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Codon optimization: Why & how to design DNA sequences for optimal soluble protein expression

Have you struggled with low protein expression levels in your experiments? This webinar will explain the principles of codon optimization and explore case studies showing how it improves protein expression up to 100-fold. Research has revealed dozens of DNA sequence features that influence the efficiency of each step required to achieve soluble target protein expression. We will review the critical publications that inform GenScript's patented algorithm and the data showing how our algorithm compares to our competitors. We will look at peer-reviewed papers that employed codon-optimized synthetic genes for heterologous protein expression in different host systems, including bacteria, yeast, plant, and human cells. Finally, we will see how GenScript's codon optimization can provide clever solutions to molecular biology problems in specialized applications.

Codon optimization: why & how to design DNA sequences for optimal soluble protein expression
Gene Synthesis OptimumGene™ Codon Optimization RBS Design
  • Gene synthesis from just $0.23/bp or $99/gene
  • Downstream molecular cloning available

  • Achieve the highest possible levels of productivity in any system
  • Results for even the most difficult sequences

  • Tunable control of translation initiation rate
  • Biophysics-based design of RBS