Gene Symbol | fermt2 |
Entrez Gene ID | 553051 |
Full Name | fermitin family member 2 |
Synonyms | PLEKHC1,im:7145859 |
General protein information |
|
Gene Type | protein-coding |
Organism | Danio rerio(zebrafish) |
ORF » Species Summary » Danio rerio » fermt2 cDNA ORF clone
gRNAs
Gene Symbol | fermt2 |
Entrez Gene ID | 553051 |
Full Name | fermitin family member 2 |
Synonyms | PLEKHC1,im:7145859 |
General protein information |
|
Gene Type | protein-coding |
Organism | Danio rerio(zebrafish) |
mRNA | Protein | Name |
---|---|---|
XM_005158917.3 | XP_005158974.1 | fermitin family homolog 2 isoform X3 |
XM_005158916.3 | XP_005158973.1 | fermitin family homolog 2 isoform X2 |
XM_005158917.4 | XP_005158974.1 | fermitin family homolog 2 isoform X3 |
NM_001256215.1 | NP_001243144.1 | fermitin family homolog 2 |
XM_005158915.3 | XP_005158972.1 | fermitin family homolog 2 isoform X1 |
XM_005158915.4 | XP_005158972.1 | fermitin family homolog 2 isoform X1 |
XM_005158916.4 | XP_005158973.1 | fermitin family homolog 2 isoform X2 |
FERMT2 | XP_001082931.1 | |
Mus musculus (house mouse) | Fermt2 | NP_666166.2 |
Bos taurus (cattle) | FERMT2 | NP_001094734.1 |
Drosophila melanogaster (fruit fly) | Fit2 | NP_648947.1 |
Drosophila melanogaster (fruit fly) | Fit1 | NP_647858.2 |
Pan troglodytes (chimpanzee) | FERMT2 | XP_003314374.1 |
Gallus gallus (chicken) | PLEKHC1 | XP_004936582.1 |
Danio rerio (zebrafish) | fermt2 | NP_001243144.1 |
Canis lupus familiaris (dog) | FERMT2 | XP_547815.5 |
Rattus norvegicus (Norway rat) | Fermt2 | NP_001011915.1 |
Caenorhabditis elegans (roundworm) | unc-112 | NP_506628.1 |
Homo sapiens (human) | FERMT2 | NP_001128471.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP002054 | XP_320993.2 |
Xenopus tropicalis (tropical clawed frog) | fermt2 | XP_004917211.1 |
FERMT2 links cortical actin structures, plasma membrane tension and focal adhesion function to stabilize podocyte morphology.
Yasuda-Yamahara M, Rogg M, Frimmel J, Trachte P, Helmstaedter M, Schroder P, Schiffer M, Schell C, Huber TB
Matrix biology : journal of the International Society for Matrix Biology(2018 Jan)
Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)
RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)
Dynamics of zebrafish fin regeneration using a pulsed SILAC approach.
Nolte H, H?lper S, Housley MP, Islam S, Piller T, Konzer A, Stainier DY, Braun T, Kr?ger M
Proteomics15(4)739-51(2015 Feb)
C-terminal COOH of integrin ?1 is necessary for ?1 association with the kindlin-2 adapter protein.
Fitzpatrick P, Shattil SJ, Ablooglu AJ
The Journal of biological chemistry289(16)11183-93(2014 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Contrary to the C terminus of proteins that engage PDZ domains, the C-terminal three residues of beta1, per se, do not contribute to kindlin-2 binding or to laterality organ development.
Title: C-terminal COOH of integrin ?1 is necessary for ?1 association with the kindlin-2 adapter protein.
Developmental angiogenesis was markedly impaired by kindlin-2 morpholinos.
Title: The integrin coactivator kindlin-2 plays a critical role in angiogenesis in mice and zebrafish.
kindlin-2 (im:7145859) is an essential component of the intercalated disc, is necessary for cytoskeletal organization at sites of membrane attachment, and is required for vertebrate myocardial formation and function
Title: Kindlin-2 is an essential component of intercalated discs and is required for vertebrate cardiac structure and function.
The following fermt2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the fermt2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ODa02481 | |
Clone ID Related Accession (Same CDS sequence) | NM_001256215.1 | |
Accession Version | NM_001256215.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2055bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-12 | |
Organism | Danio rerio(zebrafish) | |
Product | fermitin family homolog 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL928709.36. On Jan 14, 2012 this sequence version replaced XM_680444.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA4476730, SAMEA4476732 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCGCTGG ACGGTATACG GATGCCCGAT GGCTGCTATG CAGACGGGAC CTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001243144.1 |
CDS | 210..2264 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGCTGG ACGGTATACG GATGCCCGAT GGCTGCTATG CAGACGGGAC CTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ODa22902 | |
Clone ID Related Accession (Same CDS sequence) | XM_005158915.3 , XM_005158915.4 | |
Accession Version | XM_005158915.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2088bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-23 | |
Organism | Danio rerio(Zebrafish) | |
Product | fermitin family homolog 2 isoform X1 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007128.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XM_005158915.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGCTGG ACGGTATACG GATGCCCGAT GGCTGCTATG CAGACGGGAC CTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005158972.1 |
CDS | 291..2378 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGCTGG ACGGTATACG GATGCCCGAT GGCTGCTATG CAGACGGGAC CTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ODa22902 | |
Clone ID Related Accession (Same CDS sequence) | XM_005158915.3 , XM_005158915.4 | |
Accession Version | XM_005158915.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2088bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-06-14 | |
Organism | Danio rerio(zebrafish) | |
Product | fermitin family homolog 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007128.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XM_005158915.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGCTGG ACGGTATACG GATGCCCGAT GGCTGCTATG CAGACGGGAC CTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005158972.1 |
CDS | 239..2326 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGCTGG ACGGTATACG GATGCCCGAT GGCTGCTATG CAGACGGGAC CTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ODa22903 | |
Clone ID Related Accession (Same CDS sequence) | XM_005158916.3 , XM_005158916.4 | |
Accession Version | XM_005158916.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2067bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-23 | |
Organism | Danio rerio(Zebrafish) | |
Product | fermitin family homolog 2 isoform X2 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007128.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XM_005158916.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGCTGG ACGGTATACG GATGCCCGAT GGCTGCTATG CAGACGGGAC CTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005158973.1 |
CDS | 291..2357 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGCTGG ACGGTATACG GATGCCCGAT GGCTGCTATG CAGACGGGAC CTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ODa22903 | |
Clone ID Related Accession (Same CDS sequence) | XM_005158916.3 , XM_005158916.4 | |
Accession Version | XM_005158916.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2067bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-06-14 | |
Organism | Danio rerio(zebrafish) | |
Product | fermitin family homolog 2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007128.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XM_005158916.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGCTGG ACGGTATACG GATGCCCGAT GGCTGCTATG CAGACGGGAC CTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005158973.1 |
CDS | 239..2305 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGCTGG ACGGTATACG GATGCCCGAT GGCTGCTATG CAGACGGGAC CTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ODa22904 | |
Clone ID Related Accession (Same CDS sequence) | XM_005158917.3 , XM_005158917.4 | |
Accession Version | XM_005158917.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2034bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-23 | |
Organism | Danio rerio(Zebrafish) | |
Product | fermitin family homolog 2 isoform X3 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007128.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XM_005158917.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGCTGG ACGGTATACG GATGCCCGAT GGCTGCTATG CAGACGGGAC CTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005158974.1 |
CDS | 291..2324 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGCTGG ACGGTATACG GATGCCCGAT GGCTGCTATG CAGACGGGAC CTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ODa22904 | |
Clone ID Related Accession (Same CDS sequence) | XM_005158917.3 , XM_005158917.4 | |
Accession Version | XM_005158917.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2034bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-06-14 | |
Organism | Danio rerio(zebrafish) | |
Product | fermitin family homolog 2 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007128.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XM_005158917.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGCTGG ACGGTATACG GATGCCCGAT GGCTGCTATG CAGACGGGAC CTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005158974.1 |
CDS | 238..2271 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGCTGG ACGGTATACG GATGCCCGAT GGCTGCTATG CAGACGGGAC CTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
FERMT2 links cortical actin structures, plasma membrane tension and focal adhesion function to stabilize podocyte morphology. |
Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. |
RFX transcription factors are essential for hearing in mice. |
Dynamics of zebrafish fin regeneration using a pulsed SILAC approach. |
C-terminal COOH of integrin ?1 is necessary for ?1 association with the kindlin-2 adapter protein. |