SP3 Antibody, pAb, Rabbit

*This product has been discontinued!*

SP3 is an ubiquitously expressed transcription factor that binds GC and GT box sequences in the promoters of a variety of genes. Containing three zinc finger domains that determine sequence specificity of DNA binding, this transcription factor is thought to regulate nucleoside, nucleotide, and nucleic acid metabolism as well as many other “housekeeping” genes. Sp3 can be modified via sumoylation by Ubc9 and interacts with other transcription factors and histone deacetylases. SP3 acts as a transcriptional enhancer and repressor of SP1 activity in a cell- and context-dependent manner.GenScript SP3 Antibody, pAb, Rabbit is developed in rabbit using a KLH-coupled synthetic peptide from N-terminal of human SP3 (Swiss Prot: Q02447).

Cat. No.	A01532
Size	Buy in bulk

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Overview Properties Background

Overview

Specificity	GenScript SP3 Antibody, pAb, Rabbit detects endogenous levels of human SP3. Positive Control: Hela and HEK293
Host Species	Rabbit
Immunogen	KLH-coupled synthetic peptide from N-terminal of human SP3 (Swiss Prot: Q02447)
Species Reactivity	Human

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Properties

Concentration	0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution	Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Purification	Immunoaffinity chromatography

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Background

Target Background

SP3 is an ubiquitously expressed transcription factor that binds GC and GT box sequences in the promoters of a variety of genes. Containing three zinc finger domains that determine sequence specificity of DNA binding, this transcription factor is thought to regulate nucleoside, nucleotide, and nucleic acid metabolism as well as many other “housekeeping” genes. Sp3 can be modified via sumoylation by Ubc9 and interacts with other transcription factors and histone deacetylases. SP3 acts as a transcriptional enhancer and repressor of SP1 activity in a cell- and context-dependent manner.
GenScript SP3 Antibody, pAb, Rabbit is developed in rabbit using a KLH-coupled synthetic peptide from N-terminal of human SP3 (Swiss Prot: Q02447).

Synonyms

Transcription factor SP 3 Antibody;

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