Gene Symbol | gpc4 |
Entrez Gene ID | 118437 |
Full Name | glypican 4 |
Synonyms | chunp6920,gpc4,,gpc4/6,gpc6,kny,knypek,wu:fc47a08,wu:fe05f10,zgc:194854 |
General protein information |
|
Gene Type | protein-coding |
Organism | Danio rerio(zebrafish) |
ORF » Species Summary » Danio rerio » gpc4 cDNA ORF clone
gRNAs
Gene Symbol | gpc4 |
Entrez Gene ID | 118437 |
Full Name | glypican 4 |
Synonyms | chunp6920,gpc4,,gpc4/6,gpc6,kny,knypek,wu:fc47a08,wu:fe05f10,zgc:194854 |
General protein information |
|
Gene Type | protein-coding |
Organism | Danio rerio(zebrafish) |
mRNA | Protein | Name |
---|---|---|
NM_131860.2 | NP_571935.2 | glypican-4 precursor |
Rattus norvegicus (Norway rat) | Gpc4 | NP_001014130.1 |
Bos taurus (cattle) | GPC4 | NP_001192713.1 |
Mus musculus (house mouse) | Gpc4 | NP_032176.2 |
Gallus gallus (chicken) | GPC4 | XP_420222.3 |
Danio rerio (zebrafish) | gpc4 | NP_571935.2 |
Xenopus tropicalis (tropical clawed frog) | gpc4 | XP_002932634.1 |
Canis lupus familiaris (dog) | GPC4 | XP_549265.2 |
GPC4 | XP_001097252.1 | |
Drosophila melanogaster (fruit fly) | dlp | NP_996075.2 |
Caenorhabditis elegans (roundworm) | gpn-1 | NP_510582.1 |
Homo sapiens (human) | GPC4 | NP_001439.2 |
Pan troglodytes (chimpanzee) | GPC4 | XP_529161.3 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP003559 | XP_313306.5 |
Distinct requirements of wls, wnt9a, wnt5b and gpc4 in regulating chondrocyte maturation and timing of endochondral ossification.
Ling IT, Rochard L, Liao EC
Developmental biology421(2)219-232(2017 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
disruption of wls resulted in a significant loss of craniofacial bone, whereas lack of gpc4, wnt5b and wnt9a resulted in severely delayed endochondral ossification.
Title: Distinct requirements of wls, wnt9a, wnt5b and gpc4 in regulating chondrocyte maturation and timing of endochondral ossification.
A mutation in glypican4 leads to severe lateral line primordium migration defects. Glypican4 regulates the feedback loop between Wnt/beta-catenin/Fgf signaling in the primordium redundantly with other HSPGs. A mutation in glypican4 affects primordium migration non cell-autonomously
Title: Glypican4 modulates lateral line collective cell migration non cell-autonomously.
the chaperon Wls and its ligands Wnt9a and Wnt5b are expressed in the ectoderm, whereas juxtaposed chondrocytes express Frzb and Gpc4.
Title: Roles of Wnt pathway genes wls, wnt9a, wnt5b, frzb and gpc4 in regulating convergent-extension during zebrafish palate morphogenesis.
novel mechanism for Wnt5b and Gpc4 regulation of chondrocyte behavior that is independent of the core Wnt/PCP molecules and differs from their collaborative action of controlling cell movements during gastrulation
Title: A role of glypican4 and wnt5b in chondrocyte stacking underlying craniofacial cartilage morphogenesis.
glypican4 mutants do not have decreased proteolysis of ECM substrates, but instead have increased cell surface cadherin protein expression and increased intercellular adhesion.
Title: Planar cell polarity proteins differentially regulate extracellular matrix organization and assembly during zebrafish gastrulation.
The following gpc4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the gpc4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ODa38765 | |
Clone ID Related Accession (Same CDS sequence) | NM_131860.2 | |
Accession Version | NM_131860.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1674bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-15 | |
Organism | Danio rerio(zebrafish) | |
Product | glypican-4 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC163403.1. On Apr 15, 2009 this sequence version replaced NM_131860.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC163403.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGAAGATGA TCGTTGTGTT TACAGTATGT ATGTCTGTGG TGGTTTTGGC GTCGGCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_571935.2 |
CDS | 90..1763 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAAGATGA TCGTTGTGTT TACAGTATGT ATGTCTGTGG TGGTTTTGGC GTCGGCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Distinct requirements of wls, wnt9a, wnt5b and gpc4 in regulating chondrocyte maturation and timing of endochondral ossification. |