A technique to widen the scope of catalytic reactions effected by abzymes. Reactive compounds are used as antigens; some of the resulting antibodies are directed to the reaction complex with a protein or carbohydrate. The antibody can then recruit to its binding site the components of the reaction and force them into reactive juxtaposition. Wirsching, P., Ashley, J.A., Lo, C.-H., et al. (1995) Science 270, 1175-1182
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