β-Amyloid Antibody (32-40), pAb, Rabbit

A number of mutations, identified in the gene encoding the β-amyloid precursor protein (βAPP), have been linked to early-onset Familial Alzheimers Disease. βAPP is cleaved sequentially by the proteolytic enzymes β-secretase and γ-secretase to produce β-amyloid (Aβ) peptides with the Aβ1-42(43) and the Aβ1-40 forms being the most prevalent. Secreted Aβ peptides can bind to scavenger receptors and the receptor for advanced glycation endproducts. Aβ peptides are degraded either via a reuptake mechanism followed by endosomal degradation or by an extracellular insulin-degrading enzyme. Extracellular accumulation of Aβ leads to formation of aggregates, fibrils, and eventually amyloid deposits called neuritic plaques, a hallmark of Alzheimer’s disease. β-Amyloid antibodies and peptides have been developed as tools for elucidating the biology of Alzheimers disease.GenScript Rabbit Anti-β-Amyloid (32-40) Polyclonal Antibody is developed in rabbit hosts using a synthetic peptide corresponding to amino acids 32-40 of human β-Amyloid conjugated to KLH.This polyclonal antibody is highly purified from rabbit antiserum by immunoaffinity chromatography.