List by Alphabet: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

kinase cascades

Introduction: Kinase cascades are vital components of cellular signaling pathways. These sequential phosphorylation reactions play a crucial role in transmitting extracellular signals to cellular responses. This article explores the key aspects of kinase cascades and their significance in cell communication.

What Is a Kinase Cascade? A kinase cascade is a series of phosphorylation reactions driven by protein kinases. These enzymes transfer phosphate groups from ATP to specific proteins, triggering a chain reaction within the cell. Kinase cascades are initiated by extracellular signals, such as hormones or growth factors, binding to cell surface receptors.

How Kinase Cascades Work:

1. Extracellular Signal: The cascade begins when an external signal activates a receptor on the cell surface.

2. Receptor Activation: Activated receptors phosphorylate downstream protein kinases.

3. Cascade Initiation: Phosphorylated kinases further activate downstream kinases, amplifying the signal.

4. Signal Amplification: The cascade multiplies the signal as it progresses.

5. Cellular Response: The final step in the cascade modifies effector proteins, altering cellular responses.

Significance of Kinase Cascades: Kinase cascades regulate numerous cellular processes, including growth, differentiation, and responses to stimuli. For example, the MAPK cascade exerts control over cell proliferation in response to growth factors.

Termination of Signaling: To prevent excessive activation, signaling pathways are tightly regulated. Phosphatases remove phosphate groups, terminating the signal.

Conclusion: Kinase cascades are fundamental to cellular signaling, orchestrating vital processes. Understanding their mechanisms and regulation is crucial in fields like cancer research and drug development.

Related Services:

GenScript offer human RAF/MAP kinase cascade pathway

Related Publications:

Genome-wide analysis of mitogen-activated protein (MAP) kinase gene family expression in response to biotic and abiotic stresses in sugarcane (genscript.com)

Stigma Receptivity is controlled by Functionally Redundant MAPK Pathway Components in Arabidopsis (genscript.com)


Related Biology Tools

  • GenSmart™ Codon Optimization

    GenSmart Optimization is a free online tool for performing codon optimization to improve gene expression. GenScript's patented algorithms are integrated into the tool to optimize the computing capability of high-performance sequence generation.

    Learn More

  • DNA Construct Design Tool

    GenSmart™ Design is a free online DNA construct design tool developed by GenScript. GenSmart™ Design has two design modules, the Create Construct module for individual plasmid design and the Create Library module for DNA library design.

    Learn More

  • Codon Frequency Tables

    This online tool shows commonly used genetic codon frequency table in expression host organisms including Escherichia coli and other common host organisms.

    Learn More

Service and Products

Gene Synthesis

Offer gene synthesis of 100% sequence guarantee, free codon optimization, DNA synthesis in as fast as 4 days.

ORF cDNA Clones and Custom Clones

Largest commercial ORF clones database, 70,000 next-day shipping ORF clones.

Plasmid DNA Preparation

High quality plasmids supported by fully-automated platform, 100% full insert sequence accuracy guaranteed.

Express Cloning & Subcloning

$49 and 2 day turnaround, choose from over 150 IP FREE vectors.

Mutation and Library Services

Mutagenesis Portfolio offers several mutation and library services to meet various customers’ needs.

Oligo Synthesis

Bridge the gap between chemically synthesized oligos and bological applications.

If you know of any terms that have been omitted from this glossary that you feel would be useful to include, please send detail to the Editorial Office at GenScript: [email protected]

If your term is adopted, we will send 1,000 EzCoupon points to your GenScript account.

Do you like the current new website?

Hate

Dislike

Neutral

Like

Love

*