IL2RA cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Gene Symbol	IL2RA
Entrez Gene ID	403870
Full Name	interleukin 2 receptor subunit alpha
Synonyms	CD25,IL-2RA
General protein information	Preferred Names interleukin 2 receptor subunit alpha Names interleukin-2 receptor subunit alpha IL-2 receptor subunit alpha IL-2R subunit alpha TAC antigen interleukin 2 receptor alpha chain
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
XM_005617076.3	XP_005617133.1	interleukin-2 receptor subunit alpha isoform X1
XM_022405275.1	XP_022260983.1	interleukin-2 receptor subunit alpha isoform X2
XM_005617076.2	XP_005617133.1	interleukin-2 receptor subunit alpha isoform X1
NM_001003211.2	NP_001003211.2	interleukin-2 receptor subunit alpha precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Il2ra	NP_037295.1
Homo sapiens (human)	IL2RA	NP_000408.1
Pan troglodytes (chimpanzee)	IL2RA	NP_001030597.1
	IL2RA	NP_001028089.1
Bos taurus (cattle)	IL2RA	NP_776783.1
Mus musculus (house mouse)	Il2ra	NP_032393.3
Canis lupus familiaris (dog)	IL2RA	NP_001003211.1

Gene Ontology
Bibliography

Related articles in PubMed

Increased numbers of FoxP3-expressing CD4+ CD25+ regulatory T cells in peripheral blood from dogs with atopic dermatitis and its correlation with disease severity.
Hauck V, H?gli P, Meli ML, Rostaher A, Fischer N, Hofmann-Lehmann R, Favrot C
Veterinary dermatology27(1)26-e9(2016 Feb)

Genome-Wide Scan for Visceral Leishmaniasis in Mixed-Breed Dogs Identifies Candidate Genes Involved in T Helper Cells and Macrophage Signaling.
Utsunomiya YT, Ribeiro ?S, Quintal AP, Sangalli JR, Gazola VR, Paula HB, Trinconi CM, Lima VM, Perri SH, Taylor JF, Schnabel RD, Sonstegard TS, Garcia JF, Nunes CM
PloS one10(9)e0136749(2015)

Cloning and expression of canine CD25 for validation of an anti-human CD25 antibody to compare T regulatory lymphocytes in healthy dogs and dogs with osteosarcoma.
Rissetto KC, Rindt H, Selting KA, Villamil JA, Henry CJ, Reinero CR
Veterinary immunology and immunopathology135(1-2)137-45(2010 May)

Crossreactivity of antibodies to canine CD25 and Foxp3 and identification of canine CD4+CD25 +Foxp3+ cells in canine peripheral blood.
Mizuno T, Suzuki R, Umeki S, Okuda M
The Journal of veterinary medical science71(12)1561-8(2009 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that in dogs, as in humans, CD4(+) CD25(+) FoxP3(+) Tregs may contribute to the pathogenesis of canine atopic dermatitis as indicated by an association between Treg frequency and disease severity.
Title: Increased numbers of FoxP3-expressing CD4+ CD25+ regulatory T cells in peripheral blood from dogs with atopic dermatitis and its correlation with disease severity.

these findings suggest that the human and mouse model for protective response against Leishmania spp., which involves Th1 and macrophage modulation by interleukins 2, 15, gamma interferon and Notch signaling, may also hold for the canine model.
Title: Genome-Wide Scan for Visceral Leishmaniasis in Mixed-Breed Dogs Identifies Candidate Genes Involved in T Helper Cells and Macrophage Signaling.

This study indicated that the activation of canine lymphocytes might induce the production of adaptive Treg cells, as observed in humans.
Title: Crossreactivity of antibodies to canine CD25 and Foxp3 and identification of canine CD4+CD25 +Foxp3+ cells in canine peripheral blood.

The following IL2RA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL2RA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OCe34324	NM_001003211.2 Latest version!	Canis lupus familiaris interleukin 2 receptor subunit alpha (IL2RA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OCe02758	XM_005617076.3 Latest version!	Canis lupus familiaris interleukin 2 receptor subunit alpha (IL2RA), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OCe286518	XM_022405275.1 Latest version!	Canis lupus familiaris interleukin 2 receptor subunit alpha (IL2RA), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00
View Old Accession Versions >>
OCe02758	XM_005617076.2	Canis lupus familiaris interleukin 2 receptor, alpha (IL2RA), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL2RA ( NM_001003211.2 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001003211.2 Canis lupus familiaris interleukin 2 receptor subunit alpha (IL2RA), mRNA.

Price & Availability↑

CloneID	OCe34324
Clone ID Related Accession (Same CDS sequence)	NM_001003211.2
Accession Version	NM_001003211.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 807bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Canis lupus familiaris(dog)
Product	interleukin-2 receptor subunit alpha precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB501356.1 and GU207463.1. On May 9, 2015 this sequence version replaced NM_001003211.1. ##Evidence-Data-START## Transcript exon combination :: AB501356.1, AF056491.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4547746, SAMN00013598 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCAT GTTTGCTGAT GTGGGGAATC CTTACATTCA TCACAGTATC TGGCTACACG 
ACAGACCTCT GTGATGATGA CCCACCAAAC CTCAAACACG CCACATTCAA AGCTCTCACA 
TACAAGACAG GCACGGTGTT AAATTGTGAT TGTGAGAGGG GCTTCCGCAG AATAAGCAGC 
TACATGCATT GTACAGGAAA CTCTAGCCAT GCTTCCTGGG AAAACAAATG TCAGTGCAAA 
AGTATATCCC CAGAGAACAG AAAAGGAAAA GTTACCACTA AACCTGAGGA ACAGAAGGGA 
GAAAACCCCA CAGAAATGCA GAGCCAAACG CCGCCCATGG ACGAAGTTGA CCTTGTAGGT 
CACTGCAGGG AGCCTCCTCC CTGGGAACAT GAAAACTCCA AGAGAATTTA CCACTTTGTA 
GTGGGGCAGA CACTTCACTA CCAGTGCATG CAGGGATTCA CAGCCCTCCA CAGAGGTCCT 
GCCAAGAGCA TCTGCAAAAC CATCTTTGGG AAGACCAGAT GGACGCAGCC CCCGCTCAAG 
TGCATAAGTG AAAGTCAGTT TCCAGATGAC GAAGAGCTTC AAGCAAGCAC TGATGCTCCT 
GCTGGGAGGG ACACTTCGTC TCCCTTCATA ACGACAAGTA CTCCAGATTT CCACAAACAC 
ACAGAAGTGG CTACAACCAT GGAGTCATTC ATATTCACAA CCGAGTATCA GATAGCAGTG 
GCGAGCTGCG TCCTCCTGCT GATCAGCATC GTCCTGCTGA GTGGGCTCAC CTGGCAGCGG 
AGAAGGAGGA AGAGTAGAAC AATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003211.2
CDS	51..857
Translation	MEPCLLMWGILTFITVSGYTTDLCDDDPPNLKHATFKALTYKTGTVLNCDCERGFRRISSYMHCTGNSSHASWENKCQCKSISPENRKGKVTTKPEEQKGENPTEMQSQTPPMDEVDLVGHCREPPPWEHENSKRIYHFVVGQTLHYQCMQGFTALHRGPAKSICKTIFGKTRWTQPPLKCISESQFPDDEELQASTDAPAGRDTSSPFITTSTPDFHKHTEVATTMESFIFTTEYQIAVASCVLLLISIVLLSGLTWQRRRRKSRTI

Target ORF information:

RefSeq Version	NM_001003211.2
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris interleukin 2 receptor subunit alpha (IL2RA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003211.2

ORF Insert Sequence:

ATGGAGCCAT GTTTGCTGAT GTGGGGAATC CTTACATTCA TCACAGTATC TGGCTACACG 
ACAGACCTCT GTGATGATGA CCCACCAAAC CTCAAACACG CCACATTCAA AGCTCTCACA 
TACAAGACAG GCACGGTGTT AAATTGTGAT TGTGAGAGGG GCTTCCGCAG AATAAGCAGC 
TACATGCATT GTACAGGAAA CTCTAGCCAT GCTTCCTGGG AAAACAAATG TCAGTGCAAA 
AGTATATCCC CAGAGAACAG AAAAGGAAAA GTTACCACTA AACCTGAGGA ACAGAAGGGA 
GAAAACCCCA CAGAAATGCA GAGCCAAACG CCGCCCATGG ACGAAGTTGA CCTTGTAGGT 
CACTGCAGGG AGCCTCCTCC CTGGGAACAT GAAAACTCCA AGAGAATTTA CCACTTTGTA 
GTGGGGCAGA CACTTCACTA CCAGTGCATG CAGGGATTCA CAGCCCTCCA CAGAGGTCCT 
GCCAAGAGCA TCTGCAAAAC CATCTTTGGG AAGACCAGAT GGACGCAGCC CCCGCTCAAG 
TGCATAAGTG AAAGTCAGTT TCCAGATGAC GAAGAGCTTC AAGCAAGCAC TGATGCTCCT 
GCTGGGAGGG ACACTTCGTC TCCCTTCATA ACGACAAGTA CTCCAGATTT CCACAAACAC 
ACAGAAGTGG CTACAACCAT GGAGTCATTC ATATTCACAA CCGAGTATCA GATAGCAGTG 
GCGAGCTGCG TCCTCCTGCT GATCAGCATC GTCCTGCTGA GTGGGCTCAC CTGGCAGCGG 
AGAAGGAGGA AGAGTAGAAC AATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL2RA ( XM_005617076.3 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_005617133.1 Canis lupus familiaris interleukin 2 receptor subunit alpha (IL2RA), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OCe02758
Clone ID Related Accession (Same CDS sequence)	XM_005617076.3 , XM_005617076.2
Accession Version	XM_005617076.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-04
Organism	Canis lupus familiaris(dog)
Product	interleukin-2 receptor subunit alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006584.3) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Sep 5, 2017 this sequence version replaced XM_005617076.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCAT GTTTGCTGAT GTGGGGAATC CTTACATTCA TCACAGTATC TGGCTACACG 
ACAGACCTCT GTGATGATGA CCCACCAAAC CTCAAACACG CCACATTCAA AGCTCTCACA 
TACAAGACAG GCACGGTGTT AAATTGTGAT TGTGAGAGGG GCTTCCGCAG AATAAGCAGC 
TACATGCATT GTACAGGAAA CTCTAGCCAT GCTTCCTGGG AAAACAAATG TCAGTGCAAA 
AGTATATCCC CAGAGAACAG AAAAGGAAAA GTTACCACTA AACCTGAGGA ACAGAAGGGA 
GAAAACCCCA CAGAAATGCA GAGCCAAACG CCGCCCATGG ACGAAGTTGA CCTTGTAGGT 
CACTGCAGGG AGCCTCCTCC CTGGGAACAT GAAAACTCCA AGAGAATTTA CCACTTTGTA 
GTGGGGCAGA CACTTCACTA CCAGTGCATG CAGGGATTCA CAGCCCTCCA CAGAGGTCCT 
GCCAAGAGCA TCTGCAAAAC CATCTTTGGG AAGACCAGAT GGACGCAGCC CCCGCTCAAG 
TGCATAAGTG AAAGTCAGTT TCCAGATGAC GAAGAGCTTC AAGCAAGCAC TGATGCTCCT 
GCTGGGAGGG ACACTTCGTC TCCCTTCATA ACGACAAGTA CTCCAGATTT CCACAAACAC 
ACAGAAGTGG CTACAACCAT GGAGTCATTC ATATTCACAA CCGAGTATCA GATAGCAGTG 
GCGAGCTGCG TCCTCCTGCT GATCAGCATC GTCCTGCTGA GTGGGCTCAC CTGGCAGCGG 
AGAAGTTTCC AGTCTGACAT AGAAAGAACT TGGAAGCCAC TTTCTCCCCT CCTACCAACA 
AGAAAAGTCC CAAACAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005617133.1
CDS	2046..2906
Translation	MEPCLLMWGILTFITVSGYTTDLCDDDPPNLKHATFKALTYKTGTVLNCDCERGFRRISSYMHCTGNSSHASWENKCQCKSISPENRKGKVTTKPEEQKGENPTEMQSQTPPMDEVDLVGHCREPPPWEHENSKRIYHFVVGQTLHYQCMQGFTALHRGPAKSICKTIFGKTRWTQPPLKCISESQFPDDEELQASTDAPAGRDTSSPFITTSTPDFHKHTEVATTMESFIFTTEYQIAVASCVLLLISIVLLSGLTWQRRSFQSDIERTWKPLSPLLPTRKVPNN

Target ORF information:

RefSeq Version	XM_005617076.3
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris interleukin 2 receptor subunit alpha (IL2RA), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005617076.3

ORF Insert Sequence:

ATGGAGCCAT GTTTGCTGAT GTGGGGAATC CTTACATTCA TCACAGTATC TGGCTACACG 
ACAGACCTCT GTGATGATGA CCCACCAAAC CTCAAACACG CCACATTCAA AGCTCTCACA 
TACAAGACAG GCACGGTGTT AAATTGTGAT TGTGAGAGGG GCTTCCGCAG AATAAGCAGC 
TACATGCATT GTACAGGAAA CTCTAGCCAT GCTTCCTGGG AAAACAAATG TCAGTGCAAA 
AGTATATCCC CAGAGAACAG AAAAGGAAAA GTTACCACTA AACCTGAGGA ACAGAAGGGA 
GAAAACCCCA CAGAAATGCA GAGCCAAACG CCGCCCATGG ACGAAGTTGA CCTTGTAGGT 
CACTGCAGGG AGCCTCCTCC CTGGGAACAT GAAAACTCCA AGAGAATTTA CCACTTTGTA 
GTGGGGCAGA CACTTCACTA CCAGTGCATG CAGGGATTCA CAGCCCTCCA CAGAGGTCCT 
GCCAAGAGCA TCTGCAAAAC CATCTTTGGG AAGACCAGAT GGACGCAGCC CCCGCTCAAG 
TGCATAAGTG AAAGTCAGTT TCCAGATGAC GAAGAGCTTC AAGCAAGCAC TGATGCTCCT 
GCTGGGAGGG ACACTTCGTC TCCCTTCATA ACGACAAGTA CTCCAGATTT CCACAAACAC 
ACAGAAGTGG CTACAACCAT GGAGTCATTC ATATTCACAA CCGAGTATCA GATAGCAGTG 
GCGAGCTGCG TCCTCCTGCT GATCAGCATC GTCCTGCTGA GTGGGCTCAC CTGGCAGCGG 
AGAAGTTTCC AGTCTGACAT AGAAAGAACT TGGAAGCCAC TTTCTCCCCT CCTACCAACA 
AGAAAAGTCC CAAACAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL2RA ( XM_005617076.2 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_005617133.1 Canis lupus familiaris interleukin 2 receptor, alpha (IL2RA), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OCe02758
Clone ID Related Accession (Same CDS sequence)	XM_005617076.3 , XM_005617076.2
Accession Version	XM_005617076.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-09-16
Organism	Canis lupus familiaris(Dog)
Product	interleukin-2 receptor subunit alpha isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726049.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Sep 17, 2015 this sequence version replaced XM_005617076.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCAT GTTTGCTGAT GTGGGGAATC CTTACATTCA TCACAGTATC TGGCTACACG 
ACAGACCTCT GTGATGATGA CCCACCAAAC CTCAAACACG CCACATTCAA AGCTCTCACA 
TACAAGACAG GCACGGTGTT AAATTGTGAT TGTGAGAGGG GCTTCCGCAG AATAAGCAGC 
TACATGCATT GTACAGGAAA CTCTAGCCAT GCTTCCTGGG AAAACAAATG TCAGTGCAAA 
AGTATATCCC CAGAGAACAG AAAAGGAAAA GTTACCACTA AACCTGAGGA ACAGAAGGGA 
GAAAACCCCA CAGAAATGCA GAGCCAAACG CCGCCCATGG ACGAAGTTGA CCTTGTAGGT 
CACTGCAGGG AGCCTCCTCC CTGGGAACAT GAAAACTCCA AGAGAATTTA CCACTTTGTA 
GTGGGGCAGA CACTTCACTA CCAGTGCATG CAGGGATTCA CAGCCCTCCA CAGAGGTCCT 
GCCAAGAGCA TCTGCAAAAC CATCTTTGGG AAGACCAGAT GGACGCAGCC CCCGCTCAAG 
TGCATAAGTG AAAGTCAGTT TCCAGATGAC GAAGAGCTTC AAGCAAGCAC TGATGCTCCT 
GCTGGGAGGG ACACTTCGTC TCCCTTCATA ACGACAAGTA CTCCAGATTT CCACAAACAC 
ACAGAAGTGG CTACAACCAT GGAGTCATTC ATATTCACAA CCGAGTATCA GATAGCAGTG 
GCGAGCTGCG TCCTCCTGCT GATCAGCATC GTCCTGCTGA GTGGGCTCAC CTGGCAGCGG 
AGAAGTTTCC AGTCTGACAT AGAAAGAACT TGGAAGCCAC TTTCTCCCCT CCTACCAACA 
AGAAAAGTCC CAAACAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005617133.1
CDS	411..1271
Translation	MEPCLLMWGILTFITVSGYTTDLCDDDPPNLKHATFKALTYKTGTVLNCDCERGFRRISSYMHCTGNSSHASWENKCQCKSISPENRKGKVTTKPEEQKGENPTEMQSQTPPMDEVDLVGHCREPPPWEHENSKRIYHFVVGQTLHYQCMQGFTALHRGPAKSICKTIFGKTRWTQPPLKCISESQFPDDEELQASTDAPAGRDTSSPFITTSTPDFHKHTEVATTMESFIFTTEYQIAVASCVLLLISIVLLSGLTWQRRSFQSDIERTWKPLSPLLPTRKVPNN

Target ORF information:

RefSeq Version	XM_005617076.2
Organism	Canis lupus familiaris(Dog)
Definition	Canis lupus familiaris interleukin 2 receptor, alpha (IL2RA), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005617076.2

ORF Insert Sequence:

ATGGAGCCAT GTTTGCTGAT GTGGGGAATC CTTACATTCA TCACAGTATC TGGCTACACG 
ACAGACCTCT GTGATGATGA CCCACCAAAC CTCAAACACG CCACATTCAA AGCTCTCACA 
TACAAGACAG GCACGGTGTT AAATTGTGAT TGTGAGAGGG GCTTCCGCAG AATAAGCAGC 
TACATGCATT GTACAGGAAA CTCTAGCCAT GCTTCCTGGG AAAACAAATG TCAGTGCAAA 
AGTATATCCC CAGAGAACAG AAAAGGAAAA GTTACCACTA AACCTGAGGA ACAGAAGGGA 
GAAAACCCCA CAGAAATGCA GAGCCAAACG CCGCCCATGG ACGAAGTTGA CCTTGTAGGT 
CACTGCAGGG AGCCTCCTCC CTGGGAACAT GAAAACTCCA AGAGAATTTA CCACTTTGTA 
GTGGGGCAGA CACTTCACTA CCAGTGCATG CAGGGATTCA CAGCCCTCCA CAGAGGTCCT 
GCCAAGAGCA TCTGCAAAAC CATCTTTGGG AAGACCAGAT GGACGCAGCC CCCGCTCAAG 
TGCATAAGTG AAAGTCAGTT TCCAGATGAC GAAGAGCTTC AAGCAAGCAC TGATGCTCCT 
GCTGGGAGGG ACACTTCGTC TCCCTTCATA ACGACAAGTA CTCCAGATTT CCACAAACAC 
ACAGAAGTGG CTACAACCAT GGAGTCATTC ATATTCACAA CCGAGTATCA GATAGCAGTG 
GCGAGCTGCG TCCTCCTGCT GATCAGCATC GTCCTGCTGA GTGGGCTCAC CTGGCAGCGG 
AGAAGTTTCC AGTCTGACAT AGAAAGAACT TGGAAGCCAC TTTCTCCCCT CCTACCAACA 
AGAAAAGTCC CAAACAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL2RA ( XM_022405275.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_022260983.1 Canis lupus familiaris interleukin 2 receptor subunit alpha (IL2RA), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OCe286518
Clone ID Related Accession (Same CDS sequence)	XM_022405275.1
Accession Version	XM_022405275.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-04
Organism	Canis lupus familiaris(dog)
Product	interleukin-2 receptor subunit alpha isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006584.3) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCATTGTA CAGGAAACTC TAGCCATGCT TCCTGGGAAA ACAAATGTCA GTGCAAAAGT 
ATATCCCCAG AGAACAGAAA AGGAAAAGTT ACCACTAAAC CTGAGGAACA GAAGGGAGAA 
AACCCCACAG AAATGCAGAG CCAAACGCCG CCCATGGACG AAGTTGACCT TGTAGGTCAC 
TGCAGGGAGC CTCCTCCCTG GGAACATGAA AACTCCAAGA GAATTTACCA CTTTGTAGTG 
GGGCAGACAC TTCACTACCA GTGCATGCAG GGATTCACAG CCCTCCACAG AGGTCCTGCC 
AAGAGCATCT GCAAAACCAT CTTTGGGAAG ACCAGATGGA CGCAGCCCCC GCTCAAGTGC 
ATAAGTGAAA GTCAGTTTCC AGATGACGAA GAGCTTCAAG CAAGCACTGA TGCTCCTGCT 
GGGAGGGACA CTTCGTCTCC CTTCATAACG ACAAGTACTC CAGATTTCCA CAAACACACA 
GAAGTGGCTA CAACCATGGA GTCATTCATA TTCACAACCG AGTATCAGAT AGCAGTGGCG 
AGCTGCGTCC TCCTGCTGAT CAGCATCGTC CTGCTGAGTG GGCTCACCTG GCAGCGGAGA 
AGTTTCCAGT CTGACATAGA AAGAACTTGG AAGCCACTTT CTCCCCTCCT ACCAACAAGA 
AAAGTCCCAA ACAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_022260983.1
CDS	383..1060
Translation	MHCTGNSSHASWENKCQCKSISPENRKGKVTTKPEEQKGENPTEMQSQTPPMDEVDLVGHCREPPPWEHENSKRIYHFVVGQTLHYQCMQGFTALHRGPAKSICKTIFGKTRWTQPPLKCISESQFPDDEELQASTDAPAGRDTSSPFITTSTPDFHKHTEVATTMESFIFTTEYQIAVASCVLLLISIVLLSGLTWQRRSFQSDIERTWKPLSPLLPTRKVPNN

Target ORF information:

RefSeq Version	XM_022405275.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris interleukin 2 receptor subunit alpha (IL2RA), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_022405275.1

ORF Insert Sequence:

ATGCATTGTA CAGGAAACTC TAGCCATGCT TCCTGGGAAA ACAAATGTCA GTGCAAAAGT 
ATATCCCCAG AGAACAGAAA AGGAAAAGTT ACCACTAAAC CTGAGGAACA GAAGGGAGAA 
AACCCCACAG AAATGCAGAG CCAAACGCCG CCCATGGACG AAGTTGACCT TGTAGGTCAC 
TGCAGGGAGC CTCCTCCCTG GGAACATGAA AACTCCAAGA GAATTTACCA CTTTGTAGTG 
GGGCAGACAC TTCACTACCA GTGCATGCAG GGATTCACAG CCCTCCACAG AGGTCCTGCC 
AAGAGCATCT GCAAAACCAT CTTTGGGAAG ACCAGATGGA CGCAGCCCCC GCTCAAGTGC 
ATAAGTGAAA GTCAGTTTCC AGATGACGAA GAGCTTCAAG CAAGCACTGA TGCTCCTGCT 
GGGAGGGACA CTTCGTCTCC CTTCATAACG ACAAGTACTC CAGATTTCCA CAAACACACA 
GAAGTGGCTA CAACCATGGA GTCATTCATA TTCACAACCG AGTATCAGAT AGCAGTGGCG 
AGCTGCGTCC TCCTGCTGAT CAGCATCGTC CTGCTGAGTG GGCTCACCTG GCAGCGGAGA 
AGTTTCCAGT CTGACATAGA AAGAACTTGG AAGCCACTTT CTCCCCTCCT ACCAACAAGA 
AAAGTCCCAA ACAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Increased numbers of FoxP3-expressing CD4+ CD25+ regulatory T cells in peripheral blood from dogs with atopic dermatitis and its correlation with disease severity.
Veterinary dermatology27(1)26-e9(2016 Feb)
Hauck V,H?gli P,Meli ML,Rostaher A,Fischer N,Hofmann-Lehmann R,Favrot C

Genome-Wide Scan for Visceral Leishmaniasis in Mixed-Breed Dogs Identifies Candidate Genes Involved in T Helper Cells and Macrophage Signaling.
PloS one10(9)e0136749(2015)
Utsunomiya YT,Ribeiro ?S,Quintal AP,Sangalli JR,Gazola VR,Paula HB,Trinconi CM,Lima VM,Perri SH,Taylor JF,Schnabel RD,Sonstegard TS,Garcia JF,Nunes CM

Cloning and expression of canine CD25 for validation of an anti-human CD25 antibody to compare T regulatory lymphocytes in healthy dogs and dogs with osteosarcoma.
Veterinary immunology and immunopathology135(1-2)137-45(2010 May)
Rissetto KC,Rindt H,Selting KA,Villamil JA,Henry CJ,Reinero CR

Crossreactivity of antibodies to canine CD25 and Foxp3 and identification of canine CD4+CD25 +Foxp3+ cells in canine peripheral blood.
The Journal of veterinary medical science71(12)1561-8(2009 Dec)
Mizuno T,Suzuki R,Umeki S,Okuda M

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IL2RA cDNA ORF clone, Canis lupus familiaris(dog)

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ORF Insert Sequence:

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