Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
The human DHFR gene is shown in the context of the human genome below. To see information about the DHFR gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse DHFR, rat DHFR, and human DHFR, as well as on-demand DHFR ORF clones in 183 other species.
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