Overview

About the Chromatin modifying enzymes pathway

Eukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect it from damage. Access to DNA is achieved by highly regulated local chromatin decondensation. The 'building block' of chromatin is the nucleosome. This contains ~150 bp of DNA wrapped around a histone octamer which consists of two each of the core histones H2A, H2B, H3 and H4 in a 1.65 left-handed superhelical turn (Luger et al. 1997, Andrews & Luger 2011).

The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.

256 geneClick for more »

Gene Symbol Full Name
ACTB actin, beta
ACTL6A actin-like 6A
CCND1 cyclin D1
CDK4 cyclin-dependent kinase 4
CHD3 chromodomain helicase DNA binding protein 3
CHD4 chromodomain helicase DNA binding protein 4
ATF2 activating transcription factor 2
CREBBP CREB binding protein
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DR1 down-regulator of transcription 1
EP300 E1A binding protein p300
MECOM MDS1 and EVI1 complex locus
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
KAT2A K(lysine) acetyltransferase 2A
GPS2 G protein pathway suppressor 2
HIST1H2AE histone cluster 1, H2ae
HIST1H2AD histone cluster 1, H2ad
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HIST1H2BD histone cluster 1, H2bd
HIST1H2BB histone cluster 1, H2bb
HCFC1 host cell factor C1
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
PRMT1 protein arginine methyltransferase 1
JAK2 Janus kinase 2
KMT2A lysine (K)-specific methyltransferase 2A
PAX3 paired box 3
PHF2 PHD finger protein 2
ARID4A AT rich interactive domain 4A (RBP1-like)
KDM5A lysine (K)-specific demethylase 5A
RBBP4 retinoblastoma binding protein 4
RBBP5 retinoblastoma binding protein 5
RBBP7 retinoblastoma binding protein 7
REST RE1-silencing transcription factor
ATXN7 ataxin 7
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TADA2A transcriptional adaptor 2A
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TBL1X transducin (beta)-like 1X-linked
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
KDM6A lysine (K)-specific demethylase 6A
WHSC1 Wolf-Hirschhorn syndrome candidate 1
BRPF1 bromodomain and PHD finger containing, 1
KAT6A K(lysine) acetyltransferase 6A
KMT2D lysine (K)-specific methyltransferase 2D
YEATS4 YEATS domain containing 4
KDM5C lysine (K)-specific demethylase 5C
KDM5D lysine (K)-specific demethylase 5D
ARID1A AT rich interactive domain 1A (SWI-like)
HIST1H4I histone cluster 1, H4i
TRRAP transformation/transcription domain-associated protein
HIST1H2AI histone cluster 1, H2ai
HIST1H2AK histone cluster 1, H2ak
HIST1H2AJ histone cluster 1, H2aj
HIST1H2AL histone cluster 1, H2al
HIST1H2AC histone cluster 1, H2ac
HIST1H2AB histone cluster 1, H2ab
HIST1H2AM histone cluster 1, H2am
HIST2H2AA3 histone cluster 2, H2aa3
HIST2H2AC histone cluster 2, H2ac
HIST1H2BG histone cluster 1, H2bg
HIST1H2BL histone cluster 1, H2bl
HIST1H2BN histone cluster 1, H2bn
HIST1H2BM histone cluster 1, H2bm
HIST1H2BF histone cluster 1, H2bf
HIST1H2BE histone cluster 1, H2be
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BC histone cluster 1, H2bc
HIST1H2BO histone cluster 1, H2bo
HIST2H2BE histone cluster 2, H2be
HIST1H3A histone cluster 1, H3a
HIST1H3D histone cluster 1, H3d
HIST1H3C histone cluster 1, H3c
HIST1H3E histone cluster 1, H3e
HIST1H3I histone cluster 1, H3i
HIST1H3G histone cluster 1, H3g
HIST1H3J histone cluster 1, H3j
HIST1H3H histone cluster 1, H3h
HIST1H3B histone cluster 1, H3b
HIST1H4A histone cluster 1, H4a
HIST1H4D histone cluster 1, H4d
HIST1H4F histone cluster 1, H4f
HIST1H4K histone cluster 1, H4k
HIST1H4J histone cluster 1, H4j
HIST1H4C histone cluster 1, H4c
HIST1H4H histone cluster 1, H4h
HIST1H4B histone cluster 1, H4b

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