|Synonyms||Rabbit monoclonal to Humira|
|Description||Adalimumab (Humira) is a humanized monoclonal antibody that’s approved by the U.S. Food and Drug Administration for the treatment of patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, chronic psoriasis, hidradenitis suppurativa, and juvenile idiopathic arthritis. Adalimumab binds to the TNF-α (tumor necrosis factor-alpha), and blocks its interaction with TNF-α receptors, reducing the inflammatory response of autoimmune diseases.|
|Purification||Protein A affinity column|
|Concentration||0.5 mg/ml, lyophilized with PBS, pH 7.4, contains 0.02% sodium azide. (Might be eligible for customized bulk orders.)|
|Reconstitution||Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/ml.|
|Specificity||The product is specific for Adalimumab. This antibody can't block Adalimumab binding with TNF-α (Z01001, TNF-α, Human) in ELISA.|
|Storage||The lyophilized product remains stable up to 1 year at -20 °C from date of receipt. Upon reconstitution, it can be stored for 2-3 weeks at 2-8 °C or for up to 12 months at -20 °C or below. Avoid freeze/thaw cycles.|
|Note||GenScript can customize this product per customer's request including product size, buffer components, etc.|
|Working concentrations for specific applications should be determined by the investigators. The appropriate concentration may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
ELISA detection: 0.07-0.1 µg/ml
Other applications: user-optimized
ELISA binding of MonoRabᵀᴹ Anti-Adalimumab Antibody (196F3), mAb, Rabbit (GenScript, A01923-40) with Adalimumab. While the antibody does not recognize the human IgG Fc fragment (data not shown).
Coating antigen: Adalimumab, 1 µg/ml.
Anti-Adalimumab antibody (GenScript, A01923-40) dilution start from 10,000 ng/ml.
EC₅₀= 60.85 ng/ml.
|Cat. No.||Product Name||Quantity||Price|
|MonoRab™ Anti-Adalimumab Antibody (134D5), mAb, Rabbit - 40 µg||
|MonoRab™ Anti-Adalimumab Antibody (4E12), mAb, Rabbit - 40 µg||
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