About the B cell receptor signaling pathway
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.
72 gene
| Gene Symbol | Full Name |
|---|---|
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 |
| BTK | Bruton agammaglobulinemia tyrosine kinase |
| CD19 | CD19 molecule |
| CD22 | CD22 molecule |
| CD72 | CD72 molecule |
| CD79A | CD79a molecule, immunoglobulin-associated alpha |
| CD79B | CD79b molecule, immunoglobulin-associated beta |
| CD81 | CD81 molecule |
| CHUK | conserved helix-loop-helix ubiquitous kinase |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 |
| FCGR2B | Fc fragment of IgG, low affinity IIb, receptor (CD32) |
| FOS | FBJ murine osteosarcoma viral oncogene homolog |
| GRB2 | growth factor receptor-bound protein 2 |
| GSK3B | glycogen synthase kinase 3 beta |
| HRAS | Harvey rat sarcoma viral oncogene homolog |
| IKBKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta |
| INPP5D | inositol polyphosphate-5-phosphatase D |
| INPPL1 | inositol polyphosphate phosphatase-like 1 |
| JUN | jun proto-oncogene |
| KRAS | Kirsten rat sarcoma viral oncogene homolog |
| LYN | LYN proto-oncogene, Src family tyrosine kinase |
| NFATC1 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
| NFKBIB | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon |
| NRAS | neuroblastoma RAS viral (v-ras) oncogene homolog |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
| PIK3CB | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta |
| PIK3CD | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta |
| PIK3CG | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
| PIK3R2 | phosphoinositide-3-kinase, regulatory subunit 2 (beta) |
| PLCG2 | phospholipase C, gamma 2 (phosphatidylinositol-specific) |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme |
| PPP3CB | protein phosphatase 3, catalytic subunit, beta isozyme |
| PPP3CC | protein phosphatase 3, catalytic subunit, gamma isozyme |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha |
| PPP3R2 | protein phosphatase 3, regulatory subunit B, beta |
| PRKCB | protein kinase C, beta |
| MAPK1 | mitogen-activated protein kinase 1 |
| MAPK3 | mitogen-activated protein kinase 3 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 |
| MAP2K2 | mitogen-activated protein kinase kinase 2 |
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 |
| RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
| RAC2 | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) |
| RAC3 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) |
| RAF1 | Raf-1 proto-oncogene, serine/threonine kinase |
| RELA | v-rel avian reticuloendotheliosis viral oncogene homolog A |
| SOS1 | son of sevenless homolog 1 (Drosophila) |
| SOS2 | son of sevenless homolog 2 (Drosophila) |
| SYK | spleen tyrosine kinase |
| VAV1 | vav 1 guanine nucleotide exchange factor |
| VAV2 | vav 2 guanine nucleotide exchange factor |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma |
| IFITM1 | interferon induced transmembrane protein 1 |
| BCL10 | B-cell CLL/lymphoma 10 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 |
| VAV3 | vav 3 guanine nucleotide exchange factor |
| MALT1 | MALT1 paracaspase |
| LILRB3 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 |
| PIK3R5 | phosphoinositide-3-kinase, regulatory subunit 5 |
| RASGRP3 | RAS guanyl releasing protein 3 (calcium and DAG-regulated) |
| DAPP1 | dual adaptor of phosphotyrosine and 3-phosphoinositides |
| BLNK | B-cell linker |
| CARD11 | caspase recruitment domain family, member 11 |
| PIK3AP1 | phosphoinositide-3-kinase adaptor protein 1 |
