HER4.2 cDNA ORF clone, Danio rerio(Zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	HER4.2
Entrez Gene ID	30301
Full Name	hairy-related 4, tandem duplicate 2
Synonyms	HER-4,her4,her4.1,si:ch73-21g5.3,wu:fq41c06,zgc:55218
General protein information	Preferred Names hairy-related 4, tandem duplicate 2 Names hairy-related 4.2 Hes5d Hes5e ch73-21g5.2 hairy-related 4, tandem duplicate 1 hairy-related 4.1
Gene Type	protein-coding
Organism	Danio rerio(Zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_131090.4	NP_571165.3	hairy-related 4.5
NM_131090.3	NP_571165.3	hairy-related 4.2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	LOC100149066	NP_001121862.1
Homo sapiens (human)	HES5	NP_001010926.1
Mus musculus (house mouse)	Hes5	NP_034549.1
Danio rerio (zebrafish)	her4.2	NP_571165.3
Danio rerio (zebrafish)	her4.3	NP_001154880.1
Xenopus tropicalis (tropical clawed frog)	hes5	XP_004916212.1
Pan troglodytes (chimpanzee)	HES5	XP_524847.2
Canis lupus familiaris (dog)	HES5	XP_546734.2
Bos taurus (cattle)	HES5	NP_001098937.1
Rattus norvegicus (Norway rat)	Hes5	NP_077359.1
Gallus gallus (chicken)	HES5	NP_001012713.1
Xenopus tropicalis (tropical clawed frog)	hes5.1	NP_001037880.1
Danio rerio (zebrafish)	LOC100149863	NP_001096598.1
Danio rerio (zebrafish)	LOC100148329	NP_001154881.1

Gene Ontology
Bibliography

Related articles in PubMed

Rnf152 Is Essential for NeuroD Expression and Delta-Notch Signaling in the Zebrafish Embryos.
Kumar A, Huh TL, Choe J, Rhee M
Molecules and cells40(12)945-953(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

her4 is involved in a replenishing pathway that maintains populations of stem cells in the central retina, and that the magnitude of the her4-associated proliferative response mirrors the extent of retinal damage.
Title: Tracking the fate of her4 expressing cells in the regenerating retina using her4:Kaede zebrafish.

At later stages her4 expression becomes Notch-dependent in the future sensory domains but loss of her4 does not result in hair cell overproduction, suggesting that there other her genes can compensate its function.
Title: The role of her4 in inner ear development and its relationship with proneural genes and Notch signalling.

Her4-positive cells are GFAP-positive in the adult brain of zebrafish
Title: Her4-positive population in the tectum opticum is proliferating neural precursors in the adult zebrafish brain.

These observations suggest that Her4 and Notch play a role in peripheral outgrowth of sensory neurons.
Title: Her4 is necessary for establishing peripheral projections of the trigeminal ganglia in zebrafish.

her4 may be differently regulated in sensory cranial ganglia, where Notch activity is not essential for her4 expression and where Su(H) may repress her4 expression
Title: Fluorescent protein expression driven by her4 regulatory elements reveals the spatiotemporal pattern of Notch signaling in the nervous system of zebrafish embryos.

The following HER4.2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HER4.2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ODa04251	NM_131090.4 Latest version!	Danio rerio hairy-related 4, tandem duplicate 5 (her4.5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
View Old Accession Versions >>
ODa04251	NM_131090.3	Danio rerio hairy-related 4.2 (her4.2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HER4.2 ( NM_131090.4 ) cDNA ORF clone, Danio rerio(Zebrafish) -> NP_571165.3 Danio rerio hairy-related 4, tandem duplicate 5 (her4.5), mRNA.

Price & Availability↑

CloneID	ODa04251
Clone ID Related Accession (Same CDS sequence)	NM_131090.4 , NM_131090.3
Accession Version	NM_131090.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-27
Organism	Danio rerio(zebrafish)
Product	hairy-related 4.5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CU062502.10. On May 18, 2017 this sequence version replaced NM_131090.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC097007.1, GW709900.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505374, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END##

ATGGCTCCTA CAATCACTGG CTCAATCAGC AGCAGAGAAA CTCTACTGAC AAACAAGCTG 
AGAAAGCCCA TGGTGGAGAA GATCCGCCGA GAGCGAATCA ACAGCAGCAT CGAGAAGCTC 
AAGACTCTTC TGGCTCAAGA GTTCGTCAAG CAGCAGCCCG ACTCCAGACA GGAGAAAGCT 
GATATCCTGG AGATGACGCT TGATTTCTTG AGACGCTCTC AGAAAAGCAG TGCGGCTGGT 
GACGGACGCT CCAGATGTGT GCAGGAGGCC GTCAGCTTTC TGTCTCAGTG CCCAGTGCAG 
ACGCAGAGCC ACACAAGACT GATGAAGCTC TTCCTGCACA TGCAGACTCC TGCAGACCAG 
CACACACGTG TGGACAATCC TCAGACCACT GAAACACACG CAAACAGCAG CGCCAAACAA 
CACACTCCAG CCCACAGTCA CATCTGGAGA CCCTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_571165.3
CDS	53..511
Translation	MAPTITGSISSRETLLTNKLRKPMVEKIRRERINSSIEKLKTLLAQEFVKQQPDSRQEKADILEMTLDFLRRSQKSSAAGDGRSRCVQEAVSFLSQCPVQTQSHTRLMKLFLHMQTPADQHTRVDNPQTTETHANSSAKQHTPAHSHIWRPW

Target ORF information:

RefSeq Version	NM_131090.4
Organism	Danio rerio(zebrafish)
Definition	Danio rerio hairy-related 4, tandem duplicate 5 (her4.5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_131090.4

ORF Insert Sequence:

ATGGCTCCTA CAATCACTGG CTCAATCAGC AGCAGAGAAA CTCTACTGAC AAACAAGCTG 
AGAAAGCCCA TGGTGGAGAA GATCCGCCGA GAGCGAATCA ACAGCAGCAT CGAGAAGCTC 
AAGACTCTTC TGGCTCAAGA GTTCGTCAAG CAGCAGCCCG ACTCCAGACA GGAGAAAGCT 
GATATCCTGG AGATGACGCT TGATTTCTTG AGACGCTCTC AGAAAAGCAG TGCGGCTGGT 
GACGGACGCT CCAGATGTGT GCAGGAGGCC GTCAGCTTTC TGTCTCAGTG CCCAGTGCAG 
ACGCAGAGCC ACACAAGACT GATGAAGCTC TTCCTGCACA TGCAGACTCC TGCAGACCAG 
CACACACGTG TGGACAATCC TCAGACCACT GAAACACACG CAAACAGCAG CGCCAAACAA 
CACACTCCAG CCCACAGTCA CATCTGGAGA CCCTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HER4.2 ( NM_131090.3 ) cDNA ORF clone, Danio rerio(Zebrafish) -> NP_571165.3 Danio rerio hairy-related 4.2 (her4.2), mRNA.

Price & Availability↑

CloneID	ODa04251
Clone ID Related Accession (Same CDS sequence)	NM_131090.4 , NM_131090.3
Accession Version	NM_131090.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2012-10-20
Organism	Danio rerio(Zebrafish)
Product	hairy-related 4.2
Comment	PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CU062502.10. On May 30, 2009 this sequence version replaced NM_131090.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGGCTCCTA CAATCACTGG CTCAATCAGC AGCAGAGAAA CTCTACTGAC AAACAAGCTG 
AGAAAGCCCA TGGTGGAGAA GATCCGCCGA GAGCGAATCA ACAGCAGCAT CGAGAAGCTC 
AAGACTCTTC TGGCTCAAGA GTTCGTCAAG CAGCAGCCCG ACTCCAGACA GGAGAAAGCT 
GATATCCTGG AGATGACGCT TGATTTCTTG AGACGCTCTC AGAAAAGCAG TGCGGCTGGT 
GACGGACGCT CCAGATGTGT GCAGGAGGCC GTCAGCTTTC TGTCTCAGTG CCCAGTGCAG 
ACGCAGAGCC ACACAAGACT GATGAAGCTC TTCCTGCACA TGCAGACTCC TGCAGACCAG 
CACACACGTG TGGACAATCC TCAGACCACT GAAACACACG CAAACAGCAG CGCCAAACAA 
CACACTCCAG CCCACAGTCA CATCTGGAGA CCCTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_571165.3
CDS	51..509
Translation	MAPTITGSISSRETLLTNKLRKPMVEKIRRERINSSIEKLKTLLAQEFVKQQPDSRQEKADILEMTLDFLRRSQKSSAAGDGRSRCVQEAVSFLSQCPVQTQSHTRLMKLFLHMQTPADQHTRVDNPQTTETHANSSAKQHTPAHSHIWRPW

Target ORF information:

RefSeq Version	NM_131090.3
Organism	Danio rerio(Zebrafish)
Definition	Danio rerio hairy-related 4.2 (her4.2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_131090.3

ORF Insert Sequence:

ATGGCTCCTA CAATCACTGG CTCAATCAGC AGCAGAGAAA CTCTACTGAC AAACAAGCTG 
AGAAAGCCCA TGGTGGAGAA GATCCGCCGA GAGCGAATCA ACAGCAGCAT CGAGAAGCTC 
AAGACTCTTC TGGCTCAAGA GTTCGTCAAG CAGCAGCCCG ACTCCAGACA GGAGAAAGCT 
GATATCCTGG AGATGACGCT TGATTTCTTG AGACGCTCTC AGAAAAGCAG TGCGGCTGGT 
GACGGACGCT CCAGATGTGT GCAGGAGGCC GTCAGCTTTC TGTCTCAGTG CCCAGTGCAG 
ACGCAGAGCC ACACAAGACT GATGAAGCTC TTCCTGCACA TGCAGACTCC TGCAGACCAG 
CACACACGTG TGGACAATCC TCAGACCACT GAAACACACG CAAACAGCAG CGCCAAACAA 
CACACTCCAG CCCACAGTCA CATCTGGAGA CCCTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rnf152 Is Essential for NeuroD Expression and Delta-Notch Signaling in the Zebrafish Embryos.
Molecules and cells40(12)945-953(2017 Dec)
Kumar A,Huh TL,Choe J,Rhee M

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HER4.2 cDNA ORF clone, Danio rerio(Zebrafish)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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