Send Us Your mRNA Samples for Quality Control Analysis

Ensure the quality of your mRNA by leveraging GenScript’s mRNA manufacturing expertise to perform reliable QC analysis on your IVT mRNA samples.

Simply fill out the form to request a quote for your preferred QC tests and send us your mRNA sample. Analysis typically takes 1-3 weeks depending on the specific tests (see table below).

mRNA QC Service Introduction

Option mRNA QC Test TAT, days Amount Required Method
1 PolyA Tail Length Assay 7 300pmol RNase digestion and purification to recover the polyA tail fragment, followed by polyA tail length analysis by small RNA bio-analyzer kit assay or LC-MS.
2 Capping Efficiency Assay 14-21 300pmol RNase digestion to isolate a short oligo from the 5’ end of the mRNA sample to be analyzed by LC-MS to calculate the capping efficiency.
3 dsRNA Residue Assay 10 40ug Slot-blot assay using a dsRNA-specific antibody to test for dsRNA residues in mRNA sample.
4 RNA Capillary Electrophoresis 5 10ug Bioanalyzer assay to test RNA length and purity.
5 Total Protein Residue Assay 7 10ug Nano-orange assay to test the residual protein amount in mRNA sample.
6 Plasmid DNA Residue Assay 14 5ug q-PCR assay to test the residual plasmid DNA residue amount in mRNA sample.
7 Quantitative Endotoxin Assay 5 5ug GenScript ToxinSensor™ Chromogenic LAL Endotoxin Assay to test endotoxin level in mRNA sample.
8 BioBurden Assay 14 200ug TSA plate to recover a broad range of microorganisms such as aerobic and anaerobic bacteria from liquid.

Additional mRNA Offerings

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mRNA QC Services

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