SOD1 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Gene Symbol	SOD1
Entrez Gene ID	403559
Full Name	superoxide dismutase 1
General protein information	Preferred Names superoxide dismutase 1 Names superoxide dismutase [Cu-Zn] Cu/Zn superoxide dismutase superoxide dismutase 1 soluble superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA Protein Name

NM_001003035.1 NP_001003035.1 superoxide dismutase [Cu-Zn]
Pathways from BioSystems

mRNA	Protein	Name
NM_001003035.1	NP_001003035.1	superoxide dismutase [Cu-Zn]

Homologies

Canis lupus familiaris (dog)	SOD1	NP_001003035.1
Gallus gallus (chicken)	SOD1	NP_990395.1
Anopheles gambiae (African malaria mosquito)	CUSOD3	XP_311594.2
Mus musculus (house mouse)	Sod1	NP_035564.1
Caenorhabditis elegans (roundworm)	sod-5	NP_494779.1
Schizosaccharomyces pombe (fission yeast)	sod1	NP_593163.1
Homo sapiens (human)	SOD1	NP_000445.1
Pan troglodytes (chimpanzee)	SOD1	NP_001009025.1
	SOD1	NP_001027976.1
Rattus norvegicus (Norway rat)	Sod1	NP_058746.1
Caenorhabditis elegans (roundworm)	sod-1	NP_001021956.1
Xenopus tropicalis (tropical clawed frog)	sod1	NP_001016252.1
Bos taurus (cattle)	SOD1	NP_777040.1
Saccharomyces cerevisiae (baker's yeast)	SOD1	NP_012638.1
Kluyveromyces lactis	KLLA0E05567g	XP_454197.1
Magnaporthe oryzae (rice blast fungus)	MGG_02625	XP_003721165.1
Arabidopsis thaliana (thale cress)	CSD1	NP_001077494.1
Danio rerio (zebrafish)	sod1	NP_571369.1
Drosophila melanogaster (fruit fly)	Sod	NP_001261700.1
Eremothecium gossypii	AGOS_AGL321W	NP_986346.2
Neurospora crassa	NCU02133	XP_964291.2
Oryza sativa (rice)	Os03g0351500	NP_001050118.1
Oryza sativa (rice)	Os07g0665200	NP_001060564.1

Gene Ontology
Bibliography

Related articles in PubMed

Evidence of a genomic insertion in intron 2 of SOD1 causing allelic drop-out during routine diagnostic testing for canine degenerative myelopathy.
Turba ME, Loechel R, Rombol? E, Gandini G, Gentilini F
Animal genetics48(3)365-368(2017 Jun)

Distribution of superoxide dismutase 1 and glutathione peroxidase 1 in the cyclic canine endometrium.
Santos C, Pires Mdos A, Santos D, Payan-Carreira R
Theriogenology86(3)738-48(2016 Aug)

Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy.
Ivansson EL, Megquier K, Kozyrev SV, Mur?n E, K?rberg IB, Swofford R, Koltookian M, Tonomura N, Zeng R, Kolicheski AL, Hansen L, Katz ML, Johnson GC, Johnson GS, Coates JR, Lindblad-Toh K
Proceedings of the National Academy of Sciences of the United States of America113(22)E3091-100(2016 May)

Accumulation and aggregate formation of mutant superoxide dismutase 1 in canine degenerative myelopathy.
Nakamae S, Kobatake Y, Suzuki R, Tsukui T, Kato S, Yamato O, Sakai H, Urushitani M, Maeda S, Kamishina H
Neuroscience303229-40(2015 Sep)

Degenerative myelopathy in German Shepherd Dog: comparison of two molecular assays for the identification of the SOD1:c.118G>A mutation.
Capucchio MT, Spalenza V, Biasibetti E, Bottero MT, Rasero R, Dalmasso A, Sacchi P
Molecular biology reports41(2)665-70(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a genomic insertion in intron 2 of SOD1 was found during routine diagnostic testing for canine degenerative myelopathy
Title: Evidence of a genomic insertion in intron 2 of SOD1 causing allelic drop-out during routine diagnostic testing for canine degenerative myelopathy.

The cyclic changes of SOD1 and GPx1 suggest that they may play important roles in endometrial physiology, probably in apoptosis and proliferation.
Title: Distribution of superoxide dismutase 1 and glutathione peroxidase 1 in the cyclic canine endometrium.

Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy
Title: Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy.

The results of this study support the hypothesis that the cytoplasmic accumulation and aggregate formation of the mutant SOD1 protein
Title: Accumulation and aggregate formation of mutant superoxide dismutase 1 in canine degenerative myelopathy.

The SOD1:c.118G>A mutation could be a useful marker for breeding strategies intending to reduce the incidence of Degenerative myelopathy .
Title: Degenerative myelopathy in German Shepherd Dog: comparison of two molecular assays for the identification of the SOD1:c.118G>A mutation.

The following SOD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SOD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe34309	NM_001003035.1 Latest version!	Canis lupus familiaris superoxide dismutase 1 (SOD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SOD1 ( NM_001003035.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001003035.1 Canis lupus familiaris superoxide dismutase 1 (SOD1), mRNA.

Price & Availability↑

CloneID	OCe34309
Clone ID Related Accession (Same CDS sequence)	NM_001003035.1
Accession Version	NM_001003035.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Canis lupus familiaris(dog)
Product	superoxide dismutase [Cu-Zn]
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF346417.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF346417.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END##

ATGGAGATGA AGGCCGTGTG CGTGTTGAAG GGCCAGGGCC CGGTGGAGGG CACCATCCAC 
TTCGTGCAGA AGGGAAGTGG GCCTGTTGTG GTATCAGGAA CCATTACAGG GCTGACTGAA 
GGCGAGCATG GATTCCACGT CCATCAGTTT GAAGATAANA CACAAGGCTG TACTAGTGCA 
GGTCCTCACT TTAATCCTCT GTCCAAAAAA CATGGTGGGC CAAAAGATCA AGAGAGGCAT 
GTTGGAGACC TGGGCAATGT GACTGCTGGC AAGGATGGCG TGGCCATTGT GTCCATAGAA 
GATTCTCTGA TTGCACTCTC AGGAGACTAT TCCATCATTG GCCGCACCAT GGTGGTCCAC 
GAGAAACGAG ATGACTTGGG CAAAGGTGAC AATGAAGAAA GTACACAGAC AGGAAACGCC 
GGGAGTCGTT TGGCTTGTGG TGTCATTGGG ATCGCCCAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003035.1
CDS	7..468
Translation	MEMKAVCVLKGQGPVEGTIHFVQKGSGPVVVSGTITGLTEGEHGFHVHQFEDnullTQGCTSAGPHFNPLSKKHGGPKDQERHVGDLGNVTAGKDGVAIVSIEDSLIALSGDYSIIGRTMVVHEKRDDLGKGDNEESTQTGNAGSRLACGVIGIAQ

Target ORF information:

RefSeq Version	NM_001003035.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris superoxide dismutase 1 (SOD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003035.1

ORF Insert Sequence:

ATGGAGATGA AGGCCGTGTG CGTGTTGAAG GGCCAGGGCC CGGTGGAGGG CACCATCCAC 
TTCGTGCAGA AGGGAAGTGG GCCTGTTGTG GTATCAGGAA CCATTACAGG GCTGACTGAA 
GGCGAGCATG GATTCCACGT CCATCAGTTT GAAGATAANA CACAAGGCTG TACTAGTGCA 
GGTCCTCACT TTAATCCTCT GTCCAAAAAA CATGGTGGGC CAAAAGATCA AGAGAGGCAT 
GTTGGAGACC TGGGCAATGT GACTGCTGGC AAGGATGGCG TGGCCATTGT GTCCATAGAA 
GATTCTCTGA TTGCACTCTC AGGAGACTAT TCCATCATTG GCCGCACCAT GGTGGTCCAC 
GAGAAACGAG ATGACTTGGG CAAAGGTGAC AATGAAGAAA GTACACAGAC AGGAAACGCC 
GGGAGTCGTT TGGCTTGTGG TGTCATTGGG ATCGCCCAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Evidence of a genomic insertion in intron 2 of SOD1 causing allelic drop-out during routine diagnostic testing for canine degenerative myelopathy.
Animal genetics48(3)365-368(2017 Jun)
Turba ME,Loechel R,Rombol? E,Gandini G,Gentilini F

Distribution of superoxide dismutase 1 and glutathione peroxidase 1 in the cyclic canine endometrium.
Theriogenology86(3)738-48(2016 Aug)
Santos C,Pires Mdos A,Santos D,Payan-Carreira R

Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy.
Proceedings of the National Academy of Sciences of the United States of America113(22)E3091-100(2016 May)
Ivansson EL,Megquier K,Kozyrev SV,Mur?n E,K?rberg IB,Swofford R,Koltookian M,Tonomura N,Zeng R,Kolicheski AL,Hansen L,Katz ML,Johnson GC,Johnson GS,Coates JR,Lindblad-Toh K

Accumulation and aggregate formation of mutant superoxide dismutase 1 in canine degenerative myelopathy.
Neuroscience303229-40(2015 Sep)
Nakamae S,Kobatake Y,Suzuki R,Tsukui T,Kato S,Yamato O,Sakai H,Urushitani M,Maeda S,Kamishina H

Degenerative myelopathy in German Shepherd Dog: comparison of two molecular assays for the identification of the SOD1:c.118G>A mutation.
Molecular biology reports41(2)665-70(2014 Feb)
Capucchio MT,Spalenza V,Biasibetti E,Bottero MT,Rasero R,Dalmasso A,Sacchi P

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SOD1 cDNA ORF clone, Canis lupus familiaris(dog)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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