Gene Symbol | XDH |
Entrez Gene ID | 280960 |
Full Name | xanthine dehydrogenase |
Synonyms | XOR |
General protein information |
|
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » XDH cDNA ORF clone
Gene Symbol | XDH |
Entrez Gene ID | 280960 |
Full Name | xanthine dehydrogenase |
Synonyms | XOR |
General protein information |
|
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
NM_173972.2 | NP_776397.1 | xanthine dehydrogenase/oxidase |
Pan troglodytes (chimpanzee) | XDH | XP_525729.2 |
Canis lupus familiaris (dog) | XDH | XP_540143.2 |
Bos taurus (cattle) | XDH | NP_776397.1 |
Gallus gallus (chicken) | XDH | NP_990458.1 |
Drosophila melanogaster (fruit fly) | ry | NP_524337.1 |
Arabidopsis thaliana (thale cress) | XDH1 | NP_195215.2 |
Oryza sativa (rice) | Os03g0429800 | NP_001050420.1 |
Homo sapiens (human) | XDH | NP_000370.2 |
Danio rerio (zebrafish) | xdh | XP_688983.3 |
Caenorhabditis elegans (roundworm) | F55B11.1 | NP_502747.1 |
Arabidopsis thaliana (thale cress) | XDH2 | NP_195216.2 |
Magnaporthe oryzae (rice blast fungus) | MGG_12738 | XP_003716708.1 |
Neurospora crassa | NCU03350 | XP_956459.2 |
Rattus norvegicus (Norway rat) | Xdh | NP_058850.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100497499 | XP_004914866.1 |
XDH | XP_002808080.1 | |
Mus musculus (house mouse) | Xdh | NP_035853.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP007918 | XP_317568.3 |
Measurement and characterization of superoxide generation from xanthine dehydrogenase: a redox-regulated pathway of radical generation in ischemic tissues.
Lee MC, Velayutham M, Komatsu T, Hille R, Zweier JL
Biochemistry53(41)6615-23(2014 Oct)
Modeling the effects of estradiol and progesterone on the acute phase proinflammatory axis: variability in tumor necrosis factor-?, nitric oxide, and xanthine oxidase responses to endotoxin challenge in steers.
Kahl S, Elsasser TH, Li CJ
Domestic animal endocrinology40(4)213-21(2011 May)
Crystal structures of urate bound form of xanthine oxidoreductase: substrate orientation and structure of the key reaction intermediate.
Okamoto K, Kawaguchi Y, Eger BT, Pai EF, Nishino T
Journal of the American Chemical Society132(48)17080-3(2010 Dec)
Substrate orientation and catalytic specificity in the action of xanthine oxidase: the sequential hydroxylation of hypoxanthine to uric acid.
Cao H, Pauff JM, Hille R
The Journal of biological chemistry285(36)28044-53(2010 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data suggest that XDH (xanthine dehydrogenase) can be an important redox-regulated source of superoxide generation in ischemic tissue; conversion XDH to XO (xanthine oxidase) is not required to activate radical formation and subsequent tissue injury.
Title: Measurement and characterization of superoxide generation from xanthine dehydrogenase: a redox-regulated pathway of radical generation in ischemic tissues.
Plasma tumor necrosis factor-alpha response to either of two lipopolysaccharide challenges was lower in progesterone-treated than in 17beta-estradiol-treated steers. Xanthine oxidase response to either challenge was greater for estradiol-treated steers.
Title: Modeling the effects of estradiol and progesterone on the acute phase proinflammatory axis: variability in tumor necrosis factor-?, nitric oxide, and xanthine oxidase responses to endotoxin challenge in steers.
crystal structures of the urate complexes of the demolybdo-form of the D428A mutant of rat xanthine oxidoreductase and of the reduced bovine milk enzyme [XOR]
Title: Crystal structures of urate bound form of xanthine oxidoreductase: substrate orientation and structure of the key reaction intermediate.
6,8-dihydroxypurine is effectively converted to uric acid by xanthine oxidase.
Title: Substrate orientation and catalytic specificity in the action of xanthine oxidase: the sequential hydroxylation of hypoxanthine to uric acid.
Hydrogen peroxide is the major oxidant product of xanthine oxidase
Title: Hydrogen peroxide is the major oxidant product of xanthine oxidase.
The following XDH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the XDH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa41783 | |
Clone ID Related Accession (Same CDS sequence) | NM_173972.2 | |
Accession Version | NM_173972.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3999bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-20 | |
Organism | Bos taurus(cattle) | |
Product | xanthine dehydrogenase/oxidase | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X83508.1. On Jun 3, 2003 this sequence version replaced NM_173972.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X83508.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN03145412, SAMN03145413 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGACAGCAG ATGAATTGGT TTTCTTTGTG AATGGCAAAA AGGTGGTGGA GAAAAATGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_776397.1 |
CDS | 97..4095 |
Translation |
Target ORF information:
Target ORF information:
|
NM_173972.2 |
1 | ATGACAGCAG ATGAATTGGT TTTCTTTGTG AATGGCAAAA AGGTGGTGGA GAAAAATGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Measurement and characterization of superoxide generation from xanthine dehydrogenase: a redox-regulated pathway of radical generation in ischemic tissues. |
Modeling the effects of estradiol and progesterone on the acute phase proinflammatory axis: variability in tumor necrosis factor-?, nitric oxide, and xanthine oxidase responses to endotoxin challenge in steers. |
Crystal structures of urate bound form of xanthine oxidoreductase: substrate orientation and structure of the key reaction intermediate. |
Substrate orientation and catalytic specificity in the action of xanthine oxidase: the sequential hydroxylation of hypoxanthine to uric acid. |