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PE6c

PE6c

PE6c

PE6C focuses on enhancing the performance of prime editing in transgenic rice plants. This specific variant of the prime editing technology is tailored to address the challenges of genetic improvement in crops, contributing to enhanced editing precision and efficiency in agricultural applications. The effectiveness of PE6c stems from its design improvements that enable it to facilitate targeted insertions and modifications in plant genomes.
RC00007
$150.00

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Overview
Description PE6C focuses on enhancing the performance of prime editing in transgenic rice plants. This specific variant of the prime editing technology is tailored to address the challenges of genetic improvement in crops, contributing to enhanced editing precision and efficiency in agricultural applications. The effectiveness of PE6c stems from its design improvements that enable it to facilitate targeted insertions and modifications in plant genomes.

Applications
single guide RNA (sgRNA) dependent single-stranded DNA cleavage

Background
References David R Liu, et al. “Phage-assisted evolution and protein engineering yield compact, efficient prime editors”. Cell. 2023 Aug 31;186(18):3983-4002.e26.

Quality Control Specifications
Purity ≥90% by SDS-PAGE, 92% by SEC-HPLC
Residual DNase Non-specific DNase activity
Endotoxin Level Control <10EU/mg

Properties
Expression System Recombinant Cas9-based fusion with three NLS expressed by E.coli
Species S. pyogenes
Tag C-His tag
Molecular Weight 226.54KDa
Storage & Stability PE6C is supplied with storage buffer (50 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol pH7.5, at 25°C) and recommended to be stored at -80°C.

Examples
  • PE6c
    • PE6c

  • PE6c
    • PE6c