The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]
The human BDNF gene is shown in the context of the human genome below. To see information about the BDNF gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse BDNF, rat BDNF, and human BDNF, as well as on-demand BDNF ORF clones in 183 other species.
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