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polyclonal antibody

A polyclonal antibody refers to a mixture of antibodies that are generated by different B cells (immune cells) in response to a specific antigen. These antibodies recognize various epitopes (distinct regions) on the antigen, resulting in a diverse range of antibodies with varying binding specificities.

Polyclonal antibodies are naturally produced by the immune system in response to infections, vaccinations, or exposure to foreign substances. When the immune system encounters an antigen, multiple B cells are activated, each producing a slightly different antibody that can bind to different parts of the antigen.

Key characteristics of polyclonal antibodies include:

1. Diversity: Polyclonal antibodies recognize multiple epitopes on the target antigen, increasing the likelihood of successful binding and detection.

2. Broad Specificity: Due to their diverse origins, polyclonal antibodies are more likely to detect a variety of related molecules or antigen variants.

3. Complex Composition: Polyclonal antibody preparations consist of a mixture of antibodies, each produced by a different B cell clone. This complexity can be advantageous for certain applications but may also introduce variability.

Polyclonal antibodies have been widely used in various scientific and medical applications, including:

• Diagnostic Tests: Polyclonal antibodies are used in diagnostic tests, such as enzyme-linked immunosorbent assays (ELISAs) and immunohistochemistry, to detect the presence of specific antigens in samples.
• Research: Polyclonal antibodies are used in research to study the localization and expression of proteins within cells and tissues.
• Therapeutics: In some cases, polyclonal antibody preparations can be used as therapeutics, particularly in the treatment of certain infectious diseases or venomous bites.

Related Service
• Genscript offers Custom Polyclonal Antibody Production Services and Standard Polyclonal Antibody Services.
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Service and Products

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Our large-scale antibody manufacturing services offer polyclonal and monoclonal antibody production of gram quantities for industrial antibody yields.

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If you know of any terms that have been omitted from this glossary that you feel would be useful to include, please send detail to the Editorial Office at GenScript: [email protected]

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