A sequential model for the basis of co-operativity in multimeric binding proteins, originally presented as a description of oxygen binding to each of the haem groups of the haemoglobin tetramer. Unlike in the earlier Monod-Wyman-Changeux concerted model, each monomer may assume a low-affinity or a high-affinity conformation. A high-affinity ligand-bound monomer favours the high-affinity conformation of adjacent unbound monomers. In the absence of a ligand (oxygen in the case of haemoglobin) the subunits exist in a low-affinity 'taut' conformation. The ligand may bind to as many as two monomers in this conformation, at which point all four monomers convert from the low-affinity form to the high-affinity 'relaxed' conformation.
GenSmart Optimization is a free online tool for performing codon optimization to improve gene expression. GenScript's patented algorithms are integrated into the tool to optimize the computing capability of high-performance sequence generation.
GenSmart™ Design is a free online DNA construct design tool developed by GenScript. GenSmart™ Design has two design modules, the Create Construct module for individual plasmid design and the Create Library module for DNA library design.
This online tool shows commonly used genetic codon frequency table in expression host organisms including Escherichia coli and other common host organisms.
GenScript recombinant protein and rAb services provide high quality recombinant proteins and rAbs for a variety of downstream research applications.
One-stop service from Sequence to Protein starting from $1600, 4 weeks.
GenScript's BacuVance baculovirus expression system was developed by our in-house team of scientists for virus production and expression of recombinant proteins from baculovirus-infected insect cells.
Mammalian Transient Expression
Proprietary High Density (HD) expression system, enhance the protein yield up to 100 fold, achieve antibody titers up to 3 g/L.
Reagents for COVID-19 Research
Gram level, ready to ship RBD proteins, ACE2 assay cell lines and pseudovirus.
If you know of any terms that have been omitted from this glossary that you feel would be useful to include, please send detail to the Editorial Office at GenScript: [email protected]