HER4.2 cDNA ORF clone, Danio rerio(Zebrafish)
Gene Symbol | HER4.2 |
Entrez Gene ID | 30301 |
Full Name | hairy-related 4, tandem duplicate 2 |
Synonyms | HER-4,her4,her4.1,si:ch73-21g5.3,wu:fq41c06,zgc:55218 |
General protein information |
|
Gene Type | protein-coding |
Organism | Danio rerio(Zebrafish) |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_131090.4 | NP_571165.3 | hairy-related 4.5 |
NM_131090.3 | NP_571165.3 | hairy-related 4.2 |

Danio rerio (zebrafish) | LOC100149066 | NP_001121862.1 |
Homo sapiens (human) | HES5 | NP_001010926.1 |
Mus musculus (house mouse) | Hes5 | NP_034549.1 |
Danio rerio (zebrafish) | her4.2 | NP_571165.3 |
Danio rerio (zebrafish) | her4.3 | NP_001154880.1 |
Xenopus tropicalis (tropical clawed frog) | hes5 | XP_004916212.1 |
Pan troglodytes (chimpanzee) | HES5 | XP_524847.2 |
Canis lupus familiaris (dog) | HES5 | XP_546734.2 |
Bos taurus (cattle) | HES5 | NP_001098937.1 |
Rattus norvegicus (Norway rat) | Hes5 | NP_077359.1 |
Gallus gallus (chicken) | HES5 | NP_001012713.1 |
Xenopus tropicalis (tropical clawed frog) | hes5.1 | NP_001037880.1 |
Danio rerio (zebrafish) | LOC100149863 | NP_001096598.1 |
Danio rerio (zebrafish) | LOC100148329 | NP_001154881.1 |

Related articles in PubMed
Rnf152 Is Essential for NeuroD Expression and Delta-Notch Signaling in the Zebrafish Embryos.
Kumar A, Huh TL, Choe J, Rhee M
Molecules and cells40(12)945-953(2017 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
her4 is involved in a replenishing pathway that maintains populations of stem cells in the central retina, and that the magnitude of the her4-associated proliferative response mirrors the extent of retinal damage.
Title: Tracking the fate of her4 expressing cells in the regenerating retina using her4:Kaede zebrafish.
At later stages her4 expression becomes Notch-dependent in the future sensory domains but loss of her4 does not result in hair cell overproduction, suggesting that there other her genes can compensate its function.
Title: The role of her4 in inner ear development and its relationship with proneural genes and Notch signalling.
Her4-positive cells are GFAP-positive in the adult brain of zebrafish
Title: Her4-positive population in the tectum opticum is proliferating neural precursors in the adult zebrafish brain.
These observations suggest that Her4 and Notch play a role in peripheral outgrowth of sensory neurons.
Title: Her4 is necessary for establishing peripheral projections of the trigeminal ganglia in zebrafish.
her4 may be differently regulated in sensory cranial ganglia, where Notch activity is not essential for her4 expression and where Su(H) may repress her4 expression
Title: Fluorescent protein expression driven by her4 regulatory elements reveals the spatiotemporal pattern of Notch signaling in the nervous system of zebrafish embryos.
The following HER4.2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HER4.2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ODa04251 | |
Clone ID Related Accession (Same CDS sequence) | NM_131090.4 , NM_131090.3 | |
Accession Version | NM_131090.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-10-27 | |
Organism | Danio rerio(zebrafish) | |
Product | hairy-related 4.5 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CU062502.10. On May 18, 2017 this sequence version replaced NM_131090.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC097007.1, GW709900.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505374, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCTCCTA CAATCACTGG CTCAATCAGC AGCAGAGAAA CTCTACTGAC AAACAAGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_571165.3 |
CDS | 53..511 |
Translation |

Target ORF information:
Target ORF information:
|
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ORF Insert Sequence:
1 | ATGGCTCCTA CAATCACTGG CTCAATCAGC AGCAGAGAAA CTCTACTGAC AAACAAGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ODa04251 | |
Clone ID Related Accession (Same CDS sequence) | NM_131090.4 , NM_131090.3 | |
Accession Version | NM_131090.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2012-10-20 | |
Organism | Danio rerio(Zebrafish) | |
Product | hairy-related 4.2 | |
Comment | PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CU062502.10. On May 30, 2009 this sequence version replaced NM_131090.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. |
1 | ATGGCTCCTA CAATCACTGG CTCAATCAGC AGCAGAGAAA CTCTACTGAC AAACAAGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_571165.3 |
CDS | 51..509 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCTCCTA CAATCACTGG CTCAATCAGC AGCAGAGAAA CTCTACTGAC AAACAAGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
Rnf152 Is Essential for NeuroD Expression and Delta-Notch Signaling in the Zebrafish Embryos. |