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The process of assembling the DNA sequences that encode an immunoglobulin or a T-cell receptor (TCR), the cell-surface protein that recognizes an antigen. The process excises polynucleotide sequences between V (variable), D (diversity) and J (joining) sequences, with the assembly of a coding sequence that will encode a complete potential immunoglobulin or TCR. The mechanism involves excision at recombination signal sequences (RSSs) that are characterized at each end of the to-be-excised sequence by 23 and 12 bp sequences (the 12/23 rule) that will be fused together in the signal joint as the excised sequence is cyclized. The ends of the coding sequences, which were sealed as hairpin turns during the first phase of the splicing, are reopened, an overhang is filled in with the insertion of so-called P nucleotides, and ligated to form a coding joint.(see double-strand-break repair model)Bogue, M. and Roth, D.B. (1996) Curr. Opin. Immunol. 8, 175-180; Lewis, G.S.M. and Wu, G.E. (1997) Cell 88, 159-162; Oettinger, M.A. (1999) Curr. Opin Cell Biol. 11, 325-329; Landree, M.A., Wibbenmeyer, J.A. and Roth, D.B. (1999) Genes Dev. 13, 3059-3069
GenSmart Optimization is a free online tool for performing codon optimization to improve gene expression. GenScript's patented algorithms are integrated into the tool to optimize the computing capability of high-performance sequence generation.
GenSmart™ Design is a free online DNA construct design tool developed by GenScript. GenSmart™ Design has two design modules, the Create Construct module for individual plasmid design and the Create Library module for DNA library design.
This online tool shows commonly used genetic codon frequency table in expression host organisms including Escherichia coli and other common host organisms.
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If you know of any terms that have been omitted from this glossary that you feel would be useful to include, please send detail to the Editorial Office at GenScript: [email protected]