First in the market to achieve Gene-to-mRNA in just 3 weeks to drive innovations with our cutting-edge mRNA, circular RNA, and self-amplifying RNA technologies, seamlessly integrated with LNP delivery systems.
RNAs produced at GenScript are optimized with our proprietary production platform, ensuring the quality and expression efficiency.
First to achieve Gene-to-mRNA in 3 weeks, driving your innovations with advanced mRNA, circular RNA, and self-amplifying RNA technologies, integrated with LNP delivery systems
Drive Innovation
Cutting-edge mRNA, circular RNA, and self-amplifying RNA technologies, seamlessly integrated with LNP delivery systems
High-quality custom mRNA production via our proprietary IVT RNA manufacturing workflow.
Learn MoreAccelerate your research from gene to mRNA in 3 weeks!
Learn MoreCircular RNA offers improved stability and longer expression duration.
Learn MoreOur off-the-shelf mRNA is optimized with 5’ cap and polyA tails that is ready to use for your research needs
Learn MoreSend us your in house mRNA samples for expert QC analysis.
Learn MoreLNP Packaging
Learn MoreGenScript’s solution to IVT mRNA manufacturing streamlines your workflow from gene synthesis to mRNA production. Our IVT mRNAs are optimized with our proprietary production platform, ensuring the quality and expression efficiency of your mRNA.
Linear mRNA | Self-Amplifying RNA | Circular RNA | |||||
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Structure | Linear; Open 5’ and 3’ end mRNA exonuclease degradation |
Linear; Open 5’ and 3’ end mRNA exonuclease degradation |
Close loop; No free 5’ 3’ end Eliminating mRNA exonuclease degradation |
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Ribosome recruiting | 5’ Cap: Initiates translation & stabilizes mRNA |
5’ Cap: Initiates translation & stabilizes mRNA |
Internal Ribosome Entry Site (IRES) : Initiates translation |
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ORF |
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UTR | Regulatory elements in the 5’ and 3’-UTR stabilize mRNA and increase translation initiation | Replicon for further self-replication of the mRNA | Include IRES + PIE + other elements | ||||
PolyA tail | Stabilizes RNA molecule & Prevents degradation | Stabilizes RNA molecule & Prevents degradation | Not required | ||||
Protein Expression | +++ Strong | +++++ Strongest | ++++ Stronger | ||||
Expression half-life | +++ Shorter | +++++ Longest | ++++ Longer | ||||
Immunogenicity | ++++ Low | ++ High | +++ Medium | ||||
Dosage requirement | ++ High | +++++ Lowest | +++ Medium | ||||
Novelty | +++ Traditional | ++++ Novel | +++++ Novel | ||||
Institute for Biomedical Sciences at Georgia State University
GenScript mRNA has helped us make a rapid progress in developing novel vaccine projects. GenScript's service is faithful and timely provided, saving me lots of time to focus on research. This is why I have been using GenScript services for over 20 years.
Case studies showing high expression efficiency of GenScript’s mRNA for expressing SB transposase, GFP, Luciferase, eSpCas9, and more.
Free DownloadCircular RNA introduction, GenScript offering details, and case studies showing increased stability, prolonged expression, and lower immunogenicity compared to linear IVT mRNA.
Free DownloadCase studies demonstrating encapsulation and delivery efficiency of GenScript’s new LNP formulations in cell models, and mouse models via both IM and IV.
Free DownloadThis whitepaper provides valuable insights into the essential factors that vaccine and therapy developers should consider when exploring mRNA solutions
Free DownloadGet GenScript’s free application eBook on therapeutics development with mRNA manufacturing solutions
Free DownloadLearn about key structural features and functions of IVT mRNA and LNP, therapeutic modalities beyond prophylactic vaccines, mRNA candidates progressing through clinical trials.
Free DownloadLearn about the main structural components of mRNA, the functional roles of each part, what constitutes high-quality IVT mRNA and more.
Free DownloadLearn about key structural components of circRNA, the process by which circRNA is translated into protein, and more.
Free DownloadLearn about key structural components of saRNA, the processes by which saRNA replicates and is translated into protein, and more.
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