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arfgap2 cDNA ORF clone, Danio rerio(zebrafish)

Summary

Gene Symbol arfgap2
Entrez Gene ID 641490
Full Name ADP-ribosylation factor GTPase activating protein 2
Synonyms im:7148924,zgc:123303
General protein information
Preferred Names

ADP-ribosylation factor GTPase activating protein 2

Names

ADP-ribosylation factor GTPase-activating protein 2
Gene Type protein-coding
Organism Danio rerio(zebrafish)

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_005159248.3 XP_005159305.1 ADP-ribosylation factor GTPase-activating protein 2 isoform X1
NM_001037430.1 NP_001032507.1 ADP-ribosylation factor GTPase-activating protein 2

Pathways from BioSystems


Homologies


Pan troglodytes (chimpanzee) ARFGAP2 XP_001166418.1
ARFGAP2 XP_001110019.1
Danio rerio (zebrafish) arfgap2 NP_001032507.1
Gallus gallus (chicken) ARFGAP2 NP_001029043.2
Xenopus tropicalis (tropical clawed frog) arfgap2 NP_001015850.1
Homo sapiens (human) ARFGAP2 NP_115765.2
Canis lupus familiaris (dog) ARFGAP2 XP_005631327.1
Rattus norvegicus (Norway rat) Arfgap2 NP_001028879.1
Drosophila melanogaster (fruit fly) ArfGAP3 NP_001097663.1
Anopheles gambiae (African malaria mosquito) AgaP_AGAP005609 XP_315621.4
Arabidopsis thaliana (thale cress) RPA NP_565801.1
Mus musculus (house mouse) Arfgap2 NP_076343.2
Caenorhabditis elegans (roundworm) F07F6.4 NP_495029.2
Bos taurus (cattle) ARFGAP2 NP_001073696.1

Gene Ontology


Bibliography

Related articles in PubMed

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following arfgap2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the arfgap2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ODa34117 NM_001037430.1
Latest version!		 Danio rerio ADP-ribosylation factor GTPase activating protein 2 (arfgap2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $342.30
$489.00
ODa23554 XM_005159248.3
Latest version!		 Danio rerio ADP-ribosylation factor GTPase activating protein 2 (arfgap2), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $342.30
$489.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone 40% OFF
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All Other ORF Clones
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ODa34117
Clone ID Related Accession (Same CDS sequence) NM_001037430.1
Accession Version NM_001037430.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1611bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2018-11-23
Organism Danio rerio(zebrafish)
Product ADP-ribosylation factor GTPase-activating protein 2
Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC108014.1. ##Evidence-Data-START## Transcript exon combination :: BC108014.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2168446, SAMEA2168447 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCGTCGG AACCGAACAA GACAGAAATT CACACCATTT TTAAACGTTT GCGCTCCATA 
CCAACTAACA AGGCCTGTTT TGACTGTGCG GCTAAGAACC CGAGCTGGGC CAGTATTTCA 
TATGGAGTAT TTCTGTGCAT CGACTGCTCT GGAATACATC GCTCTTTGGG AGTGCACTTG 
AGCTTTATCA GATCCACAGA ACTGGATTCC AACTGGAACT GGTTTCAGCT GAGATGCATG 
CAGGTTGGAG GAAACGCCAA TGCGATGGGT TTTTTCCGCC AGCATGGCTG TACCACCAAT 
GACACTAATG CGAAGTATAA CAGTCGTGCG GCTCAGATGT ACAGAGAGAA GATTCGACAG 
CTTGCCAACG CTGCCCTCTC TAAGTATGGC ACCGATCTGT GGATTGACAG CTCCAGCTGT 
GCTCAACCAT CACCTGTAGA GAAGAGAGAG ACTGACTTCT TTGACGAGCA CACACAGCCT 
GCCATCAGTT GGGACATGGC GTCCCCTTCC CTAACAGATC AGAATGGAGC TGAAAATGTT 
AATCCTCAGC TAGCACAGAG CAATCCTAAG AATTCAGAAA CTACCAACAC CCAGCCTGAA 
GAGGGTCCAA GCATTGAAGG ACTGAGCACA AGTCCTAAAG CCACAATAGA CGTCAAACCT 
TCCATCATTG GAAAGAAGAA GCCAGTAGCT GCAAAGAAAG GGCTTGGCGC TAAAAAGGGT 
CTTGGTGCCC AGAAGGTGAG CAGCAAGAGT TTCAATGAGG TGGAAAAACA AGCCCAGGTG 
GCAGAGAAAA TGAGAGAGGA GCAGGCCGCC GAAGCCAAGA AACAAGCCGA CGAGTCCATA 
GTGGCCTCAA TGCGACTGGC CTACAAAGAG CTGGAGATCG ACCGCAAGAT GGAGGAGAAG 
AAAATGCAGA ATCTGGAGGG GAAGAAGAAG GAGCAGGCGG AGAGGCTGGG CATGGGATTC 
GGCAACAGGA GTGCCGTGTC TCATTCGGTG ATGGCCGAGA TGCTGGTGAT CGAGCAGGAG 
ACCCCGGTGG GAGTCAAATC CTCCTCTCGC TCTAAGCTGG ATATGTTTGA GGAGCCTGGA 
TTTGCTTCCG GACCACCAAA GTACAAGGAC AACCCTTTCA CATCAGGAGA CAGCTTTGGG 
TCACGGTGGG ACAATGATGG CGGGTCGTCG TTCTCCTCCT GGGCTCTGGA GAAGGAGGAG 
CCTAAAGACA GCGAGGTCAC CATCTCAAGC ATCCAGCCAA TCGGAGAAAG GTTGCCCAGC 
AGACGGAAGC CGGAGGTTTC TGTGCCAGTC TCAGAGTCTA GCGAAGCGCG CCAGAAGTTT 
GCGAATGCTA AAGCCATCTC ATCAGACATG TTCTTCGGCC GTGAGAGCAA CCCAGAGTAT 
GAAGCAAAGA CTCGTCTGGA GGGTATGTCT GGAAGCACCT CCATCAGTTC TGCTGACCTG 
TTCGGTGATG GCAGTGTTCG TCCCTCTGGC TCAACAGGGT TTGACAGCGT CCTTCCCTCT 
GGTCCAGACA TCGCTCAGTT CAAGCAGGGT GTGAAGACCG TAGCAGGGAA GATGGCAGTG 
CTGGCTAATG GGGTCATGAA CACCATTCAG GATCGCTATG GATCATACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001032507.1
CDS24..1634
Translation

Target ORF information:

RefSeq Version NM_001037430.1
Organism Danio rerio(zebrafish)
Definition Danio rerio ADP-ribosylation factor GTPase activating protein 2 (arfgap2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001037430.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCGTCGG AACCGAACAA GACAGAAATT CACACCATTT TTAAACGTTT GCGCTCCATA 
CCAACTAACA AGGCCTGTTT TGACTGTGCG GCTAAGAACC CGAGCTGGGC CAGTATTTCA 
TATGGAGTAT TTCTGTGCAT CGACTGCTCT GGAATACATC GCTCTTTGGG AGTGCACTTG 
AGCTTTATCA GATCCACAGA ACTGGATTCC AACTGGAACT GGTTTCAGCT GAGATGCATG 
CAGGTTGGAG GAAACGCCAA TGCGATGGGT TTTTTCCGCC AGCATGGCTG TACCACCAAT 
GACACTAATG CGAAGTATAA CAGTCGTGCG GCTCAGATGT ACAGAGAGAA GATTCGACAG 
CTTGCCAACG CTGCCCTCTC TAAGTATGGC ACCGATCTGT GGATTGACAG CTCCAGCTGT 
GCTCAACCAT CACCTGTAGA GAAGAGAGAG ACTGACTTCT TTGACGAGCA CACACAGCCT 
GCCATCAGTT GGGACATGGC GTCCCCTTCC CTAACAGATC AGAATGGAGC TGAAAATGTT 
AATCCTCAGC TAGCACAGAG CAATCCTAAG AATTCAGAAA CTACCAACAC CCAGCCTGAA 
GAGGGTCCAA GCATTGAAGG ACTGAGCACA AGTCCTAAAG CCACAATAGA CGTCAAACCT 
TCCATCATTG GAAAGAAGAA GCCAGTAGCT GCAAAGAAAG GGCTTGGCGC TAAAAAGGGT 
CTTGGTGCCC AGAAGGTGAG CAGCAAGAGT TTCAATGAGG TGGAAAAACA AGCCCAGGTG 
GCAGAGAAAA TGAGAGAGGA GCAGGCCGCC GAAGCCAAGA AACAAGCCGA CGAGTCCATA 
GTGGCCTCAA TGCGACTGGC CTACAAAGAG CTGGAGATCG ACCGCAAGAT GGAGGAGAAG 
AAAATGCAGA ATCTGGAGGG GAAGAAGAAG GAGCAGGCGG AGAGGCTGGG CATGGGATTC 
GGCAACAGGA GTGCCGTGTC TCATTCGGTG ATGGCCGAGA TGCTGGTGAT CGAGCAGGAG 
ACCCCGGTGG GAGTCAAATC CTCCTCTCGC TCTAAGCTGG ATATGTTTGA GGAGCCTGGA 
TTTGCTTCCG GACCACCAAA GTACAAGGAC AACCCTTTCA CATCAGGAGA CAGCTTTGGG 
TCACGGTGGG ACAATGATGG CGGGTCGTCG TTCTCCTCCT GGGCTCTGGA GAAGGAGGAG 
CCTAAAGACA GCGAGGTCAC CATCTCAAGC ATCCAGCCAA TCGGAGAAAG GTTGCCCAGC 
AGACGGAAGC CGGAGGTTTC TGTGCCAGTC TCAGAGTCTA GCGAAGCGCG CCAGAAGTTT 
GCGAATGCTA AAGCCATCTC ATCAGACATG TTCTTCGGCC GTGAGAGCAA CCCAGAGTAT 
GAAGCAAAGA CTCGTCTGGA GGGTATGTCT GGAAGCACCT CCATCAGTTC TGCTGACCTG 
TTCGGTGATG GCAGTGTTCG TCCCTCTGGC TCAACAGGGT TTGACAGCGT CCTTCCCTCT 
GGTCCAGACA TCGCTCAGTT CAAGCAGGGT GTGAAGACCG TAGCAGGGAA GATGGCAGTG 
CTGGCTAATG GGGTCATGAA CACCATTCAG GATCGCTATG GATCATACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ODa23554
Clone ID Related Accession (Same CDS sequence) XM_005159248.3
Accession Version XM_005159248.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1656bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-06-14
Organism Danio rerio(zebrafish)
Product ADP-ribosylation factor GTPase-activating protein 2 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007129.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XM_005159248.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGGCGTCGG AACCGAACAA GACAGAAATT CACACCATTT TTAAACGTTT GCGCTCCATA 
CCAACTAACA AGGCCTGTTT TGACTGTGCG GCTAAGAACC CGAGCTGGGC CAGTATTTCA 
TATGGAGTAT TTCTGTGCAT CGACTGCTCT GGAATACATC GCTCTTTGGG AGTGCACTTG 
AGCTTTATCA GATCCACAGA ACTGGATTCC AACTGGAACT GGTTTCAGCT GAGATGCATG 
CAGGTTGGAG GAAACGCCAA TGCGATGGGT TTTTTCCGCC AGCATGGCTG TACCACCAAT 
GACACTAATG CGAAGTATAA CAGTCGTGCG GCTCAGATGT ACAGAGAGAA GATTCGACAG 
CTTGCCAACG CTGCCCTCTC TAAGTATGGC ACCGATCTGT GGATTGACAG CTCCAGCTGT 
GCTCAACCAT CACCTGTTGA GAAGAGAGAG ACTGACTTCT TTGACGAGCA CACACAGCCT 
GCCATCAGTT GGGACATGGC GTCCCCTTCA CTAACAGATC AGAATGGAGC TGAAAATGTT 
AATCCTCAGC TAGCACAGAG CAATCCTAAG AATTCAGAAA CTCCCAACAC CCAGCCTGAA 
GAGGGTCCAA GCATTGAAGG ACTGAGCACA AGTCCTAAAG CCACGATAGA GGACTCCATG 
AGACTGACTT CTGAGGAGCC TCAGTCTCCT AAAGACGTCA AACCTTCCAT CATTGGAAAG 
AAGAAGCCAG TAGCTGCAAA GAAAGGGCTT GGCGCTAAAA AGGGTCTTGG TGCCCAGAAG 
GTGAGCAGCA AGAGTTTCAG TGAGGTGGAA AAACAAGCCC AGGTGGCAGA GAAAATGAGA 
GAGGAGCAGG CCGCCGAAGC CAAGAAACAA GCCGACGAGT CCATAGTGGC CTCAATGCGA 
CTGGCCTACA AAGAGCTGGA GATCGACCGC AAGATGGAGG AGAAGAAAAT GCAGAATCTG 
GAGGGGAAGA AGAAGGAGCA GGCGGAGAGG CTGGGCATGG GATTCGGCAA CAGGAGTGCC 
GTGTCTCATT CGGTGATGGC CGAGATGCAG GTGATCGAGC AGGAGACCCC GGTGGGAGTC 
AAATCCTCCT CTCGCTCTAA GCTGGATATG TTTGAGGAGC CTGGATTTGC TTCCGGACCA 
CCAAAGTACA AGGACAACCC TTTCACATCA GGAGACAGCT TTGGGTCACG GTGGGACAAT 
GATGGCGGGT CGTCGTTCTC CTCCTGGGCT CTGGAGAAGG AGGAGCCTAA AGACAGCGAG 
GTCACCATCT CAAGCATCCA GCCAATCGGA GAAAGGTTGC CCAGCAGACG GAAGCCGGAG 
GTTTCTGTGC CGGTCTCAGA GTCTAGCGAA GCGCGCCAGA AGTTTGCGAA TGCTAAAGCC 
ATCTCATCAG ACATGTTCTT CGGCCGTGAG AGCAACCCAG AGTATGAAGC AAAGACTCGT 
CTGGAGGGTA TGTCTGGAAG CACCTCCATC AGTTCTGCTG ACCTGTTCGG TGATGGCAGT 
GTTCGTCCCT CTGGCTCAAC AGGGTTTGAC AGCGTCCTTC CCTCTGGTCC AGACATCGCT 
CAGTTCAAGC AGGGTGTGAA GACCGTAGCA GGGAAGATGG CAGTGCTGGC TAATGGGGTC 
ATGAACACCA TTCAGGATCG CTATGGATCA TACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005159305.1
CDS54..1709
Translation

Target ORF information:

RefSeq Version XM_005159248.3
Organism Danio rerio(zebrafish)
Definition Danio rerio ADP-ribosylation factor GTPase activating protein 2 (arfgap2), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_005159248.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGGCGTCGG AACCGAACAA GACAGAAATT CACACCATTT TTAAACGTTT GCGCTCCATA 
CCAACTAACA AGGCCTGTTT TGACTGTGCG GCTAAGAACC CGAGCTGGGC CAGTATTTCA 
TATGGAGTAT TTCTGTGCAT CGACTGCTCT GGAATACATC GCTCTTTGGG AGTGCACTTG 
AGCTTTATCA GATCCACAGA ACTGGATTCC AACTGGAACT GGTTTCAGCT GAGATGCATG 
CAGGTTGGAG GAAACGCCAA TGCGATGGGT TTTTTCCGCC AGCATGGCTG TACCACCAAT 
GACACTAATG CGAAGTATAA CAGTCGTGCG GCTCAGATGT ACAGAGAGAA GATTCGACAG 
CTTGCCAACG CTGCCCTCTC TAAGTATGGC ACCGATCTGT GGATTGACAG CTCCAGCTGT 
GCTCAACCAT CACCTGTTGA GAAGAGAGAG ACTGACTTCT TTGACGAGCA CACACAGCCT 
GCCATCAGTT GGGACATGGC GTCCCCTTCA CTAACAGATC AGAATGGAGC TGAAAATGTT 
AATCCTCAGC TAGCACAGAG CAATCCTAAG AATTCAGAAA CTCCCAACAC CCAGCCTGAA 
GAGGGTCCAA GCATTGAAGG ACTGAGCACA AGTCCTAAAG CCACGATAGA GGACTCCATG 
AGACTGACTT CTGAGGAGCC TCAGTCTCCT AAAGACGTCA AACCTTCCAT CATTGGAAAG 
AAGAAGCCAG TAGCTGCAAA GAAAGGGCTT GGCGCTAAAA AGGGTCTTGG TGCCCAGAAG 
GTGAGCAGCA AGAGTTTCAG TGAGGTGGAA AAACAAGCCC AGGTGGCAGA GAAAATGAGA 
GAGGAGCAGG CCGCCGAAGC CAAGAAACAA GCCGACGAGT CCATAGTGGC CTCAATGCGA 
CTGGCCTACA AAGAGCTGGA GATCGACCGC AAGATGGAGG AGAAGAAAAT GCAGAATCTG 
GAGGGGAAGA AGAAGGAGCA GGCGGAGAGG CTGGGCATGG GATTCGGCAA CAGGAGTGCC 
GTGTCTCATT CGGTGATGGC CGAGATGCAG GTGATCGAGC AGGAGACCCC GGTGGGAGTC 
AAATCCTCCT CTCGCTCTAA GCTGGATATG TTTGAGGAGC CTGGATTTGC TTCCGGACCA 
CCAAAGTACA AGGACAACCC TTTCACATCA GGAGACAGCT TTGGGTCACG GTGGGACAAT 
GATGGCGGGT CGTCGTTCTC CTCCTGGGCT CTGGAGAAGG AGGAGCCTAA AGACAGCGAG 
GTCACCATCT CAAGCATCCA GCCAATCGGA GAAAGGTTGC CCAGCAGACG GAAGCCGGAG 
GTTTCTGTGC CGGTCTCAGA GTCTAGCGAA GCGCGCCAGA AGTTTGCGAA TGCTAAAGCC 
ATCTCATCAG ACATGTTCTT CGGCCGTGAG AGCAACCCAG AGTATGAAGC AAAGACTCGT 
CTGGAGGGTA TGTCTGGAAG CACCTCCATC AGTTCTGCTG ACCTGTTCGG TGATGGCAGT 
GTTCGTCCCT CTGGCTCAAC AGGGTTTGAC AGCGTCCTTC CCTCTGGTCC AGACATCGCT 
CAGTTCAAGC AGGGTGTGAA GACCGTAGCA GGGAAGATGG CAGTGCTGGC TAATGGGGTC 
ATGAACACCA TTCAGGATCG CTATGGATCA TACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J


book

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R