SOCS3 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Gene Symbol	SOCS3
Entrez Gene ID	282081
Full Name	suppressor of cytokine signaling 3
Synonyms	SSI-3
General protein information	Preferred Names suppressor of cytokine signaling 3 Names suppressor of cytokine signaling 3 SOCS-3
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
XM_005221139.4	XP_005221196.1	suppressor of cytokine signaling 3 isoform X1
XM_005221139.3	XP_005221196.1	suppressor of cytokine signaling 3 isoform X1
NM_174466.2	NP_776891.1	suppressor of cytokine signaling 3

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SOCS3	NP_776891.1
Mus musculus (house mouse)	Socs3	NP_031733.1
Danio rerio (zebrafish)	socs3a	NP_956244.1
Xenopus tropicalis (tropical clawed frog)	socs3	NP_001005696.1
Canis lupus familiaris (dog)	SOCS3	NP_001026801.1
Rattus norvegicus (Norway rat)	Socs3	NP_446017.1
Pan troglodytes (chimpanzee)	SOCS3	XP_001157032.1
Homo sapiens (human)	SOCS3	NP_003946.3
	SOCS3	XP_001106015.2
Gallus gallus (chicken)	SOCS3	NP_989931.1
Danio rerio (zebrafish)	socs3b	NP_998469.1

Gene Ontology
Bibliography

Related articles in PubMed

SOCS3-mediated blockade reveals major contribution of JAK2/STAT5 signaling pathway to lactation and proliferation of dairy cow mammary epithelial cells in vitro.
Huang YL, Zhao F, Luo CC, Zhang X, Si Y, Sun Z, Zhang L, Li QZ, Gao XJ
Molecules (Basel, Switzerland)18(10)12987-3002(2013 Oct)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Expression of interleukin-10 and suppressor of cytokine signaling-3 associated with susceptibility of cattle to infection with Mycobacterium avium subsp paratuberculosis.
Weiss DJ, Evanson OA, Souza CD
American journal of veterinary research66(7)1114-20(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro.
Title: SOCS3-mediated blockade reveals major contribution of JAK2/STAT5 signaling pathway to lactation and proliferation of dairy cow mammary epithelial cells in vitro.

Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
Title: Expression of interleukin-10 and suppressor of cytokine signaling-3 associated with susceptibility of cattle to infection with Mycobacterium avium subsp paratuberculosis.

The following SOCS3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SOCS3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OBa01448	NM_174466.2 Latest version!	Bos taurus suppressor of cytokine signaling 3 (SOCS3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OBa01448	XM_005221139.4 Latest version!	Bos taurus suppressor of cytokine signaling 3 (SOCS3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
View Old Accession Versions >>
OBa01448	XM_005221139.3	Bos taurus suppressor of cytokine signaling 3 (SOCS3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SOCS3 ( NM_174466.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776891.1 Bos taurus suppressor of cytokine signaling 3 (SOCS3), mRNA.

Price & Availability↑

CloneID	OBa01448
Clone ID Related Accession (Same CDS sequence)	XM_005221139.4 , XM_005221139.3 , NM_174466.2
Accession Version	NM_174466.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 690bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Bos taurus(cattle)
Product	suppressor of cytokine signaling 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY026859.1. On Jun 3, 2003 this sequence version replaced NM_174466.1. ##Evidence-Data-START## Transcript exon combination :: AY026859.1 [ECO:0000332] ##Evidence-Data-END##

ATGGTCACCC ACAGCAAGTT TCCCGCCGCC GGGATGAGCC GCCCCCTGGA CACCAGCCTG 
CGCCTCAAGA CCTTCAGCTC CAAGAGCGAG TACCAGCTGG TGGTGAACGC AGTGCGCAAG 
CTGCAGGAGA GCGGCTTTTA CTGGAGCACC GTGACGGGCG GCGAAGCGAA CTTGCTGCTG 
AGCGCCGAGC CCGCGGGCAC CTTCCTCATC CGCGACAGCT CGGACCAGCG CCACTTTTTC 
ACCCTCAGCG TCAAGACCCA GTCGGGGACC AAGAACCTGC GCATCCAGTG CGAGGGGGGC 
AGCTTCTCTC TCCAGAGCGA CCCCCGGAGC ACGCAGCCCG TGCCCCGCTT CGACTGCGTG 
CTCAAGCTGG TGCATCACTA CATGCCCGCC GCCGGCGCCC CCTCGTTCTC CCAGCCCCCC 
GCTGAACCCT CCTCCTCGCC CTCCTCCGAG GTGCCCGAGC AGCCACCGGC CCAGCCGCTC 
TCCGGGAACC CCCCCAGGAG AGCCTATTAC ATCTACTCGG GGGGCGAGAA GATCCCTCTG 
GTGTTGAGCC GGCCCCTCTC CTCCAACGTG GCCACTCTCC AACATCTCTG TCGGAAGACC 
GTCAACGGCC ACCTGGACTC CTACGAGAAA GTCACCCAGC TGCCTGGGCC CATTCGGGAG 
TTCCTGGACC AGTACGATGC CCCGCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776891.1
CDS	11..700
Translation	MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSTVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPAAGAPSFSQPPAEPSSSPSSEVPEQPPAQPLSGNPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL

Target ORF information:

RefSeq Version	NM_174466.2
Organism	Bos taurus(cattle)
Definition	Bos taurus suppressor of cytokine signaling 3 (SOCS3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174466.2

ORF Insert Sequence:

ATGGTCACCC ACAGCAAGTT TCCCGCCGCC GGGATGAGCC GCCCCCTGGA CACCAGCCTG 
CGCCTCAAGA CCTTCAGCTC CAAGAGCGAG TACCAGCTGG TGGTGAACGC AGTGCGCAAG 
CTGCAGGAGA GCGGCTTTTA CTGGAGCACC GTGACGGGCG GCGAAGCGAA CTTGCTGCTG 
AGCGCCGAGC CCGCGGGCAC CTTCCTCATC CGCGACAGCT CGGACCAGCG CCACTTTTTC 
ACCCTCAGCG TCAAGACCCA GTCGGGGACC AAGAACCTGC GCATCCAGTG CGAGGGGGGC 
AGCTTCTCTC TCCAGAGCGA CCCCCGGAGC ACGCAGCCCG TGCCCCGCTT CGACTGCGTG 
CTCAAGCTGG TGCATCACTA CATGCCCGCC GCCGGCGCCC CCTCGTTCTC CCAGCCCCCC 
GCTGAACCCT CCTCCTCGCC CTCCTCCGAG GTGCCCGAGC AGCCACCGGC CCAGCCGCTC 
TCCGGGAACC CCCCCAGGAG AGCCTATTAC ATCTACTCGG GGGGCGAGAA GATCCCTCTG 
GTGTTGAGCC GGCCCCTCTC CTCCAACGTG GCCACTCTCC AACATCTCTG TCGGAAGACC 
GTCAACGGCC ACCTGGACTC CTACGAGAAA GTCACCCAGC TGCCTGGGCC CATTCGGGAG 
TTCCTGGACC AGTACGATGC CCCGCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SOCS3 ( XM_005221139.4 ) cDNA ORF clone, Bos taurus(cattle) -> XP_005221196.1 Bos taurus suppressor of cytokine signaling 3 (SOCS3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OBa01448
Clone ID Related Accession (Same CDS sequence)	XM_005221139.4 , XM_005221139.3 , NM_174466.2
Accession Version	XM_005221139.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 690bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-06
Organism	Bos taurus(cattle)
Product	suppressor of cytokine signaling 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037346.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 7, 2018 this sequence version replaced XM_005221139.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCACCC ACAGCAAGTT TCCCGCCGCC GGGATGAGCC GCCCCCTGGA CACCAGCCTG 
CGCCTCAAGA CCTTCAGCTC CAAGAGCGAG TACCAGCTGG TGGTGAACGC AGTGCGCAAG 
CTGCAGGAGA GCGGCTTTTA CTGGAGCACC GTGACGGGCG GCGAAGCGAA CTTGCTGCTG 
AGCGCCGAGC CCGCGGGCAC CTTCCTCATC CGCGACAGCT CGGACCAGCG CCACTTTTTC 
ACCCTCAGCG TCAAGACCCA GTCGGGGACC AAGAACCTGC GCATCCAGTG CGAGGGGGGC 
AGCTTCTCTC TCCAGAGCGA CCCCCGGAGC ACGCAGCCCG TGCCCCGCTT CGACTGCGTG 
CTCAAGCTGG TGCATCACTA CATGCCCGCC GCCGGCGCCC CCTCGTTCTC CCAGCCCCCC 
GCTGAACCCT CCTCCTCGCC CTCCTCCGAG GTGCCCGAGC AGCCACCGGC CCAGCCGCTC 
TCCGGGAACC CCCCCAGGAG AGCCTATTAC ATCTACTCGG GGGGCGAGAA GATCCCTCTG 
GTGTTGAGCC GGCCCCTCTC CTCCAACGTG GCCACTCTCC AACATCTCTG TCGGAAGACC 
GTCAACGGCC ACCTGGACTC CTACGAGAAA GTCACCCAGC TGCCTGGGCC CATTCGGGAG 
TTCCTGGACC AGTACGATGC CCCGCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005221196.1
CDS	278..967
Translation	MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSTVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPAAGAPSFSQPPAEPSSSPSSEVPEQPPAQPLSGNPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL

Target ORF information:

RefSeq Version	XM_005221139.4
Organism	Bos taurus(cattle)
Definition	Bos taurus suppressor of cytokine signaling 3 (SOCS3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005221139.4

ORF Insert Sequence:

ATGGTCACCC ACAGCAAGTT TCCCGCCGCC GGGATGAGCC GCCCCCTGGA CACCAGCCTG 
CGCCTCAAGA CCTTCAGCTC CAAGAGCGAG TACCAGCTGG TGGTGAACGC AGTGCGCAAG 
CTGCAGGAGA GCGGCTTTTA CTGGAGCACC GTGACGGGCG GCGAAGCGAA CTTGCTGCTG 
AGCGCCGAGC CCGCGGGCAC CTTCCTCATC CGCGACAGCT CGGACCAGCG CCACTTTTTC 
ACCCTCAGCG TCAAGACCCA GTCGGGGACC AAGAACCTGC GCATCCAGTG CGAGGGGGGC 
AGCTTCTCTC TCCAGAGCGA CCCCCGGAGC ACGCAGCCCG TGCCCCGCTT CGACTGCGTG 
CTCAAGCTGG TGCATCACTA CATGCCCGCC GCCGGCGCCC CCTCGTTCTC CCAGCCCCCC 
GCTGAACCCT CCTCCTCGCC CTCCTCCGAG GTGCCCGAGC AGCCACCGGC CCAGCCGCTC 
TCCGGGAACC CCCCCAGGAG AGCCTATTAC ATCTACTCGG GGGGCGAGAA GATCCCTCTG 
GTGTTGAGCC GGCCCCTCTC CTCCAACGTG GCCACTCTCC AACATCTCTG TCGGAAGACC 
GTCAACGGCC ACCTGGACTC CTACGAGAAA GTCACCCAGC TGCCTGGGCC CATTCGGGAG 
TTCCTGGACC AGTACGATGC CCCGCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SOCS3 ( XM_005221139.3 ) cDNA ORF clone, Bos taurus(cattle) -> XP_005221196.1 Bos taurus suppressor of cytokine signaling 3 (SOCS3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OBa01448
Clone ID Related Accession (Same CDS sequence)	XM_005221139.4 , XM_005221139.3 , NM_174466.2
Accession Version	XM_005221139.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 690bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-01-25
Organism	Bos taurus(cattle)
Product	suppressor of cytokine signaling 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003104499.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 26, 2016 this sequence version replaced XM_005221139.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCACCC ACAGCAAGTT TCCCGCCGCC GGGATGAGCC GCCCCCTGGA CACCAGCCTG 
CGCCTCAAGA CCTTCAGCTC CAAGAGCGAG TACCAGCTGG TGGTGAACGC AGTGCGCAAG 
CTGCAGGAGA GCGGCTTTTA CTGGAGCACC GTGACGGGCG GCGAAGCGAA CTTGCTGCTG 
AGCGCCGAGC CCGCGGGCAC CTTCCTCATC CGCGACAGCT CGGACCAGCG CCACTTTTTC 
ACCCTCAGCG TCAAGACCCA GTCGGGGACC AAGAACCTGC GCATCCAGTG CGAGGGGGGC 
AGCTTCTCTC TCCAGAGCGA CCCCCGGAGC ACGCAGCCCG TGCCCCGCTT CGACTGCGTG 
CTCAAGCTGG TGCATCACTA CATGCCCGCC GCCGGCGCCC CCTCGTTCTC CCAGCCCCCC 
GCTGAACCCT CCTCCTCGCC CTCCTCCGAG GTGCCCGAGC AGCCACCGGC CCAGCCGCTC 
TCCGGGAACC CCCCCAGGAG AGCCTATTAC ATCTACTCGG GGGGCGAGAA GATCCCTCTG 
GTGTTGAGCC GGCCCCTCTC CTCCAACGTG GCCACTCTCC AACATCTCTG TCGGAAGACC 
GTCAACGGCC ACCTGGACTC CTACGAGAAA GTCACCCAGC TGCCTGGGCC CATTCGGGAG 
TTCCTGGACC AGTACGATGC CCCGCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005221196.1
CDS	140..829
Translation	MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSTVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPAAGAPSFSQPPAEPSSSPSSEVPEQPPAQPLSGNPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL

Target ORF information:

RefSeq Version	XM_005221139.3
Organism	Bos taurus(cattle)
Definition	Bos taurus suppressor of cytokine signaling 3 (SOCS3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005221139.3

ORF Insert Sequence:

ATGGTCACCC ACAGCAAGTT TCCCGCCGCC GGGATGAGCC GCCCCCTGGA CACCAGCCTG 
CGCCTCAAGA CCTTCAGCTC CAAGAGCGAG TACCAGCTGG TGGTGAACGC AGTGCGCAAG 
CTGCAGGAGA GCGGCTTTTA CTGGAGCACC GTGACGGGCG GCGAAGCGAA CTTGCTGCTG 
AGCGCCGAGC CCGCGGGCAC CTTCCTCATC CGCGACAGCT CGGACCAGCG CCACTTTTTC 
ACCCTCAGCG TCAAGACCCA GTCGGGGACC AAGAACCTGC GCATCCAGTG CGAGGGGGGC 
AGCTTCTCTC TCCAGAGCGA CCCCCGGAGC ACGCAGCCCG TGCCCCGCTT CGACTGCGTG 
CTCAAGCTGG TGCATCACTA CATGCCCGCC GCCGGCGCCC CCTCGTTCTC CCAGCCCCCC 
GCTGAACCCT CCTCCTCGCC CTCCTCCGAG GTGCCCGAGC AGCCACCGGC CCAGCCGCTC 
TCCGGGAACC CCCCCAGGAG AGCCTATTAC ATCTACTCGG GGGGCGAGAA GATCCCTCTG 
GTGTTGAGCC GGCCCCTCTC CTCCAACGTG GCCACTCTCC AACATCTCTG TCGGAAGACC 
GTCAACGGCC ACCTGGACTC CTACGAGAAA GTCACCCAGC TGCCTGGGCC CATTCGGGAG 
TTCCTGGACC AGTACGATGC CCCGCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SOCS3-mediated blockade reveals major contribution of JAK2/STAT5 signaling pathway to lactation and proliferation of dairy cow mammary epithelial cells in vitro.
Molecules (Basel, Switzerland)18(10)12987-3002(2013 Oct)
Huang YL,Zhao F,Luo CC,Zhang X,Si Y,Sun Z,Zhang L,Li QZ,Gao XJ

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Expression of interleukin-10 and suppressor of cytokine signaling-3 associated with susceptibility of cattle to infection with Mycobacterium avium subsp paratuberculosis.
American journal of veterinary research66(7)1114-20(2005 Jul)
Weiss DJ,Evanson OA,Souza CD

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SOCS3 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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