Gene Symbol | COMP |
Entrez Gene ID | 281088 |
Full Name | cartilage oligomeric matrix protein |
General protein information |
|
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » COMP cDNA ORF clone
Gene Symbol | COMP |
Entrez Gene ID | 281088 |
Full Name | cartilage oligomeric matrix protein |
General protein information |
|
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
NM_001166517.1 | NP_001159989.1 | cartilage oligomeric matrix protein precursor |
NM_001166517.2 | NP_001159989.2 | cartilage oligomeric matrix protein precursor |
COMP | XP_001115565.1 | |
Canis lupus familiaris (dog) | COMP | XP_533869.2 |
Gallus gallus (chicken) | COMP | XP_418238.2 |
Homo sapiens (human) | COMP | NP_000086.2 |
Danio rerio (zebrafish) | im:7154332 | XP_002663752.3 |
Rattus norvegicus (Norway rat) | Comp | NP_036966.1 |
Drosophila melanogaster (fruit fly) | Tsp | NP_523495.2 |
Xenopus tropicalis (tropical clawed frog) | comp | XP_002940251.2 |
Pan troglodytes (chimpanzee) | COMP | NP_001092035.1 |
Bos taurus (cattle) | COMP | NP_001159989.1 |
Mus musculus (house mouse) | Comp | NP_057894.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP002157 | XP_308033.5 |
Differential response of cartilage oligomeric matrix protein (COMP) to morphogens of bone morphogenetic protein/transforming growth factor-? family in the surface, middle and deep zones of articular cartilage.
Motaung SC, Di Cesare PE, Reddi AH
Journal of tissue engineering and regenerative medicine5(6)e87-96(2011 Jun)
A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)
COMP acts as a catalyst in collagen fibrillogenesis.
Hal?sz K, Kassner A, M?rgelin M, Heineg?rd D
The Journal of biological chemistry282(43)31166-73(2007 Oct)
Expression of PSACH-associated mutant COMP in tendon fibroblasts leads to increased apoptotic cell death irrespective of the secretory characteristics of mutant COMP.
Weirich C, Keene DR, Kirsch K, Heil M, Neumann E, Dinser R
Matrix biology : journal of the International Society for Matrix Biology26(4)314-23(2007 May)
Effects of simple and complex motion patterns on gene expression of chondrocytes seeded in 3D scaffolds.
Grad S, Gogolewski S, Alini M, Wimmer MA
Tissue engineering12(11)3171-9(2006 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
COMP synthesis is differentially regulated by TGFbeta1 in the surface and middle zones of bovine articular cartilage.
Title: Differential response of cartilage oligomeric matrix protein (COMP) to morphogens of bone morphogenetic protein/transforming growth factor-? family in the surface, middle and deep zones of articular cartilage.
COMP acts as a catalyst in collagen fibrillogenesis.
Title: COMP acts as a catalyst in collagen fibrillogenesis.
COMP mutant expression in tendon fibroblasts leads to increased apoptotic cell death irrespective of the secretory characteristics of mutant COMP
Title: Expression of PSACH-associated mutant COMP in tendon fibroblasts leads to increased apoptotic cell death irrespective of the secretory characteristics of mutant COMP.
COMP mRNA expression level was markedly increased by ball oscillation.
Title: Effects of simple and complex motion patterns on gene expression of chondrocytes seeded in 3D scaffolds.
role for proteinases other than MMPs in the degradation of COMP in cartilage
Title: Cleavage of cartilage oligomeric matrix protein (thrombospondin-5) by matrix metalloproteinases and a disintegrin and metalloproteinase with thrombospondin motifs.
The following COMP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COMP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa239184 | |
Clone ID Related Accession (Same CDS sequence) | NM_001166517.2 | |
Accession Version | NM_001166517.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2271bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-30 | |
Organism | Bos taurus(cattle) | |
Product | cartilage oligomeric matrix protein precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from NKLS02000007.1. On May 30, 2018 this sequence version replaced NM_001166517.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN03145415, SAMN03145418 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGTTCTCG CCGCCGCCCG CGTTCTCTTG CTCACGCTGG CTGCCCTCGG GGCATCAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001159989.2 |
CDS | 28..2298 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001166517.2 |
1 | ATGGTTCTCG CCGCCGCCCG CGTTCTCTTG CTCACGCTGG CTGCCCTCGG GGCATCAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa44504 | |
Clone ID Related Accession (Same CDS sequence) | NM_001166517.1 | |
Accession Version | NM_001166517.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2271bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-01-03 | |
Organism | Bos taurus(cattle) | |
Product | cartilage oligomeric matrix protein precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AAFC03073993.1 and AAFC03073995.1. On Oct 27, 2009 this sequence version replaced XM_591255.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN01093729, SAMN01093733 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGTTCTCG CCGCCGCCCG CGTTCTCTTG CTCACGCTGG CTGCCCTCGG GGCATCAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001159989.1 |
CDS | 28..2298 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001166517.1 |
1 | ATGGTTCTCG CCGCCGCCCG CGTTCTCTTG CTCACGCTGG CTGCCCTCGG GGCATCAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Differential response of cartilage oligomeric matrix protein (COMP) to morphogens of bone morphogenetic protein/transforming growth factor-? family in the surface, middle and deep zones of articular cartilage. |
A whole-genome assembly of the domestic cow, Bos taurus. |
COMP acts as a catalyst in collagen fibrillogenesis. |
Expression of PSACH-associated mutant COMP in tendon fibroblasts leads to increased apoptotic cell death irrespective of the secretory characteristics of mutant COMP. |
Effects of simple and complex motion patterns on gene expression of chondrocytes seeded in 3D scaffolds. |