Gene Symbol | SLC1A2 |
Entrez Gene ID | 403750 |
Full Name | solute carrier family 1 member 2 |
Synonyms | GLT1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Canis lupus familiaris(Dog) |
ORF » Species Summary » Canis lupus familiaris » SLC1A2 cDNA ORF clone
Gene Symbol | SLC1A2 |
Entrez Gene ID | 403750 |
Full Name | solute carrier family 1 member 2 |
Synonyms | GLT1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Canis lupus familiaris(Dog) |
mRNA | Protein | Name |
---|---|---|
XM_022405058.1 | XP_022260766.1 | excitatory amino acid transporter 2 isoform X2 |
XM_014120860.2 | XP_013976335.1 | excitatory amino acid transporter 2 isoform X1 |
XM_022405059.1 | XP_022260767.1 | excitatory amino acid transporter 2 isoform X3 |
NM_001003138.2 | NP_001003138.2 | excitatory amino acid transporter 2 |
XM_022405060.1 | XP_022260768.1 | excitatory amino acid transporter 2 isoform X4 |
XM_014120860.1 | XP_013976335.1 | excitatory amino acid transporter 2 isoform X1 |
Canis lupus familiaris (dog) | SLC1A2 | NP_001003138.1 |
Bos taurus (cattle) | SLC1A2 | XP_002693569.2 |
Rattus norvegicus (Norway rat) | Slc1a2 | NP_058911.2 |
SLC1A2 | XP_001115008.1 | |
Mus musculus (house mouse) | Slc1a2 | NP_001070982.1 |
Xenopus tropicalis (tropical clawed frog) | slc1a2 | XP_002937340.1 |
Homo sapiens (human) | SLC1A2 | NP_004162.2 |
Gallus gallus (chicken) | SLC1A2 | NP_001012917.1 |
Pan troglodytes (chimpanzee) | SLC1A2 | XP_003313030.1 |
Danio rerio (zebrafish) | slc1a2b | NP_956273.1 |
Caenorhabditis elegans (roundworm) | glt-1 | NP_001024393.1 |
Neuronal loss and decreased GLT-1 expression observed in the spinal cord of Pembroke Welsh Corgi dogs with canine degenerative myelopathy.
Ogawa M, Uchida K, Yamato O, Inaba M, Uddin MM, Nakayama H
Veterinary pathology51(3)591-602(2014 May)
Association analysis between canine behavioural traits and genetic polymorphisms in the Shiba Inu breed.
Takeuchi Y, Kaneko F, Hashizume C, Masuda K, Ogata N, Maki T, Inoue-Murayama M, Hart BL, Mori Y
Animal genetics40(5)616-22(2009 Oct)
Increased internalisation and degradation of GLT-1 glial glutamate transporter in a cell model for familial amyotrophic lateral sclerosis (ALS).
Vanoni C, Massari S, Losa M, Carrega P, Perego C, Conforti L, Pietrini G
Journal of cell science117(Pt 22)5417-26(2004 Oct)
Inherited defects of sodium-dependent glutamate transport mediated by glutamate/aspartate transporter in canine red cells due to a decreased level of transporter protein expression.
Sato K, Inaba M, Suwa Y, Matsuu A, Hikasa Y, Ono K, Kagota K
The Journal of biological chemistry275(9)6620-7(2000 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Excitotoxicity related to the reduced expression of GLT-1, but not GLAST, may be involved in neuron loss in canine degenerative myelopathy.
Title: Neuronal loss and decreased GLT-1 expression observed in the spinal cord of Pembroke Welsh Corgi dogs with canine degenerative myelopathy.
The c.471T>C polymorphism in the solute carrier family 1 (neuronal/epithelial high-affinity glutamate transporter) member 2 (SLC1A2) gene is associated with some types of aggressive behaviour in the Shiba Inu.
Title: Association analysis between canine behavioural traits and genetic polymorphisms in the Shiba Inu breed.
the continuous expression of mutant SOD1 causes the downregulation of GLT-1 by increasing the internalisation and degradation of the surface transporter, and the cytosolic tail of GLT-1 is required to targets the transporter to degradation
Title: Increased internalisation and degradation of GLT-1 glial glutamate transporter in a cell model for familial amyotrophic lateral sclerosis (ALS).
The following SLC1A2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC1A2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCe140213 | |
Clone ID Related Accession (Same CDS sequence) | NM_001003138.2 | |
Accession Version | NM_001003138.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1698bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-22 | |
Organism | Canis lupus familiaris(dog) | |
Product | excitatory amino acid transporter 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AAEX03011384.1 and AAEX03011386.1. On Sep 4, 2015 this sequence version replaced NM_001003138.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AF167076.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCCCAAGC AGGTGGAAGT ACGAATGCAC GACAGCCATC TCAGCTCAGA GGAGCCGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001003138.2 |
CDS | 75..1772 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001003138.2 |
1 | ATGCCCAAGC AGGTGGAAGT ACGAATGCAC GACAGCCATC TCAGCTCAGA GGAGCCGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe294576 | |
Clone ID Related Accession (Same CDS sequence) | XM_022405058.1 | |
Accession Version | XM_022405058.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1761bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | excitatory amino acid transporter 2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006600.3) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTACGAGA GTGGAGATGT GCTGGTCACT CAGGCGGGTG GACAAGGAGT GCGAAGTTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_022260766.1 |
CDS | 27..1787 |
Translation |
Target ORF information:
Target ORF information:
|
XM_022405058.1 |
1 | ATGTACGAGA GTGGAGATGT GCTGGTCACT CAGGCGGGTG GACAAGGAGT GCGAAGTTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe294577 | |
Clone ID Related Accession (Same CDS sequence) | XM_022405059.1 | |
Accession Version | XM_022405059.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1740bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | excitatory amino acid transporter 2 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006600.3) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGAGGC CTGAGGACCA TATCCGGAGA AGTGCCAACA ACATGCCCAA GCAGGTGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_022260767.1 |
CDS | 117..1856 |
Translation |
Target ORF information:
Target ORF information:
|
XM_022405059.1 |
1 | ATGAAGAGGC CTGAGGACCA TATCCGGAGA AGTGCCAACA ACATGCCCAA GCAGGTGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe294578 | |
Clone ID Related Accession (Same CDS sequence) | XM_022405060.1 | |
Accession Version | XM_022405060.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1716bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | excitatory amino acid transporter 2 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006600.3) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGTCAGTG CCAACAACAT GCCCAAGCAG GTGGAAGTAC GAATGCACGA CAGCCATCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_022260768.1 |
CDS | 15..1730 |
Translation |
Target ORF information:
Target ORF information:
|
XM_022405060.1 |
1 | ATGGTCAGTG CCAACAACAT GCCCAAGCAG GTGGAAGTAC GAATGCACGA CAGCCATCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe41036 | |
Clone ID Related Accession (Same CDS sequence) | XM_014120860.2 , XM_014120860.1 | |
Accession Version | XM_014120860.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1797bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | excitatory amino acid transporter 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006600.3) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 5, 2017 this sequence version replaced XM_014120860.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTACGAGA GTGGAGATGT GCTGGTCACT CAGGCGGGTG GACAAGGAGT GCGAAGTTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_013976335.1 |
CDS | 26..1822 |
Translation |
Target ORF information:
Target ORF information:
|
XM_014120860.2 |
1 | ATGTACGAGA GTGGAGATGT GCTGGTCACT CAGGCGGGTG GACAAGGAGT GCGAAGTTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe41036 | |
Clone ID Related Accession (Same CDS sequence) | XM_014120860.2 , XM_014120860.1 | |
Accession Version | XM_014120860.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1797bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-09-16 | |
Organism | Canis lupus familiaris(Dog) | |
Product | excitatory amino acid transporter 2 isoform X1 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726092.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTACGAGA GTGGAGATGT GCTGGTCACT CAGGCGGGTG GACAAGGAGT GCGAAGTTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_013976335.1 |
CDS | 11..1807 |
Translation |
Target ORF information:
Target ORF information:
|
XM_014120860.1 |
1 | ATGTACGAGA GTGGAGATGT GCTGGTCACT CAGGCGGGTG GACAAGGAGT GCGAAGTTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Neuronal loss and decreased GLT-1 expression observed in the spinal cord of Pembroke Welsh Corgi dogs with canine degenerative myelopathy. |
Association analysis between canine behavioural traits and genetic polymorphisms in the Shiba Inu breed. |
Increased internalisation and degradation of GLT-1 glial glutamate transporter in a cell model for familial amyotrophic lateral sclerosis (ALS). |
Inherited defects of sodium-dependent glutamate transport mediated by glutamate/aspartate transporter in canine red cells due to a decreased level of transporter protein expression. |