Antimicrobial resistance is fast rising to the top of the list of concerns of scientists, and policy makers alike. Antimicrobial resistance is not just limited to drugs aimed at microbes. Every class of antibiotics is affected by antimicrobial resistance including antivirals, antiparasitic and antifungal drugs.
Antibacterial drugs were originally isolated from natural sources, but as the threat of antibacterial resistance looms, the development of intelligently designed antimicrobial drugs, including small molecules and custom antimicrobial peptides has been fostered. This webpage is dedicated to highlighting the most recent news in the war on antimicrobial resistance, with an emphasis on how the development of novel antimicrobial peptides are playing a role.
The distinct activity of antimicrobial peptides governs their sequence, namely, the incorporation of these peptides into microbial cell membranes. As a result, these sequences usually consist of >50% hydrophobic residues. Due to the negative charge of many microbial membrane components (e.g. phospholipids, lipopolysaccharides and teichonic acids), antimicrobial peptides are often cationic in nature. In addition, they may contain modifications such as cyclization or disulfide bonds.
Custom Peptide Synthesis
- Custom antimicrobial peptide sequences synthesized to order, including hydrophobic synthesis expertise
- Peptide library screen from 24 to 100s of peptide sequences for antimicrobial activity
- Comprehensive modifications including disulfide bonds and cyclization
- Solubility testing – customized dissolution profiles for hard to dissolve peptides
- Instant online quotations
- Peptide Products
Get up to speed on antimicrobial resistance current events
- Nature publishes “Three-step plan for antibiotics” (May 2014)
- Nature publishes “ Antibiotic resistance sweeping developing world” (May 2014)
- Nature publishes “ Policy: An intergovernmental panel on antimicrobial resistance” (May 2014)
- WHO releases "2014 Antimicrobial Resistance Global Surveillance Report" (April 2014)
|Contact lenses coated with antimicrobial peptides pass safety study|
|Cyclic peptidomimetics control antibacterial activity with light|
|De novo designed peptides combat antibacterial resistance|