IL-4 Antibody(2G6A8), mAb, Mouse

IL4 is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It is a ligand for Interleukin 4 receptor. The Interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. IL4 elicits many different biological responses, among them there are two dominant functions. The first is regulating differentiation of CD4+ T cell to the Th2 type. Th2 cells produce IL4, IL5, IL10, and IL13 and tend to favor a humoral immune response while suppressing a cell mediated immune response controlled by Th1 cells. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. The second function is regulating IgE and IgG1 production by B cells. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.GenScript Human IL-4 Antibody (2G6A8), mAb, Mouse is produced from the hybridoma resulting from fusion of Sp2/0 myeloma and lymphocytes obtained from mouse immunized with purified full length human recombinant IL-4 protein (Swiss Prot: P05112).