCFs

Stem cell factor is a growth factor that is expressed by fibroblasts and endothelial cells throughout the body. It interacts with the c-KIT receptor and plays an essential role in regulating cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, mast cell development, migration, and function.[1][2]

Popular Product List

Cat. No. Product Name Quantity Price Order
Z02692
SCF, Human (P. pastoris-expressed)
$90.00
 
Z02997
SCF, Mouse
$90.00
 
Z03094
SCF, Rat
$90.00
 
Z03110
SCF, Rat (HEK 293-expressed)
$90.00
 

Reference

  1. Baba, Hidehiko , H. Uchiwa , and S. Watanabe . "UVB Irradiation Increases the Release of SCF from Human Epidermal Cells." Journal of Investigative Dermatology 124.5(2005):1075-1077.
  2. Lennartsson, J. , and L. Ronnstrand . "Stem Cell Factor Receptor/c-Kit: From Basic Science to Clinical Implications." Physiological Reviews 92.4(2012):1619-1649.

TGFs

Transforming growth factors (TGFs) are peptides that affect the growth and phenotype of cultured cells and bring about in nonmalignant fibroblastic cells phenotypic properties that resemble those of malignant cells [1]. Type alpha TGFs are usually mitogenic for fibroblasts, whereas type beta TGFs have bifunctional effects on cell growth and can either stimulate or inhibit growth of the same cells, depending on conditions. The interactions of type alpha and beta TGFs can be either synergistic or antagonistic. Though the development of peptide antagonists to type alpha TGFs can potentially have therapeutic potential for the treatment of malignancy, type beta TGFs can potentially inhibit tumorigenesis [2].

Popular Product List

Cat. No. Product Name Quantity Price Order
Z03332
TGF-α, Human
$30.00
 
Z03411
TGF-β1, Human
$155.00
 
Z03429
TGF-β 2, Human
$205.00
 
Z03430
TGF-β 3, Human
$205.00
 
Z03431
TGF-β 1, Mouse
$205.00
 
Z03432
TGF-β 2, Mouse
$205.00
 

Reference

  1. Keski‐Oja, Jorma, et al. "Transforming growth factors and control of neoplastic cell growth."  Journal of cellular biochemistry 33.2 (1987): 95-107.Papadopoulos, Natalia, and Johan Lennartsson. "The PDGF/PDGFR pathway as a drug target."  Molecular aspects of medicine 62 (2018): 75-88.
  2. Roberts, A. B., and M. B. Sporn. "Transforming growth factors." Cancer surveys 4.4 (1985): 683-705.

VEGFs

The Vascular endothelial growth factor (VEGF) family consists of 5 members in the mammalian genome - VEGFA, VEGFB, VEGFC, VEGFD and placenta growth factor (PGF). VEGFA is the first identified VEGF member and has been studied most. VEGFs can affect the blood supply, thereby suppressing the size of solid cancers. Conversely, cancer cells that express VEGF are able to grow and metastasize. Overexpression of VEGF can lead to vascular disease in the retina of the eye and other parts of the body, but drugs such as bevacizumab and pegatanide can inhibit VEGF and control or slow the progression of these diseases [1][2].

Popular Product List

Cat. No. Product Name Quantity Price Order
Z02689
VEGF165, Human
$90.00
 
Z02690
VEGF164, Mouse (P. pastoris-expressed)
$1545.00 1 mg
 
Z02779
VEGF120, Mouse
$165.00
 
Z02780
VEGF164, Mouse
$165.00 10 μg
 
Z03006
VEGF164, Rat (CHO-expressed)
$90.00
 
Z03073
VEGF165, Human(HEK 293-expressed)
$90.00
 
Z03125
VEGF-D, Human
$100.00
 
Z03140
VEGF121, Human
$90.00
 
Z03286
VEGF-C, Human
$65.00
 

Reference

  1. Keifer, Orion P., Deirdre M. O'Connor, and Nicholas M. Boulis. "Gene and Protein Therapies Utilizing VEGF for ALS." Pharmacology & Therapeutics 141.3 (2014): 261-71.
  2. Simon, Thomas, Teresa Gagliano, and Georgios Giamas. "Direct Effects of Anti-Angiogenic Therapies On Tumor Cells: VEGF Signaling." Trends in Molecular Medicine 23.3 (2017): 282-92.

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