Overview

About the Downstream signal transduction pathway

The role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains.

The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.

323 geneClick for more »

Gene Symbol Full Name
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
BIRC5 baculoviral IAP repeat containing 5
CCND1 cyclin D1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND2 cyclin D2
CCND3 cyclin D3
CCNE1 cyclin E1
CCNH cyclin H
CDK1 cyclin-dependent kinase 1
CDK11B cyclin-dependent kinase 11B
CDC6 cell division cycle 6
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
CDC27 cell division cycle 27
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CENPA centromere protein A
CENPC centromere protein C
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CETN2 centrin, EF-hand protein, 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
DCTN1 dynactin 1
DHFR dihydrofolate reductase
DNA2 DNA replication helicase/nuclease 2
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F3 E2F transcription factor 3
E2F4 E2F transcription factor 4, p107/p130-binding
E2F5 E2F transcription factor 5, p130-binding
EMD emerin
ENSA endosulfine alpha
EP300 E1A binding protein p300
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
CENPI centromere protein I
GOLGA2 golgin A2
HIST1H2AE histone cluster 1, H2ae
HIST1H2AD histone cluster 1, H2ad
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HIST1H2BD histone cluster 1, H2bd
HIST1H2BB histone cluster 1, H2bb
H3F3A H3 histone, family 3A
H3F3B H3 histone, family 3B (H3.3B)
HDAC1 histone deacetylase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
INCENP inner centromere protein antigens 135/155kDa
KIF2A kinesin heavy chain member 2A
LIG1 ligase I, DNA, ATP-dependent
LMNA lamin A/C
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAX MYC associated factor X
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
RAB8A RAB8A, member RAS oncogene family
MNAT1 MNAT CDK-activating kinase assembly factor 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R12B protein phosphatase 1, regulatory subunit 12B
NEK2 NIMA-related kinase 2
NUMA1 nuclear mitotic apparatus protein 1
NUP88 nucleoporin 88kDa
NUP98 nucleoporin 98kDa
ODF2 outer dense fiber of sperm tails 2
ORC1 origin recognition complex, subunit 1
ORC2 origin recognition complex, subunit 2
ORC4 origin recognition complex, subunit 4
ORC5 origin recognition complex, subunit 5
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PCM1 pericentriolar material 1
PCNA proliferating cell nuclear antigen
PCNT pericentrin

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