anks3 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	anks3
Entrez Gene ID	100136846
Full Name	ankyrin repeat and sterile alpha motif domain containing 3
Synonyms	zgc:172142
General protein information	Preferred Names ankyrin repeat and sterile alpha motif domain containing 3 Names ankyrin repeat and SAM domain-containing protein 3 ankyrin repeat and sterile alpha motif domain containing 3-like
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001114565.1	NP_001108037.1	ankyrin repeat and SAM domain-containing protein 3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ANKS3	XP_005621653.1
Homo sapiens (human)	ANKS3	NP_597707.1
Xenopus tropicalis (tropical clawed frog)	anks3	XP_002932472.1
Bos taurus (cattle)	ANKS3	NP_001193158.1
Rattus norvegicus (Norway rat)	Anks3	NP_001009676.1
Pan troglodytes (chimpanzee)	ANKS3	XP_003314981.1
Gallus gallus (chicken)	ANKS3	XP_001231827.2
Danio rerio (zebrafish)	zgc:172142	NP_001108037.1
Mus musculus (house mouse)	Anks3	NP_082577.2
Caenorhabditis elegans (roundworm)	CELE_Y39C12A.1	NP_502319.2

Gene Ontology
Bibliography

Related articles in PubMed

ANKS3 is mutated in a family with autosomal recessive laterality defect.
Shamseldin HE, Yakulov TA, Hashem A, Walz G, Alkuraya FS
Human genetics135(11)1233-1239(2016 Nov)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

Anks3 interacts with nephronophthisis proteins and is required for normal renal development.
Yakulov TA, Yasunaga T, Ramachandran H, Engel C, M?ller B, Hoff S, Dengjel J, Lienkamp SS, Walz G
Kidney international87(6)1191-200(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Consistent with the proposed role of the ANKS3 variant in the pathogenesis of the reported family's phenotype, we show that the mutant RNA failed to rescue the laterality defect in anks3 morphants compared to wild-type RNA. Furthermore, we describe a new mutant anks3 line that also displays laterality defect in the homozygous state
Title: ANKS3 is mutated in a family with autosomal recessive laterality defect.

Thus, developmental defects associated with Anks3 depletion in zebrafish suggest that ANKS3 mutations may cause nephronophthisis (NPH) or NPH-like disease in humans.
Title: Anks3 interacts with nephronophthisis proteins and is required for normal renal development.

The following anks3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the anks3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa32874	NM_001114565.1 Latest version!	Danio rerio ankyrin repeat and sterile alpha motif domain containing 3 (anks3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

anks3 ( NM_001114565.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001108037.1 Danio rerio ankyrin repeat and sterile alpha motif domain containing 3 (anks3), mRNA.

Price & Availability↑

CloneID	ODa32874
Clone ID Related Accession (Same CDS sequence)	NM_001114565.1
Accession Version	NM_001114565.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1869bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-23
Organism	Danio rerio(zebrafish)
Product	ankyrin repeat and SAM domain-containing protein 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC154552.1. ##Evidence-Data-START## Transcript exon combination :: BC154552.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGTCTGAGC TCAGTGATGA GGCCAGCAGT GAGTCGGATC AGCTGGGCGC GAGTCTGTCC 
GTGTGGCAGG CCGGAGGCGC AGGTGCTCTG ATCGGCCCGG AGGAGCTGAA TGTTCCGCTG 
GATCTTCACA CCGCCTGCTC CATTGGACAG TATGATGTGG TTTCCGAGTG TATCCGCAGG 
GGAGATGTGG ATTTGGATGG TCAGAACATT GGCGGCTGGA CTCCTCTGAT GTACGCTGCT 
TACATCGGTC ATGATAACAT CGCTAACCTG CTGCTAGAGA CTGGCGTTAA CGTCAACGCC 
ACCACATCGA AAGGCCTGAC GCCACTGATG CTCGCCGCCA GCTGCGGGAA CGAGAGCATT 
GCTCACTTCC TCTTGCAGAA AGGAGCACAG CTGGAGTGTA AAGATGTGCG TGGATGGACG 
GCTCTGTTGT ACAGCACAGC TACCGGACAT CAGCAGATGG TCAAATTCCT ATTAGAGCAT 
CACGCCAATG CAAATGTCAA GGAGCCACTG TCAGGATTCA CACCGCTCAT GGAAGCCGCA 
GCGTCCGGTC ATGAAATCAT CGTCCAGTAC CTGCTCAGCC ATGGCGCGCG AACAGAGGAC 
CGAAACATGA AGGGAGAAAC AGCGAGAGCT CTGGCCATGA TGTACGGACA CATCAAAATC 
GCCAGCCTCA TCGACATGCA CGTCATAAGA GCCAAATCAT CTATGTATGA GGAGCTGAGC 
TCGTCTGAAG AAGAAAACCC AAGTCCTAGA GTCCGTTCAG CTCACAGCAG AACCAGAGGA 
CCCAGCATTC ACGATGGCCC ACAGGCTATC GCACGATTCA GAGTCGGATC CAAACACGAA 
GTTCCTGCAG CTCCTCCAGG ATACGTGACC TTCCGCGATG TTGGAGATCA GAGCGAGGGA 
ATCTGCAATC GTGACGTCAC TTCCCCCATC AATGAGCTGG ACGGACAGAG CAACAGCAGT 
AGAGATGAGC TGTTTTTCGA TAACGACATG CCCACGCTGA AGAGCAGCAG CAGCAGCAGT 
GAAAGTTTGT CACATCTGCT TGGGCTAAGC AGGGAAGCGT CGCTGGAAAG CAATGAGGAC 
TCTGACCAAG CAAAGAGAAG CTGTCCACGT CGATCTAACA AACTCCAGCA CTCCAAAAGC 
AGGAGTCCTT ATAACAGCAG AGGCAGCGCA GGTTACAGAG AGGTGCGGTC TTCCTCTGGA 
CCTCCACCTT CATACACTGG ACCAAAGGAT CTCTCAGAGT TCCTGGAGCA GATTGGGTTC 
AGTAAGTATC TCCCTCTGCT GGAGGAGCAA GACATCGACC TGAGAATCTT CCTCACGCTC 
ACCGAGAATG ACCTTAAGGA AATCGGCATC ACTCTCTTTG GTCCTAAGAG GAGAATGACA 
TCAGCAATAG CTCGTTGGCA TAGTAACGCA CGGCCACCCA GCGATGCATT AGAACAGGCA 
TATGCAGACC AACTGGAGGC TGAGATGCAG GAAATGGCCA TTCAGCTTCA TAAGCGTTGT 
GTGGAGGTGG AGTCTTTTCA GGGTCAAGTG ACCCAGGAGA AAGAGCTGCG TGCTGTGATG 
GAGGGATGCC TGATGGAGGA GAAGATGGCA TGGAAAAGGG TTCAGGCAGA ACTGCAGGAA 
AACGCTAAAC GCATGCAGAC GCTGAACGCA AAACTACACA CTCTACAGAA CACGCACACA 
CAACTCAAAC AGATCACACA GGATGACGGT CGATCTGTGG GAAAAGGTGA TGGTTTGATG 
TGCTCTCAGC TCCTGACTAA GATGGATACT CATATAGCAG ATCTTGCTGA AAGTGTGAAG 
GAAATCTGTC ACAGTCTCCA GCATCTGTGC ACTTCAGAGA AAAACTCACA CAACTGGGAA 
GAATCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001108037.1
CDS	75..1943
Translation	MSELSDEASSESDQLGASLSVWQAGGAGALIGPEELNVPLDLHTACSIGQYDVVSECIRRGDVDLDGQNIGGWTPLMYAAYIGHDNIANLLLETGVNVNATTSKGLTPLMLAASCGNESIAHFLLQKGAQLECKDVRGWTALLYSTATGHQQMVKFLLEHHANANVKEPLSGFTPLMEAAASGHEIIVQYLLSHGARTEDRNMKGETARALAMMYGHIKIASLIDMHVIRAKSSMYEELSSSEEENPSPRVRSAHSRTRGPSIHDGPQAIARFRVGSKHEVPAAPPGYVTFRDVGDQSEGICNRDVTSPINELDGQSNSSRDELFFDNDMPTLKSSSSSSESLSHLLGLSREASLESNEDSDQAKRSCPRRSNKLQHSKSRSPYNSRGSAGYREVRSSSGPPPSYTGPKDLSEFLEQIGFSKYLPLLEEQDIDLRIFLTLTENDLKEIGITLFGPKRRMTSAIARWHSNARPPSDALEQAYADQLEAEMQEMAIQLHKRCVEVESFQGQVTQEKELRAVMEGCLMEEKMAWKRVQAELQENAKRMQTLNAKLHTLQNTHTQLKQITQDDGRSVGKGDGLMCSQLLTKMDTHIADLAESVKEICHSLQHLCTSEKNSHNWEES

Target ORF information:

RefSeq Version	NM_001114565.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio ankyrin repeat and sterile alpha motif domain containing 3 (anks3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001114565.1

ORF Insert Sequence:

ATGTCTGAGC TCAGTGATGA GGCCAGCAGT GAGTCGGATC AGCTGGGCGC GAGTCTGTCC 
GTGTGGCAGG CCGGAGGCGC AGGTGCTCTG ATCGGCCCGG AGGAGCTGAA TGTTCCGCTG 
GATCTTCACA CCGCCTGCTC CATTGGACAG TATGATGTGG TTTCCGAGTG TATCCGCAGG 
GGAGATGTGG ATTTGGATGG TCAGAACATT GGCGGCTGGA CTCCTCTGAT GTACGCTGCT 
TACATCGGTC ATGATAACAT CGCTAACCTG CTGCTAGAGA CTGGCGTTAA CGTCAACGCC 
ACCACATCGA AAGGCCTGAC GCCACTGATG CTCGCCGCCA GCTGCGGGAA CGAGAGCATT 
GCTCACTTCC TCTTGCAGAA AGGAGCACAG CTGGAGTGTA AAGATGTGCG TGGATGGACG 
GCTCTGTTGT ACAGCACAGC TACCGGACAT CAGCAGATGG TCAAATTCCT ATTAGAGCAT 
CACGCCAATG CAAATGTCAA GGAGCCACTG TCAGGATTCA CACCGCTCAT GGAAGCCGCA 
GCGTCCGGTC ATGAAATCAT CGTCCAGTAC CTGCTCAGCC ATGGCGCGCG AACAGAGGAC 
CGAAACATGA AGGGAGAAAC AGCGAGAGCT CTGGCCATGA TGTACGGACA CATCAAAATC 
GCCAGCCTCA TCGACATGCA CGTCATAAGA GCCAAATCAT CTATGTATGA GGAGCTGAGC 
TCGTCTGAAG AAGAAAACCC AAGTCCTAGA GTCCGTTCAG CTCACAGCAG AACCAGAGGA 
CCCAGCATTC ACGATGGCCC ACAGGCTATC GCACGATTCA GAGTCGGATC CAAACACGAA 
GTTCCTGCAG CTCCTCCAGG ATACGTGACC TTCCGCGATG TTGGAGATCA GAGCGAGGGA 
ATCTGCAATC GTGACGTCAC TTCCCCCATC AATGAGCTGG ACGGACAGAG CAACAGCAGT 
AGAGATGAGC TGTTTTTCGA TAACGACATG CCCACGCTGA AGAGCAGCAG CAGCAGCAGT 
GAAAGTTTGT CACATCTGCT TGGGCTAAGC AGGGAAGCGT CGCTGGAAAG CAATGAGGAC 
TCTGACCAAG CAAAGAGAAG CTGTCCACGT CGATCTAACA AACTCCAGCA CTCCAAAAGC 
AGGAGTCCTT ATAACAGCAG AGGCAGCGCA GGTTACAGAG AGGTGCGGTC TTCCTCTGGA 
CCTCCACCTT CATACACTGG ACCAAAGGAT CTCTCAGAGT TCCTGGAGCA GATTGGGTTC 
AGTAAGTATC TCCCTCTGCT GGAGGAGCAA GACATCGACC TGAGAATCTT CCTCACGCTC 
ACCGAGAATG ACCTTAAGGA AATCGGCATC ACTCTCTTTG GTCCTAAGAG GAGAATGACA 
TCAGCAATAG CTCGTTGGCA TAGTAACGCA CGGCCACCCA GCGATGCATT AGAACAGGCA 
TATGCAGACC AACTGGAGGC TGAGATGCAG GAAATGGCCA TTCAGCTTCA TAAGCGTTGT 
GTGGAGGTGG AGTCTTTTCA GGGTCAAGTG ACCCAGGAGA AAGAGCTGCG TGCTGTGATG 
GAGGGATGCC TGATGGAGGA GAAGATGGCA TGGAAAAGGG TTCAGGCAGA ACTGCAGGAA 
AACGCTAAAC GCATGCAGAC GCTGAACGCA AAACTACACA CTCTACAGAA CACGCACACA 
CAACTCAAAC AGATCACACA GGATGACGGT CGATCTGTGG GAAAAGGTGA TGGTTTGATG 
TGCTCTCAGC TCCTGACTAA GATGGATACT CATATAGCAG ATCTTGCTGA AAGTGTGAAG 
GAAATCTGTC ACAGTCTCCA GCATCTGTGC ACTTCAGAGA AAAACTCACA CAACTGGGAA 
GAATCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ANKS3 is mutated in a family with autosomal recessive laterality defect.
Human genetics135(11)1233-1239(2016 Nov)
Shamseldin HE,Yakulov TA,Hashem A,Walz G,Alkuraya FS

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

Anks3 interacts with nephronophthisis proteins and is required for normal renal development.
Kidney international87(6)1191-200(2015 Jun)
Yakulov TA,Yasunaga T,Ramachandran H,Engel C,M?ller B,Hoff S,Dengjel J,Lienkamp SS,Walz G

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anks3 cDNA ORF clone, Danio rerio(zebrafish)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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