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HER4.2 cDNA ORF clone, Danio rerio(Zebrafish)

Summary

Gene Symbol HER4.2
Entrez Gene ID 30301
Full Name hairy-related 4, tandem duplicate 2
Synonyms HER-4,her4,her4.1,si:ch73-21g5.3,wu:fq41c06,zgc:55218
General protein information
Preferred Names

hairy-related 4, tandem duplicate 2

Names

hairy-related 4.2
Hes5d
Hes5e
ch73-21g5.2
hairy-related 4, tandem duplicate 1
hairy-related 4.1
Gene Type protein-coding
Organism Danio rerio(Zebrafish)

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_131090.4 NP_571165.3 hairy-related 4.5
NM_131090.3 NP_571165.3 hairy-related 4.2

Pathways from BioSystems


Homologies


Danio rerio (zebrafish) LOC100149066 NP_001121862.1
Homo sapiens (human) HES5 NP_001010926.1
Mus musculus (house mouse) Hes5 NP_034549.1
Danio rerio (zebrafish) her4.2 NP_571165.3
Danio rerio (zebrafish) her4.3 NP_001154880.1
Xenopus tropicalis (tropical clawed frog) hes5 XP_004916212.1
Pan troglodytes (chimpanzee) HES5 XP_524847.2
Canis lupus familiaris (dog) HES5 XP_546734.2
Bos taurus (cattle) HES5 NP_001098937.1
Rattus norvegicus (Norway rat) Hes5 NP_077359.1
Gallus gallus (chicken) HES5 NP_001012713.1
Xenopus tropicalis (tropical clawed frog) hes5.1 NP_001037880.1
Danio rerio (zebrafish) LOC100149863 NP_001096598.1
Danio rerio (zebrafish) LOC100148329 NP_001154881.1

Gene Ontology


Bibliography

Related articles in PubMed

Rnf152 Is Essential for NeuroD Expression and Delta-Notch Signaling in the Zebrafish Embryos.
Kumar A, Huh TL, Choe J, Rhee M
Molecules and cells40(12)945-953(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

her4 is involved in a replenishing pathway that maintains populations of stem cells in the central retina, and that the magnitude of the her4-associated proliferative response mirrors the extent of retinal damage.
Title: Tracking the fate of her4 expressing cells in the regenerating retina using her4:Kaede zebrafish.

At later stages her4 expression becomes Notch-dependent in the future sensory domains but loss of her4 does not result in hair cell overproduction, suggesting that there other her genes can compensate its function.
Title: The role of her4 in inner ear development and its relationship with proneural genes and Notch signalling.

Her4-positive cells are GFAP-positive in the adult brain of zebrafish
Title: Her4-positive population in the tectum opticum is proliferating neural precursors in the adult zebrafish brain.

These observations suggest that Her4 and Notch play a role in peripheral outgrowth of sensory neurons.
Title: Her4 is necessary for establishing peripheral projections of the trigeminal ganglia in zebrafish.

her4 may be differently regulated in sensory cranial ganglia, where Notch activity is not essential for her4 expression and where Su(H) may repress her4 expression
Title: Fluorescent protein expression driven by her4 regulatory elements reveals the spatiotemporal pattern of Notch signaling in the nervous system of zebrafish embryos.

The following HER4.2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HER4.2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ODa04251 NM_131090.4
Latest version!		 Danio rerio hairy-related 4, tandem duplicate 5 (her4.5), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $104.30
$149.00
View Old Accession Versions >>
ODa04251 NM_131090.3 Danio rerio hairy-related 4.2 (her4.2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $104.30
$149.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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2-4 Clone 40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ODa04251
Clone ID Related Accession (Same CDS sequence) NM_131090.4 , NM_131090.3
Accession Version NM_131090.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 459bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2018-10-27
Organism Danio rerio(zebrafish)
Product hairy-related 4.5
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CU062502.10. On May 18, 2017 this sequence version replaced NM_131090.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC097007.1, GW709900.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505374, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END## 

1
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ATGGCTCCTA CAATCACTGG CTCAATCAGC AGCAGAGAAA CTCTACTGAC AAACAAGCTG 
AGAAAGCCCA TGGTGGAGAA GATCCGCCGA GAGCGAATCA ACAGCAGCAT CGAGAAGCTC 
AAGACTCTTC TGGCTCAAGA GTTCGTCAAG CAGCAGCCCG ACTCCAGACA GGAGAAAGCT 
GATATCCTGG AGATGACGCT TGATTTCTTG AGACGCTCTC AGAAAAGCAG TGCGGCTGGT 
GACGGACGCT CCAGATGTGT GCAGGAGGCC GTCAGCTTTC TGTCTCAGTG CCCAGTGCAG 
ACGCAGAGCC ACACAAGACT GATGAAGCTC TTCCTGCACA TGCAGACTCC TGCAGACCAG 
CACACACGTG TGGACAATCC TCAGACCACT GAAACACACG CAAACAGCAG CGCCAAACAA 
CACACTCCAG CCCACAGTCA CATCTGGAGA CCCTGGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_571165.3
CDS53..511
Translation

Target ORF information:

RefSeq Version NM_131090.4
Organism Danio rerio(zebrafish)
Definition Danio rerio hairy-related 4, tandem duplicate 5 (her4.5), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_131090.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGCTCCTA CAATCACTGG CTCAATCAGC AGCAGAGAAA CTCTACTGAC AAACAAGCTG 
AGAAAGCCCA TGGTGGAGAA GATCCGCCGA GAGCGAATCA ACAGCAGCAT CGAGAAGCTC 
AAGACTCTTC TGGCTCAAGA GTTCGTCAAG CAGCAGCCCG ACTCCAGACA GGAGAAAGCT 
GATATCCTGG AGATGACGCT TGATTTCTTG AGACGCTCTC AGAAAAGCAG TGCGGCTGGT 
GACGGACGCT CCAGATGTGT GCAGGAGGCC GTCAGCTTTC TGTCTCAGTG CCCAGTGCAG 
ACGCAGAGCC ACACAAGACT GATGAAGCTC TTCCTGCACA TGCAGACTCC TGCAGACCAG 
CACACACGTG TGGACAATCC TCAGACCACT GAAACACACG CAAACAGCAG CGCCAAACAA 
CACACTCCAG CCCACAGTCA CATCTGGAGA CCCTGGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ODa04251
Clone ID Related Accession (Same CDS sequence) NM_131090.4 , NM_131090.3
Accession Version NM_131090.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 459bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2012-10-20
Organism Danio rerio(Zebrafish)
Product hairy-related 4.2
Comment PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CU062502.10. On May 30, 2009 this sequence version replaced NM_131090.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. 

1
61
121
181
241
301
361
421
ATGGCTCCTA CAATCACTGG CTCAATCAGC AGCAGAGAAA CTCTACTGAC AAACAAGCTG 
AGAAAGCCCA TGGTGGAGAA GATCCGCCGA GAGCGAATCA ACAGCAGCAT CGAGAAGCTC 
AAGACTCTTC TGGCTCAAGA GTTCGTCAAG CAGCAGCCCG ACTCCAGACA GGAGAAAGCT 
GATATCCTGG AGATGACGCT TGATTTCTTG AGACGCTCTC AGAAAAGCAG TGCGGCTGGT 
GACGGACGCT CCAGATGTGT GCAGGAGGCC GTCAGCTTTC TGTCTCAGTG CCCAGTGCAG 
ACGCAGAGCC ACACAAGACT GATGAAGCTC TTCCTGCACA TGCAGACTCC TGCAGACCAG 
CACACACGTG TGGACAATCC TCAGACCACT GAAACACACG CAAACAGCAG CGCCAAACAA 
CACACTCCAG CCCACAGTCA CATCTGGAGA CCCTGGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_571165.3
CDS51..509
Translation

Target ORF information:

RefSeq Version NM_131090.3
Organism Danio rerio(Zebrafish)
Definition Danio rerio hairy-related 4.2 (her4.2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_131090.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGCTCCTA CAATCACTGG CTCAATCAGC AGCAGAGAAA CTCTACTGAC AAACAAGCTG 
AGAAAGCCCA TGGTGGAGAA GATCCGCCGA GAGCGAATCA ACAGCAGCAT CGAGAAGCTC 
AAGACTCTTC TGGCTCAAGA GTTCGTCAAG CAGCAGCCCG ACTCCAGACA GGAGAAAGCT 
GATATCCTGG AGATGACGCT TGATTTCTTG AGACGCTCTC AGAAAAGCAG TGCGGCTGGT 
GACGGACGCT CCAGATGTGT GCAGGAGGCC GTCAGCTTTC TGTCTCAGTG CCCAGTGCAG 
ACGCAGAGCC ACACAAGACT GATGAAGCTC TTCCTGCACA TGCAGACTCC TGCAGACCAG 
CACACACGTG TGGACAATCC TCAGACCACT GAAACACACG CAAACAGCAG CGCCAAACAA 
CACACTCCAG CCCACAGTCA CATCTGGAGA CCCTGGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Rnf152 Is Essential for NeuroD Expression and Delta-Notch Signaling in the Zebrafish Embryos.
Molecules and cells40(12)945-953(2017 Dec)
Kumar A,Huh TL,Choe J,Rhee M