Calreticulin Antibody, pAb, Rabbit

*This product has been discontinued!*

Calreticulin is a multifunctional protein that serves as a major Ca2+-binding protein in the lumen of the endoplasmic reticulum. It binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of nuclear receptors. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin also serves as a recognition and clearance ligand by activating the internalization receptor LRP1 on the responding phagocyte cell surface.GenScript Rabbit Anti-Calreticulin Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human Calreticulin (Swiss Prot: P27797).

Cat. No.	A01443
Size	Buy in bulk

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Overview Properties Background

Overview

Specificity	GenScript Rabbit Anti-Calreticulin Polyclonal Antibody detects endogenous levels of human Calreticulin. It is predicted to react with mouse and rat Calreticulin according to sequence homology. Positive Control: Hela and HepG2
Host Species	Rabbit
Immunogen	KLH-coupled synthetic peptide from C-terminal of human Calreticulin (Swiss Prot: P27797).
Species Reactivity	Human. This product has not been tested for other species yet.

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Properties

Concentration	0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution	Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Purification	Immunoaffinity chromatography.

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Background

Target Background

Calreticulin is a multifunctional protein that serves as a major Ca²⁺-binding protein in the lumen of the endoplasmic reticulum. It binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of nuclear receptors. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin also serves as a recognition and clearance ligand by activating the internalization receptor LRP1 on the responding phagocyte cell surface.
GenScript Rabbit Anti-Calreticulin Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human Calreticulin (Swiss Prot: P27797).

Synonyms

Rabbit Anti-CALR antibody;

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